King's College London

Research portal

Dr Nick Powell

  1. Five-year review of corticosteroid duration and complications in the management of immune checkpoint inhibitor-related diarrhoea and colitis in advanced melanoma

    Favara, D. M., Spain, L., Au, L., Clark, J., Daniels, E., DIem, S., Chauhan, D., Turajlic, S., Powell, N., Larkin, J. M. & Yousaf, N., 8 Jul 2020, In: ESMO Open. 5, 4, 000585.

    Research output: Contribution to journalArticlepeer-review

  2. Adaptation of the British Society of Gastroenterology guidelines on the management of acute severe ulcerative colitis in the context of the COVID-19 pandemic: a RAND appropriateness panel

    Din, S., Kent, A., Pollok, R. C., Meade, S., Kennedy, N. A., Arnott, I., Beattie, M. R., Chua, F., Cooney, R., Dart, R., Galloway, J., Gaya, D. R., Ghosh, S., Griffiths, M., Hancock, L., Hansen, R., Hart, A., Lamb, C. A., Lees, C. W., Limdi, J. K. & 14 others, Lindsay, J. O., Murray, C., Patel, K., Powell, N., Probert, C., Raine, T., Selinger, C., Sebastian, S., Smith, P. J., Tozer, P. J., Ustianowski, A., Younge, L., Samaan, M. A. & Irving, P., 8 Jun 2020, In: Gut.

    Research output: Contribution to journalArticlepeer-review

  3. Immune checkpoint inhibitor therapy in patients with preexisting inflammatory bowel disease

    Abu-Sbeih, H., Faleck, D. M., Ricciuti, B., Mendelsohn, R. B., Naqash, A. R., Cohen, J. V., Sellers, M. C., Balaji, A., Ben-Betzalel, G., Hajir, I., Zhang, J., Awad, M. M., Leonardi, G. C., Johnson, D. B., Pinato, D. J., Owen, D. H., Weiss, S. A., Lamberti, G., Lythgoe, M. P., Manuzzi, L. & 9 others, Arnold, C., Qiao, W., Naidoo, J., Markel, G., Powell, N., Yeung, S. C. J., Sharon, E., Dougan, M. & Wang, Y., 20 Feb 2020, In: Journal of Clinical Oncology. 38, 6, p. 576-583 8 p.

    Research output: Contribution to journalArticlepeer-review

  4. Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

    Powell, N., Pantazi, E., Pavlidis, P., Tsakmaki, A., Li, K., Yang, F., Parker, A., Pin, C., Cozzetto, D., Minns, D., Stolarczyk, E., Saveljeva, S., Mohamed, R., Lavender, P., Afzali, B., Digby-Bell, J., Tjir-Li, T., Kaser, A., Friedman, J., MacDonald, T. T. & 2 others, Bewick, G. A. & Lord, G. M., 7 Feb 2020, In: Gut. 69, 3, p. 578-590 13 p.

    Research output: Contribution to journalReview articlepeer-review

  5. Effectiveness and safety of vedolizumab in inflammatory bowel disease patients aged 60 and over: An observational multicenter uk experience

    Ibraheim, H., Samaan, M. A., Srinivasan, A., Brain, O., Digby-Bell, J., Irving, P. M., Norman, I., Jawad, I., Biedermann, J., Ibarra, A., Kok, K. B., Parkes, G., Rimmer, J., Compot, E., Parkes, M., Segal, J., Oppong, P., Hart, A., Hayee, BH. & Powell, N., 1 Jan 2020, In: Annals of Gastroenterology. 33, 2, p. 170-177 8 p.

    Research output: Contribution to journalArticlepeer-review

  6. Interrogating host immunity to predict treatment response in inflammatory bowel disease

    Digby-Bell, J. L., Atreya, R., Monteleone, G. & Powell, N., 1 Jan 2020, In: Nature Reviews Gastroenterology and Hepatology. 17, 1, p. 9-20 12 p.

    Research output: Contribution to journalReview articlepeer-review

  7. Science in Focus: The Microbiome and Cancer Therapy

    Alexander, J. L., Kohoutova, D. & Powell, N., 1 Jan 2019, In: Clinical Oncology. 31, 1, p. 1-4 4 p.

    Research output: Contribution to journalEditorialpeer-review

  8. Interleukin 22 orchestrates a pathological endoplasmic reticulum stress response transcriptional program in colonic epithelial cells

    Powell, N., 2019, (Accepted/In press) In: Gut.

    Research output: Contribution to journalArticlepeer-review

  9. Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

    Povoleri, G. A. M., Nova-Lamperti, E., Scottà, C., Fanelli, G., Chen, Y-C., Becker, P. D., Boardman, D., Costantini, B., Romano, M., Pavlidis, P., McGregor, R., Pantazi, E., Chauss, D., Sun, H-W., Shih, H-Y., Cousins, D. J., Cooper, N., Powell, N., Kemper, C., Pirooznia, M. & 5 others, Laurence, A., Kordasti, S., Kazemian, M., Lombardi, G. & Afzali, B., 1 Dec 2018, In: Nature Immunology. 19, 12, p. 1403–1414

    Research output: Contribution to journalArticlepeer-review

  10. Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management

    Samaan, M. A., Pavlidis, P., Papa, S., Powell, N. & Irving, P. M., 7 Mar 2018, (E-pub ahead of print) In: Nature reviews. Gastroenterology & hepatology.

    Research output: Contribution to journalReview articlepeer-review

  11. Advances in mesenchymal stromal cell therapy in the management of Crohn’s disease

    Ibraheim, H., Giacomini, C., Kassam, Z., Dazzi, F. & Powell, N., 1 Feb 2018, In: Expert Review of Gastroenterology and Hepatology. 12, 2, p. 141-153 13 p.

    Research output: Contribution to journalReview articlepeer-review

  12. An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

    Halim, L., Romano, M., McGregor, R., Correa, I., Pavlidis, P., Grageda, N., Hoong, S-J., Yuksel, M., Jassem, W., Hannen, R. F., Ong, M., Mckinney, O., Hayee, BH., Karagiannis, S. N., Powell, N., Lechler, R. I., Nova-Lamperti, E. & Lombardi, G., 18 Jul 2017, In: Cell Reports. 20, 3, p. 757-770 14 p.

    Research output: Contribution to journalArticlepeer-review

  13. Recent advances in gut immunology

    Powell, N. & MacDonald, T. T., 1 Jun 2017, In: Parasite Immunology. 39, 6, e12430.

    Research output: Contribution to journalReview articlepeer-review

  14. The mucosal immune system: Master regulator of bidirectional gut-brain communications

    Powell, N., Walker, M. M. & Talley, N. J., 1 Mar 2017, In: Nature Reviews Gastroenterology & Hepatology. 14, 3, p. 143-159 17 p.

    Research output: Contribution to journalReview articlepeer-review

  15. Vedolizumab: toward a personalized therapy paradigm for people with ulcerative colitis

    Dart, R. J., Samaan, M. A., Powell, N. & Irving, P. M., 2017, In: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 10, p. 57-66 10 p.

    Research output: Contribution to journalReview articlepeer-review

  16. Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

    Canavan, J. B., Scottà, C., Vossenkämper, A., Goldberg, R., Elder, M. J., Shoval, I., Marks, E., Stolarczyk, E., Lo, J. W., Powell, N., Fazekasova, H., Irving, P. M., Sanderson, J. D., Howard, J. K., Yagel, S., Afzali, B., MacDonald, T. T., Hernandez-Fuentes, M. P., Shpigel, N. Y., Lombardi, G. & 1 others, Lord, G. M., 9 Mar 2016, In: Gut. 65, 4, p. 584-594 11 p.

    Research output: Contribution to journalArticlepeer-review

  17. Interleukin 6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation

    Powell, N., Lo, J. W., Biancheri, P., Vossenkämper, A., Pantazi, E., Walker, A. W., Stolarczyk, E., Ammoscato, F., Goldberg, R., Scott, P., Canavan, J. B., Perucha, E., Garrido-Mesa, N., Irving, P. M., Sanderson, J. D., Hayee, B., Howard, J. K., Parkhill, J., MacDonald, T. T. & Lord, G. M., 1 Aug 2015, In: Gastroenterology. 149, 2, p. 456-467.e15

    Research output: Contribution to journalArticlepeer-review

  18. The unusual suspects-innate lymphoid cells as novel therapeutic targets in IBD

    Goldberg, R., Prescott, N., Lord, G. M., MacDonald, T. T. & Powell, N., 5 May 2015, In: Nature reviews. Gastroenterology & hepatology. 12, 5, p. 271-283 13 p.

    Research output: Contribution to journalArticlepeer-review

  19. Atopy and the gastrointestinal tract--a review of a common association in unexplained gastrointestinal disease

    Walker, M. M., Powell, N. & Talley, N. J., Mar 2014, In: Expert review of gastroenterology & hepatology. 8, 3, p. 289-99 11 p.

    Research output: Contribution to journalReview articlepeer-review

  20. The challenges of stratifying patients for trials in inflammatory bowel disease

    Biancheri, P., Powell, N., Monteleone, G., Lord, G. & MacDonald, T. T., Nov 2013, In: TRENDS IN IMMUNOLOGY. 34, 11, p. 564-571 8 p.

    Research output: Contribution to journalArticlepeer-review

  21. 2013 Digestive Disease Week. AGA-Horizon Pharma Fellow Abstract Prize

    Canavan, J., Shoval, I., Elder, M., Fazekasova, H., Powell, N., Afzali, B., Stolarczyk, E., Marks, E., Lo, J., Scotta, C., Irving, P., Sanderson, J., Yagel, S., MacDonald, T., Hernandez Fuentes, M., Lombardi, G., Shpigel, N. & Lord, G., May 2013, 2013 Digestive Disease Week. .

    Research output: Chapter in Book/Report/Conference proceedingMeeting abstract

  22. Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet

    Stolarczyk, E., Vong, C. T., Perucha, E., Jackson, I., Cawthorne, M. A., Wargent, E. T., Powell, N., Canavan, J. B., Lord, G. M. & Howard, J. K., 2 Apr 2013, In: CELL METABOLISM. 17, 4, p. 520-533 14 p.

    Research output: Contribution to journalArticlepeer-review

  23. Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4

    Gökmen, M. R., Dong, R., Kanhere, A., Powell, N., Perucha, E., Jackson, I., Howard, J. K., Hernandez-Fuentes, M., Jenner, R. G. & Lord, G. M., 2013, In: Journal of Immunology. 191, 12, p. 5925-5932 8 p.

    Research output: Contribution to journalArticlepeer-review

  24. The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor(+) Innate Lymphoid Cells

    Powell, N., Walker, A. W., Stolarczyk, E., Canavan, J. B., Goekmen, M. R., Marks, E., Jackson, I., Hashim, A., Curtis, M. A., Jenner, R. G., Howard, J. K., Parkhill, J., MacDonald, T. T. & Lord, G. M., 19 Oct 2012, In: Immunity. 37, 4, p. 674-684 11 p.

    Research output: Contribution to journalArticlepeer-review

  25. Enhanced insulin sensitivity despite increased adiposity in mice lacking the Th1 cell transcription factor T-bet

    Stolarczyk, E., Vong, C. T., Perucha, E., Powell, N., Canavan, J. B., Lord, G. M. & Howard, J. K., Dec 2011, In: Immunology. 135, p. 35-35 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  26. Monocytes control natural killer cell differentiation to effector phenotypes

    Soderquest, K., Powell, N., Luci, C., van Rooijen, N., Hidalgo, A., Geissmann, F., Walzer, T., Lord, G. M. & Martin-Fontecha, A., 28 Apr 2011, In: Blood. 117, 17, p. 4511 - 4518 8 p.

    Research output: Contribution to journalArticlepeer-review

  27. Transcriptional regulation of the mucosal immune system mediated by T-bet

    Powell, N., Canavan, J. B., MacDonald, T. T. & Lord, G. M., Nov 2010, In: Mucosal Immunology. 3, 6, p. 567 - 577 11 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  28. Gastrointestinal eosinophils in health, disease and functional disorders

    Powell, N., Walker, M. M. & Talley, N. J., Mar 2010, In: Nature Reviews Gastroenterology & Hepatology. 7, 3, p. 146 - 156 11 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  29. Helicobacter pylori induces in vivo expansion of human regulatory T cells through stimulating IL-1 beta-production by dendritic cells

    Mitchell, P. J., Afzali, B., Fraser, H., Daxin, C., Powell, N., Ali, N., Lechler, R. I. & Lombardi, G., 2010, In: Immunology. 131, p. 178 - 178 1 p.

    Research output: Contribution to journalMeeting abstract

  30. T-bet deficiency in the innate immune compartment exacerbates T-cell mediated intestinal inflammation

    Powell, N., Canavan, J. B., Stolarcyzk, E., MacDonald, T. T. & Lord, G. M., 2010, In: Immunology. 131, p. 175 - 175 1 p.

    Research output: Contribution to journalMeeting abstract

  31. Increased prevalence of gastrointestinal symptoms in patients with allergic disease

    Powell, N., Huntley, B., Beech, T., Knight, W., Knight, H. & Corrigan, C. J., Mar 2007, In: Postgraduate Medical Journal. 83, 977, p. 182-186 5 p.

    Research output: Contribution to journalArticlepeer-review

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