Search results

• Active

  Cardiac structure and function in people with first episode psychosis

  Howes, O. (Primary Investigator) & Pillinger, T. (Co-Investigator)

  Academy of Medical Sciences

  6/06/2024 → 5/05/2026

  Project: Research

• PUMA: Early Psychosis Multi-arm Multi-stage Platform Trial (PUMA)

  Emsley, R. (Primary Investigator) & Howes, O. (Co-Investigator)

  Wellcome Trust

  1/04/2024 → 30/09/2026

  Project: Research

• The mechanisms underlying the antidepressant effects of physical activity

  Howes, O. (Primary Investigator)

  Wellcome Trust

  4/09/2023 → 3/09/2028

  Project: Research

• Immune mechanisms of antipsychotic treatment response

  Pollak, T. (Primary Investigator) & Howes, O. (Co-Investigator)

  Wellcome Trust

  1/08/2023 → 31/07/2031

  Project: Research

• PET imaging synapses in psychotic disorders

  Howes, O. (Primary Investigator)

  PSYCHIATRY RESEARCH TRUST

  1/06/2023 → 30/03/2026

  Project: Research

• Psych-STRATA: Psych-STRATA - A Stratified Treatment Algorithm in Psychiatry: A programme on stratified pharmacogenomics in severe mental illness

  Howes, O. (Primary Investigator), Cleare, A. (Co-Investigator), Juruena, M. (Co-Investigator), Strawbridge, B. (Co-Investigator) & Young, A. (Co-Investigator)

  TSB Technology Strategy Board

  1/10/2022 → 30/09/2027

  Project: Research

• The role of glutamatergic function in the pathophysiology of treatment resistant schizophrenia and the potential of novel treatment targeting it

  Howes, O. (Primary Investigator), Emsley, R. (Co-Investigator) & Lythgoe, D. (Co-Investigator)

  MRC Medical Research Council

  1/01/2022 → 31/12/2025

  Project: Research

• Psychiatric Imaging Programme Transition

  Howes, O. (Primary Investigator) & academic, A. (Co-Investigator)

  MRC Medical Research Council

  1/12/2021 → 30/11/2026

  Project: Research

• CLEAR: (CLozapine in EARly psychosis) A Multi-Centre, Randomised Controlled trial of Clozapine for Young People with Treatment Resistant Psychosis in Real World Settings

  Maccabe, J. (Primary Investigator), Byford, S. (Co-Investigator), Emsley, R. (Co-Investigator), Howes, O. (Co-Investigator) & academic, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2021 → 28/02/2027

  Project: Research

• Finished

  fellowship t: Therapeutic potential of TAAR1 agonists to address positive, negative, and cognitive symptoms of schizophrenia

  Howes, O. (Primary Investigator)

  Guarantors of Brain

  1/09/2023 → 31/08/2024

  Project: Research

• NARSAD Molecular mechanisms underlying increased striatal DSC in schizophrenia

  Rogdaki, M. (Primary Investigator), Howes, O. (Co-Investigator) & Srivastava, D. (Co-Investigator)

  Brain and Behavior Research Foundation

  1/01/2022 → 31/12/2023

  Project: Research

• Maria Rogdaki Academy of Medical Sciences

  Rogdaki, M. (Primary Investigator), Howes, O. (Co-Investigator), Srivastava, D. (Co-Investigator) & Vernon, A. (Co-Investigator)

  Academy of Medical Sciences

  2/09/2021 → 2/09/2024

  Project: Research

• Targeting glutamatergic function in treatment-resistant schizophrenia [KHP] Howes

  Howes, O. (Primary Investigator), Emsley, R. (Co-Investigator) & Lythgoe, D. (Co-Investigator)

  KHP R&D challenge fund

  1/10/2020 → 30/09/2021

  Project: Research

• ATLANTIS: AnTiconvuLsant AugmeNtation Trial In Schizophrenia

  Howes, O. (Primary Investigator), Romeo, R. (Co-Investigator) & Emsley, R. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/03/2020 → 31/08/2024

  Project: Research

• Automated Analysis Framework for FDOPA PET Imaging as a Biomarker for Treatment Stratification in Psychosis

  Veronese, M. (Primary Investigator), Williams, S. (Co-Investigator), Leech, R. (Co-Investigator) & Howes, O. (Co-Investigator)

  Wellcome Trust

  1/12/2019 → 31/12/2022

  Project: Research

• From brain to cell and back again: determining the molecular mechanisms of psychosis and developing a cellular platform for novel drug discovery

  Srivastava, D. (Primary Investigator), Howes, O. (Co-Investigator) & Vernon, A. (Co-Investigator)

  MRC Medical Research Council

  1/11/2017 → 31/10/2018

  Project: Research

• A pilot study to link cortical interneuron dysfunction and striatal hyperdopaminergia in mice

  Marin, O. (Primary Investigator), Rico, B. (Co-Investigator) & Howes, O. (Co-Investigator)

  MRC Medical Research Council

  1/10/2017 → 31/03/2018

  Project: Research

• Cardiac function in Schizophrenia

  Howes, O. (Primary Investigator)

  BMA British Medical Association

  1/09/2017 → 31/08/2020

  Project: Research

• The role of glutamate and the N-methyl-D-aspartate receptor (NMDAR) in schizophrenia

  Beck, K. (Primary Investigator), Hammers, A. (Co-Investigator), Howes, O. (Co-Investigator) & McGuire, P. (Co-Investigator)

  4/08/2017 → 4/08/2020

  Project: Research

• The role of glutamate and the N-methyl-D-aspartate receptor (NMDAR) in schizophrenia

  Beck, K. (Primary Investigator), Hammers, A. (Co-Investigator), Howes, O. (Co-Investigator) & McGuire, P. (Co-Investigator)

  Royal College of Psychiatrists

  1/06/2017 → 31/01/2023

  Project: Research

• MICA: Targeting neuro-inflammation in Schizophrenia

  Howes, O. (Primary Investigator), Reis Marques, T. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Veronese, M. (Co-Investigator)

  MRC Medical Research Council

  1/04/2017 → 30/09/2022

  Project: Research

• The role of glutamate and the N-methyl-D-aspartate receptor (NMDAR) in schizophrenia

  Beck, K. (Primary Investigator), Hammers, A. (Co-Investigator), Howes, O. (Co-Investigator) & McGuire, P. (Co-Investigator)

  2/02/2017 → 2/02/2020

  Project: Research

• Neurobiology of response to clozapine in treatment resistant schizophrenia

  Egerton, A. (Primary Investigator), Barker, G. (Co-Investigator), Howes, O. (Co-Investigator), Maccabe, J. (Co-Investigator), McGuire, P. (Co-Investigator), Stone, J. (Co-Investigator) & Zelaya, F. (Co-Investigator)

  MRC Medical Research Council

  1/02/2017 → 31/08/2018

  Project: Research

• PHAGO - Targeting TREM2 and CD33 of phagocytes for treatment of Alzheimer’s disease

  Hodges, A. (Primary Investigator), Gee, T. (Co-Investigator), Politis, M. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Howes, O. (Co-Investigator)

  Eli Lilly & Co Ltd, EC European Commission

  1/11/2016 → 30/04/2022

  Project: Research

• The role of endocannabinoids in the development of schizophrenia

  Bhattacharyya, S. (Primary Investigator), Appiah-Kusi, E. (Co-Investigator), Howes, O. (Co-Investigator), Kempton, M. (Co-Investigator) & McGuire, P. (Co-Investigator)

  1/09/2016 → 31/08/2019

  Project: Research

• The trans-diagnostic role of dopamine in psychosis: a test-of-concept in bipolar disorder.

  Howes, O. (Primary Investigator), Veronese, M. (Co-Investigator) & Young, A. (Co-Investigator)

  1/08/2016 → 1/08/2019

  Project: Research

• The neural mechanisms linking psychotic disorders and the social environment

  McCutcheon, R. (Primary Investigator), Howes, O. (Co-Investigator), McGuire, P. (Co-Investigator) & Mehta, M. (Co-Investigator)

  25/07/2016 → 25/07/2019

  Project: Research

• The neural mechanisms linking psychotic disorders and the social environment

  McCutcheon, R. (Primary Investigator), Howes, O. (Co-Investigator), McGuire, P. (Co-Investigator) & Mehta, M. (Co-Investigator)

  Wellcome Trust

  1/05/2016 → 28/02/2021

  Project: Research

• Targeting Neuro-Inflammation in Schizophrenia

  Howes, O. (Primary Investigator)

  1/04/2016 → 1/04/2018

  Project: Research

• Does Kv3 channel modulation reduce dopamine synthesis capacity and reduce abnormal neural responses in schizophrenia?

  Howes, O. (Primary Investigator), Kapur, S. (Co-Investigator) & McGuire, P. (Co-Investigator)

  Innovate UK

  1/07/2015 → 30/06/2018

  Project: Research

• New Approaches to Treatment for Schizophrenia (NATS)

  Howes, O. (Primary Investigator)

  31/01/2015 → 30/01/2020

  Project: Research

• The dopaminergic system as a neurobiological marker of dissociation

  Reinders, S. (Primary Investigator), David, A. (Co-Investigator) & Howes, O. (Co-Investigator)

  5/01/2015 → 30/06/2015

  Project: Research

• DOPAMINERGIC BASIS OF THE EFFECT OF OXYTOCIN ON SOCIAL COGNITION

  Fusar-Poli, P. (Primary Investigator), Howes, O. (Co-Investigator) & McGuire, P. (Co-Investigator)

  1/01/2015 → 31/12/2016

  Project: Research

• Dopaminergic basis of the effect of oxytocin on social cognition

  Fusar-Poli, P. (Primary Investigator), Howes, O. (Co-Investigator) & McGuire, P. (Co-Investigator)

  1/01/2015 → 31/12/2016

  Project: Research

• STRATA - Schizophrenia: Treatment Resistance and Therapeutic Advances

  Maccabe, J. (Primary Investigator), Barker, G. (Co-Investigator), Egerton, A. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator), Lythgoe, D. (Co-Investigator), McCrone, P. (Co-Investigator), McGuire, P. (Co-Investigator), Murray, R. (Co-Investigator), Pickles, A. (Co-Investigator), Rose, D. (Co-Investigator) & Stone, J. (Co-Investigator)

  MRC Medical Research Council

  1/10/2014 → 30/09/2019

  Project: Research

• STRATA - Schizophrenia: Treatment Resistance and Therapeutic Advances

  Maccabe, J. (Primary Investigator), Barker, G. (Co-Investigator), Egerton, A. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator), Lythgoe, D. (Co-Investigator), McCrone, P. (Co-Investigator), McGuire, P. (Co-Investigator), Murray, R. (Co-Investigator), Pickles, A. (Co-Investigator), Rose, D. (Co-Investigator) & Stone, J. (Co-Investigator)

  MRC Medical Research Council

  1/10/2014 → 31/12/2019

  Project: Research

• Development and preliminary evaluation of a Clozapine Decision Aid

  Henderson, C. (Primary Investigator), Howes, O. (Co-Investigator), Rose, D. (Co-Investigator) & Taylor, D. (Co-Investigator)

  1/09/2014 → 31/08/2015

  Project: Research

• DOPAMINERIC BASIS OF THE EFFECT OF OXYTOCIN ON SOCIAL BEHAVIOUR

  Fusar-Poli, P. (Primary Investigator), Howes, O. (Co-Investigator) & McGuire, P. (Co-Investigator)

  1/09/2014 → 31/08/2016

  Project: Research

• Beyond dopamine receptors in schizophrenia - evaluating the role of phosphodiesterase 10A in disease and treatment using PET imaging

  Kapur, S. (Primary Investigator), Howes, O. (Co-Investigator), Natesan, S. (Co-Investigator), Rabiner, E. (Co-Investigator) & Reis Marques, T. (Co-Investigator)

  MRC Medical Research Council

  30/06/2014 → 29/06/2017

  Project: Research

• A molecular and pathological examination of system dysfunction of the basal ganglia in schizophrenia and depression

  Howes, O. (Co-Investigator) & Williams, M. (Co-Investigator)

  1/06/2014 → 31/05/2019

  Project: Research

• Integration of genetic and environmental risk factors and neuroimaging measures to predict outcomes in people at high risk for psychosis

  Prata, D. (Primary Investigator), Howes, O. (Co-Investigator) & McGuire, P. (Co-Investigator)

  1/05/2014 → 1/04/2016

  Project: Research

• Beyond dopamine in Schizophrenia - evaluating the role of Phosphodiesterase 10A using PET imaging

  Reis Marques, T. (Primary Investigator), Howes, O. (Co-Investigator) & Kapur, S. (Co-Investigator)

  1/04/2014 → 1/04/2017

  Project: Research

• Neurobiological determinants of psychosis

  Howes, O. (Primary Investigator), DO NOT USE, P. (Co-Investigator), McGuire, P. (Co-Investigator) & Zelaya, F. (Co-Investigator)

  1/03/2014 → 28/02/2018

  Project: Research

• Neurobiology of response to clozapine in treatment resistant schizophrenia

  Egerton, A. (Primary Investigator), Barker, G. (Co-Investigator), Howes, O. (Co-Investigator), Maccabe, J. (Co-Investigator), McGuire, P. (Co-Investigator), Stone, J. (Co-Investigator) & Zelaya, F. (Co-Investigator)

  MRC Medical Research Council

  1/02/2014 → 31/01/2017

  Project: Research

• NIHR professorial fellowship

  Howes, O. (Primary Investigator)

  10/01/2014 → 30/09/2019

  Project: Research

• Inflammation and Psychosis : translating research findings into clincal practice

  Mondelli, V. (Primary Investigator), Bhattacharyya, S. (Co-Investigator), Cattaneo, A. (Co-Investigator), Dazzan, P. (Co-Investigator), Howes, O. (Co-Investigator), McGuire, P. (Co-Investigator), Pariante, C. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Zunszain, P. (Co-Investigator)

  1/01/2014 → 31/12/2017

  Project: Research

• Inflammation and psychosis : translating research findings into clinical practise

  Mondelli, V. (Primary Investigator), Bhattacharyya, S. (Co-Investigator), Cattaneo, A. (Co-Investigator), Dazzan, P. (Co-Investigator), Howes, O. (Co-Investigator), McGuire, P. (Co-Investigator), Pariante, C. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Zunszain, P. (Co-Investigator)

  1/12/2013 → 30/11/2018

  Project: Research

• Neuroinflammation in psychosis : a proof-of-concept mechanistic study of changes in myelin content and microglia activation using the anti-inflammatory , Minocycline

  Giordano, A. (Primary Investigator), Dazzan, P. (Co-Investigator), Howes, O. (Co-Investigator), Pariante, C. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Williams, S. (Co-Investigator)

  1/10/2013 → 30/09/2016

  Project: Research

• Neuroinflammation in psychosis : a proof-of-concept mechanistic study of changes in myelin content and microglia activation using the anti-inflammatory, Minocycline

  Giordano, A. (Primary Investigator), Dazzan, P. (Co-Investigator), Howes, O. (Co-Investigator), Pariante, C. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Williams, S. (Co-Investigator)

  1/10/2013 → 30/09/2016

  Project: Research

• Dissecting brain inflammation in depression : Integrating behaviour,PET,MRS,MRI,cytokines and transcriptomics

  Pariante, C. (Primary Investigator), Barker, G. (Co-Investigator), Cleare, A. (Co-Investigator), Dazzan, P. (Co-Investigator), Dobson, R. (Co-Investigator), Hayday, A. (Co-Investigator), Hotopf, M. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator), Pickles, A. (Co-Investigator), Rabiner, E. (Co-Investigator), Taylor, M. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Tylee, A. (Co-Investigator)

  1/10/2013 → 30/09/2016

  Project: Research