Patrick Doherty

2022

A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson’s Disease

Clarke, E., Stocki, P., Sinclair, E. H., Gauhar, A., Fletcher, E. J. R., Krawczun-Rygmaczewska, A., Duty, S., Walsh, F. S., Doherty, P. & Rutkowski, J. L., Jul 2022, In: Pharmaceutics. 14, 7, 1335.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

2021

Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB₁Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster

Tortoriello, G., Beiersdorf, J., Romani, S., Williams, G., Cameron, G. A., Mackie, K., Williams, M. J., Di Marzo, V., Keimpema, E., Doherty, P. & Harkany, T., Apr 2021, In: Cannabis and cannabinoid research. 6, 2, p. 119-136 18 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2020

Drug repositioning and repurposing for Alzheimer disease

Aarsland, D., Ballard, C. G., Cummings, J., Doherty, P. & Williams, G., 30 Jul 2020, (Accepted/In press) In: Nature Reviews Neurology.

Research output: Contribution to journal › Article › peer-review

Transcription-based drug repurposing for COVID-19

Killick, R., Ballard, C., Doherty, P. & Williams, G., Dec 2020, In: Virus Research. 290, 198176.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2019

2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity

Lu, L., Williams, G. & Doherty, P., 1 Dec 2019, In: Cannabis and cannabinoid research. 4, 4, p. 231-239 9 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Alzheimer's Disease Progression in the 5×FAD Mouse Captured with a Multiplex Gene Expression Array

Gatt, A., Whitfield, D. R., Ballard, C., Doherty, P. & Williams, G., 1 Jan 2019, In: Journal of Alzheimer's disease : JAD. 72, 4, p. 1177-1191 15 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons

Williams, G., Gatt, A., Clarke, E., Corcoran, J., Doherty, P., Chambers, D. & Ballard, C., 2019, In: Translational psychiatry. 9, 1, 220.

Research output: Contribution to journal › Article › peer-review

Open Access

File

44 Citations (Scopus)

191 Downloads (Pure)

No transcriptional evidence for active Na_v channels in two classes of cancer cell

Hompoonsup, S., Chambers, D., Doherty, P. & Williams, G., 2019, In: Channels . 13, 1, p. 311-320 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

105 Downloads (Pure)

Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats.

Duty, S., Fletcher, E. J. R., Williams, G., Doherty, P. & Jamieson, A., 6 Jun 2019, In: Scientific Reports. 9, p. 1-9 8336.

Research output: Contribution to journal › Article › peer-review

Open Access

File

20 Citations (Scopus)

185 Downloads (Pure)

2017

Endocannabinoid Turnover

Fowler, C. J., Doherty, P. & Alexander, S. P. H., 25 May 2017, (E-pub ahead of print) In: Advances in Pharmacology. 80

Research output: Contribution to journal › Article › peer-review

Open Access

File

28 Citations (Scopus)

515 Downloads (Pure)

Nanoscale Structural Plasticity of the Active Zone Matrix Modulates Presynaptic Function

Glebov, O. O., Jackson, R. E., Winterflood, C. M., Owen, D. M., Barker, E. A., Doherty, P., Ewers, H. & Burrone, J., 14 Mar 2017, In: Cell Reports. 18, 11, p. 2715-2728 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

58 Citations (Scopus)

266 Downloads (Pure)

2016

A novel live cell assay to measure diacylglycerol lipase α activity

Singh, P. K., Markwick, R., Howell, F. V., Williams, G. & Doherty, P., 1 Jul 2016, In: Bioscience Reports. 36, 3, e00331.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

181 Downloads (Pure)

Assay and inhibition of the purified catalytic domain of diacylglycerol lipase beta

Singh, P. K., Markwick, R., Lu, L., Howell, F. V., Williams, G. & Doherty, P., 26 Apr 2016, (E-pub ahead of print) In: Biochemistry.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

311 Downloads (Pure)

Regulated endosomal trafficking of Diacylglycerol lipase alpha (DAGLα) generates distinct cellular pools; implications for endocannabinoid signaling

Zhou, Y., Howell, F. V., Glebov, O., Albrecht, D., Williams, G. & Doherty, P., 1 Oct 2016, In: Molecular and Cellular Neuroscience. 76 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

11 Citations (Scopus)

342 Downloads (Pure)

2015

Drebrin regulates neuroblast migration in the postnatal Mammalian brain

Sonego, M., Oberoi, M., Stoddart, J., Gajendra, S., Hendricusdottir, R., Oozeer, F., Worth, D. C., Hobbs, C., Eickholt, B. J., Gordon-Weeks, P. R., Doherty, P. & Lalli, G., 6 May 2015, In: PLoS One. 10, 5, 26 p., e0126478.

Research output: Contribution to journal › Article › peer-review

Open Access

File

30 Citations (Scopus)

217 Downloads (Pure)

Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream

Zhou, Y., Oudin, M., Gajendra, S., Sonego, M., Falenta, K., Williams, G., Lalli, G. & Doherty, P., Jan 2015, In: Molecular and Cellular Neuroscience. 64, p. 32-43 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

2014

Programming of neural cells by (endo)cannabinoids: From physiological rules to emerging therapies

MacCarrone, M., Guzmán, M., MacKie, K., Doherty, P. & Harkany, T., 11 Dec 2014, In: NATURE REVIEWS NEUROSCIENCE. 15, 12, p. 786-801 16 p.

Research output: Contribution to journal › Review article › peer-review

230 Citations (Scopus)

RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development

Das, A., Gajendra, S., Falenta, K., Oudin, M., Peschard, P., Feng, S., Wu, B., Marshall, C. J., Doherty, P., Guo, W. & Lalli, G., 28 Feb 2014, In: Journal of Cell Science. 127, 3, p. 686-699 14 p.

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond

Keimpema, E., Hökfelt, T., Harkany, T. & Doherty, P., Feb 2014, In: European Journal of Neuroscience. 39, 3, p. 334-343 10 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2013

Fascin Regulates the Migration of Subventricular Zone-Derived Neuroblasts in the Postnatal Brain

Sonego, M., Gajendra, S., Parsons, M., Ma, Y., Hobbs, C., Zentar, M. P., Williams, G., Machesky, L. M., Doherty, P. & Lalli, G., 24 Jul 2013, In: Journal of Neuroscience. 33, 30, p. 12171-12185 15 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

In vivo postnatal electroporation and time-lapse imaging of neuroblast migration in mouse acute brain slices.

Sonego, M., Zhou, Y., Oudin, M. J., Doherty, P. & Lalli, G., 2013, In: Journal of Visualized Experiments. 81

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons

Keimpema, E., Tortoriello, G., Alpár, A., Capsoni, S., Arisi, I., Calvigioni, D., Hu, S. S. J., Cattaneo, A., Doherty, P., Mackie, K. & Harkany, T., 29 Jan 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1935-1940 6 p.

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Nucleofection of rodent neuroblasts to study neuroblast migration in vitro

Falenta, K., Gajendra, S., Sonego, M., Doherty, P. & Lalli, G., 11 Dec 2013, In: Journal of Visualized Experiments. 81, 10 p., e50989.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Targeted Lipidomics in Drosophila melanogaster Identifies Novel 2-Monoacylglycerols and N-acyl Amides

Tortoriello, G., Rhodes, B. P., Takacs, S. M., Stuart, J. M., Basnet, A., Raboune, S., Widlanski, T. S., Doherty, P., Harkany, T. & Bradshaw, H. B., 11 Jul 2013, In: PL o S One . 8, 7, e67865.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Citations (Scopus)

The molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function

Suetterlin, P., Williams, E., Chambers, D., Saraf, K., von Schack, D., Reisenberg, M., Doherty, P. & Williams, G., Jan 2013, In: Molecular and Cellular Neurosciences. 52, 1, p. 20 - 30 11 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Transcriptional basis for the inhibition of neural stem cell proliferation and migration by the TGFbeta-family member GDF11

Williams, G., Zentar, M., Gajendra, S., Sonego, M., Doherty, P. & Lalli, G., Nov 2013, In: PLoS ONE. 8, 11, p. N/A e78478.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (Scopus)

2012

Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Bryson, J. B., Hobbs, C., Parsons, M. J., Bosch, K. D., Pandraud, A., Walsh, F. S., Doherty, P. & Greensmith, L., 1 Sept 2012, In: Human Molecular Genetics. 21, 17, p. 3871-3882 12 p., dds215.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Citations (Scopus)

The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling

Reisenberg, M., Singh, P. K., Williams, G. & Doherty, P., 5 Dec 2012, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 367, 1607, p. 3264-3275 12 p.

Research output: Contribution to journal › Literature review › peer-review

123 Citations (Scopus)

2011

DAGL-dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis

Oudin, M. J., Hobbs, C. & Doherty, P., Nov 2011, In: European Journal of Neuroscience. 34, 10, p. 1634-1646 13 p.

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Endocannabinoids Regulate the Migration of Subventricular Zone-Derived Neuroblasts in the Postnatal Brain

Oudin, M. J., Gajendra, S., Williams, G., Hobbs, C., Lalli, G. & Doherty, P., 16 Mar 2011, In: Journal of Neuroscience. 31, 11, p. 4000 - 4011 12 p.

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

2010

Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons

Gao, Y., Deng, K., Cao, Z., Graziani, E. I., Gilbert, A. M., Koehn, F. E., Wood, A., Doherty, P. & Walsh, F. S., Jun 2010, In: Journal of Neurochemistry. 113, 5, p. 1331 - 1342 12 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

A retinoic acid receptor β agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord

Agudo, M., Yip, P., Davies, M., Bradbury, E., Doherty, P., McMahon, S., Maden, M. & Corcoran, J. P. T., Jan 2010, In: Neurobiology of Disease. 37, 1, p. 147 - 155 9 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Down-Regulation of Diacylglycerol Lipase-alpha During Neural Stem Cell Differentiation: Identification of Elements that Regulate Transcription

Walker, D. J., Suetterlin, P., Reisenberg, M., Williams, G. & Doherty, P., Mar 2010, In: Journal of Neuroscience Research. 88, 4, p. 735 - 745 11 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Importance of Neurogenesis in a Rodent Model of Stroke

Rossetti, T. R., Goncalves, M. B., Yip, P., Doherty, P., Hainsworth, A. H. & Yanez-Munoz, R. J., 2010, In: Human Gene Therapy. 21, 4, p. 520 - 521 2 p.

Research output: Contribution to journal › Meeting abstract

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

Gao, Y., Vasilyev, D. V., Goncalves, M. B., Howell, F. V., Hobbs, C., Reisenberg, M., Shen, R., Zhang, M.-Y., Strassle, B. W., Lu, P., Mark, L., Piesla, M. J., Deng, K., Kouranova, E. V., Ring, R. H., Whiteside, G. T., Bates, B., Walsh, F. S., Williams, G. & Pangalos, M. N. & 2 others, Samad, T. A. & Doherty, P., 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2017 - 2024 8 p.

Research output: Contribution to journal › Article › peer-review

394 Citations (Scopus)

Overcoming Amino-Nogo-induced Inhibition of Cell Spreading and Neurite Outgrowth by 12-O-Tetradecanoylphorbol-13-acetate-type TumorPromoters

Deng, K., Gao, Y., Cao, Z., Graziani, E. I., Wood, A., Doherty, P. & Walsh, F. S., 26 Feb 2010, In: Journal of Biological Chemistry. 285, 9, p. 6425 - 6433 9 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Receptors for myelin inhibitors: Structures and therapeutic opportunities

Cao, Z., Gao, Y., Deng, K., Williams, G., Doherty, P. & Walsh, F. S., Jan 2010, In: Molecular and Cellular Neurosciences. 43, 1, p. 1 - 14 14 p.

Research output: Contribution to journal › Literature review › peer-review

61 Citations (Scopus)

The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain

Goncalves, M. B., Williams, E.-J., Yip, P., Yanez-Munoz, R. J., Williams, G. & Doherty, P., Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1118 - 1125 8 p.

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

2009

BDNF regulates neuronal sensitivity to endocannabinoids

Maison, P., Walker, D. J., Walsh, F. S., Williams, G. & Doherty, P., 25 Dec 2009, In: Neuroscience Letters. 467, 2, p. 90 - 94 5 p.

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

New insights into endocannabinoid signalling and function based on the expression of the dag lipases

Doherty, P., 2009, In: Journal of Neurochemistry. 110, p. 103 - 103 1 p.

Research output: Contribution to journal › Meeting abstract

2008

A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner

Goncalves, M. B., Suetterlin, P., Yip, P., Molina-Holgado, F., Walker, D. J., Oudin, M. J., Zentar, M. P., Pollard, S., Yanez-Munoz, R. J., Williams, G., Walsh, F. S., Pangalos, M. N. & Doherty, P., 4 Aug 2008, In: Molecular and Cellular Neurosciences. 38, 4, p. 526 - 536 11 p.

Research output: Contribution to journal › Article › peer-review

155 Citations (Scopus)

Ganglioside inhibition of neurite outgrowth requires Nogo receptor function - Identification of interaction sites and development of novel antagonists

Williams, G., Wood, A., Williams, E. J., Gao, Y., Mercado, M. L., Katz, A., Joseph-McCarthy, D., Bates, B., Ling, H. P., Aulabaugh, A., Zaccardi, J., Xie, Y. H., Pangalos, M. N., Walsh, F. S. & Doherty, P., 13 Jun 2008, In: Journal of Biological Chemistry. 283, 24, p. 16641 - 16652 12 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITP alpha during axonal extension in hippocampal neurons

Cosker, K. E., Shadan, S., Van Diepen, M., Morgan, C., Li, M., len-Baume, V., Hobbs, C., Doherty, P., Cockcroft, S. & Eickholt, B. J., 15 Mar 2008, In: Journal of Cell Science. 121, 6, p. 796 - 803 8 p.

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Tandem Repeat Peptide Strategy for the Design of Neurotrophic Factor Mimetics

Molina-Holgado, F., Doherty, P. & Williams, G., Feb 2008, In: Cns & Neurological Disorders-Drug Targets. 7, 1, p. 110 - 119 10 p.

Research output: Contribution to journal › Literature review › peer-review

15 Citations (Scopus)

The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation

Watson, S., Chambers, D., Hobbs, C., Doherty, P. & Graham, A., May 2008, In: Molecular and Cellular Neurosciences. 38, 1, p. 89 - 97 9 p.

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Wiring and firing neuronal networks: endocannabinoids take center stage

Harkany, T., Mackie, K. & Doherty, P., Jun 2008, In: CURRENT OPINION IN NEUROBIOLOGY. 18, 3, p. 338 - 345 8 p.

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

2007

Efficient gene transfer and RNAi with integration-deficient lentiviral vectors

Foster, E., Moon, L., Hutson, T., Yip, P., Doherty, P., McMahon, S. B. & Yanez-Munoz, R. J., 2007, In: Human Gene Therapy. 18, 10, p. 1037 - 1038 2 p.

Research output: Contribution to journal › Meeting abstract

2006

Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis

Holzbaur, E. L. F., Howland, D. S., Weber, N., Wallace, K., She, Y. J., Kwak, S., Tchistiakova, L. A., Murphy, E., Hinson, J., Karim, R., Tan, X. Y., Kelley, P., McGill, K. C., Williams, G., Hobbs, C., Doherty, P., Zaleska, M. M., Pangalos, M. N. & Walsh, F. S., Sept 2006, In: Neurobiology of Disease. 23, 3, p. 697 - 707 11 p.

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

The FGF receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of NCAM.

Sanchez-Heras, E., Howell, F., Williams, G. & Patrick, D., 17 Nov 2006, In: Journal of Biological Chemistry. 281, 46, p. 35208 - 35216 9 p.

Research output: Contribution to journal › Article › peer-review

107 Citations (Scopus)

2005

A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists

Williams, G., Eickholt, B. J., Maison, P., Prinjha, R., Walsh, F. S. & Doherty, P., Mar 2005, In: Journal of Neurochemistry. 92, 5, p. 1180 - 1190 11 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Patrick Doherty

Research output

Search results