King's College London

Research portal

Dr Paul Caton

  1. Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

    Tang, S., Garzon Sanz, M., Smith, O., Krämer, A., Egbase, D., Caton, P. W., Knapp, S. & Butterworth, S., 2022, (Accepted/In press) In: Acta Pharmaceutica Sinica B.

    Research output: Contribution to journalArticlepeer-review

  2. Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress

    Lavilla, C. J., Billacura, M. P., Hanna, K., Boocock, D. J., Coveney, C., Miles, A. K., Foulds, G. A., Murphy, A., Tan, A., Jackisch, L., Sayers, S. R., Caton, P. W., Doig, C. L., McTernan, P. G., Colombo, S. L., Sale, C. & Turner, M. D., 1 Nov 2021, In: Free Radical Biology and Medicine. 175, p. 65-79 15 p.

    Research output: Contribution to journalArticlepeer-review

  3. Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome

    Evans, E., Sayers, S., Kodji, X., Xia, Y., Shaikh, M., Rizvi, A., Frame, J., Brain, S., Philpott, M., Hannen, R. & Caton, P., Nov 2020, In: Molecular Metabolism. 41, 101047.

    Research output: Contribution to journalArticlepeer-review

  4. Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes

    Sayers, S. R., Beavil, R. L., Fine, N. H. F., Huang, G. C., Choudhary, P., Pacholarz, K. J., Barran, P. E., Butterworth, S., Mills, C. E., Cruickshank, J. K., Silvestre, M. P., Poppitt, S. D., McGill, A. T., Lavery, G. G., Hodson, D. J. & Caton, P. W., Feb 2020, In: Diabetologia. 63, 2, p. 313-323 11 p.

    Research output: Contribution to journalArticlepeer-review

  5. Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion

    Cripps, M. J., Bagnati, M., Jones, T. A., Ogunkolade, B. W., Sayers, S. R., Caton, P. W., Hanna, K., Billacura, M. P., Fair, K., Nelson, C., Lowe, R., Hitman, G. A., Berry, M. D. & Turner, M. D., 1 Jan 2020, In: Biochemical Pharmacology. 171, 113685.

    Research output: Contribution to journalArticlepeer-review

  6. A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

    Kieswich, J. E., Chen, J., Alliouachene, S., Caton, P. W., McCafferty, K., Thiemermann, C. & Yaqoob, M. M., 4 Dec 2018, In: BMC Nephrology. 19, 1, 1155.

    Research output: Contribution to journalArticlepeer-review

  7. Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis

    Caton, P. W., Evans, E. A., Philpott, M. P. & Hannen, R. F., Dec 2017, In: Current Opinion in Pharmacology. 37, p. 59-64

    Research output: Contribution to journalArticlepeer-review

  8. Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake

    Cripps, M. J., Hanna, K., Lavilla, C., Sayers, S., Caton, P., Sims, C., De Girolamo, L., Sale, C. & Turner, M. D., 17 Oct 2017, (E-pub ahead of print) In: Scientific Reports. 7, 1, 13313.

    Research output: Contribution to journalArticlepeer-review

  9. Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment

    Kieswich, J., Sayers, S. R., Silvestre, M., harwood, S., Yaqoob, M. & Caton, P. W., Nov 2016, In: Diabetologia. 59, 11

    Research output: Contribution to journalArticlepeer-review

  10. Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

    Bagnati, M., Ogunkolade, B. W., Marshal, C., Tucci, C., Hanna, K., Jones, T. A., Bugliani, M., Nedjai, B., Caton, P. W., Kieswich, J., Yaqoob, M. M., Ball, G. R., Marchetti, P., Hitman, G. A. & Turner, M. D., 11 Aug 2016, (E-pub ahead of print) In: Cell Death and Disease. e2329.

    Research output: Contribution to journalArticlepeer-review

  11. Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice

    Holland, M. L., Lowe, R., Caton, P. W., Gemma, C., Carbajosa, G., Danson, A. F., Carpenter, A. M., Loche, E., Ozanne, S. E. & Rakyan, V. K., 29 Jul 2016, In: Science. 353, 6298, p. 495-498 4 p.

    Research output: Contribution to journalArticlepeer-review

  12. The kiln XML publishing framework

    Caton, P. & Vieira, M., 2016, Balisage Series on Markup Technologies. Mulberry Tecnologies, Inc., Vol. 18.

    Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

  13. A Key Role for Interferon Regulatory Factors in Mediating Early-Life Metabolic Defects in Male Offspring of Maternal Protein Restricted Rats

    Silvestre, M., Kieswich, J., Yaqoob, M., Holness, M., Sugden, M. & Caton, P. W., Apr 2014, In: Hormone and Metabolic Research. 46, 4, p. 252-258

    Research output: Contribution to journalArticlepeer-review

  14. The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions

    Silvestre, M. F. P., Viollet, B., Caton, P. W., Leclerc, J., Sakakibara, I., Foretz, M., Holness, M. C. & Sugden, M. C., 28 Mar 2014, In: Life Sciences. p. 55-60

    Research output: Contribution to journalArticlepeer-review

  15. Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

    Chapagain, A., Caton, P. W., Kieswich, J., Andrikopoulos, P., Nayuni, N., Long, J., Harwood, S., Webster, S., Raftery, M., Thiemermann, C., Walker, B. R., Seckl, J., Corder, R. & Yaqoob, M., 11 Mar 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 10, p. 3817-3822

    Research output: Contribution to journalArticlepeer-review

  16. Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients

    Caton, P. W., Richardson, S. J., Kieswich, J., Bugliani, M., Holland, M. L., Marchetti, P., Morgan, N. G., Yaqoob, M., Holness, M. & Sugden, M., May 2013, In: Diabetologia.

    Research output: Contribution to journalArticlepeer-review

  17. Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.

    Caton, P. W., Kieswich, J., Yaqoob, M., Holness, M. & Sugden, M., Dec 2011, In: DIABETES OBESITY AND METABOLISM. 13, 12, p. 1097-1104

    Research output: Contribution to journalArticlepeer-review

  18. Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function

    Caton, P. W., Kieswich, J., Yaqoob, M., Holness, M. & Sugden, M., Dec 2011, In: Diabetologia. 54, 12, p. 3083–3092

    Research output: Contribution to journalArticlepeer-review

  19. PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status

    Caton, P. W., Holness, M., Bishop-Bailey, D. & Sugden, M., 1 Aug 2011, In: Biochemical Journal.

    Research output: Contribution to journalArticlepeer-review

  20. Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism

    Caton, P. W., Nayuni, N., Khan, N., Wood, E. & Corder, R., Mar 2011, In: Journal of Endocrinology.

    Research output: Contribution to journalArticlepeer-review

  21. Regulation of vascular endothelial function by procyanidin-rich foods and beverages

    Caton, P. W., Pothecary, M. R., Lees, D. M., Khan, N., Wood, E., Shoji, T., Kanda, T., Rull, G. & Corder, R., 14 Apr 2010, In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.

    Research output: Contribution to journalArticlepeer-review

  22. Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

    Caton, P. W., Nayuni, N., Kieswich, J., Khan, N., Yaqoob, M. & Corder, R., Apr 2010, In: Journal of Endocrinology.

    Research output: Contribution to journalArticlepeer-review

  23. PPAR control: it's SIRTainly as easy as PGC

    Sugden, M., Caton, P. W. & Holness, M., Feb 2010, In: Journal of Endocrinology.

    Research output: Contribution to journalArticlepeer-review

  24. Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase

    Caton, P. W., Nayuni, N., Murch, O. & Corder, R., 22 May 2009, In: Life Sciences.

    Research output: Contribution to journalArticlepeer-review

  25. Nuclear Speckle-Associated Protein Pnn/DRS Binds to the Transcriptional Corepressor CtBP and Relieves CtBP- Mediated Repression of the E-Cadherin Gene

    Alpatov, R., Munguba, G., Caton, P. W., Joo, JH., Shi, Y., Shi, Y., Hunt, ME. & Sugrue, SP., Dec 2004, In: Molecular and Cellular Biology. 24, 23, p. 10223-10235

    Research output: Contribution to journalArticlepeer-review

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