Paul Sharp

2023

A two-gene strategy increases iron and zinc concentrations in wheat flour, improving mineral bioaccessibility

Harrington, S. A., Connorton, J. M., Nyangoma, N. I. M., McNelly, R., Morgan, Y. M. L., Aslam, M. F., Sharp, P. A., Johnson, A. A. T., Uauy, C. & Balk, J., 2 Jan 2023, In: Plant physiology. 191, 1, p. 528-541 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Content and Availability of Minerals in Plant-Based Burgers Compared with a Meat Burger

Latunde-Dada, G. O., Kajarabille, N., Rose, S., Arafsha, S. M., Kose, T., Aslam, M. F., Hall, W. L. & Sharp, P. A., Jun 2023, In: Nutrients. 15, 12, 2732.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Ferulic acid protects HepG2 cells and mouse liver from iron-induced damage

Kose, T., Moreno-Fernandez, J., Vera-Aviles, M., Sharp, P. A. & Latunde-Dada, G. O., 1 Sept 2023, In: Biochemistry and Biophysics Reports . 35, 101521.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Cytotoxicity of Fenugreek Sprout and Seed Extracts and Their Bioactive Constituents on MCF-7 Breast Cancer Cells

Khoja, K. K., Howes, M. J. R., Hider, R., Sharp, P. A., Farrell, I. W. & Latunde-Dada, G. O., 13 Feb 2022, In: Nutrients. 14, 4, 784.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

53 Downloads (Pure)

Localisation of iron and zinc in grain of biofortified wheat

Wan, Y., Stewart, T., Amrahli, M., Evans, J., Sharp, P., Govindan, V., Hawkesford, M. J. & Shewry, P. R., May 2022, In: JOURNAL OF CEREAL SCIENCE. 105, 103470.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Zinc induces hephaestin expression via a PI3K-CDX2 dependent mechanism to regulate iron transport in intestinal Caco-2 cells

Ramavath, H. N., Chandra Mashurabad, P., Yaduvanshi, P. S., Veleri, S., Sharp, P. A. & Pullakhandam, R., 20 Oct 2022, In: Biochemical and Biophysical Research Communications. 626, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

4 Downloads (Pure)

2021

Effect of zinc depletion/repletion on intestinal iron absorption and iron status in rats

Kondaiah, P., Palika, R., Mashurabad, P., Singh Yaduvanshi, P., Sharp, P. & Pullakhandam, R., Nov 2021, In: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 97, 108800.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

In vitro bioaccessibility and bioavailability of iron from fenugreek, baobab and moringa

Khoja, K. K., Aslam, M. F., Sharp, P. A. & Latunde-dada, G. O., 15 Jan 2021, In: FOOD CHEMISTRY. 335, p. 127671 127671.

Research output: Contribution to journal › Article › peer-review

Open Access

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19 Citations (Scopus)

298 Downloads (Pure)

Iron

Fairweather-Tait, S. & Sharp, P., Jan 2021, The Latest Research and Development of Minerals in Human Nutrition. Eskin, N. A. M. (ed.). ACADEMIC PRESS INC, p. 219-250 32 p. (Advances in Food and Nutrition Research; vol. 96).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Citations (Scopus)

2020

Biofortification of wheat with zinc for eliminating deficiency in Pakistan: study protocol for a cluster-randomised, double-blind, controlled effectiveness study (BIZIFED2)

Lowe, N. M., Zaman, M., Moran, V. H., Ohly, H., Sinclair, J., Fatima, S., Broadley, M. R., Joy, E. J. M., Mahboob, U., Lark, R. M., Zia, M. H., Ander, E. L., Sharp, P. A., Bailey, E. H., Young, S. D. & Khan, M. J., 18 Nov 2020, In: BMJ Open. 10, 11, p. e039231 039231.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Inhibition of the facilitative sugar transporters (GLUTs) by tea extracts and catechins

Ni, D., Ai, Z., Munoz-Sandoval, D., Suresh, R., Ellis, P. R., Yuqiong, C., Sharp, P. A., Butterworth, P. J., Yu, Z. & Corpe, C. P., 1 Aug 2020, In: Faseb Journal. 34, 8, p. 9995-10010 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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27 Citations (Scopus)

119 Downloads (Pure)

In vitro bioaccessibility and bioavailability of iron from mature and microgreen fenugreek, rocket and broccoli

Khoja, K. K., Buckley, A., Aslam, M. F., Sharp, P. A. & Latunde-Dada, G. O., Apr 2020, In: Nutrients. 12, 4, p. 1-12 1057.

Research output: Contribution to journal › Article › peer-review

Open Access

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12 Citations (Scopus)

94 Downloads (Pure)

Iron elevates mesenchymal and metastatic biomarkers in HepG2 cells

Mehta, K. & Sharp, P., 14 Dec 2020, In: Scientific Reports. 10, 1, 1 p., 21926.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption

Kondaiah, P., Sharp, P. A. & Pullakhandam, R., 19 Mar 2020, In: Biochemical and Biophysical Research Communications. 523, 4, p. 987-992 6 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

2019

Curcumin and (−)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells Against Iron Toxicity and Erastin-Induced Ferroptosis

Kose, T., Vera Aviles, M. L., Sharp, P. A. & Latunde-Dada, G. O., 6 Feb 2019, In: Pharmaceuticals. 12, 1, 26.

Research output: Contribution to journal › Article › peer-review

Open Access

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72 Citations (Scopus)

170 Downloads (Pure)

Improving wheat as a source of iron and zinc for global nutrition

Balk, J., Connorton, J., Wang, Y., Lovergrove, A., Moore, K., Uauy, C., Sharp, P. A. & Shewry, P., 1 Mar 2019, In: Nutrition Bulletin. 44, 1, p. 53-59 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Citations (Scopus)

Iron and liver fibrosis: Mechanistic and clinical aspects

Mehta, K. J., Farnaud, S. J. & Sharp, P. A., 2019, In: World Journal of Gastroenterology. 25, 5, p. 521-538 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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146 Citations (Scopus)

80 Downloads (Pure)

Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption?

Kondaiah, P., Yaduvanshi, P. S., Sharp, P. A. & Pullakhandam, R., 13 Aug 2019, In: Nutrients. 11, 8, 1885.

Research output: Contribution to journal › Review article › peer-review

Open Access

76 Citations (Scopus)

Wheat flour fortification to prevent iron-deficiency anemia

Latunde-Dada, G. O., Aslam, M. F., Ellis, P. R., Berry, S. E. & Sharp, P. A., 1 Jan 2019, Flour and Breads and Their Fortification in Health and Disease Prevention. Elsevier, p. 485-491 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism

Kondaiah, P., Aslam, M. F., Mashurabad, P. C., Sharp, P. A. & Pullakhandam, R., 11 Jun 2019, In: Biochemical Journal. 476, 11, p. 1573-1583 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

300 Downloads (Pure)

2018

DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression

Sharp, P. A., Clarkson, R., Hussain, A., Weeks, R. J. & Morison, I. M., 17 May 2018, (E-pub ahead of print) In: PloS one. 13, 5

Research output: Contribution to journal › Article › peer-review

Open Access

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12 Citations (Scopus)

166 Downloads (Pure)

Enhancing mineral bioavailability from cereals: Current strategies and future perspectives

Aslam, M. F., Ellis, P. R., Berry, S. E., Latunde-Dada, G. O. & Sharp, P. A., 8 May 2018, (E-pub ahead of print) In: Nutrition Bulletin. p. 184-188

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

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28 Citations (Scopus)

259 Downloads (Pure)

Pea ferritin stability under gastric pH conditions determines the mechanism of iron uptake in Caco-2 cells

Perfecto, A., Rodriguez-Ramiro, I., Rodriguez-Celma, J., Sharp, P., Balk, J. & Fairweather-Tait, S., 1 Aug 2018, In: Journal of Nutrition. 148, 8, p. 1229–1235

Research output: Contribution to journal › Article › peer-review

Open Access

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23 Citations (Scopus)

176 Downloads (Pure)

2017

Conjugated linoleic acid isomers exert differential effects on an adipocyte model of HIV-associated lipodystrophy

Loonam, C. R., O’Dell, S. D., Sharp, P. & Mullen, A., 1 Jan 2017, In: CURRENT HIV RESEARCH. 15, 1, p. 46-55 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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305 Downloads (Pure)

Measurement of hepcidin isoforms in human serum by liquid chromatography with high resolution mass spectrometry

Handley, S., Couchman, L., Sharp, P., Macdougall, I. & Moniz, C., Mar 2017, In: Bioanalysis. 9, 6, p. 541-553 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

382 Downloads (Pure)

Mechanisms of iron uptake from ferric phosphate nanoparticles in human intestinal Caco-2 cells

Perfecto, A., Elgy, C., Valsami-Jones, E., Sharp, P., Hilty, F. & Fairweather-Tait, S., 4 Apr 2017, In: Nutrients. 9, 4, 359.

Research output: Contribution to journal › Article › peer-review

Open Access

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35 Citations (Scopus)

90 Downloads (Pure)

2016

In vitro assessment of iron availability from commercial Young Child Formulae supplemented with prebiotics

Christides, T., Ganis, J. C. & Sharp, P. A., 9 Dec 2016, In: EUROPEAN JOURNAL OF NUTRITION. p. 1-10

Research output: Contribution to journal › Article › peer-review

Open Access

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16 Citations (Scopus)

152 Downloads (Pure)

Microarray Analysis Reveals Altered Lipid and Glucose Metabolism Genes in Differentiated, Ritonavir-Treated 3T3-L1 Adipocytes

Loonam, C. R., O'Dell, S. D., Sharp, P. A. & Mullen, A., Jan 2016, In: CURRENT HIV RESEARCH. 14, 1, p. 37-46 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

77 Downloads (Pure)

2015

Iron bioavailability from commercially available iron supplements

Christides, T., Wray, D., McBride, R., Fairweather, R. & Sharp, P., 2015, In: EUROPEAN JOURNAL OF NUTRITION. 54, 8, p. 1345-52 8 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

2014

Alginate inhibits iron absorption from ferrous gluconate in a randomized controlled trial and reduces iron uptake into Caco-2 cells

Wawer, A. A., Harvey, L. J., Dainty, J. R., Perez-Moral, N., Sharp, P. & Fairweather-Tait, S. J., 2014, In: PLoS ONE. 9, 11, p. e112144

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Iron in Eukarya

Sharp, P., 2014, In: RSC Metallobiology. 2014-January, 2, p. 282-302 21 p.

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Micromilling enhances iron bioaccessibility from wholegrain wheat

Latunde-Dada, G. O., Li, X., Parodi, A., Edwards, C. H., Ellis, P. R. & Sharp, P. A., 19 Nov 2014, In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 62, 46, p. 11222-7 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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21 Citations (Scopus)

280 Downloads (Pure)

Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro

Lesjak, M., Hoque, R., Balesaria, S., Skinner, V., Debnam, E. S., Srai, S. K. S. & Sharp, P. A., 24 Jul 2014, In: PLoS ONE. 9, 7, 10 p., e102900.

Research output: Contribution to journal › Article › peer-review

Open Access

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81 Citations (Scopus)

66 Downloads (Pure)

2013

Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2 alpha and Altered Expression of Iron Absorption Genes in Mice

Matak, P., Zumerle, S., Mastrogiannaki, M., El Balkhi, S., Delga, S., Mathieu, J. R. R., Canonne-Hergaux, F., Poupon, J., Sharp, P. A., Vaulont, S. & Peyssonnaux, C., 28 Mar 2013, In: PL o S One . 8, 3, 9 p., e59538.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Citations (Scopus)

Regulation of Glucose Transporter Expression in Human Intestinal Caco-2 Cells following Exposure to an Anthocyanin-Rich Berry Extract

Alzaid, F., Cheung, H-M., Preedy, V. R. & Sharp, P. A., 13 Nov 2013, In: PL o S One . 8, 11, 6 p., e78932.

Research output: Contribution to journal › Article › peer-review

Open Access

102 Citations (Scopus)

Sugars Increase Non-Heme Iron Bioavailability in Human Epithelial Intestinal and Liver Cells

Christides, T. & Sharp, P., 10 Dec 2013, In: PL o S One . 8, 12, 8 p., e83031.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Citations (Scopus)

2012

Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2 alpha

Pourvali, K., Matak, P., Latunde-Dada, G. O., Solomou, S., Mastrogiannaki, M., Peyssonnaux, C. & Sharp, P. A., 30 Jul 2012, In: FEBS Letters. 586, 16, p. 2423-2427 5 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Evidence for an Enhancing Effect of Alginate on Iron Availability in Caco-2 Cells

Wawer, A. A., Sharp, P. A., Perez-Moral, N. & Fairweather-Tait, S. J., 14 Nov 2012, In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 60, 45, p. 11318-11322 5 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

2011

Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling

Chaston, T. B., Matak, P., Pourvali, K., Srai, S. K., McKie, A. T. & Sharp, P. A., 1 Apr 2011, In: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 300, 4, p. C888 - C895 8 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Citations (Scopus)

Quercetin-iron chelates are transported via glucose transporters

Vlachodimitropoulou, E., Sharp, P. A. & Naftalin, R. J., 15 Apr 2011, In: Free Radical Biology and Medicine. 50, 8, p. 934 - 944 11 p.

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

2010

Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3-ascorbate complex

Thumser, A. E., Rashed, A. A., Sharp, P. A. & Lodge, J. K., 15 Nov 2010, In: FOOD CHEMISTRY. 123, 2, p. 281 - 285 5 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Development of a Modified Caco-2 Cell Model System for Studying Iron Availability in Eggs

Thompson, B., Sharp, P., Elliott, R., Al-Mutairi, S. & Fairweather-Tait, S. J., 24 Mar 2010, In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 58, 6, p. 3833 - 3839 7 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure

Srai, S. K., Chung, B., Marks, J., Pourvali, K., Solanky, N., Rapisarda, C., Chaston, T. B., Hanif, R., Unwin, R. J., Debnam, E. S. & Sharp, P. A., Oct 2010, In: Kidney International. 78, 7, p. 660 - 667 8 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Inhibitory Effect of Calcium on Non-heme Iron Absorption May Be Related to Trans location of DMT-1 at the Apical Membrane of Enterocytes

Thompson, B. A. V., Sharp, P. A., Elliott, R. & Fairweather-Tait, S. J., 28 Jul 2010, In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 58, 14, p. 8414 - 8417 4 p.

Research output: Contribution to journal › Article › peer-review