Research output per year
Research output per year
Personal profile
Research interests
I am interested in the phenomenon of Endothelial Derived Hyperpolarizing Factor and have developed a new approach to investigate it. This forms an important part of the regulation of blood flow through tissues and its dysfunction is one of the elements that contribute to hypertension.
I have a long standing interest in the regulation of brain capillary permeability and how it increases dramatically following stroke and trauma. Retinal and skeletal capillary permeability are also studied to help our understanding of how inflammatory merdiators signal permeability changes and how their signalling can be altered during inflammation.
Research interests (short)
The regulation of blood flow through the microcirculation and its permeability in inflammation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Tnik: A redox sensor in endothelial cell permeability
Joachim, J., Maselli, D., Petsolari, E., Aman, J., Swiatlowska, P., Killock, D., Chaudhry, H., Zarban, A. A., Sarker, M., Fraser, P., Cleary, S. J., Amison, R., Cuthbert, I., Yang, Y., Meier, M., Fraternali, F., Brain, S. D., Shah, A. M. & Ivetic, A., 20 Dec 2024, In: Science Advances. 10, 51, p. eadk6583Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy
Thakore, P., Clark, J. E., Aubdool, A. A., Thapa, D., Starr, A., Fraser, P. A., Farrell-Dillon, K., Fernandes, E. S., McFadzean, I. & Brain, S. D., 4 Apr 2024, In: Biomolecules. 14, 4, 442.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: consequences for sulforaphane mediated protection against hypoxia-reoxygenation
Warpsinski, G., Srivastava, S., Smith, M. J., Keeley, T. P., Siow, R. C. M., Fraser, P. A. & Mann, G. E., 1 Oct 2020, In: Redox Biology. 37, 101708.Research output: Contribution to journal › Article › peer-review
Open Access63 Citations (Scopus) -
Redox regulation of microvascular permeability: IL-1β potentiation of bradykinin-induced permeability is prevented by simvastatin
Freitas, F., Tibiriçá, E., Singh, M., Fraser, P. A. & Mann, G. E., Dec 2020, In: Antioxidants. 9, 12, p. 1-16 16 p., 1269.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
P-288 - Nrf2 redox signalling in brain endothelial cells adapted to physiological O2: an in vitro model for ischaemia-reperfusion injury in stroke
Warpsinski, G., Srivastava, S., Keeley, T. P., Fraser, P. & Mann, G. E., 20 May 2018, In: Free Radical Biology and Medicine. 120, Supplement 1, p. S132Research output: Contribution to journal › Meeting abstract › peer-review
Projects
- 19 Finished
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The role of Inositol (1,4,5)trisphosphate receptor 2 ( IP3R2) in platelet function, thrombus formation and vascular permeability
Authi, K. (Primary Investigator), Fraser, P. (Co-Investigator) & Mann, G. (Co-Investigator)
1/02/2017 → 31/01/2019
Project: Research
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Nrf2-regulated redox signalling in brain endothelial cells adapted to physiological oxygen levels: consequences for ischaemia-reperfusion injury and protection by sulforaphane
Mann, G. (Primary Investigator) & Fraser, P. (Co-Investigator)
1/10/2016 → 20/11/2019
Project: Research
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The role of inositol (1,4,5) trisphosphate receptor 2 in platelet function, thrombus formation and vascular permeability
Authi, K. (Primary Investigator), Fraser, P. (Co-Investigator) & Mann, G. (Co-Investigator)
1/05/2016 → 1/04/2018
Project: Research
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Therapeutic potential of sulforaphane in protection against blood-brain barrier breakdown and inflammation in experimental stroke
Mann, G. (Primary Investigator) & Fraser, P. (Co-Investigator)
2/02/2015 → 5/02/2018
Project: Research
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Improving outcome after stroke by targeting the Nrf2-Keap 1 pathway for neurovascular protection
Mann, G. (Primary Investigator), Fraser, P. (Co-Investigator) & Siow, R. (Co-Investigator)
1/09/2013 → 28/02/2014
Project: Research