Research output per year
Research output per year
Personal profile
Research interests
I am interested in the phenomenon of Endothelial Derived Hyperpolarizing Factor and have developed a new approach to investigate it. This forms an important part of the regulation of blood flow through tissues and its dysfunction is one of the elements that contribute to hypertension.
I have a long standing interest in the regulation of brain capillary permeability and how it increases dramatically following stroke and trauma. Retinal and skeletal capillary permeability are also studied to help our understanding of how inflammatory merdiators signal permeability changes and how their signalling can be altered during inflammation.
Research interests (short)
The regulation of blood flow through the microcirculation and its permeability in inflammation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: consequences for sulforaphane mediated protection against hypoxia-reoxygenation
Warpsinski, G., Srivastava, S., Smith, M. J., Keeley, T. P., Siow, R. C. M., Fraser, P. A. & Mann, G. E., 1 Oct 2020, In: Redox Biology. 37, 101708.Research output: Contribution to journal › Article › peer-review
Open Access30 Citations (Scopus) -
Redox regulation of microvascular permeability: IL-1β potentiation of bradykinin-induced permeability is prevented by simvastatin
Freitas, F., Tibiriçá, E., Singh, M., Fraser, P. A. & Mann, G. E., Dec 2020, In: Antioxidants. 9, 12, p. 1-16 16 p., 1269.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
P-288 - Nrf2 redox signalling in brain endothelial cells adapted to physiological O2: an in vitro model for ischaemia-reperfusion injury in stroke
Warpsinski, G., Srivastava, S., Keeley, T. P., Fraser, P. & Mann, G. E., 20 May 2018, In: Free Radical Biology and Medicine. 120, Supplement 1, p. S132Research output: Contribution to journal › Meeting abstract › peer-review
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P-360 - The dietary isothiocyanate sulforaphane reduces peri-infarct constriction frequency in mouse focal cerebral ischaemia via Nrf2-independent mechanisms
Farrell-Dillon, K., Fraser, P. & Mann, G., 20 May 2018, In: Free Radical Biology and Medicine. 120, Supplement 1, p. S154Research output: Contribution to journal › Meeting abstract › peer-review
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YO-05 - Long-term contribution of Nrf2 to behavioral recovery following focal cerebral ischemia-reperfusion injury: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017 Metabolic Stress and Redox Regulation Berlin, Germany 21-23 June 2017
Farrell-Dillon, K., Chapple, S., Fraser, P. & Mann, G., Jul 2017, In: Free Radical Biology and Medicine. 108, Supplement 1, p. S16Research output: Contribution to journal › Meeting abstract › peer-review
Projects
- 19 Finished
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The role of Inositol (1,4,5)trisphosphate receptor 2 ( IP3R2) in platelet function, thrombus formation and vascular permeability
Authi, K., Fraser, P. & Mann, G.
1/02/2017 → 31/01/2019
Project: Research
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The role of inositol (1,4,5) trisphosphate receptor 2 in platelet function, thrombus formation and vascular permeability
Authi, K., Fraser, P. & Mann, G.
1/05/2016 → 1/04/2018
Project: Research
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Improving outcome after stroke by targeting the Nrf2-Keap 1 pathway for neurovascular protection
Mann, G., Fraser, P. & Siow, R.
1/09/2013 → 28/02/2014
Project: Research