Research output per year
Research output per year
- 38 results
Search results
-
2024
Tnik: A redox sensor in endothelial cell permeability
Joachim, J., Maselli, D., Petsolari, E., Aman, J., Swiatlowska, P., Killock, D., Chaudhry, H., Zarban, A. A., Sarker, M., Fraser, P., Cleary, S. J., Amison, R., Cuthbert, I., Yang, Y., Meier, M., Fraternali, F., Brain, S. D., Shah, A. M. & Ivetic, A., 20 Dec 2024, In: Science Advances. 10, 51, p. eadk6583Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy
Thakore, P., Clark, J. E., Aubdool, A. A., Thapa, D., Starr, A., Fraser, P. A., Farrell-Dillon, K., Fernandes, E. S., McFadzean, I. & Brain, S. D., 4 Apr 2024, In: Biomolecules. 14, 4, 442.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
2020
Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: consequences for sulforaphane mediated protection against hypoxia-reoxygenation
Warpsinski, G., Srivastava, S., Smith, M. J., Keeley, T. P., Siow, R. C. M., Fraser, P. A. & Mann, G. E., 1 Oct 2020, In: Redox Biology. 37, 101708.Research output: Contribution to journal › Article › peer-review
Open Access62 Citations (Scopus) -
Redox regulation of microvascular permeability: IL-1β potentiation of bradykinin-induced permeability is prevented by simvastatin
Freitas, F., Tibiriçá, E., Singh, M., Fraser, P. A. & Mann, G. E., Dec 2020, In: Antioxidants. 9, 12, p. 1-16 16 p., 1269.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
2018
P-288 - Nrf2 redox signalling in brain endothelial cells adapted to physiological O2: an in vitro model for ischaemia-reperfusion injury in stroke
Warpsinski, G., Srivastava, S., Keeley, T. P., Fraser, P. & Mann, G. E., 20 May 2018, In: Free Radical Biology and Medicine. 120, Supplement 1, p. S132Research output: Contribution to journal › Meeting abstract › peer-review
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P-360 - The dietary isothiocyanate sulforaphane reduces peri-infarct constriction frequency in mouse focal cerebral ischaemia via Nrf2-independent mechanisms
Farrell-Dillon, K., Fraser, P. & Mann, G., 20 May 2018, In: Free Radical Biology and Medicine. 120, Supplement 1, p. S154Research output: Contribution to journal › Meeting abstract › peer-review
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2017
YO-05 - Long-term contribution of Nrf2 to behavioral recovery following focal cerebral ischemia-reperfusion injury: Abstracts of the OCC World Congress and Annual SFRR-E Conference 2017 Metabolic Stress and Redox Regulation Berlin, Germany 21-23 June 2017
Farrell-Dillon, K., Chapple, S., Fraser, P. & Mann, G., Jul 2017, In: Free Radical Biology and Medicine. 108, Supplement 1, p. S16Research output: Contribution to journal › Meeting abstract › peer-review
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2016
Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxation
Stead, R., Musa, M. G., Bryant, C. L., Lanham, S. A., Johnston, D. A., Reynolds, R., Torrens, C., Fraser, P. A. & Clough, G. F., 1 Mar 2016, In: Journal of Hypertension. 34, 3, p. 452-463 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)155 Downloads (Pure) -
O-23 - Focal cerebal ischemia-reperfusion induces the Nrf2 downstream target PPARγ in mouse cerebrovascular endothelium: SFRR-E Conference Abstracts 2016
Farrell-Dillon, K., Chapple, S. J., Alfieri, A., Srivastava, S., Duchen, M., Fraser, P. A. & Mann, G. E., Jul 2016, In: Free Radical Biology and Medicine. 96, Supplement 1, p. S30-S31Research output: Contribution to journal › Meeting abstract › peer-review
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P-03 - Sulforaphane modulates microvascular permeability via redox sensitive and insensitive pathways: SFRR-E Conference Abstracts 2016
Farrell-Dillon, K., Fraser, P. A. & Mann, G. E., Jul 2016, In: Free Radical Biology and Medicine. 96, Supplement 1, p. S33Research output: Contribution to journal › Meeting abstract › peer-review
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Pro-oxidant Nrf2 inducers: Promiscuity and protection
Farrell-Dillon, K. & Fraser, P. A., 1 Dec 2016, In: VASCULAR PHARMACOLOGY. 87, p. 26-29 4 p.Research output: Contribution to journal › Article › peer-review
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Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca2+ release
Chidgey, J., Fraser, P. A. & Aaronson, P. I., 16 Jun 2016, In: Free Radical Biology and Medicine.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)212 Downloads (Pure) -
2014
Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers
Hudson, N., Powner, M. B., Sarker, M. H., Burgoyne, T., Campbell, M., Ockrim, Z. K., Martinelli, R., Futter, C. E., Grant, M. B., Fraser, P. A., Shima, D. T., Greenwood, J. & Turowski, P., 8 Sept 2014, In: Developmental Cell. 30, 5, p. 541-552 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Citations (Scopus)109 Downloads (Pure) -
2013
Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke
Alfieri, A., Srivastava, S., Siow, R. C. M., Cash, D., Modo, M., Duchen, M. R., Fraser, P. A., Williams, S. C. R. & Mann, G. E., Dec 2013, In: Free Radical Biology and Medicine. 65, p. 1012-1022 11 p.Research output: Contribution to journal › Article › peer-review
205 Citations (Scopus) -
Temporal and spatial distribution of Nrf2 in rat brain following stroke: quantitation of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique
Srivastava, S., Alfieri, A., Siow, R. C. M., Mann, G. E. & Fraser, P. A., 15 Jul 2013, In: The Journal of Physiology. 591, p. 3525-3538 14 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
2011
Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia-reperfusion
Woodfin, A., Hu, D.-E., Sarker, M., Kurokawa, T. & Fraser, P., 15 Feb 2011, In: Free Radical Biology and Medicine. 50, 4, p. 518 - 524 7 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke
Alfieri, A., Srivastava, S., Siow, R. C. M., Modo, M., Fraser, P. A. & Mann, G. E., 1 Sept 2011, In: The Journal of physiology. 589, 17, p. 4125-4136 12 p.Research output: Contribution to journal › Article › peer-review
Open Access178 Citations (Scopus) -
The role of free radical generation in increasing cerebrovascular permeability
Fraser, P. A., 1 Sept 2011, In: Free Radical Biology and Medicine. 51, 5, p. 967 - 977 11 p.Research output: Contribution to journal › Literature review › peer-review
128 Citations (Scopus) -
2010
Hyperglycemia attenuates acute permeability response to advanced glycation end products in retinal microvasculature
Warboys, C. M. & Fraser, P. A., Jul 2010, In: Microvascular Research. 80, 1, p. 174 - 176 3 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Regulation of Cerebromicrovascular Permeability by Lysophosphatidic Acid
Sarker, M. H., Hu, D.-E. & Fraser, P. A., Jan 2010, In: Microcirculation. 17, 1, p. 39 - 46 8 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
The Endothelial [Ca2+](i) Increase During Endothelial Derived Hyperpolarising factor (EDHF) Responses is Mediated by Reactive Oxygen Species (ROS) from Cytochrome P450
Chidgey, J. G., Aaronson, P. I. & Fraser, P. A., 2010, In: Free Radical Biology and Medicine. 49, p. S17 - S17Research output: Contribution to journal › Meeting abstract
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2009
Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies
Joice, S. L., Mydeen, F., Couraud, P.-O., Weksler, B. B., Romero, I. A., Fraser, P. A. & Easton, A. S., 28 Oct 2009, In: Brain Research. 1298, p. 13 - 23 11 p.Research output: Contribution to journal › Article › peer-review
72 Citations (Scopus) -
Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation
Warboys, C. M., Toh, H.-B. & Fraser, P. A., Mar 2009, In: Investigative Ophthalmology & Visual Science. 50, 3, p. 1319 - 1328 10 p.Research output: Contribution to journal › Article › peer-review
53 Citations (Scopus) -
2008
CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI
Collot-Teixeira, S., Barbatis, C., Bultelle, F., Koutouzis, M., Pasterkamp, G., Fraser, P., Kyriakides, Z. S., Poston, R. N., Ristagno, A., McGregor, L., Boulanger, C. M., Leseche, G. & McGregor, J. L., 2008, In: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2008, 1, 813236.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
2007
Novel technique for estimating cerebrovascular permeability demonstrates capsazepine protection following ischemia-reperfusion
Cauden, V., Hu, D. E., Kurokawa, T., Sarker, M. H. & Fraser, P. A., Nov 2007, In: Microcirculation. 14, 8, p. 767 - 778 12 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
Norman, P. J., bi-Rached, L., Gendzekhadze, K., Korbel, D., Gleimer, M., Rowley, D., Bruno, D., Carrington, C. V. F., Chandanayingyong, D., Chang, Y. H., Crespi, C., Saruhan-Direskeneli, G., Fraser, P. A., Hameed, K., Kamkamidze, G., Koram, K. A., Layrisse, Z., Matamoros, N., Mila, J. & Park, M. H. & 12 others, , Sept 2007, In: Nature Genetics. 39, 9, p. 1092 - 1099 8 p.Research output: Contribution to journal › Article › peer-review
197 Citations (Scopus) -
Unusual Selection on the KIR3DL1/S1 natural killer receptor in Africans.
Norman, P., Abi-Rached, L., Gendzekhadze, K., Korbel, D., Gleimer, M., Rowley, D., Bruno, D., Carrington, C., Chandanayingyong, D., Chang, Y., Crespi, C., Saruhan-Direskenli, G., Fraser, P., Hameed, K., Kamkamidze, G., Koram, K., Layrisse, Z., Matamoros, N., Mila, J. & Park, M. & 11 others, , 2007, In: Nature Genetics. 39, p. 10920 - 10929 10 p.Research output: Contribution to journal › Article › peer-review
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2006
Can a broken barrier be repaired?
Fraser, P. A., 1 Jun 2006, In: The Journal of Physiology. 573, 2, p. 287 - 287 1 p.Research output: Contribution to journal › Editorial › peer-review
1 Citation (Scopus) -
2005
TRPV1 activation results in disruption of the blood-brain barrier in the rat
Hu, D. E., Easton, A. S. & Fraser, P. A., Oct 2005, In: British Journal of Pharmacology. 146, 4, p. 576 - 584 9 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
2002
Measurement of intracapillary pH to investigate the role of bicarbonate in H+ transport across the blood-brain barrier in the anaesthetized rat
Akanmu, D. & Fraser, P. A., 2002, In: The Journal of Physiology. 539, p. 91P - 92PResearch output: Contribution to journal › Meeting abstract
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MRI measurement of blood-brain barrier permeability following spontaneous reperfusion in the starch microsphere model of ischemia
Harris, N. G., Gauden, V., Fraser, P. A., Williams, S. R. & Parker, G. J. M., 2002, In: Magnetic Resonance Imaging. 20, 3, p. 221 - 230 10 p.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus) -
The role of guanylyl cyclases in the permeability response to inflammatory mediators in pial venular capillaries in the rat
Sarker, M. H. & Fraser, P. A., 1 Apr 2002, In: The Journal of Physiology. 540, 1, p. 209 - 218 10 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
2001
Confocal imaging of islet microcirculation in vivo: nitric oxide dependence of flow response to glucose
Sarker, M. H., Fraser, P. A. & Pedley, K. C., 2001, In: The Journal of Physiology. 536, p. 168P - 169PResearch output: Contribution to journal › Meeting abstract
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2000
Acute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat
Sarker, M. H., Hu, D. E. & Fraser, P. A., 1 Oct 2000, In: The Journal of Physiology. 528, 1, p. 177 - 187 11 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
Free radicals promote cerebrovascular leakage transiently following ischeamia
Gauden, V. & Fraser, P. A., 2000, In: Faseb Journal. 14, 4, p. A12 - A12Research output: Contribution to journal › Meeting abstract
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Particulate guanylate cyclase is required for acute permeability response to bradykinin in rat brain venules
Sarker, M. H. & Fraser, P. A., 2000, In: Faseb Journal. 14, 4, p. A24 - A24Research output: Contribution to journal › Meeting abstract
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1997
The effect of distance on long-range chromatin interactions
Dillon, N., Trimborn, T., Strouboulis, J., Fraser, P. & Grosveld, F., Dec 1997, In: MOLECULAR CELL. 1, 1, p. 131-9 9 p.Research output: Contribution to journal › Article › peer-review
170 Citations (Scopus) -
1996
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription
Milot, E., Strouboulis, J., Trimborn, T., Wijgerde, M., de Boer, E., Langeveld, A., Tan-Un, K., Vergeer, W., Yannoutsos, N., Grosveld, F. & Fraser, P., 4 Oct 1996, In: Cell. 87, 1, p. 105-14 10 p.Research output: Contribution to journal › Article › peer-review
292 Citations (Scopus)