Research output per year
Research output per year
Personal profile
Research interests
The laboratory studies cells that mediate asthma, we are interested in how gene expression is both upregulated and repressed and the molecular basis of glucocorticoid resistance in asthmatic patients.
Research interests (short)
Transcription, chromatin, asthma.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Identification of a transcription factor network regulating anti-TNF mediated IL10 expression in human CD4+ T cells
Povoleri, G., Ridley, M., Marrow, R., Lalnunhlimi, S., Ryan, S., Kelly, A., Lavender, P. & Taams, L., 27 Jul 2024, In: Discovery Immunology. 3, 1, kyae013.Research output: Contribution to journal › Article › peer-review
Open Access -
Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in Acute Promyelocytic Leukemia
Dillon, R., Villiers, W., Osborne, C. & Lavender, P., 24 Jan 2023, (Accepted/In press) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
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Autocrine vitamin D signaling switches off pro-inflammatory programs of T
Chauss, D., Freiwald, T., McGregor, R., Yan, B., Wang, L., Nova-Lamperti, E., Kumar, D., Zhang, Z., Teague, H., West, E. E., Vannella, K. M., Ramos-Benitez, M. J., Bibby, J., Kelly, A., Malik, A., Freeman, A. F., Schwartz, D. M., Portilla, D., Chertow, D. S. & John, S. & 9 others, , Jan 2022, In: Nature Immunology. 23, 1, p. 62-74 13 p.Research output: Contribution to journal › Article › peer-review
Open Access140 Citations (Scopus) -
Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis
Kim, S., Boehme, L., Nel, L., Casian, A., Sangle, S., Nova-Lamperti, E., Seitan, V., Spencer, J., Lavender, P., D'Cruz, D. P. & John, S., 15 Feb 2022, In: Journal of immunology (Baltimore, Md. : 1950). 208, 4, p. 807-818 12 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
Switzer, C. H., Cho, H. J., Eykyn, T. R., Lavender, P. & Eaton, P., 24 May 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 21, p. e2200022119 e2200022119.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus)
Projects
- 26 Finished
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Innate immunity driven HIV-1gp140 linked HSP70 mucosal vaccine in a phase 2 clinical trial in women
Lehner, T. (Primary Investigator), Lavender, P. (Co-Investigator), Neil, S. (Co-Investigator) & Peters, B. (Co-Investigator)
1/07/2016 → 30/06/2020
Project: Research
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Determining the molecular mechanisms underlying IL-10 expression in human CD4+ T-cells following TNF blockade
Taams, L. (Primary Investigator), Dionne, M. (Co-Investigator) & Lavender, P. (Co-Investigator)
1/04/2016 → 31/07/2023
Project: Research
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Identification and targeting of chromatin interactions in airway epithelial cells of people with asthma during viral infection
McErlean, K. (Primary Investigator) & Lavender, P. (Co-Investigator)
1/10/2015 → 30/09/2018
Project: Research
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Interferon stimulated genes in SLE of stress-mediated CD4+ memory T cells
Lehner, T. (Primary Investigator), Lavender, P. (Co-Investigator) & Smyth, L. (Co-Investigator)
1/02/2015 → 31/01/2016
Project: Research
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Defining immune phenotypes in steroid sensitive and steroid refractory asthma patients, and how this is altered by vitamin D: in vitro and in vivo investigations
Hawrylowicz, C. (Primary Investigator), Corrigan, C. (Co-Investigator) & Lavender, P. (Co-Investigator)
1/10/2013 → 30/09/2016
Project: Research
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Environment, epigenome and asthma
Lavender, P. (Speaker)
4 Jun 2019Activity: Talk or presentation › Invited talk
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Epigenetic control of of gene expression and epigenome editing in asthma
Lavender, P. (Speaker)
29 May 2018Activity: Talk or presentation › Invited talk
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Journal of Biological Chemistry (Journal)
Lavender, P. (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Journal of Immunology (Journal)
Lavender, P. (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review
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European Respiratory Society: Reversal of histone and DNA methylation
Lavender, P. (Keynote/plenary speaker)
2001 → …Activity: Participating in or organising an event › Participation in conference