Pei-Chien Tsai

2024

Enhanced resolution profiling in twins reveals differential methylation signatures of Type 2 Diabetes with links to its complications

Christiansen, C., Potier, L., Martin, T. C., Villicana Munoz, S., Castillo Fernandez, J., Mangino, M., Menni, C., Tsai, P-C., Campbell, P. J., Mullin, S., Ordoñana, J. R., Monteagudo, O., Sachdev, P. S., Mather, K. A., Trollor, J. N., Pietiläinen, K. H., Ollikainen, M., Dalgård, C., Kyvik, K. O., Christensen, K., & 9 othersvan Dongen, J., Willemsen, G., Boomsma, D. I., Magnusson, P. KE., Pedersen, N. L., Wilson, S. G., Grundberg, E., Spector, T. & Bell, J., 2024, In: EBioMedicine. 103, 105096.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9

Weihs, A., Chaker, L., Martin, T. C., Braun, K. V. E., Campbell, P. J., Cox, S. R., Fornage, M., Gieger, C., Grabe, H. J., Grallert, H., Harris, S. E., Kühnel, B., Marioni, R. E., Martin, N. G., Mccartney, D. L., Mcrae, A. F., Meisinger, C., Van meurs, J. B. J., Nano, J., Nauck, M., & 21 othersPeters, A., Prokisch, H., Roden, M., Selvin, E., Beekman, M., Van heemst, D., Slagboom, E. P., Swenson, B. R., Tin, A., Tsai, P-C., Uitterlinden, A., Visser, W. E., Völzke, H., Waldenberger, M., Walsh, J. P., Köttgen, A., Wilson, S. G., Peeters, R. P., Bell, J. T., Medici, M. & Teumer, A., 16 Mar 2023, In: Thyroid. 33, 3, p. 301-311 11 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Genetic impacts on DNA methylation help elucidate regulatory genomic processes

Villicaña, S., Castillo-Fernandez, J., Hannon, E., Christiansen, C., Tsai, P-C., Maddock, J., Kuh, D., Suderman, M., Power, C., Relton, C., Ploubidis, G., Wong, A., Hardy, R., Goodman, A., Ong, K. K. & Bell, J., 31 Jul 2023, In: Genome Biology. 24, 1, 176.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

2022

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

BIOS Consortium, 3 May 2022, In: Nature Communications. 13, 1, p. 2408 1 p., 2408.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

2021

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Karabegović, I., Portilla-Fernandez, E., Li, Y., Ma, J., Maas, S. C. E., Sun, D., Hu, E. A., Kühnel, B., Zhang, Y., Ambatipudi, S., Fiorito, G., Huang, J., Castillo-Fernandez, J. E., Wiggins, K. L., de Klein, N., Grioni, S., Swenson, B. R., Polidoro, S., Treur, J. L., Cuenin, C., & 30 othersTsai, P. C., Costeira, R., Chajes, V., Braun, K., Verweij, N., Kretschmer, A., Franke, L., van Meurs, J. B. J., Uitterlinden, A. G., de Knegt, R. J., Ikram, M. A., Dehghan, A., Peters, A., Schöttker, B., Gharib, S. A., Sotoodehnia, N., Bell, J. T., Elliott, P., Vineis, P., Relton, C., Herceg, Z., Brenner, H., Waldenberger, M., Rebholz, C. M., Voortman, T., Pan, Q., Fornage, M., Levy, D., Kayser, M. & Ghanbari, M., Dec 2021, In: Nature Communications. 12, 1, 2830.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Citations (Scopus)

Identical twins carry a persistent epigenetic signature of early genome programming

Genetics of DNA Methylation Consortium & BIOS Consortium, 1 Sept 2021, In: Nature Communications. 12, 1, 1 p., 5618.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

2020

Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals

Colicino, E., Marioni, R., Ward-Caviness, C., Gondalia, R., Guan, W., Chen, B., Tsai, P. C., Huan, T., Xu, G., Golareh, A., Schwartz, J., Vokonas, P., Just, A., Starr, J. M., McRae, A. F., Wray, N. R., Visscher, P. M., Bressler, J., Zhang, W., Tanaka, T., & 29 othersMoore, A. Z., Pilling, L. C., Zhang, G., Stewart, J. D., Li, Y., Hou, L., Castillo-Fernandez, J., Spector, T., Kiel, D. P., Murabito, J. M., Liu, C., Mendelson, M., Assimes, T., Absher, D., Tsaho, P. S., Lu, A. T., Ferrucci, L., Wilson, R., Waldenberger, M., Prokisch, H., Bandinelli, S., Bell, J. T., Levy, D., Deary, I. J., Horvath, S., Pankow, J., Peters, A., Whitsel, E. A. & Baccarelli, A., 31 Jul 2020, In: Aging. 12, 14, p. 14092-14124 33 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

2019

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals

Mandaviya, P. R., Joehanes, R., Brody, J., Castillo-Fernandez, J. E., Dekkers, K. F., Do, A. N., Graff, M., Hänninen, I. K., Tanaka, T., de Jonge, E. A. L., Kiefte-de Jong, J. C., Absher, D. M., Aslibekyan, S., de Rijke, Y. B., Fornage, M., Hernandez, D. G., Hurme, M. A., Ikram, M. A., Jacques, P. F., Justice, A. E., & 27 othersKiel, D. P., Lemaitre, R. N., Mendelson, M. M., Mikkilä, V., Moore, A. Z., Pallister, T., Raitakari, O. T., Schalkwijk, C. G., Sha, J., Slagboom, E. P. E., Smith, C. E., Stehouwer, C. D. A., Tsai, P. C., Uitterlinden, A. G., van der Kallen, C. J. H., van Heemst, D., Arnett, D. K., Bandinelli, S., Bell, J. T., Heijmans, B. T., Lehtimäki, T., Levy, D., North, K. E., Sotoodehnia, N., van Greevenbroek, M. M. J., van Meurs, J. B. J. & Heil, S. G., 1 Aug 2019, In: The American journal of clinical nutrition. 110, 2, p. 437-450 14 p.

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

DNA methylation-based estimator of telomere length

Lu, A. T., Seeboth, A., Tsai, P. C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., Li, Y., Harris, S. E., Corley, J., Taylor, A., Deary, I. J., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Chen, W., Li, S., & 7 othersMangino, M., Bell, J. T., Wilson, J. G., Aviv, A., Marioni, R. E., Raj, K. & Horvath, S., 18 Aug 2019, In: Aging. 11, 16, p. 5895-5923 29 p.

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Open Access

193 Citations (Scopus)

Epigenetic findings in periodontitis in UK twins: a cross sectional study

Kurushima, Y., Tsai, P-C., Castillo-Fernandez, J., Couto Alves, A., El-Sayed Moustafa, J. S., Le Roy, C., Ide, M., Hughes, F., Glastonbury, C. A., Small, K. S., Steves, C. J. & Bell, J. T., 13 Feb 2019, In: Clinical Epigenetics . 11, 1, 13 p., 27.

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35 Citations (Scopus)

210 Downloads (Pure)

2018

Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

Viñuela, A., Brown, A. A., Buil, A., Tsai, P-C., Davies, M. N., Bell, J. T., Dermitzakis, E. T., Spector, T. D. & Small, K. S., 15 Feb 2018, In: Human Molecular Genetics. 27, 4, p. 732–741

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64 Citations (Scopus)

205 Downloads (Pure)

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

Zaghlool, S. B., Mook-Kanamori, D. O., Kader, S., Stephan, N., Halama, A., Engelke, R., Sarwath, H., Al-Dous, E. K., Mohamoud, Y. A., Roemisch-Margl, W., Adamski, J., Kastenmüller, G., Friedrich, N., Visconti, A., Tsai, P-C., Spector, T., Bell, J., Falchi, M., Wahl, A., Waldenberger, M., & 7 othersPeters, A., Gieger, C., Pezer, M., Lauc, G., Graumann, J., Malek, J. A. & Suhre, K., 8 Jan 2018, (E-pub ahead of print) In: Human Molecular Genetics.

Research output: Contribution to journal › Article › peer-review

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33 Citations (Scopus)

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Lu, A. T., Xue, L., Salfati, E. L., Chen, B. H., Ferrucci, L., Levy, D., Joehanes, R., Murabito, J. M., Kiel, D. P., Tsai, P. C., Yet, I., Bell, J. T., Mangino, M., Tanaka, T., McRae, A. F., Marioni, R. E., Visscher, P. M., Wray, N. R., Deary, I. J., Levine, M. E., & 19 othersQuach, A., Assimes, T., Tsao, P. S., Absher, D., Stewart, J. D., Li, Y., Reiner, A. P., Hou, L., Baccarelli, A. A., Whitsel, E. A., Aviv, A., Cardona, A., Day, F. R., Wareham, N. J., Perry, J. R. B., Ong, K. K., Raj, K., Lunetta, K. L. & Horvath, S., 26 Jan 2018, (E-pub ahead of print) In: Nature Communications. 9, 1, 387.

Research output: Contribution to journal › Article › peer-review

Open Access

134 Citations (Scopus)

Meta-analysis of epigenome-wide association studies of cognitive abilities

Marioni, R. E., McRae, A. F., Bressler, J., Colicino, E., Hannon, E., Li, S., Prada, D., Smith, J. A., Trevisi, L., Tsai, P-C., Vojinovic, D., Simino, J., Levy, D., Liu, C., Mendelson, M., Satizabal, C. L., Yang, Q., Jhun, M. A., Kardia, S. L. R., Zhao, W., & 27 othersBandinelli, S., Ferrucci, L., Hernandez, D. G., Singleton, A. B., Harris, S. E., Starr, J. M., Kiel, D. P., McLean, R. R., Just, A. C., Schwartz, J., Spiro, A., Vokonas, P., Amin, N., Ikram, M. A., Uitterlinden, A. G., van Meurs, J. B. J., Spector, T. D., Steves, C., Baccarelli, A. A., Bell, J. T., van Duijn, C. M., Fornage, M., Hsu, Y-H., Mill, J., Mosley, T. H., Seshadri, S. & Deary, I. J., 8 Jan 2018, (E-pub ahead of print) In: Molecular Psychiatry. 23, 11, p. 2133-2144

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

Small, K. S., Marijana, M., Civelek, M., El-Sayed Moustafa, J. S., Wang, X., Simon, M. M., Tajes, J. F., Mahajan, A., Horikoshi, M., Hugill, A., Glastonbury, C. A., Quaye, L., Neville, M. J., Sethi, S., Yon, M., Pan, C., Che, N., Vinuela, A., Tsai, P-C., Nag, A., & 17 othersBuil, A., Thorleifsson, G., Raghavan, A., Ding, Q., Morris, A. P., Bell, J. T., Thorsteinsdottir, U., Stefansson, K., Laakso, M., Dahlman, I., Arner, P., Gloyn, A. L., Musunuru, K., Lusis, A. J., Cox, R. D., Karpe, F. & McCarthy, M. I., Apr 2018, In: Nature Genetics. 50, p. 572–580

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112 Citations (Scopus)

240 Downloads (Pure)

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health 06 Biological Sciences 0604 Genetics

Tsai, P. C., Glastonbury, C. A., Eliot, M. N., Bollepalli, S., Yet, I., Castillo-Fernandez, J. E., Carnero-Montoro, E., Hardiman, T., Martin, T. C., Vickers, A., Mangino, M., Ward, K., Pietiläinen, K. H., Deloukas, P., Spector, T. D., Viñuela, A., Loucks, E. B., Ollikainen, M., Kelsey, K. T., Small, K. S., & 1 othersBell, J. T., 20 Oct 2018, In: Clinical Epigenetics. 10, 1, 126.

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Open Access

89 Citations (Scopus)

2016

Epigenetic associations of type 2 diabetes and BMI in an Arab population

Al Muftah, W. A., Al-Shafai, M., Zaghlool, S. B., Visconti, A., Tsai, P-C., Kumar, P., Spector, T., Bell, J., Falchi, M. & Suhre, K., 2016, In: Clinical Epigenetics . 8, 13.

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102 Citations (Scopus)

291 Downloads (Pure)

Genetic and environmental impacts on DNA methylation levels in twins

Yet, I., Tsai, P. C., Castillo-Fernandez, J. E., Carnero-Montoro, E. & Bell, J. T., 1 Jan 2016, In: Epigenomics. 8, 1, p. 105-117 13 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity

Mangino, M., Cecelja, M., Menni, C., Tsai, P. C., Yuan, W., Small, K., Bell, J., Mitchell, G. F., AortaGen Consortium, Chowienczyk, P. & Spector, T. D., 1 Jan 2016, In: Journal of Hypertension. 34, 1, p. 79-87 9 p.

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17 Citations (Scopus)

261 Downloads (Pure)

2015

coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns

Martin, T. C., Yet, I., Tsai, P-C. & Bell, J. T., 28 Apr 2015, In: BMC Bioinformatics. 16, 131.

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92 Citations (Scopus)

226 Downloads (Pure)

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

Tsai, P. C., Van Dongen, J., Tan, Q., Willemsen, G., Christiansen, L., Boomsma, D. I., Spector, T. D., Valdes, A. M. & Bell, J. T., Dec 2015, In: TWIN RESEARCH AND HUMAN GENETICS. 18, 6, p. 635-646

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation

Tsai, P-C. & Bell, J. T., 13 May 2015, In: International Journal of Epidemiology. 44, 4, p. 1429-1441

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163 Citations (Scopus)

216 Downloads (Pure)

2014

Epigenome-Wide DNA Methylation in Hearing Ability: New Mechanisms for an Old Problem

Wolber, L. E., Steves, C. J., Tsai, P-C., Deloukas, P., Spector, T. D., Bell, J. T. & Williams, F. M. K., 3 Sept 2014, In: PL o S One . 9, 9, 11 p., e105729.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

Davies, M. N., Krause, L., Bell, J. T., Gao, F., Ward, K. J., Wu, H., Lu, H., Liu, Y., Tsai, P-C., Collier, D. A., Murphy, T., Dempster, E., Mill, J., Battle, A., Mostafavi, S., Zhu, X., Henders, A., Byrne, E., Wray, N. R., Martin, N. G., & 3 othersSpector, T. D., Wang, J. & UK Brain Expression Consortium, 2014, In: GENOME BIOLOGY. 15, 4, 12 p., R56.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Citations (Scopus)

Obesity accelerates epigenetic aging of human liver

Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., von Schönfels, W., Ahrens, M., Heits, N., Bell, J. T., Tsai, P-C., Spector, T. D., Deloukas, P., Siebert, R., Sipos, B., Becker, T., Röcken, C., Schafmayer, C. & Hampe, J., 28 Oct 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15538-15543 6 p.

Research output: Contribution to journal › Article › peer-review

534 Citations (Scopus)

Pei-Chien Tsai

Research output

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