King's College London

Research portal

Dr Pei-Chien Tsai

  1. Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals

    Colicino, E., Marioni, R., Ward-Caviness, C., Gondalia, R., Guan, W., Chen, B., Tsai, P. C., Huan, T., Xu, G., Golareh, A., Schwartz, J., Vokonas, P., Just, A., Starr, J. M., McRae, A. F., Wray, N. R., Visscher, P. M., Bressler, J., Zhang, W., Tanaka, T. & 29 others, Moore, A. Z., Pilling, L. C., Zhang, G., Stewart, J. D., Li, Y., Hou, L., Castillo-Fernandez, J., Spector, T., Kiel, D. P., Murabito, J. M., Liu, C., Mendelson, M., Assimes, T., Absher, D., Tsaho, P. S., Lu, A. T., Ferrucci, L., Wilson, R., Waldenberger, M., Prokisch, H., Bandinelli, S., Bell, J. T., Levy, D., Deary, I. J., Horvath, S., Pankow, J., Peters, A., Whitsel, E. A. & Baccarelli, A., 31 Jul 2020, In : Aging. 12, 14, p. 14092-14124 33 p.

    Research output: Contribution to journalArticle

  2. DNA methylation-based estimator of telomere length

    Lu, A. T., Seeboth, A., Tsai, P. C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., Li, Y., Harris, S. E., Corley, J., Taylor, A., Deary, I. J., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Chen, W., Li, S. & 7 others, Mangino, M., Bell, J. T., Wilson, J. G., Aviv, A., Marioni, R. E., Raj, K. & Horvath, S., 18 Aug 2019, In : Aging. 11, 16, p. 5895-5923 29 p.

    Research output: Contribution to journalArticle

  3. Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals

    Mandaviya, P. R., Joehanes, R., Brody, J., Castillo-Fernandez, J. E., Dekkers, K. F., Do, A. N., Graff, M., Hänninen, I. K., Tanaka, T., de Jonge, E. A. L., Kiefte-de Jong, J. C., Absher, D. M., Aslibekyan, S., de Rijke, Y. B., Fornage, M., Hernandez, D. G., Hurme, M. A., Ikram, M. A., Jacques, P. F., Justice, A. E. & 27 others, Kiel, D. P., Lemaitre, R. N., Mendelson, M. M., Mikkilä, V., Moore, A. Z., Pallister, T., Raitakari, O. T., Schalkwijk, C. G., Sha, J., Slagboom, E. P. E., Smith, C. E., Stehouwer, C. D. A., Tsai, P. C., Uitterlinden, A. G., van der Kallen, C. J. H., van Heemst, D., Arnett, D. K., Bandinelli, S., Bell, J. T., Heijmans, B. T., Lehtimäki, T., Levy, D., North, K. E., Sotoodehnia, N., van Greevenbroek, M. M. J., van Meurs, J. B. J. & Heil, S. G., 1 Aug 2019, In : The American journal of clinical nutrition. 110, 2, p. 437-450 14 p.

    Research output: Contribution to journalArticle

  4. Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health 06 Biological Sciences 0604 Genetics

    Tsai, P. C., Glastonbury, C. A., Eliot, M. N., Bollepalli, S., Yet, I., Castillo-Fernandez, J. E., Carnero-Montoro, E., Hardiman, T., Martin, T. C., Vickers, A., Mangino, M., Ward, K., Pietiläinen, K. H., Deloukas, P., Spector, T. D., Viñuela, A., Loucks, E. B., Ollikainen, M., Kelsey, K. T., Small, K. S. & 1 others, Bell, J. T., 20 Oct 2018, In : Clinical Epigenetics. 10, 1, 126.

    Research output: Contribution to journalArticle

  5. Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

    Small, K. S., Marijana, M., Civelek, M., El-Sayed Moustafa, J. S., Wang, X., Simon, M. M., Tajes, J. F., Mahajan, A., Horikoshi, M., Hugill, A., Glastonbury, C. A., Quaye, L., Neville, M. J., Sethi, S., Yon, M., Pan, C., Che, N., Vinuela, A., Tsai, P-C., Nag, A. & 17 others, Buil, A., Thorleifsson, G., Raghavan, A., Ding, Q., Morris, A. P., Bell, J. T., Thorsteinsdottir, U., Stefansson, K., Laakso, M., Dahlman, I., Arner, P., Gloyn, A. L., Musunuru, K., Lusis, A. J., Cox, R. D., Karpe, F. & McCarthy, M. I., Apr 2018, In : Nature Genetics. 50, p. 572–580

    Research output: Contribution to journalArticle

  6. Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

    Viñuela, A., Brown, A. A., Buil, A., Tsai, P-C., Davies, M. N., Bell, J. T., Dermitzakis, E. T., Spector, T. D. & Small, K. S., 15 Feb 2018, In : Human Molecular Genetics. 27, 4, p. 732–741

    Research output: Contribution to journalArticle

  7. GWAS of epigenetic aging rates in blood reveals a critical role for TERT

    Lu, A. T., Xue, L., Salfati, E. L., Chen, B. H., Ferrucci, L., Levy, D., Joehanes, R., Murabito, J. M., Kiel, D. P., Tsai, P. C., Yet, I., Bell, J. T., Mangino, M., Tanaka, T., McRae, A. F., Marioni, R. E., Visscher, P. M., Wray, N. R., Deary, I. J., Levine, M. E. & 19 others, Quach, A., Assimes, T., Tsao, P. S., Absher, D., Stewart, J. D., Li, Y., Reiner, A. P., Hou, L., Baccarelli, A. A., Whitsel, E. A., Aviv, A., Cardona, A., Day, F. R., Wareham, N. J., Perry, J. R. B., Ong, K. K., Raj, K., Lunetta, K. L. & Horvath, S., 26 Jan 2018, In : Nature Communications. 9, 1, 387.

    Research output: Contribution to journalArticle

  8. Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

    Zaghlool, S. B., Mook-Kanamori, D. O., Kader, S., Stephan, N., Halama, A., Engelke, R., Sarwath, H., Al-Dous, E. K., Mohamoud, Y. A., Roemisch-Margl, W., Adamski, J., Kastenmüller, G., Friedrich, N., Visconti, A., Tsai, P-C., Spector, T., Bell, J., Falchi, M., Wahl, A., Waldenberger, M. & 7 others, Peters, A., Gieger, C., Pezer, M., Lauc, G., Graumann, J., Malek, J. A. & Suhre, K., 8 Jan 2018, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  9. Meta-analysis of epigenome-wide association studies of cognitive abilities

    Marioni, R. E., McRae, A. F., Bressler, J., Colicino, E., Hannon, E., Li, S., Prada, D., Smith, J. A., Trevisi, L., Tsai, P-C., Vojinovic, D., Simino, J., Levy, D., Liu, C., Mendelson, M., Satizabal, C. L., Yang, Q., Jhun, M. A., Kardia, S. L. R., Zhao, W. & 27 others, Bandinelli, S., Ferrucci, L., Hernandez, D. G., Singleton, A. B., Harris, S. E., Starr, J. M., Kiel, D. P., McLean, R. R., Just, A. C., Schwartz, J., Spiro, A., Vokonas, P., Amin, N., Ikram, M. A., Uitterlinden, A. G., van Meurs, J. B. J., Spector, T. D., Steves, C., Baccarelli, A. A., Bell, J. T., van Duijn, C. M., Fornage, M., Hsu, Y-H., Mill, J., Mosley, T. H., Seshadri, S. & Deary, I. J., 8 Jan 2018, In : Molecular Psychiatry. 23, 11, p. 2133-2144

    Research output: Contribution to journalArticle

  10. Genetic and environmental impacts on DNA methylation levels in twins

    Yet, I., Tsai, P. C., Castillo-Fernandez, J. E., Carnero-Montoro, E. & Bell, J. T., 1 Jan 2016, In : Epigenomics. 8, 1, p. 105-117 13 p.

    Research output: Contribution to journalArticle

  11. Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity

    Mangino, M., Cecelja, M., Menni, C., Tsai, P. C., Yuan, W., Small, K., Bell, J., Mitchell, G. F., AortaGen Consortium, Chowienczyk, P. & Spector, T. D., 1 Jan 2016, In : Journal of Hypertension. 34, 1, p. 79-87 9 p.

    Research output: Contribution to journalArticle

  12. Epigenetic associations of type 2 diabetes and BMI in an Arab population

    Al Muftah, W. A., Al-Shafai, M., Zaghlool, S. B., Visconti, A., Tsai, P-C., Kumar, P., Spector, T., Bell, J., Falchi, M. & Suhre, K., 2016, In : Clinical Epigenetics . 8, 13.

    Research output: Contribution to journalArticle

  13. DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

    Tsai, P. C., Van Dongen, J., Tan, Q., Willemsen, G., Christiansen, L., Boomsma, D. I., Spector, T. D., Valdes, A. M. & Bell, J. T., Dec 2015, In : TWIN RESEARCH AND HUMAN GENETICS. 18, 6, p. 635-646

    Research output: Contribution to journalArticle

  14. Obesity accelerates epigenetic aging of human liver

    Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., von Schönfels, W., Ahrens, M., Heits, N., Bell, J. T., Tsai, P-C., Spector, T. D., Deloukas, P., Siebert, R., Sipos, B., Becker, T., Röcken, C., Schafmayer, C. & Hampe, J., 28 Oct 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15538-15543 6 p.

    Research output: Contribution to journalArticle

  15. Epigenome-Wide DNA Methylation in Hearing Ability: New Mechanisms for an Old Problem

    Wolber, L. E., Steves, C. J., Tsai, P-C., Deloukas, P., Spector, T. D., Bell, J. T. & Williams, F. M. K., 3 Sep 2014, In : PL o S One . 9, 9, 11 p., e105729.

    Research output: Contribution to journalArticle

  16. Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

    Davies, M. N., Krause, L., Bell, J. T., Gao, F., Ward, K. J., Wu, H., Lu, H., Liu, Y., Tsai, P-C., Collier, D. A., Murphy, T., Dempster, E., Mill, J., Battle, A., Mostafavi, S., Zhu, X., Henders, A., Byrne, E., Wray, N. R., Martin, N. G. & 3 others, Spector, T. D., Wang, J. & UK Brain Expression Consortium, 2014, In : GENOME BIOLOGY. 15, 4, 12 p., R56.

    Research output: Contribution to journalArticle

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