King's College London

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Miss Petroula Proitsi

  1. Disentangling the Complex Relationship Between Hypertension and Dementia

    Proitsi, P., 15 Apr 2021, In: Biological psychiatry. 89, 8, p. 742-744 3 p.

    Research output: Contribution to journalComment/debatepeer-review

  2. An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

    Roubroeks, J. A. Y., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., Hannon, E. J., Kłoszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Wahlund, L. O., Aarsland, D., Proitsi, P., Hodges, A., Lovestone, S., Newhouse, S. J., Dobson, R. J. B., Mill, J. & 2 others, van den Hove, D. L. A. & Lunnon, K., Nov 2020, In: Neurobiology of Aging. 95, p. 26-45 20 p.

    Research output: Contribution to journalArticlepeer-review

  3. Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics

    Iacoangeli, A., Lin, T., Al Khleifat, A., Jones, A. R., Opie-Martin, S., Coleman, J. R. I., Shatunov, A., Sproviero, W., Williams, K. L., Garton, F., Restuadi, R., Henders, A. K., Mather, K. A., Needham, M., Mathers, S., Nicholson, G. A., Rowe, D. B., Henderson, R., McCombe, P. A., Pamphlett, R. & 11 others, Blair, I. P., Schultz, D., Sachdev, P. S., Newhouse, S. J., Proitsi, P., Fogh, I., Ngo, S. T., Dobson, R. J. B., Wray, N. R., Steyn, F. J. & Al-Chalabi, A., 27 Oct 2020, In: Cell Reports. 33, 4, p. 108323

    Research output: Contribution to journalArticlepeer-review

  4. Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease

    AddNeuroMed Consortium, 21 Sep 2020, In: Translational Neurodegeneration. 9, 1, p. 36 36.

    Research output: Contribution to journalArticlepeer-review

  5. Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

    Pishva, E., Creese, B., Smith, A. R., Viechtbauer, W., Proitsi, P., van den Hove, D. L. A., Ballard, C., Mill, J. & Lunnon, K., May 2020, In: Neurobiology of Aging. 89, p. 83-88 6 p.

    Research output: Contribution to journalArticlepeer-review

  6. Exploration of Plasma Lipids in Mild Cognitive Impairment due to Alzheimer's Disease

    Bergland, A. K., Proitsi, P., Kirsebom, B. E., Soennesyn, H., Hye, A., Larsen, A. I., Xu, J., Legido-Quigley, C., Rajendran, L., Fladby, T. & Aarsland, D., 2020, In: Journal of Alzheimer's Disease. 77, 3, p. 1117-1127 11 p.

    Research output: Contribution to journalArticlepeer-review

  7. Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease

    AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative, 1 Dec 2019, In: Translational psychiatry. 9, 1, 1 p., 273.

    Research output: Contribution to journalArticlepeer-review

  8. A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

    Stamate, D., Kim, M., Proitsi, P., Westwood, S., Baird, A., Nevado-Holgado, A., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Teunissen, C. E., Kate, M. T., Scheltens, P., Gabel, S., Meersmans, K., Blin, O., Richardson, J., De Roeck, E., Engelborghs, S., Sleegers, K. & 25 others, Bordet, R., Ramit, L., Kettunen, P., Tsolaki, M., Verhey, F., Alcolea, D., Lléo, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Blennow, K., Zetterberg, H., Streffer, J., Visser, P. J., Lovestone, S. & Legido-Quigley, C., 1 Jan 2019, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 933-938 6 p.

    Research output: Contribution to journalArticlepeer-review

  9. Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

    Kim, M., Nevado-Holgado, A., Whiley, L., Snowden, S. G., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Thambisetty, M., Dobson, R. J. B., Powell, J. E., Lupton, M. K., Simmons, A., Velayudhan, L., Lovestone, S., Proitsi, P. & Legido-Quigley, C., 3 Oct 2017, In: JOURNAL OF ALZHEIMERS DISEASE. 60, 3, p. 809-817

    Research output: Contribution to journalArticlepeer-review

  10. DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION: 2017 Abstract Supplement

    Westwood, S., Hye, A., Lleó, A., Nevado-Holgado, A. J., Baird, A. L., Wallin, A., Leslie, A., Jimenez, B., Liu, B. Y., Legido-Quigley, C., Dima, D., Ruvolo, D., Holmes, E., D'Hondt, E., Westman, E., Barkhof, F., Frisoni, G. B., Zetterberg, H., Bos, I., Pearce, J. & 27 others, Streffer, J., Molinuevo, J. L., Popp, J., Bertram, L., Whiley, L., Maslen, L., Gomez-Romero, M., David, M., Lewis, M., Kurbatova, N., Ashton, N. J., Voyle, N., Kowalczyk, O., Martinez-Lage, P., Proitsi, P., Scheltens, P., Visser, P. J., Dobson, R. JB., Vandenberghe, R., Engelborghs, S., Vos, S. J. B., Snowden, S. G., Athersuch, T., Ashby, T., Kimhofer, T., Verachtert, W. & Lovestone, S., Jul 2017, In: Alzheimer's & Dementia. 13, 7, Supplement, p. P174-P175

    Research output: Contribution to journalMeeting abstractpeer-review

  11. Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease

    Sattlecker, M., Khondoker, M., Proitsi, P., Williams, S., Soininen, H., K??oszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S. & Dobson, R. J., 23 Nov 2015, In: JOURNAL OF ALZHEIMERS DISEASE. 49, 4, p. 1105-1114 10 p.

    Research output: Contribution to journalArticlepeer-review

  12. Genetic influences on metabolite levels in Alzheimer’s disease

    Proitsi, P., Min, K., Whiley, L., Newhouse, S., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M. & Vellas, B., 2015, In: Alzheimer's Dementia: The Journal of the Alzheimer's Association. 11, 7, p. P279-P280

    Research output: Contribution to journalArticlepeer-review

  13. Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

    Whiley, L., Sen, A., Heaton, J., Proitsi, P., Garcia-Gomez, D., Leung, R., Smith, N., Thambisetty, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S. & Legido Quigley, C., 1 Feb 2014, In: Neurobiology of Aging. 35, 2, p. 271-278 8 p.

    Research output: Contribution to journalArticlepeer-review

  14. Candidate Blood Proteome Markers of Alzheimer's Disease Onset and Progression: A Systematic Review and Replication Study

    Kiddle, S. J., Sattlecker, M., Proitsi, P., Simmons, A., Westman, E., Bazenet, C., Nelson, S. K., Williams, S., Hodges, A., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Newhouse, S., Lovestone, S. & Dobson, R. J. B., 2014, In: JOURNAL OF ALZHEIMERS DISEASE. 38, 3, p. 515-531 17 p., N/A.

    Research output: Contribution to journalLiterature reviewpeer-review

  15. Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study

    Kiddle, S. J., Sattlecker, M., Proitsi, P., Simmons, A., Westman, E., Bazenet, C., Nelson, S. K., Williams, S., Hodges, A. & Johnston, C., 2014, In: Journal of Alzheimer's Disease. 38, 3, p. 515-531 17 p.

    Research output: Contribution to journalArticlepeer-review

  16. The role of ABCA1 gene sequence variants on risk of Alzheimer's disease

    Lupton, M. K., Proitsi, P., Lin, K., Hamilton, G., Daniilidou, M., Tsolaki, M. & Powell, J. F., 2014, In: Journal of Alzheimer's disease : JAD. 38, 4, p. 897-906 10 p.

    Research output: Contribution to journalArticlepeer-review

  17. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Lambert, J-C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., Jun, G., DeStefano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thornton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N. & 34 others, Kamatani, Y., Lin, C-F., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M. L., Ruiz, A., Bihoreau, M-T., Choi, S-H., Reitz, C., Pasquier, F., Hollingworth, P., Ramirez, A., Hanon, O., Fitzpatrick, A. L., Buxbaum, J. D., Campion, D., Crane, P. K., Baldwin, C., Becker, T., Gudnason, V., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., De Jager, P. L., Lovestone, S., Proitsi, P., Powell, J. F., EADI, GERAD, ADGC & CHARGE, Dec 2013, In: Nature Genetics. 45, 12, p. 1452-1458 7 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  18. HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B

    Seto, W-K., Wong, D. K-H., Kopaniszen, M., Proitsi, P., Sham, P-C., Hung, I. F-N., Fung, J., Lai, C-L. & Yuen, M-F., Jun 2013, In: Clinical Infectious Diseases. 56, 12, p. 1695-1703 9 p.

    Research output: Contribution to journalArticlepeer-review

  19. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., Jones, N., Thomas, C., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C. & 67 others, Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Bussche, H. V. D., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Sleegers, K., Bettens, K., Engelborghs, S., Deyn, P. P. D., Broeckhoven, C. V., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Tsolaki, M., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K-H., Klopp, N., Wichmann, H-E., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Holmans, P. A., OtextquotesingleDonovan, M., Owen, M. J. & Williams, J., 1 May 2013, In: Nature Genetics. 45, 6, p. 712-712 1 p.

    Research output: Contribution to journalArticlepeer-review

  20. A Blood Gene Expression Marker of Early Alzheimer's Disease

    Lunnon, K., Sattlecker, M., Furney, S. J., Coppola, G., Simmons, A., Proitsi, P., Lupton, M. K., Lourdusamy, A., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Geschwind, D., Lovestone, S., Dobson, R., Hodges, A. & AddNeuroMed Consortium, 2013, In: JOURNAL OF ALZHEIMERS DISEASE. 33, 3, p. 737-753 17 p.

    Research output: Contribution to journalArticlepeer-review

  21. Candidate Blood Proteome Markers of Alzheimer’s Disease Onset and Progression: A Systematic Review and Replication Study

    Kiddle, S., Sattlecker, M., Proitsi, P., Simmons, A., Westman, E., Bazenet, C., Nelson, S., Williams, S., Hodges, A., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Newhouse, S., Lovestone, S. & Dobson, R., 2013, In: JOURNAL OF ALZHEIMERS DISEASE. N/A, N/A, p. N/A N/A.

    Research output: Contribution to journalArticlepeer-review

  22. Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease

    Velayudhan, L., Proitsi, P., Westman, E., Muehlboeck, J-S., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., Spenger, C., Hodges, A., Powell, J., Lovestone, S., Simmons, A. & AddNeuroMed Consortium, 2013, In: JOURNAL OF ALZHEIMERS DISEASE. 33, 3, p. 755-766 12 p.

    Research output: Contribution to journalArticlepeer-review

  23. Missense substitutions associated with behavioural disturbances in Alzheimer's disease (AD)

    Proitsi, P. & Powell, J. F., 1 Aug 2012, In: Brain Research Bulletin. 88, 5, p. 394-405 12 p.

    Research output: Contribution to journalArticlepeer-review

  24. Genome-wide association analysis identifies common variants associated with measures of disease progression in patients with Alzheimer's disease

    Newhouse, S., Proitsi, P., Sattlecker, M., Lunnon, K., Ibrahim, Z., Johnston, C., Lourdusamy, A., Lupton, M., Powell, J., Khondoker, M., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A. & Dobson, R., Jul 2012, In: Alzheimer's & Dementia. 8, 4, Supplement, p. P101-P101 1 p., O1-09-03.

    Research output: Contribution to journalMeeting abstractpeer-review

  25. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia

    Proitsi, P., Lupton, M. K., Reeves, S. J., Hamilton, G., Archer, N., Martin, B. M., Iyegbe, C., Hollingworth, P., Lawlor, B., Gill, M., Brayne, C., Rubinsztein, D. C., Owen, M. J., Williams, J., Lovestone, S. & Powell, J. F., 1 Apr 2012, In: Neurobiology of Aging. 33, 4, p. 791 - 803 13 p.

    Research output: Contribution to journalArticlepeer-review

  26. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

    Sims, R., Dwyer, S., Harold, D., Gerrish, A., Hollingworth, P., Chapman, J., Jones, N., Abraham, R., Ivanov, D., Pahwa, J. S., Moskvina, V., Dowzell, K., Thomas, C., Stretton, A., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C. & 29 others, Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuiness, B., Todd, S., Johnston, J. A., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Mead, S., Fox, N., Rossor, M., Collinge, J., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Jones, L., Holmans, P. A., O'Donovan, M., Owen, M. J. & Williams, J., Dec 2011, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 156B, 7, p. 764-71 8 p.

    Research output: Contribution to journalArticlepeer-review

  27. A genotype risk score based on Type 2 diabetes risk factors is associated with lower risk for Alzheimertextquotesingles disease in APOE e4 carriers

    Proitsi, P., Lupton, M., Tsolaki, M., Daniilidou, M., Soininen, H., Vellas, B., Kloszewska, I., Mecocci, P., Passmore, P., Williams, J. & Lovestone, S., 1 Jul 2011, In: Alzheimer's & Dementia. 7, 4 , p. e28-e29

    Research output: Contribution to journalArticlepeer-review

  28. Genetic Variants Influencing Human Longevity from Late-Onset Alzheimer's Disease (LOAD) Genome-Wide Association Studies (GWAS)

    Shi, H., Medway, C., Brown, K., Kalsheker, N., Goate, A., Proitsi, P., Powell, J., Lovestone, S., Carrasquillo, M. & Younkin, S., 1 Jul 2011, In: Alzheimer's & Dementia. 7, 4, p. S195

    Research output: Contribution to journalArticlepeer-review

  29. A blood gene expression biomarker of early Alzheimer's disease

    Hodges, A., Lunnon, K., Furney, S., Proitsi, P., Sattlecker, M., Dobson, R., Lourdusamy, A., Simmons, A., Coppola, G., Lupton, M. & Soininen, H., Jul 2011, In: Alzheimer's & Dementia. 7, 4, Supplement, p. e13-e14 2 p.

    Research output: Contribution to journalArticlepeer-review

  30. Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimertextquotesingles Disease

    Lupton, M. K., Proitsi, P., Danillidou, M., Tsolaki, M., Hamilton, G., Wroe, R., Pritchard, M., Lord, K., Martin, B. M., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Harold, D., Hollingworth, P., Lovestone, S., Powell, J. F. & Roberts, R. (ed.), 1 Feb 2011, In: PloS one. 6, 2, p. e17298

    Research output: Contribution to journalArticlepeer-review

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