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  CharacteriSing The physiological changes induced by mitRal rEgurgitation reduction and Subsequent ventricular and functional recovery in patientS undergoing transcatheter Mitral edge to edge Repair (STRESS MR)

  Redwood, S. (Primary Investigator) & Chowienczyk, P. (Co-Investigator)

  BHF British Heart Foundation

  9/05/2022 → 8/05/2025

  Project: Research

• Mechanisms of reduction of first-phase ejection fraction and association with miRNA-130a and myocardial fibrosis in transverse aortic constriction rat model

  Chowienczyk, P. (Primary Investigator) & Gu, H. (Co-Investigator)

  Royal Society

  31/03/2022 → 30/03/2025

  Project: Research

• Investigating the relevance of skin sodium and salt sensitivity of blood pressure in determining the response to anti-hypertensive treatment

  Chowienczyk, P. (Primary Investigator)

  BHF British Heart Foundation

  1/02/2022 → 31/01/2024

  Project: Research

• First-phase ejection fraction to guide elective aortic valve replacement in asymptomatic aortic stenosis

  Chowienczyk, P. (Primary Investigator), Gu, H. (Co-Investigator), Shah, A. (Co-Investigator) & Bunce, C. (Co-Investigator)

  BHF British Heart Foundation

  1/08/2019 → 31/07/2022

  Project: Research

• First-phase ejection fraction guided management of aortic stenosis

  Gu, H. (Primary Investigator) & Chowienczyk, P. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/07/2019 → 30/06/2023

  Project: Research

• BHF Research Excellence Award

  Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)

  BHF British Heart Foundation

  1/04/2019 → 31/03/2024

  Project: Research

• Non-Invasive Tracking of Cardiac Output

  Chowienczyk, P. (Primary Investigator), Alastruey, J. (Co-Investigator) & Chiribiri, A. (Co-Investigator)

  MRC Medical Research Council, NIHR National Institute For Health & Care Research

  1/10/2018 → 28/02/2021

  Project: Research

  • Cardiac Output 100%
  • Heart Output 100%

• Attractor Reconstruction: A novel mathematical approach for the early recognition of sepsis

  Nandi, M. (Primary Investigator) & Chowienczyk, P. (Co-Investigator)

  MRC Medical Research Council

  5/02/2018 → 4/02/2019

  Project: Research

  • Medicine 100%
  • Waveform Morphology 100%
  • Pulse Oximetry 100%
  • Blood Pressure 100%
  • Electrocardiogram 100%

• BPandMe - Patient empowered Blood Pressure and Cardiovascular Risk Management mHealth System

  Chowienczyk, P. (Primary Investigator)

  1/01/2018 → 31/12/2022

  Project: Research

• Partitioning the determinants of pulse pressure into those due to ventricular ejection and characteristics of the arterial tree

  Chowienczyk, P. (Primary Investigator), Alastruey, J. (Co-Investigator) & Chiribiri, A. (Co-Investigator)

  BHF British Heart Foundation

  1/09/2017 → 28/08/2021

  Project: Research

• First-phase ejection fraction as a diagnostic marker and therapeutic target in cardiac disease.

  Chowienczyk, P. (Primary Investigator) & Gu, H. (Co-Investigator)

  BHF British Heart Foundation

  1/08/2017 → 31/07/2019

  Project: Research

• Partitioning the determinants of pulse pressure into those due to ventricular ejection and characteristics of the arterial tree

  Chowienczyk, P. (Primary Investigator), Alastruey, J. (Co-Investigator) & Chiribiri, A. (Co-Investigator)

  1/06/2017 → 1/06/2020

  Project: Research

• NIHR Biomedical Research Centre. Funding for Financial Years 2017/18, 2018/19

  Wolfe, C. (Primary Investigator), Parsons, M. (Primary Investigator), Gould, H. (Primary Investigator), Corrigan, C. (Primary Investigator), Greenough, A. (Primary Investigator), Peakman, M. (Primary Investigator), Vyse, T. (Primary Investigator), Antoniou, M. (Primary Investigator), Oakey, R. (Primary Investigator), McGrath, J. (Primary Investigator), Karagiannis, S. (Primary Investigator), Barker, J. (Primary Investigator), Flohr, C. (Primary Investigator), Tziotzios, C. (Primary Investigator), Whittaker, S. (Primary Investigator), Spector, T. (Primary Investigator), Watt, F. (Primary Investigator), Hayday, A. (Primary Investigator), Spencer, J. (Primary Investigator), Cope, A. (Primary Investigator), Malim, M. (Primary Investigator), Martin Serrano, J. (Primary Investigator), Edgeworth, J. (Primary Investigator), Cason, J. (Primary Investigator), Lord, G. (Primary Investigator), Dorling, A. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Lombardi, G. (Primary Investigator), Ostermann, M. (Primary Investigator), Shah, A. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Wells, C. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Sawyer, E. (Primary Investigator), Maher, J. (Primary Investigator), Tribe, R. (Primary Investigator), Ilic, D. (Primary Investigator), Poston, L. (Primary Investigator), Rutherford, M. (Primary Investigator), Gee, T. (Primary Investigator), Blower, P. (Primary Investigator), Edwards, D. (Primary Investigator), Sharpe, P. (Primary Investigator), Streit, A. (Primary Investigator), Naglik, J. (Primary Investigator), Tavassoli, M. (Primary Investigator) & McNaughton, P. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/04/2017 → 31/03/2022

  Project: Research

  • Biomedical Research 100%

• The health impact of industrial interesterification of dietary fats

  Berry, S. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Hall, W. (Co-Investigator), Harding, S. (Co-Investigator) & Pot, G. (Co-Investigator)

  3/10/2016 → 2/10/2018

  Project: Research

• The health impact of industrial interesterification of dietary fats

  Berry, S. (Primary Investigator), Hall, W. (Primary Investigator), Chowienczyk, P. (Co-Investigator) & Harding, S. (Co-Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/10/2016 → 31/10/2019

  Project: Research

• First-phase ejection fraction as an early indicator of diastolic heart failure

  Chowienczyk, P. (Primary Investigator)

  MRC Medical Research Council

  1/08/2016 → 31/07/2017

  Project: Research

• The renoprotective effects of Ursodeoxycholic acid in patients with type 1 diabetes and macroalbuminuria

  Karalliedde, J. (Primary Investigator), Ayis, S. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Cornelius, V. (Co-Investigator), Gnudi, L. (Co-Investigator) & Gulliford, M. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/07/2016 → 31/05/2021

  Project: Research

• Non-invasive assessment of Pulmonary Hypertension by Image and PULSE wave analysis (PH-IMPULSE)

  Alastruey, J. (Primary Investigator), Chowienczyk, P. (Co-Investigator) & Razavi, R. (Co-Investigator)

  1/06/2016 → 31/05/2019

  Project: Research

• Non-Invasive, MR/Echo-Based Assessment of Aortic Blood Pressure, Left Ventricular Pressure, Myocardial Wall Stress and Work

  Alastruey, J. (Primary Investigator), Chowienczyk, P. (Co-Investigator) & Hussain, M. (Co-Investigator)

  1/05/2016 → 30/04/2019

  Project: Research

• Non-Invasive, MR/Echo-Based Assessment of Aortic Blood Pressure, Left Ventricular Pressure, Myocardial Wall Stress and Work

  Alastruey, J. (Primary Investigator), Chowienczyk, P. (Co-Investigator) & Hussain, M. (Co-Investigator)

  1/05/2016 → 30/04/2019

  Project: Research

• Role of neuronal nitric oxide synthase (nNOS) in the pathophysiology of human heart failure

  Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator) & Eaton, P. (Co-Investigator)

  4/04/2016 → 3/04/2021

  Project: Research

• Role of neuronal nitric oxide synthase (nNOS) in the pathophysiology of human heart failure with preserved ejection fraction (HFPEF)

  Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chiribiri, A. (Co-Investigator), Chowienczyk, P. (Co-Investigator) & Eaton, P. (Co-Investigator)

  4/04/2016 → 3/04/2021

  Project: Research

• Nitrite's different vasodilatory mechanisms in large and small arteries

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Shah, A. (Co-Investigator) & Taylor, P. (Co-Investigator)

  1/01/2016 → 31/12/2018

  Project: Research

• Nitrite’s divergent vasodilatory mechanisms in large and small arteries

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Shah, A. (Co-Investigator) & Taylor, P. (Co-Investigator)

  1/01/2016 → 31/12/2017

  Project: Research

• Mechanisms of action of Nitrite in patients with heart failure with preserved ejection fraction (HFpEF)

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator) & Shah, A. (Co-Investigator)

  1/01/2016 → 31/12/2018

  Project: Research

• Nitrite’s selective mechanisms - conduit arteries, diastolic dynamics, and heart failure with preserved ejection fraction (HFpEF)

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator) & Shah, A. (Co-Investigator)

  1/01/2016 → 31/12/2018

  Project: Research

• Fractional flow reserve in serial and diffuse coronary artery disease

  Perera, D. (Primary Investigator), Chowienczyk, P. (Co-Investigator) & Modi, B. (Co-Investigator)

  BHF British Heart Foundation

  1/10/2015 → 31/10/2018

  Project: Research

• Multi-omic fingerprinting of left ventricular structure and function using 3D magnetic resonance imaging: a twin study

  Montana, G. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Hussain, M. (Co-Investigator), Razavi, R. (Co-Investigator) & Spector, T. (Co-Investigator)

  1/10/2015 → 1/10/2018

  Project: Research

• Molecular Mechanisms of Arterial Stiffening

  Cecelja, M. (Primary Investigator) & Chowienczyk, P. (Co-Investigator)

  1/09/2015 → 31/08/2019

  Project: Research

• How accurate are our clinical measures of aortic stiffness? A combined in vitro, in silico and in vivo study

  Alastruey, J. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Gaddum, N. (Co-Investigator) & Hussain, M. (Co-Investigator)

  BHF British Heart Foundation

  1/05/2015 → 8/01/2020

  Project: Research

• Neurovascular coupling in health and disease: direct manipulation of Nitric Oxide availability

  Zelaya, F. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Goadsby, P. (Co-Investigator) & Shah, A. (Co-Investigator)

  1/04/2015 → 31/03/2016

  Project: Research

• Pilot Pharmacokinetic Phase I Study: Prototype Modified Release Formulations of Sodium Nitrite

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Forbes, B. (Co-Investigator) & Martini, G. (Co-Investigator)

  1/12/2014 → 31/08/2015

  Project: Research

• Molecular mechanisms of arterial stiffening and calcification

  Cecelja, M. (Primary Investigator) & Chowienczyk, P. (Co-Investigator)

  1/11/2014 → 1/11/2018

  Project: Research

• The effects of alfacalcidol on bone at multiple skeletal sites in patients with moderate to severe CKD: an evaluation using a non-invasive imaging biomarker of bone formation

  academic, A. (Primary Investigator), Blake, G. (Co-Investigator), Chowienczyk, P. (Co-Investigator) & Fogelman, I. (Co-Investigator)

  1/09/2014 → 29/02/2016

  Project: Research

• Mechanisms leading to an impairment of vascular homeostasis during acute stress: interaction between sympathetic activity and neuronal nitric oxide synthase

  Chowienczyk, P. (Primary Investigator), Shah, A. (Co-Investigator), Williams, S. (Co-Investigator) & Zelaya, F. (Co-Investigator)

  BHF British Heart Foundation

  1/09/2014 → 30/09/2017

  Project: Research

• Numerical, physical and clinical assessment of novel and existing methods for measuring aortic stiffness

  Alastruey, J. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Gaddum, N. (Co-Investigator), Hussain, M. (Co-Investigator) & Schaeffter, T. (Co-Investigator)

  1/09/2014 → 31/08/2017

  Project: Research

• Metabolic-vascular interactions with the (dietary) nitrate-nitrate-NO pathway: carbonic anhydrase inhibition with thiazide-like diuretics & renin status

  Webb, A. (Primary Investigator) & Chowienczyk, P. (Co-Investigator)

  1/05/2014 → 30/04/2016

  Project: Research

• Ancestry and biological Informative Markers for stratification of Hypertension: the AIM HY study

  Chowienczyk, P. (Primary Investigator), Brown, M. (Co-Investigator), Chaturvedi, N. (Co-Investigator), Cruickshank, K. (Co-Investigator), Delaney, B. (Co-Investigator), Heagerty, A. (Co-Investigator), Hughes, A. (Co-Investigator), Lewis, C. (Co-Investigator), Mander, A. (Co-Investigator), Mant, J. (Co-Investigator), Martini, G. (Co-Investigator), McKevitt, C. (Co-Investigator), Parkin, D. (Co-Investigator), Prevost, T. (Co-Investigator), Spector, T. (Co-Investigator), Valdes, A. (Co-Investigator), Weale, M. (Co-Investigator), Wilkinson, I. (Co-Investigator) & Wolfe, C. (Co-Investigator)

  MRC Medical Research Council

  14/04/2014 → 31/12/2023

  Project: Research

• Assessment of 18F-NaF PET/CT and MRI to Measure Metabolically Active Aortic Calcification

  Cecelja, M. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Frost, M. (Co-Investigator), Greil, G. (Co-Investigator) & Hussain, M. (Co-Investigator)

  1/04/2014 → 31/03/2015

  Project: Research

• Control of Aortic systolic Blood Pressure with Sodium Nutrite in Aortic Dissection

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Forbes, B. (Co-Investigator) & Martini, G. (Co-Investigator)

  1/03/2014 → 28/02/2018

  Project: Research

• Markers of ardiometabolic disease and endothelial dysfunction in patients with severe gout

  Spector, T. (Primary Investigator) & Chowienczyk, P. (Co-Investigator)

  1/01/2014 → 31/12/2015

  Project: Research

• Pilot Pharmacokinetic Phase I Study: Prototype Modified Release Formulations of Sodium Nitrite

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Forbes, B. (Co-Investigator) & Martini, G. (Co-Investigator)

  5/11/2013 → 4/08/2014

  Project: Research

• Non-invasive assessment of left ventricular pressure, myocardial wall stress and work

  Chowienczyk, P. (Primary Investigator), Alastruey, J. (Co-Investigator), Schaeffter, T. (Co-Investigator) & Smith, N. (Co-Investigator)

  1/11/2013 → 31/10/2016

  Project: Research

• VP2HF - Computer model derived indices for optimal patient-specific treatment selection and planning in Heart Failure

  Razavi, R. (Primary Investigator), Smith, N. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Penney, G. (Co-Investigator), Rhode, K. (Co-Investigator) & Schaeffter, T. (Co-Investigator)

  EC European Commission

  1/10/2013 → 31/03/2017

  Project: Research

• Non-invasive assessment of left ventricular pressure, myocardial wall stress and work

  Chowienczyk, P. (Primary Investigator), Alastruey, J. (Co-Investigator), Schaeffter, T. (Co-Investigator) & Smith, N. (Co-Investigator)

  1/10/2013 → 30/09/2016

  Project: Research

• Cardiovascular and coronary physiology during exercise in patients with aortic stenosis

  Perera, D. (Primary Investigator), Chambers, J. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Lumley, M. (Co-Investigator) & Nagel, E. (Co-Investigator)

  BHF British Heart Foundation

  1/10/2013 → 30/09/2015

  Project: Research

• Effect of intervention in pregnant obese women on childhood cardiovascular function

  Poston, L. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Groves, A. (Co-Investigator), Pasupathy, D. (Co-Investigator) & Taylor, P. (Co-Investigator)

  BHF British Heart Foundation

  1/09/2013 → 31/08/2016

  Project: Research

• Uncovering Contributors to Hypertension through Experimental and Computational Simulation (CHECS)

  Alastruey, J. (Primary Investigator), Schaeffter, T. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Figueroa, A. (Co-Investigator) & Gaddum, N. (Co-Investigator)

  EPSRC Engineering and Physical Sciences Research Council

  1/07/2013 → 31/03/2017

  Project: Research

• Control of central aortic blood pressures with sodium nitrite in type B aortic dissection

  Webb, A. (Primary Investigator), Chowienczyk, P. (Co-Investigator), Forbes, B. (Co-Investigator) & Martini, G. (Co-Investigator)

  1/07/2013 → 30/06/2017

  Project: Research

• Role of neuronal nitric oxide synthase (nNos) in the pathophysiology of humn hear failure

  Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator) & Nagel, E. (Co-Investigator)

  7/01/2013 → 6/01/2018

  Project: Research