Research output per year
Research output per year
Personal profile
Research interests
The redox-dependent regulation of protein function in the setting of ischaemia and reperfusion.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Philip Eaton is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
Switzer, C. H., Cho, H. J., Eykyn, T. R., Lavender, P. & Eaton, P., 24 May 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 21, p. e2200022119 e2200022119.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells
Switzer, C. H., Guttzeit, S., Eykyn, T. R. & Eaton, P., Nov 2021, In: Redox Biology. 47, 102155.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
Enhanced Heart Failure in Redox-Dead Cys17Ser PKARIα Knock-In Mice
Islam, M. M. T., Tarnowski, D., Zhang, M., Trum, M., Lebek, S., Mustroph, J., Daniel, H., Moellencamp, J., Pabel, S., Sossalla, S., El-Armouche, A., Nikolaev, V. O., Shah, A. M., Eaton, P., Maier, L. S., Sag, C. M. & Wagner, S., 5 Oct 2021, In: Journal of the American Heart Association. 10, 19, p. e021985 e021985.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
Queiroz, R. F., Stanley, C. P., Wolhuter, K., Kong, S. M. Y., Rajivan, R., McKinnon, N., Nguyen, G. T. H., Roveri, A., Guttzeit, S., Eaton, P., Donald, W. A., Ursini, F., Winterbourn, C. C., Ayer, A. & Stocker, R., Dec 2021, In: Nature Communications. 12, 1, 6626.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling
Feelisch, M., Akaike, T., Griffiths, K., Ida, T., Prysyazhna, O., Goodwin, J. J., Gollop, N. D., Fernandez, B. O., Minnion, M., Cortese-Krott, M. M., Borgognone, A., Hayes, R. M., Eaton, P., Frenneaux, M. P. & Madhani, M., 1 Jan 2020, In: Cardiovascular Research. 116, 1, p. 51-62 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access34 Citations (Scopus)
Projects
- 57 Finished
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BHF Research Excellence Award
Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)
1/04/2019 → 31/03/2024
Project: Research
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Thiol-disulfide redox switches in protein kinases and their role in cardiovascular health and disease
Eaton, P. (Primary Investigator), Francois, A. (Co-Investigator) & Prysyazhna, O. (Co-Investigator)
1/05/2018 → 30/04/2023
Project: Research
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Furthering our understanding of PKGIα in cardiovascular health and disease
Eaton, P. (Primary Investigator), Prysyazhna, O. (Co-Investigator), Cho, H. (Co-Investigator) & Francois, A. (Co-Investigator)
1/03/2018 → 28/02/2023
Project: Research
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An investigation of the potential therapeutic effects of Sulforadex in Noonan syndrome
Eaton, P. (Primary Investigator) & Cho, H. (Co-Investigator)
1/09/2017 → 31/08/2020
Project: Research
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PKG-activating drugs as a novel therapy for hypertension
Eaton, P. (Primary Investigator) & Cho, H. (Co-Investigator)
1/07/2017 → 30/09/2018
Project: Research
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European Meeting of the Society of Free Radical Research, De Vere Belfry Hotel, UK, Protein S-glutathiolation and S-nitrosylation implications for intracellular signalling
Eaton, P. (Keynote/plenary speaker)
Jul 2005 → …Activity: Participating in or organising an event › Participation in conference
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German Cardiac Society in Mannheim, Oxidative stress during cardiac ischemia and reperfusion
Eaton, P. (Keynote/plenary speaker)
Mar 2005 → …Activity: Participating in or organising an event › Participation in conference
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Forum Issue of Antioxidants and Redox Signaling where 17 manuscripts on protein S-thiolation were compiled on Protein S-Thiolation: Emphasis on Cell Signaling and Gene Expression. See Eaton P and Shattock M.J. Editorial: Antioxidant and Redox Signaling 7 (7-8):839-840 2005 (Journal)
Eaton, P. (Associate Editor)
2005 → …Activity: Publication peer-review and editorial work › Editorial activity
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Oxidative Post-Translational Modifications in the Cardiovascular System Meeting, Boston University School of Medicine. Cardiac protein S-thiolation: from detection to functional impact
Eaton, P. (Keynote/plenary speaker)
Oct 2004 → …Activity: Participating in or organising an event › Participation in conference
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ISHR Dresden meeting, Protein S-thiolation and HSP27
Eaton, P. (Keynote/plenary speaker)
Jun 2004 → …Activity: Participating in or organising an event › Participation in conference