King's College London

Research portal

Professor Philip Eaton

  1. Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy

    Fernandez-Caggiano, M., Kamynina, A., Francois, A. A., Prysyazhna, O., Eykyn, T. R., Krasemann, S., Crespo-Leiro, M. G., Vieites, M. G., Bianchi, K., Morales, V., Domenech, N. & Eaton, P., Nov 2020, In: Nature Metabolism. 2, 11, p. 1223-1231 9 p.

    Research output: Contribution to journalArticlepeer-review

  2. Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling

    Feelisch, M., Akaike, T., Griffiths, K., Ida, T., Prysyazhna, O., Goodwin, J. J., Gollop, N. D., Fernandez, B. O., Minnion, M., Cortese-Krott, M. M., Borgognone, A., Hayes, R. M., Eaton, P., Frenneaux, M. P. & Madhani, M., 1 Jan 2020, In: Cardiovascular Research. 116, 1, p. 51-62 12 p.

    Research output: Contribution to journalReview articlepeer-review

  3. Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

    Rudyk, O., Rowan, A., Prysyazhna, O., Krasemann, S., Hartmann, K., Zhang, M., Shah, A. M., Ruppert, C., Weiss, A., Schermuly, R. T., Ida, T., Akaike, T., Zhao, L. & Eaton, P., 25 Jun 2019, In: PNAS. 116, 26, p. 13016-13025 10 p.

    Research output: Contribution to journalArticlepeer-review

  4. Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

    Dunham-Snary, K. J., Wu, D., Potus, F., Sykes, E. A., Mewburn, J. D., Charles, R. L., Eaton, P., Sultanian, R. A. & Archer, S. L., 7 Jun 2019, In: Circulation Research. 124, 12, p. 1727-1746 20 p.

    Research output: Contribution to journalArticlepeer-review

  5. PKG1α oxidation negatively regulates food seeking behaviour and reward

    Duraffourd, C., Huckstepp, R. T. R., Braren, I., Fernandes, C., Brock, O., Delogu, A., Prysyazhna, O., Burgoyne, J. & Eaton, P., 28 Feb 2019, In: Redox Biology. 21, p. 101077

    Research output: Contribution to journalArticlepeer-review

  6. Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

    Stanley, C. P., Maghzal, G. J., Ayer, A., Talib, J., Giltrap, A. M., Shengule, S., Wolhuter, K., Wang, Y., Chadha, P., Suarna, C., Prysyazhna, O., Scotcher, J., Dunn, L. L., Prado, F. M., Nguyen, N., Odiba, J. O., Baell, J. B., Stasch, J. P., Yamamoto, Y., Di Mascio, P. & 3 others, Eaton, P., Payne, R. J. & Stocker, R., 28 Feb 2019, In: Nature. 566, 7745, p. 548-552 5 p.

    Research output: Contribution to journalLetterpeer-review

  7. Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System

    Cuello, F. & Eaton, P., 10 Feb 2019, In: Annual Review of Physiology. 81, 1, p. 63-87 25 p.

    Research output: Contribution to journalReview articlepeer-review

  8. The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules

    De Nicola, G. F., Bassi, R., Nichols, C., Fernandez-Caggiano, M., Golforoush, P. A., Thapa, D., Anderson, R., Martin, E. D., Verma, S., Kleinjung, J., Laing, A., Hutchinson, J. P., Eaton, P., Clark, J. & Marber, M. S., 23 Aug 2018, In: JCI Insight. 3, 16, p. 1-17

    Research output: Contribution to journalArticlepeer-review

  9. Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation

    Wolhuter, K., Whitwell, H. J., Switzer, C. H., Burgoyne, J. R., Timms, J. F. & Eaton, P., 1 Feb 2018, In: MOLECULAR CELL. 69, 3, p. 438-450.e5

    Research output: Contribution to journalArticlepeer-review

  10. Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity

    Donzelli, S., Goetz, M., Schmidt, K., Wolters, M., Stathopoulou, K., Diering, S., Prysyazhna, O., Polat, V., Scotcher, J., Dees, C., Subramanian, H., Butt, E., Kamynina, A., Schobesberger, S., King, S. B., Nikolaev, V. O., De Wit, C., Leichert, L. I., Feil, R., Eaton, P. & 1 others, Cuello, F., 1 Dec 2017, In: Scientific Reports. 7, 1, 9938.

    Research output: Contribution to journalArticlepeer-review

  11. 174 - Modulation of Cardiac Function by Oxidized Type I Protein Kinase A: SfRBM 2017 SfRBM's 24th Annual Meeting Program and Abstracts November 29 - December 2, 2017 Hilton Baltimore Baltimore, MD USA

    Towhidul Islam, M. M., Eaton, P., Maier, L. & Wagner, S., Nov 2017, In: Free Radical Biology and Medicine. 112, Supplement 1, p. 123-124 2 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  12. Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3

    Bassi, R., Burgoyne, J. R., DeNicola, G. F., Rudyk, O., DeSantis, V., Charles, R. L., Eaton, P. & Marber, M. S., 29 Sep 2017, In: Journal of Biological Chemistry. 292, 39, p. 16161-16173 13 p.

    Research output: Contribution to journalArticlepeer-review

  13. Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure

    Sag, C. M., Schnelle, M., Zhang, J., Murdoch, C. E., Kossmann, S., Protti, A., Santos, C. X. C., Sawyer, G. J., Zhang, X., Mongue-Din, H., Richards, D. A., Brewer, A. C., Prysyazhna, O., Maier, L. S., Wenzel, P., Eaton, P. J. & Shah, A. M., 30 May 2017, In: Circulation (Baltimore). 135, 22, p. 2163-2177

    Research output: Contribution to journalArticlepeer-review

  14. Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain

    Valek, L., Häussler, A., Dröse, S., Eaton, P., Schröder, K. & Tegeder, I., Apr 2017, In: Redox Biology. 11, p. 176-191 16 p.

    Research output: Contribution to journalArticlepeer-review

  15. Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response

    Scotcher, J., Prysyazhna, O., Boguslavskyi, A., Kistamas, K., Hadgraft, N., Martin, E. D., Worthington, J., Rudyk, O., Rodriguez Cutillas, P., Cuello, F., Shattock, M. J., Marber, M. S., Conte, M. R., Greenstein, A., Greensmith, D. J., Venetucci, L., Timms, J. F. & Eaton, P., 26 Oct 2016, In: Nature Communications. 7, 1, 11 p., 13187.

    Research output: Contribution to journalArticlepeer-review

  16. Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation

    Akashi, S., Ahmed, K. A., Sawa, T., Ono, K., Tsutsuki, H., Burgoyne, J. R., Ida, T., Horio, E., Prysyazhna, O., Oike, Y., Rahaman, M. M., Eaton, P., Fujii, S. & Akaike, T., 9 Feb 2016, In: Biochemistry. 55, 5, p. 751-61 11 p.

    Research output: Contribution to journalArticlepeer-review

  17. Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice

    Burgoyne, J., Rudyk, O., Cho, H. J., Prysyazhna, O., Hathaway, N., Weeks, A., Evans, R., Ng, T., Schröder, K., Brandes, R. P., Shah, A. M. & Eaton, P., 10 Aug 2015, In: Nature Communications. 6, 1, 8 p., 7920.

    Research output: Contribution to journalArticlepeer-review

  18. Oxidant-Induced Activation of cGMP-Dependent Protein Kinase I alpha Mediates Neuropathic Pain After Peripheral Nerve Injury

    Lorenz, J. E., Kallenborn-Gerhardt, W., Lu, R., Syhr, K. M. J., Eaton, P., Geisslinger, G. & Schmidtko, A., 11 Sep 2014, In: ANTIOXIDANTS AND REDOX SIGNALING. 21, 10, p. 1504-1515 12 p.

    Research output: Contribution to journalArticlepeer-review

  19. Preface for redox signalling in the cardiovascular system

    Eaton, P. & Shah, A. M., Aug 2014, In: Journal of Molecular and Cellular Cardiology. 73, p. 1-1 1 p.

    Research output: Contribution to journalEditorialpeer-review

  20. Gel-based methods in redox proteomics

    Charles, R., Jayawardhana, T. & Eaton, P., Feb 2014, In: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 1840, 2, p. 830-837 8 p.

    Research output: Contribution to journalArticlepeer-review

  21. Meeting highlights from the 2013 European society of cardiology heart failure association winter meeting on translational heart failure research

    Hohl, M., Ardehali, H., Azuaje, F. J., Breckenridge, R. A., Doehner, W., Eaton, P., Ehret, G. B., Fujita, T., Gaetani, R., Giacca, M., Hasenfuß, G., Heymans, S., Leite-Moreira, A. F., Linke, W. A., Linz, D., Lyon, A., Mamas, M. A., Orešič, M., Papp, Z., Pedrazzini, T. & 10 others, Piepoli, M., Prosser, B., Rizzuto, R., Tarone, G., Tian, R., Van Craenenbroeck, E., Van Rooij, E., Wai, T., Weiss, G. & Maack, C., 1 Jan 2014, In: EUROPEAN JOURNAL OF HEART FAILURE. 16, 1, p. 6-14 9 p.

    Research output: Contribution to journalReview articlepeer-review

  22. Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system

    Burgoyne, J. R., Oka, S., Ale-Agha, N. & Eaton, P., 14 Feb 2013, In: Antioxidants & redox signaling. 18, 9, p. 1042-52 11 p.

    Research output: Contribution to journalArticlepeer-review

  23. Response to "Detailed aspects of redox signaling in cardiac physiology and pathology"

    Burgoyne, J. R., Din, H. M., Eaton, P. & Shah, A. M., 4 Jan 2013, In: Circulation Research. 112, 1, p. e2-e2 1 p., N/A.

    Research output: Contribution to journalLetterpeer-review

  24. Approaches for monitoring PKG1α oxidative activation

    Burgoyne, J. R. & Eaton, P., 2013, Methods in Molecular Biology. Vol. 1020. p. 163-173 11 p. (Methods in Molecular Biology; vol. 1020).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  25. Detecting disulfide-bound complexes and the oxidative regulation of cyclic nucleotide-dependent protein kinases by H2O2

    Burgoyne, J. R. & Eaton, P., 2013, Methods in Enzymology. Vol. 528. p. 111-128 18 p. (Methods in Enzymology; vol. 528).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  26. cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation Implications for Blood Pressure Control

    Burgoyne, J., Prysyazhna, O., Rudyk, O. & Eaton, P., Nov 2012, In: Hypertension. 60, 5, p. 1301-1308 11 p.

    Research output: Contribution to journalArticlepeer-review

  27. Redox Signaling in Cardiac Physiology and Pathology

    Burgoyne, J., Mongue Din, H., Eaton, P. & Shah, A. M., 28 Sep 2012, In: Circulation Research. 111, 8, p. 1091-1106 16 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  28. Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling

    Zhang, M., Takimoto, E., Lee, D., Xavier Da Costa Dos Santos, C. S., Nakamura, T., Hsu, S., Jiang, A., Nagayama, T., Bedja, D., Yuan, Y., Eaton, P., Shah, A. M. & Kass, D. A., 21 Aug 2012, In: Circulation (Baltimore). 126, 8, p. 942-U96 19 p.

    Research output: Contribution to journalArticlepeer-review

  29. Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1α Knock-In Mouse

    Rudyk, O., Prysyazhna, O., Burgoyne, J. & Eaton, P., 17 Jul 2012, In: Circulation (Baltimore). 126, 3, p. 287-295 13 p.

    Research output: Contribution to journalArticlepeer-review

  30. Redox modification of cell signaling in the cardiovascular system

    Shao, D., Oka, S., Brady, C. D., Haendeler, J., Eaton, P. & Sadoshima, J., Mar 2012, In: Journal of Molecular and Cellular Cardiology. 52, 3, p. 550 - 558 9 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  31. Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

    Prysyazhna, O., Rudyk, O. & Eaton, P., Feb 2012, In: Nature Medicine. 18, 2, p. 286 - 290 5 p.

    Research output: Contribution to journalArticlepeer-review

  32. Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation

    Burgoyne, J. R. & Eaton, P., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1260-7 8 p.

    Research output: Contribution to journalArticlepeer-review

  33. Frontiers in nitric oxide and redox signaling Preface

    Akaike, T., van der Vliet, A. & Eaton, P., 1 Aug 2011, In: NITRIC OXIDE. 25, 2, p. 57 - 58 2 p.

    Research output: Contribution to journalEditorialpeer-review

  34. Nitrosative protein oxidation is modulated during early endotoxemia

    Burgoyne, J. R., Rudyk, O., Mayr, M. & Eaton, P., 1 Aug 2011, In: NITRIC OXIDE. 25, 2, p. 118 - 124 7 p.

    Research output: Contribution to journalArticlepeer-review

  35. Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo

    Ray, R., Murdoch, C. E., Wang, M., Santos, C. X., Zhang, M., Alom-Ruiz, S., Anilkumar, N., Ouattara, A., Cave, A. C., Walker, S. J., Grieve, D. J., Charles, R. L., Eaton, P., Brewer, A. C. & Shah, A. M., Jun 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 6, p. 1368-1376 9 p.

    Research output: Contribution to journalArticlepeer-review

  36. Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-Delta-Prostaglandin J(2) Controls Coronary Hypoxic Vasodilation

    Charles, R. L., Burgoyne, J. R., Mayr, M., Weldon, S. M., Hubner, N., Dong, H., Morisseau, C., Hammock, B. D., Landar, A. & Eaton, P., 4 Feb 2011, In: Circulation Research. 108, 3, p. 324 - 334 11 p.

    Research output: Contribution to journalArticlepeer-review

  37. Altered PDE5 Targeting in Pathologic Hearts. Switching From NO-cGMP to ANP/BNP-cGMP

    Zhang, M., Takimoto, E., Lee, D. I., Xavier Da Costa Dos Santos, C. S., Hsu, S., Bedja, D., Yuan, Y., Eaton, P., Shah, A. & Kass, D., 2011, In: Circulation (Baltimore). 124, 21

    Research output: Contribution to journalMeeting abstract

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