Personal profile
Research interests
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
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A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective
Charles, R. L., Fernandez-Caggiano, M., Rudyk, O., Tyson-Hirst, I., Ehteramyan, M., Switzer, C. H., Buccafusca, R., Rajeeve, V., Bianchi, K., Morales, V., Finch, A. J. & Eaton, P., 28 Feb 2026, In: Redox Biology. 89, 103974.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
Switzer, C. H., Cho, H. J., Eykyn, T. R., Lavender, P. & Eaton, P., 24 May 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 21, p. e2200022119 e2200022119.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells
Switzer, C. H., Guttzeit, S., Eykyn, T. R. & Eaton, P., Nov 2021, In: Redox Biology. 47, 102155.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
Enhanced Heart Failure in Redox-Dead Cys17Ser PKARIα Knock-In Mice
Islam, M. M. T., Tarnowski, D., Zhang, M., Trum, M., Lebek, S., Mustroph, J., Daniel, H., Moellencamp, J., Pabel, S., Sossalla, S., El-Armouche, A., Nikolaev, V. O., Shah, A. M., Eaton, P., Maier, L. S., Sag, C. M. & Wagner, S., 5 Oct 2021, In: Journal of the American Heart Association. 10, 19, p. e021985 e021985.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
Queiroz, R. F., Stanley, C. P., Wolhuter, K., Kong, S. M. Y., Rajivan, R., McKinnon, N., Nguyen, G. T. H., Roveri, A., Guttzeit, S., Eaton, P., Donald, W. A., Ursini, F., Winterbourn, C. C., Ayer, A. & Stocker, R., Dec 2021, In: Nature Communications. 12, 1, 6626.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus)
Projects
- 57 Finished
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BHF Research Excellence Award
Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)
1/04/2019 → 31/03/2024
Project: Research
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Thiol-disulfide redox switches in protein kinases and their role in cardiovascular health and disease
Eaton, P. (Primary Investigator), Francois, A. (Co-Investigator) & Prysyazhna, O. (Co-Investigator)
1/05/2018 → 30/04/2023
Project: Research
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Furthering our understanding of PKGIα in cardiovascular health and disease
Eaton, P. (Primary Investigator), Prysyazhna, O. (Co-Investigator), Cho, H. (Co-Investigator) & Francois, A. (Co-Investigator)
1/03/2018 → 28/02/2023
Project: Research
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An investigation of the potential therapeutic effects of Sulforadex in Noonan syndrome
Eaton, P. (Primary Investigator) & Cho, H. (Co-Investigator)
1/09/2017 → 31/08/2020
Project: Research
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Furthering our understanding of the redox regulation of Protein Kinase A in the cardiovascular system
Eaton, P. (Primary Investigator) & Prysyazhna, O. (Co-Investigator)
1/07/2017 → 30/09/2020
Project: Research
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European Meeting of the Society of Free Radical Research, De Vere Belfry Hotel, UK, Protein S-glutathiolation and S-nitrosylation implications for intracellular signalling
Eaton, P. (Keynote/plenary speaker)
Jul 2005 → …Activity: Participating in or organising an event › Participation in conference
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German Cardiac Society in Mannheim, Oxidative stress during cardiac ischemia and reperfusion
Eaton, P. (Keynote/plenary speaker)
Mar 2005 → …Activity: Participating in or organising an event › Participation in conference
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Forum Issue of Antioxidants and Redox Signaling where 17 manuscripts on protein S-thiolation were compiled on Protein S-Thiolation: Emphasis on Cell Signaling and Gene Expression. See Eaton P and Shattock M.J. Editorial: Antioxidant and Redox Signaling 7 (7-8):839-840 2005 (Journal)
Eaton, P. (Associate Editor)
2005 → …Activity: Publication peer-review and editorial work › Editorial activity
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Oxidative Post-Translational Modifications in the Cardiovascular System Meeting, Boston University School of Medicine. Cardiac protein S-thiolation: from detection to functional impact
Eaton, P. (Keynote/plenary speaker)
Oct 2004 → …Activity: Participating in or organising an event › Participation in conference
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ISHR Dresden meeting, Protein S-thiolation and HSP27
Eaton, P. (Keynote/plenary speaker)
Jun 2004 → …Activity: Participating in or organising an event › Participation in conference