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Philip Moore

Professor

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Research interests

Research in this group concentrates on the study of the physiological and pathophysiological significance of H2S which is increasingly being accepted as the third gaseous mediator alongside nitric oxide and carbon monoxide. Work ongoing includes an investigation of the effect of H2S on vascular, cardiac and platelet function using in vitro and in vivo techniques whilst studying the underlying mechanisms in terms of effects on receptor and transduction mechanisms in tissues, cell culture and isolated enzyme systems. Significant cross talk occurs between H2S and NO and this aspect is also under scrutiny as H2S not only exerts direct effects in its own right but also affects cardiovascular function indirectly by interaction with the L-arginine/NO system. An additional major interest is the part played by H2S in inflammation. It is still unclear whether this gas exerts pro-inflammatory or anti-inflammatory activity or both depending on the experimental circumstances but it is clear that manipulation of endogenous H2S levels has the potential to lead to useful therapeutics to treat inflammation.

Research interests (short)

The biological roles of naturally occurring gasomediators including nitric oxide and hydrogen sulphide.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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