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Pierre Gressens

Pierre Gressens

Professor

 https://orcid.org/0000-0002-0909-4221
  • 26513
    Citations

Personal profile

Research interests

Our overarching objective is to understand the underlying mechanisms of perinatal brain injury in particular related to mitochondrial involvement and inflammation. We will seek to understand how inflammation during fetal/neonatal life affects brain development and tunes central nervous system vulnerability to further insults later in life. Based on this knowledge, we hope to develop novel neuroprotective and preventive strategies both for infants suffering from encephalopathy and infants at risk for developing brain injury. We hope to improve the efficacy of hypothermic treatment during the secondary phase of injury through add-on therapies.  There is also a potential possibility to develop treatments that are effective beyond the immediate post-insult period that promote repair and compensatory connectivity during the so-called tertiary phase. 

Education/Academic qualification

Doctor of Philosophy, Université catholique de Louvain

Award Date: 1 Jan 1995

Doctor of Medicine, Université catholique de Louvain

Award Date: 1 Jan 1989

Keywords

  • RJ101 Child Health. Child health services
  • perinatal brain damage
  • neuroprotection
  • neuroinflammation
  • translational research

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 2 - Zero Hunger
    SDG 2 Zero Hunger
  2. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  3. SDG 4 - Quality Education
    SDG 4 Quality Education
  4. SDG 10 - Reduced Inequalities
    SDG 10 Reduced Inequalities
  5. SDG 16 - Peace, Justice and Strong Institutions
    SDG 16 Peace, Justice and Strong Institutions

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Collaborations and top research areas from the last five years

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  • Microglia states and nomenclature: A field at its crossroads

    Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M. E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G. C. & Butovsky, O. & 76 others, Carson, M. J., Castellano, B., Colonna, M., Cowley, S. A., Cunningham, C., Davalos, D., De Jager, P. L., de Strooper, B., Denes, A., Eggen, B. J. L., Eyo, U., Galea, E., Garel, S., Ginhoux, F., Glass, C. K., Gokce, O., Gomez-Nicola, D., González, B., Gordon, S., Graeber, M. B., Greenhalgh, A. D., Gressens, P., Greter, M., Gutmann, D. H., Haass, C., Heneka, M. T., Heppner, F. L., Hong, S., Hume, D. A., Jung, S., Kettenmann, H., Kipnis, J., Koyama, R., Lemke, G., Lynch, M., Majewska, A., Malcangio, M., Malm, T., Mancuso, R., Masuda, T., Matteoli, M., McColl, B. W., Miron, V. E., Molofsky, A. V., Monje, M., Mracsko, E., Nadjar, A., Neher, J. J., Neniskyte, U., Neumann, H., Noda, M., Peng, B., Peri, F., Perry, V. H., Popovich, P. G., Pridans, C., Priller, J., Prinz, M., Ragozzino, D., Ransohoff, R. M., Salter, M. W., Schaefer, A., Schafer, D. P., Schwartz, M., Simons, M., Smith, C. J., Streit, W. J., Tay, T. L., Tsai, L. H., Verkhratsky, A., von Bernhardi, R., Wake, H., Wittamer, V., Wolf, S. A., Wu, L. J. & Wyss-Coray, T., 2 Nov 2022, In: Neuron. 110, 21, p. 3458-3483 26 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    1491 Citations (Scopus)

  • Hypothermia is not therapeutic in a neonatal piglet model of inflammation-sensitized hypoxia–ischemia

    Martinello, K. A., Meehan, C., Avdic-Belltheus, A., Lingam, I., Mutshiya, T., Yang, Q., Akin, M. A., Price, D., Sokolska, M., Bainbridge, A., Hristova, M., Tachtsidis, I., Tann, C. J., Peebles, D., Hagberg, H., Wolfs, T. G. A. M., Klein, N., Kramer, B. W., Fleiss, B. & Gressens, P. & 2 others, Golay, X. & Robertson, N. J., 2021, (Accepted/In press) In: Pediatric Research.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Citations (Scopus)

  • Microglial inflammasome activation drives developmental white matter injury

    Holloway, R. K., Ireland, G., Sullivan, G., Becher, J. C., Smith, C., Boardman, J. P., Gressens, P. & Miron, V. E., May 2021, In: GLIA. 69, 5, p. 1268-1280 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    22 Citations (Scopus)

  • Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly

    Journiac, N., Gilabert-Juan, J., Cipriani, S., Benit, P., Liu, X., Jacquier, S., Faivre, V., Delahaye-Duriez, A., Csaba, Z., Hourcade, T., Melinte, E., Lebon, S., Violle-Poirsier, C., Oury, J.-F., Adle-Biassette, H., Wang, Z.-Q., Mani, S., Rustin, P., Gressens, P. & Nardelli, J., 14 Apr 2020, In: Cell Reports. 31, 2, 107506.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    42 Citations (Scopus)
    154 Downloads (Pure)

  • Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders

    Fleiss, B., Gressens, P. & Stolp, H. B., 14 Jul 2020, In: Frontiers in Neurology. 11, 575.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    File
    44 Citations (Scopus)
    146 Downloads (Pure)
View all 401 research outputs
View all 16 projects