Research output per year
Research output per year
Personal profile
Biographical details
Rafael T. M. de Rosales (Granada, Spain) obtained his BSc in Chemistry from the Universidad de Granada in 2001. He then moved to Scotland to carry out PhD studies in bioinorganic chemistry at the University of Edinburgh. During this time, he synthesised and developed small metal complexes as synthetic models of nucleases (the enzymes that cleave DNA and RNA). In 2004 he moved to the University of Naples (Italy) thanks to a Marie Curie Postdoctoral Fellowship and developed one of the first biomimetic synthetic metallopeptides capable of catalysing oxidation reactions in collaboration with Prof. A. Lombardi and Prof. V. Pavone. He then returned to the UK and joined the groups of Dr. G. Britovsek and Prof. V. C. Gibson FRS at Imperial College London where he explored novel bio-inspired transition metal complexes as oxidation catalysts. In 2007, he moved to the School of Biomedical Engineering & Imaging Sciences at King’s College London, where he has developed several radiometal probes for PET and SPECT imaging as well as novel methods to radiolabel and image nanoparticle-based drug delivery systems and cell therapies.
Research interests
- Design and synthesis of radiometal-based imaging agents.
- Tracking nanomedicines and therapeutic cells using PET imaging.
- Total-body PET and multimodal imaging (PET-MRI)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University of Edinburgh
Award Date: 1 Jan 2005
Bachelor of Science, University of Granada
Award Date: 1 Jan 2001
Keywords
- QD Chemistry
- imaging
- Nanomedicine
- PET
- SPECT
- MRI
- R Medicine (General)
- Imaging
- diagnosis
- theranostics
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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In vivo real-time positron emission particle tracking (PEPT) and single particle PET
Pellico Saez, J., Vass, L., Minino, A., Man, F., Kim, J., Sunassee, K., Parker, D., Blower, P., Marsden, P. & T. M. de Rosales, R., May 2024, In: Nature Nanotechnology. 19, 5, p. 668-676 9 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging
Gawne, P., Man, F., Blower, P. & T. M. de Rosales, R., 8 Jun 2022, In: Chemical Reviews. 122, 11, p. 10266-10318 53 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile85 Citations (Scopus)352 Downloads (Pure) -
In Vivo PET Tracking of 89Zr-Labeled Vγ9Vδ2 T Cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate
Man, F., Lim, L., Volpe, A., Gabizon, A., Shmeeda, H., Draper, B., Parente-Pereira, A. C., Maher, J., Blower, P. J., Fruhwirth, G. O. & T.M. de Rosales, R., 2 Jan 2019, In: Molecular Therapy. 27, 1, p. 219-229 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Citations (Scopus)337 Downloads (Pure) -
Radiolabelling of Nanomaterials for Medical Imaging and Therapy
Pellico , J., Gawne, P. & T. M. de Rosales, R., 7 Mar 2021, In: CHEMICAL SOCIETY REVIEWS. 50, 5, p. 3355-3423 69 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile192 Citations (Scopus)350 Downloads (Pure) -
PET Imaging of Small Extracellular Vesicles via [89Zr]Zr(oxinate)4 Direct Radiolabeling
Khan, A., Man, F., Muhammad Faruqu, F., Kim, J., Al-Salemee, F., Minino, A., Volpe, A., Liam-Or, R., Simpson, P., Fruhwirth, G., Al-Jamal, K. & T. M. de Rosales, R., 16 Mar 2022, In: Bioconjugate Chemistry. 33, 3, p. 473-485 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)151 Downloads (Pure)
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Imaging-guided Development of Polysarcosine-based Drug-delivery Systems
T. M. de Rosales, R. (Primary Investigator) & Witney, T. (Co-Investigator)
1/10/2021 → 30/09/2025
Project: Research
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Smart+: MRC mid-range equipment - State-of-the-Art Equipment for Preclinical Targeted Radiotherapy
Terry, S. (Primary Investigator), Barrington, S. (Co-Investigator), Blower, P. (Co-Investigator), Fruhwirth, G. (Co-Investigator), Hewitt, G. (Co-Investigator), Kong, A. (Co-Investigator), Modarai, B. (Co-Investigator), Southworth, R. (Co-Investigator), Stasiuk, G. (Co-Investigator), Sunassee, K. (Co-Investigator), T. M. de Rosales, R. (Co-Investigator), Tavassoli, M. (Co-Investigator), Witney, T. (Co-Investigator) & Yan, R. (Co-Investigator)
1/08/2023 → 29/02/2024
Project: Research
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Wellcome/EPSRC Centre for Medical Engineering Extension
Ourselin, S. (Primary Investigator), Barker, G. (Co-Investigator), Barnes, A. (Co-Investigator), Barrington, S. (Co-Investigator), Bergeles, C. (Co-Investigator), Bishop, M. (Co-Investigator), Blower, P. (Co-Investigator), Booth, T. (Co-Investigator), Botnar, R. (Co-Investigator), Cardoso, J. (Co-Investigator), Carmichael, D. (Co-Investigator), Chiribiri, A. (Co-Investigator), Clough, R. (Co-Investigator), Cook, G. (Co-Investigator), Counsell, S. (Co-Investigator), Dasgupta, P. (Co-Investigator), De Vecchi, A. (Co-Investigator), De Vita, E. (Co-Investigator), Edwards, D. (Co-Investigator), Goh, V. (Co-Investigator), Hajnal, J. (Co-Investigator), Hammers, A. (Co-Investigator), Hutter, J. (Co-Investigator), Ipek, O. (Co-Investigator), King, A. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Liu, H. (Co-Investigator), Malik, S. (Co-Investigator), Marsden, P. (Co-Investigator), Modat, M. (Co-Investigator), Niederer, S. (Co-Investigator), Razavi, R. (Co-Investigator), Reader, A. (Co-Investigator), Rhode, K. (Co-Investigator), Roujol, S. (Co-Investigator), Rutherford, M. (Co-Investigator), Shapey, J. (Co-Investigator), Sparks, R. (Co-Investigator), T. M. de Rosales, R. (Co-Investigator), Terry, S. (Co-Investigator), Tournier, J.-D. (Co-Investigator), Vercauteren, T. (Co-Investigator), Williams, S. (Co-Investigator), Xia, W. (Co-Investigator), Young, A. (Co-Investigator) & academic, A. (Co-Investigator)
28/04/2022 → 27/10/2024
Project: Research
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Development of simple methodology for ultra-high specific activity radiolabelling of single particles for biomedical applications of Positron Emitting Particle Tracking (PEPT)
T. M. de Rosales, R. (Primary Investigator), Blower, P. (Co-Investigator), Pellico Saez, J. (Co-Investigator) & Vass, L. (Co-Investigator)
EPSRC Engineering and Physical Sciences Research Council
1/07/2021 → 30/06/2022
Project: Research
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Do nanoparticulate environmental pollutants enter the brain when inhaled nasally? A potential answer from SPECT and PET in humans
T. M. de Rosales, R. (Primary Investigator)
1/03/2021 → 28/02/2022
Project: Research
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Annual Congress of the European-Association-of-Nuclear-Medicine
T. M. de Rosales, R. (Invited speaker)
19 Oct 2013Activity: Participating in or organising an event › Participation in conference
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Gordon Research Conference on Cancer Nanotechnology
T. M. de Rosales, R. (Invited speaker)
14 Jul 2013 → 19 Jul 2013Activity: Participating in or organising an event › Participation in conference
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European Symposium on Radiopharmacy and Radiopharmaceuticals
T. M. de Rosales, R. (Invited speaker)
26 Apr 2012Activity: Participating in or organising an event › Participation in conference
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Chemical Science (Journal)
T. M. de Rosales, R. (Peer reviewer)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
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MOLECULAR IMAGING AND BIOLOGY (Journal)
T. M. de Rosales, R. (Peer reviewer)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
Datasets
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PET and CT data for 52Mn-DOXIL in a healthy mouse - 1h, 24h and 72 h post injection
T. M. de Rosales, R. & Gawne, P., King's College London, 13 Sept 2018
DOI: 10.18742/rdm01-283, https://kcl.figshare.com/articles/dataset/PET_and_CT_data_for_52Mn-DOXIL_in_a_healthy_mouse_-_1h_24h_and_72_h_post_injection/16473777
Dataset
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PEPT - Wholebody 60s KCL logo
T. M. de Rosales, R., King's College London, 2 Feb 2024
DOI: 10.18742/24033966, https://kcl.figshare.com/articles/media/PEPT_-_Wholebody_60s_KCL_logo/24033966/1
Dataset
Prizes
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Bill Newton Award - Royal Society of Chemistry (Radiochemistry group)
T. M. de Rosales, R. (Recipient), 30 Apr 2018
Prize: Prize (including medals and awards)
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Confidence in Collaboration in Advanced Therapies Award
T. M. de Rosales, R. (Recipient), 2019
Prize: Prize (including medals and awards)