Research output per year
Research output per year
Personal profile
Biographical details
Rafael T. M. de Rosales (Granada, Spain) obtained his BSc in Chemistry from the Universidad de Granada in 2001. He then moved to Scotland to carry out PhD studies in bioinorganic chemistry at the University of Edinburgh. During this time, he synthesised and developed small metal complexes as synthetic models of nucleases (the enzymes that cleave DNA and RNA). In 2004 he moved to the University of Naples (Italy) thanks to a Marie Curie Postdoctoral Fellowship and developed one of the first biomimetic synthetic metallopeptides capable of catalysing oxidation reactions in collaboration with Prof. A. Lombardi and Prof. V. Pavone. After one year he returned to the UK and joined the groups of Dr. G. Britovsek and Prof. V. C. Gibson FRS at Imperial College London where he explored novel bio-inspired transition metal complexes as oxidation catalysts. In 2007, he moved to the Division of Imaging Sciences & Biomedical Engineering at King’s College London, where he has developed several radiometal probes for the imaging of bone metastases using PET and SPECT as well as novel methods to radiolabel and image nanomedicines.
Research interests
- Design and synthesis of radiometal-based imaging agents.
- Tracking nanomedicines and therapeutic cells using PET imaging.
- Multimodal imaging (PET-MRI)
Research interests (short)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University of Edinburgh
Award Date: 1 Jan 2005
Bachelor of Science, University of Granada
Award Date: 1 Jan 2001
Keywords
- QD Chemistry
- imaging
- Nanomedicine
- PET
- SPECT
- MRI
- R Medicine (General)
- Imaging
- diagnosis
- theranostics
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In Vivo PET Tracking of 89Zr-Labeled Vγ9Vδ2 T Cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate
Man, F., Lim, L., Volpe, A., Gabizon, A., Shmeeda, H., Draper, B., Parente-Pereira, A. C., Maher, J., Blower, P. J., Fruhwirth, G. O. & T.M. de Rosales, R., 2 Jan 2019, In: Molecular Therapy. 27, 1, p. 219-229 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)227 Downloads (Pure) -
Nuclear Imaging of Liposomal Drug Delivery Systems: A Critical Review of Radiolabelling Methods and Applications in Nanomedicine
Man, F. A. W. M., Gawne, P. J. & T. M. de Rosales, R., 2019, In: ADVANCED DRUG DELIVERY REVIEWS. 143, p. 134-160 27 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile68 Citations (Scopus)219 Downloads (Pure) -
Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines
Edmonds, S., Volpe, A., Shmeeda, H., Parente-Pereira, A. C., Radia, R., Baguña-Torres, J., Szanda, I., Severin, G. W., Livieratos, L., Blower, P. J., Maher, J., Fruhwirth, G. O., Gabizon, A. & T M de Rosales, R., 22 Nov 2016, In: ACS Nano. 10, 11, p. 10294–10307Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Citations (Scopus)274 Downloads (Pure) -
Bisphosphonate-anchored PEGylation and radiolabeling of superparamagnetic iron oxide: long-circulating nanoparticles for in vivo multimodal (T1 MRI-SPECT) imaging
Sandiford, L., Phinikaridou, A., Protti, A., Meszaros, L. K., Cui, X., Yan, Y., Frodsham, G., Williamson, P. A., Gaddum, N., Botnar, R. M., Blower, P. J., Green, M. A. & de Rosales, R. T. M., 22 Jan 2013, In: ACS Nano. 7, 1, p. 500-12 13 p.Research output: Contribution to journal › Article › peer-review
225 Citations (Scopus) -
Synthesis of Cu-64(II)-Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET-MRI Agent
de Rosales, R. T. M., Tavare, R., Paul, R. L., Jauregui-Osoro, M., Protti, A., Glaria, A., Varma, G., Szanda, I. & Blower, P. J., 6 Jun 2011, In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 50, 24, p. 5509 - 5513 5 p.Research output: Contribution to journal › Article › peer-review
152 Citations (Scopus)
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PET-Guided MRI Using Multimodal Nanoparticles: A Pre-Operative Imaging Method To Improve Sentinel Lymph Node Biopsy
4/01/2015 → 4/01/2018
Project: Research
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KCL-UCL Comprehensive Cancer Imaging Centre
Blower, P., Cook, G., Ng, T., O'Doherty, M., Sarker, D., Siddique, M. & T. M. de Rosales, R.
1/12/2013 → 30/11/2019
Project: Research
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Wellcome/EPSRC Centre for Medical Engineering Extension
Ourselin, S., Barker, G., Barnes, A., Barrington, S., Bergeles, C., Bishop, M., Blower, P., Booth, T., Botnar, R., Cardoso, J., Carmichael, D., Chiribiri, A., Cook, G., Counsell, S., Dasgupta, P., De Vecchi, A., De Vita, E., Edwards, D., Goh, V., Hajnal, J., Hammers, A., Hutter, J., Ipek, O., King, A., Lamata de la Orden, P., Liu, H., Malik, S., Marsden, P., Modat, M., Niederer, S., Razavi, R., Reader, A., Rhode, K., Roujol, S., Rutherford, M., Shapey, J., Sparks, R., T. M. de Rosales, R., Terry, S., Tournier, J., Vercauteren, T., Williams, S., Xia, W., Young, A. & academic, A.
28/04/2022 → 27/10/2024
Project: Research
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CDT Studentship 2021-005 - Imaging-guided Development of Polysarcosine-based Drug-delivery Systems
T. M. de Rosales, R. & Witney, T.
1/10/2021 → 30/09/2025
Project: Research
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Annual Congress of the European-Association-of-Nuclear-Medicine
Rafael T. M. de Rosales (Invited speaker)
19 Oct 2013Activity: Participating in or organising an event › Participation in conference
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Gordon Research Conference on Cancer Nanotechnology
Rafael T. M. de Rosales (Invited speaker)
14 Jul 2013 → 19 Jul 2013Activity: Participating in or organising an event › Participation in conference
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European Symposium on Radiopharmacy and Radiopharmaceuticals
Rafael T. M. de Rosales (Invited speaker)
26 Apr 2012Activity: Participating in or organising an event › Participation in conference
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MOLECULAR IMAGING AND BIOLOGY (Journal)
Rafael T. M. de Rosales (Peer reviewer)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Chemical Science (Journal)
Rafael T. M. de Rosales (Peer reviewer)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
Prizes
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Bill Newton Award - Royal Society of Chemistry (Radiochemistry group)
T. M. de Rosales, Rafael (Recipient), 30 Apr 2018
Prize: Prize (including medals and awards)
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Confidence in Collaboration in Advanced Therapies Award
T. M. de Rosales, Rafael (Recipient), 2019
Prize: Prize (including medals and awards)