King's College London

Research portal

Professor Ralph Sinkus

  1. Magnetic Resonance Elastography Reconstruction for Anisotropic Tissues

    Babaei, B., Fovargue, D., Lloyd, R. A., Miller, R., Jugé, L., Kaplan, M., Sinkus, R., Nordsletten, D. & Bilston, L. E., 20 Sep 2021, In: Medical Image Analysis. 74, 102212.

    Research output: Contribution to journalArticlepeer-review

  2. Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis

    Schregel, K., Baufeld, C., Palotai, M., Meroni, R., Fiorina, P., Wuerfel, J., Sinkus, R., Zhang, Y. Z., McDannold, N., White, P. J. & Guttmann, C. R. G., 12 May 2021, In: Frontiers in Neuroscience. 15, 665722.

    Research output: Contribution to journalArticlepeer-review

  3. Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods

    Svensson, S. F., De Arcos, J., Darwish, O. I., Fraser-Green, J., Storås, T. H., Holm, S., Vik-Mo, E. O., Sinkus, R. & Emblem, K. E., May 2021, In: Journal of Magnetic Resonance Imaging. 53, 5, p. 1510-1521 12 p.

    Research output: Contribution to journalArticlepeer-review

  4. Elastography Validity Criteria Definition Using Numerical Simulations and MR Acquisitions on a Low-Cost Structured Phantom

    Yushchenko, M., Sarracanie, M., Amann, M., Sinkus, R., Wuerfel, J. & Salameh, N., 29 Apr 2021, In: Frontiers in Physics. 9, 620331.

    Research output: Contribution to journalArticlepeer-review

  5. A Viscoelastic Model for Human Myocardium

    Nordsletten, D., Capilnasiu, A., Zhang, W., Wittgenstein, A. S., Hadjicharalambous, M., Sommer, G., Sinkus, R. & Holzapfel, G., 2021, (Accepted/In press) In: Acta Biomaterialia.

    Research output: Contribution to journalArticlepeer-review

  6. Assessment of Imaging Modalities Against Liver Biopsy in Nonalcoholic Fatty Liver Disease: The Amsterdam NAFLD-NASH Cohort

    Troelstra, M. A., Witjes, J. J., van Dijk, A. M., Mak, A. L., Gurney-Champion, O., Runge, J. H., Zwirs, D., Stols-Gonçalves, D., Zwinderman, A. H., ten Wolde, M., Monajemi, H., Ramsoekh, S., Sinkus, R., van Delden, O. M., Beuers, U. H., Verheij, J., Nieuwdorp, M., Nederveen, A. J. & Holleboom, A. G., 2021, (Accepted/In press) In: Journal of Magnetic Resonance Imaging.

    Research output: Contribution to journalArticlepeer-review

  7. Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity

    Troelstra, M., Runge, J., Burnhope, E., Polcaro, A., Guenthner, C., Schneider, T., Razavi, R., Ismail, T., Martorell, J. & Sinkus, R., 30 Nov 2020, (Accepted/In press) In: Nature Scientific Reports.

    Research output: Contribution to journalArticlepeer-review

  8. Nonlinear viscoelastic constitutive model for bovine liver tissue

    Capilnasiu, A. I., Bilston, L., Sinkus, R. & Nordsletten, D., 1 Oct 2020, In: Biomechanics and Modeling in Mechanobiology. 19, 5, p. 1641-1662 22 p.

    Research output: Contribution to journalArticlepeer-review

  9. Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model

    Schregel, K., Nowicki, M. O., Palotai, M., Nazari, N., Zane, R., Sinkus, R., Lawler, S. E. & Patz, S., 12 May 2020, In: Cancer Imaging. 20, 1, 35.

    Research output: Contribution to journalArticlepeer-review

  10. Biomarkers of liver fibrosis: prospective comparison of multimodal magnetic resonance, serum algorithms and transient elastography

    Forsgren, M. F., Nasr, P., Karlsson, M., Dahlström, N., Norén, B., Ignatova, S., Sinkus, R., Cedersund, G., Leinhard, O. D., Ekstedt, M., Kechagias, S. & Lundberg, P., 1 Jan 2020, In: Scandinavian Journal of Gastroenterology. p. 1-12 12 p.

    Research output: Contribution to journalArticlepeer-review

  11. Unipolar MR elastography: Theory, numerical analysis and implementation

    Guenthner, C., Sethi, S., Troelstra, M., van Gorkum, R. J. H., Gastl, M., Sinkus, R. & Kozerke, S., 1 Jan 2020, In: NMR in Biomedicine. 33, 1, e4138.

    Research output: Contribution to journalArticlepeer-review

  12. MR elastography: Principles, guidelines, and terminology

    Manduca, A., Bayly, P. J., Ehman, R. L., Kolipaka, A., Royston, T. J., Sack, I., Sinkus, R. & Van Beers, B. E., 2020, (Accepted/In press) In: Magnetic Resonance in Medicine.

    Research output: Contribution to journalReview articlepeer-review

  13. Assessing Tumor Mechanics by MR Elastography at Different Strain Levels

    Pagé, G., Tardieu, M., Besret, L., Blot, L., Lopes, J., Sinkus, R., Van Beers, B. E. & Garteiser, P., 1 Dec 2019, In: Journal of Magnetic Resonance Imaging. 50, 6, p. 1982-1989 8 p.

    Research output: Contribution to journalArticlepeer-review

  14. Investigating the contribution of collagen to the tumor biomechanical phenotype with noninvasive magnetic resonance elastography

    Li, J., Zormpas-Petridis, K., Boult, J. K. R., Reeves, E. L., Heindl, A., Vinci, M., Lopes, F., Cummings, C., Springer, C. J., Chesler, L., Jones, C., Bamber, J. C., Yuan, Y., Sinkus, R., Jamin, Y. & Robinson, S. P., 15 Nov 2019, In: Cancer Research. 79, 22, p. 5874-5883

    Research output: Contribution to journalArticlepeer-review

  15. Magnetic resonance elastography of skeletal muscle deep tissue injury

    Nelissen, J. L., Sinkus, R., Nicolay, K., Nederveen, A. J., Oomens, C. W. J. & Strijkers, G. J., Jun 2019, In: NMR in Biomedicine. 32, 6, e4087.

    Research output: Contribution to journalArticlepeer-review

  16. Ristretto MRE: A generalized multi-shot GRE-MRE sequence

    Guenthner, C., Sethi, S., Troelstra, M., Dokumaci, A. S., Sinkus, R. & Kozerke, S., 1 May 2019, In: NMR in Biomedicine. 32, 5, p. e4049 e4049.

    Research output: Contribution to journalArticlepeer-review

  17. Imaging localized neuronal activity at fast time scales through biomechanics

    Patz, S., Fovargue, D., Schregel, K., Nazari, N., Palotai, M., Barbone, P. E., Fabry, B., Hammers, A., Holm, S., Kozerke, S., Nordsletten, D. & Sinkus, R., 17 Apr 2019, In: Science Advances. 5, 4, 13 p., eaav3816.

    Research output: Contribution to journalArticlepeer-review

  18. Imaging localized neuronal activity at fast timescales through biomechanics

    Fovargue, D., Patz, S., Schregel, K., Nazari, N., Palotai, M., Barbone, P. E., Fabry, B., Hammers, A., Holm, S., Kozerke, S., Nordsletten, D. & Sinkus, R., 28 Feb 2019, (Accepted/In press) In: Science Advances.

    Research output: Contribution to journalArticlepeer-review

  19. A novel magnetic resonance elastography transducer concept based on a rotational eccentric mass: preliminary experiences with the gravitational transducer

    Runge, J. H., Hoelzl, S. H., Sudakova, J., Dokumaci, A. S., Nelissen, J. L., Guenthner, C., Lee, J., Troelstra, M., Fovargue, D., Stoker, J., Nederveen, A. J., Nordsletten, D. & Sinkus, R., 6 Feb 2019, In: Physics in Medicine and Biology. 64, 4, 1 p., 045007.

    Research output: Contribution to journalArticlepeer-review

  20. Exploration of new contrasts, targets, and MR imaging and spectroscopy techniques for neuromuscular disease-A workshop report of working group 3 of the biomedicine and molecular biosciences COST action BM1304 MYO-MRI

    Strijkers, G. J., Araujo, E. C. A., Azzabou, N., Bendahan, D., Blamire, A., Burakiewicz, J., Carlier, P. G., Damon, B., Deligianni, X., Froeling, M., Heerschap, A., Hollingsworth, K. G., Hooijmans, M. T., Karampinos, D. C., Loudos, G., Madelin, G., Marty, B., Nagel, A. M., Nederveen, A. J., Nelissen, J. L. & 9 others, Santini, F., Scheidegger, O., Schick, F., Sinclair, C., Sinkus, R., De Sousa, P. L., Straub, V., Walter, G. & Kan, H. E., 5 Feb 2019, In: Journal of Neuromuscular Diseases. 6, 1, p. 1-30 30 p.

    Research output: Contribution to journalReview articlepeer-review

  21. Special issue on MR elastography

    Sinkus, R., 1 Oct 2018, In: NMR in Biomedicine. 31, 10, e4003.

    Research output: Contribution to journalEditorialpeer-review

  22. Breast magnetic resonance elastography: A review of clinical work and future perspectives

    Bohte, A. E., Nelissen, J. L., Runge, J. H., Holub, O., Lambert, S. A., de Graaf, L., Kolkman, S., van der Meij, S., Stoker, J., Strijkers, G. J., Nederveen, A. J. & Sinkus, R., Oct 2018, In: NMR in Biomedicine.

    Research output: Contribution to journalArticlepeer-review

  23. Magnetic resonance elastography in nonlinear viscoelastic materials under load

    Capilnasiu, A., Hadjicharalambous, M., Fovargue, D., Patel, D., Holub, O., Bilston, L., Screen, H., Sinkus, R. & Nordsletten, D., 27 Aug 2018, (E-pub ahead of print) In: Biomechanics and Modeling in Mechanobiology.

    Research output: Contribution to journalArticlepeer-review

  24. Rheological determinants for simultaneous staging of hepatic fibrosis and inflammation in patients with chronic liver disease

    Sinkus, R., Lambert, S., Abd-Elmoniem, K. Z., Morse, C., Heller, T., Guenthner, C., Ghanem, A. M., Holm, S. & Gharib, A. M., 30 Jul 2018, (E-pub ahead of print) In: NMR in Biomedicine. p. e3956

    Research output: Contribution to journalArticlepeer-review

  25. Thymidine metabolism as a confounding factor for 3'-Deoxy-3'-18F-fluorothymidine uptake after therapy in a colorectal cancer model

    Schelhaas, S., Wachsmuth, L., Hermann, S., Rieder, N., Heller, A., Heinzmann, K., Honess, D. J., Smith, D. M., Fricke, I. B., Just, N., Doblas, S., Sinkus, R., Döring, C., Schäfers, K. P., Griffiths, J. R., Faber, C., Schneider, R., Aboagye, E. O. & Jacobs, A. H., 1 Jul 2018, In: Journal of Nuclear Medicine. 59, 7, p. 1063-1069 7 p.

    Research output: Contribution to journalArticlepeer-review

  26. Characterization of Small Renal Tumors with MR Elastography: A Feasibility Study

    Prezzi, D., Neji, R., Kelly-Morland, C., O'Brien, T., Challacombe, B., Chandra, A., Sinkus, R. & Goh, V., 1 Jun 2018, In: Investigative Radiology. 53, 6, p. 344-351

    Research output: Contribution to journalArticlepeer-review

  27. Stiffness reconstruction methods for MR elastography

    Fovargue, D., Nordsletten, D. & Sinkus, R., 18 May 2018, (E-pub ahead of print) In: NMR in Biomedicine.

    Research output: Contribution to journalArticlepeer-review

  28. Analysis and improvement of motion encoding in magnetic resonance elastography

    Guenthner, C., Runge, J. H., Sinkus, R. & Kozerke, S., 1 May 2018, In: NMR in Biomedicine. 31, 5, e3908.

    Research output: Contribution to journalArticlepeer-review

  29. Robust MR elastography stiffness quantification using a localized divergence free finite element reconstruction

    Fovargue, D., Kozerke, S., Sinkus, R. & Nordsletten, D., 8 Dec 2017, (E-pub ahead of print) In: Medical Image Analysis. 44, p. 126-142

    Research output: Contribution to journalArticlepeer-review

  30. Acquisition and reconstruction conditions in silico for accurate and precise magnetic resonance elastography

    Yue, J. L., Tardieu, M., Julea, F., Boucneau, T., Sinkus, R., Pellot-Barakat, C. & Maître, X., 1 Nov 2017, (E-pub ahead of print) In: Physics in Medicine and Biology. 62, 22, p. 8655-8670 16 p.

    Research output: Contribution to journalArticlepeer-review

  31. Experiment for validation of fluid-structure interaction models and algorithms

    Hessenthaler, A., Gaddum, N. R., Holub, O., Sinkus, R., Röhrle, O. & Nordsletten, D., 1 Sep 2017, In: International Journal For Numerical Methods In Biomedical Engineering. 33, 9, e2848.

    Research output: Contribution to journalArticlepeer-review

  32. Magnetic resonance elastography shear wave velocity correlates with liver fibrosis and hepatic venous pressure gradient in adults with advanced liver disease

    Gharib, A. M., Han, M. A. T., Meissner, E. G., Kleiner, D. E., Zhao, X., McLaughlin, M., Matthews, L., Rizvi, B., Abd-Elmoniem, K. Z., Sinkus, R., Levy, E., Koh, C., Myers, R. P., Subramanian, G. M., Kottilil, S., Heller, T., Kovacs, J. A. & Morse, C. G., 5 Apr 2017, In: BioMed Research International. 2017, 2067479.

    Research output: Contribution to journalArticlepeer-review

  33. Liver stiffness values are lower in pediatric subjects than in adults and increase with age: A multifrequency MR elastography study

    Etchell, E., Jugé, L., Hatt, A., Sinkus, R. & Bilston, L. E., 1 Apr 2017, In: Radiology. 283, 1, p. 222-230 9 p.

    Research output: Contribution to journalArticlepeer-review

  34. A MRI-compatible combined mechanical loading and mr elastography setup to study deformation-induced skeletal muscle damage in rats

    Nelissen, J. L., De Graaf, L., Traa, W. A., Schreurs, T. J. L., Moerman, K. M., Nederveen, A. J., Sinkus, R., Oomens, C. W. J., Nicolay, K. & Strijkers, G. J., 11 Jan 2017, In: PL o S One . 12, 1, 22 p., e0169864.

    Research output: Contribution to journalArticlepeer-review

  35. Characterization of glioblastoma in an orthotopic mouse model with magnetic resonance elastography

    Schregel, K., Nazari, N., Nowicki, M. O., Palotai, M., Lawler, S. E., Sinkus, R., Barbone, P. E. & Patz, S., 1 Jan 2017, (Accepted/In press) In: NMR in Biomedicine.

    Research output: Contribution to journalArticlepeer-review

  36. Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial

    Meissner, E. G., McLaughlin, M., Matthews, L., Gharib, A. M., Wood, B. J., Levy, E., Sinkus, R., Virtaneva, K., Sturdevant, D., Martens, C., Porcella, S. F., Goodman, Z. D., Kanwar, B., Myers, R. P., Subramanian, M., Hadigan, C., Masur, H., Kleiner, D. E., Heller, T., Kottilil, S. & 2 others, Kovacs, J. A. & Morse, C. G., 1 Dec 2016, In: LIVER INTERNATIONAL. 36, 12, p. 1783-1792 10 p.

    Research output: Contribution to journalArticlepeer-review

  37. Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases

    Heskamp, S., Heijmen, L., Gerrits, D., Molkenboer-Kuenen, J. D. M., Ter Voert, E. G. W., Heinzmann, K., Honess, D. J., Smith, D. M., Griffiths, J. R., Doblas, S., Sinkus, R., Laverman, P., Oyen, W. J. G., Heerschap, A. & Boerman, O. C., 31 Oct 2016, (E-pub ahead of print) In: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. p. 1-10 10 p.

    Research output: Contribution to journalArticlepeer-review

  38. Breast conserving surgery outcome prediction: A patient-specific, integrated multi-modal imaging and mechano-biological modelling framework

    Eiben, B., Lacher, R., Vavourakis, V., Hipwell, J. H., Stoyanov, D., Williams, N. R., Sabczynski, J., Bülow, T., Kutra, D., Meetz, K., Young, S., Barschdorf, H., Oliveira, H. P., Cardoso, J. S., Monteiro, J. P., Zolfagharnasab, H., Sinkus, R., Gouveia, P., Liefers, G. J., Molenkamp, B. & 4 others, van de Velde, C. J. H., Hawkes, D. J., Cardoso, M. J. & Keshtgar, M., 17 Jun 2016, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Springer‐Verlag Berlin Heidelberg, Vol. 9699. p. 274-281 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 9699).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  39. Changes in Rat Brain Tissue Microstructure and Stiffness during the Development of Experimental Obstructive Hydrocephalus

    Jugé, L., Pong, A. C., Bongers, A., Sinkus, R., Bilston, L. E., Cheng, S. & Cercignani, M. (ed.), 5 Feb 2016, In: PL o S One . 11, 2, p. e0148652

    Research output: Contribution to journalArticlepeer-review

  40. Microvasculature alters the dispersion properties of shear waves - a multi-frequency MR elastography study

    Jugé, L., Petiet, A., Lambert, S. A., Nicole, P., Chatelin, S., Vilgrain, V., Van Beers, B. E., Bilston, L. E. & Sinkus, R., 1 Dec 2015, In: NMR in Biomedicine. 28, 12, p. 1763-1771 9 p.

    Research output: Contribution to journalArticlepeer-review

  41. Bridging Three Orders of Magnitude: Multiple Scattered Waves Sense Fractal Microscopic Structures via Dispersion

    Lambert, S. A., Näsholm, S. P., Nordsletten, D., Michler, C., Juge, L., Serfaty, J. M., Bilston, L., Guzina, B., Holm, S. & Sinkus, R., 26 Aug 2015, In: Physical Review Letters. 115, 9, 094301.

    Research output: Contribution to journalArticlepeer-review

  42. MR Elastography Can Be Used to Measure Brain Stiffness Changes as a Result of Altered Cranial Venous Drainage During Jugular Compression

    Hatt, A., Cheng, S., Tan, K., Sinkus, R. & Bilston, L. E., 4 Jun 2015, (E-pub ahead of print) In: AJNR. American journal of neuroradiology. 7 p.

    Research output: Contribution to journalArticlepeer-review

  43. A framework for optimization-based design of motion encoding in magnetic resonance elastography

    Nir, G., Sahebjavaher, R. S., Sinkus, R. & Salcudean, S. E., 1 Apr 2015, In: Magnetic Resonance in Medicine. 73, 4, p. 1514-1525 12 p.

    Research output: Contribution to journalArticlepeer-review

  44. Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography

    Jamin, Y., Boult, J. K. R., Li, J., Popov, S., Garteiser, P., Ulloa, J. L., Cummings, C., Box, G., Eccles, S. A., Jones, C., Waterton, J. C., Bamber, J. C., Sinkus, R. & Robinson, S. P., 1 Apr 2015, In: Cancer Research. 75, 7, p. 1216-1224 9 p.

    Research output: Contribution to journalArticlepeer-review

  45. MR elastography and diffusion-weighted imaging of ex vivo prostate cancer: Quantitative comparison to histopathology

    Sahebjavaher, R. S., Nir, G., Gagnon, L. O., Ischia, J., Jones, E. C., Chang, S. D., Yung, A., Honarvar, M., Fazli, L., Goldenberg, S. L., Rohling, R., Sinkus, R., Kozlowski, P. & Salcudean, S. E., Jan 2015, In: NMR in Biomedicine. 28, 1, p. 89-100 12 p.

    Research output: Contribution to journalArticlepeer-review

  46. MR elastography of prostate cancer: Quantitative comparison with histopathology and repeatability of methods

    Sahebjavaher, R. S., Nir, G., Honarvar, M., Gagnon, L. O., Ischia, J., Jones, E. C., Chang, S. D., Fazli, L., Goldenberg, S. L., Rohling, R., Kozlowski, P., Sinkus, R. & Salcudean, S. E., Jan 2015, In: NMR in Biomedicine. 28, 1, p. 124-139 16 p.

    Research output: Contribution to journalArticlepeer-review

  47. In vivo anisotropic mechanical properties of dystrophic skeletal muscles measured by anisotropic MR elastographic imaging: The mdx mouse model of muscular dystrophy

    Qin, E. C., Jugé, L., Lambert, S. A., Paradis, V., Sinkus, R. & Bilston, L. E., Dec 2014, In: Radiology. 273, 3, p. 726-735 10 p.

    Research output: Contribution to journalArticlepeer-review

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