Ralph Sinkus

2025

Tumor Biomechanics Quantified Using MR Elastography to Predict Response to Neoadjuvant Chemotherapy in Individuals with Breast Cancer

Sinha, A., Purushotham, A., Jurrius, P., van Schelt, A.-S., Darwish, O., Shifa, B., Annio, G., Peterson, Z., jeffrey, H., Welsh, K., Metafa, A., Spence, J., Kothari, A., Hamed, H., Bitsakou, G., Karydakis, V., Thorat, M., Shaari, E., Sever, A. & Rigg, A. & 3 others, Ng, T., Pinder, S. & Sinkus, R., Mar 2025, In: Radiology. Imaging cancer. 7, 2, p. e240138 e240138.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

59 Downloads (Pure)

2023

Diffusion phase-imaging in anisotropic media using non-linear gradients for diffusion encoding

Wochner, P., Schneider, T., Stockmann, J., Lee, J. & Sinkus, R., Mar 2023, In: PLoS ONE. 18, 3 March, e0281332.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

2022

Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow

Fløgstad Svensson, S., Fuster-Garcia, E., Latysheva, A., Fraser-Green, J., Nordhøy, W., Isam Darwish, O., Thokle Hovden, I., Holm, S., Vik-Mo, E. O., Sinkus, R. & Eeg Emblem, K., Feb 2022, In: European Journal of Radiology. 147, 110136.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model

Palotai, M., Schregel, K., Nazari, N., Merchant, J. P., Taylor, W. M., Guttmann, C. R. G., Sinkus, R., Young-Pearse, T. L. & Patz, S., 1 Jul 2022, In: Journal of Neuroimaging. 32, 4, p. 617-628 12 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Magnetic resonance elastography with guided pressure waves

Tardieu, M., Salameh, N., Souris, L., Rousseau, D., Jourdain, L., Skeif, H., Prévot, F., de Rochefort, L., Ducreux, D., Louis, B., Garteiser, P., Sinkus, R., Darrasse, L., Poirier-Quinot, M. & Maître, X., Jul 2022, In: NMR in Biomedicine. 35, 7, e4701.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

2021

Assessment of Imaging Modalities Against Liver Biopsy in Nonalcoholic Fatty Liver Disease: The Amsterdam NAFLD-NASH Cohort

Troelstra, M. A., Witjes, J. J., van Dijk, A. M., Mak, A. L., Gurney-Champion, O., Runge, J. H., Zwirs, D., Stols-Gonçalves, D., Zwinderman, A. H., ten Wolde, M., Monajemi, H., Ramsoekh, S., Sinkus, R., van Delden, O. M., Beuers, U. H., Verheij, J., Nieuwdorp, M., Nederveen, A. J. & Holleboom, A. G., Dec 2021, In: Journal of Magnetic Resonance Imaging. 54, 6, p. 1937-1949 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

A Viscoelastic Model for Human Myocardium

Nordsletten, D., Capilnasiu, A., Zhang, W., Wittgenstein, A. S., Hadjicharalambous, M., Sommer, G., Sinkus, R. & Holzapfel, G., 2021, (Accepted/In press) In: Acta Biomaterialia.

Research output: Contribution to journal › Article › peer-review

Elastography Validity Criteria Definition Using Numerical Simulations and MR Acquisitions on a Low-Cost Structured Phantom

Yushchenko, M., Sarracanie, M., Amann, M., Sinkus, R., Wuerfel, J. & Salameh, N., 29 Apr 2021, In: Frontiers in Physics. 9, 620331.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Impact of axisymmetric deformation on MR elastography of a nonlinear tissue-mimicking material and implications in peri-tumour stiffness quantification

Fiorito, M., Fovargue, D., Capilnasiu, A., Hadjicharalambous, M., Nordsletten, D., Sinkus, R. & Lee, J., 28 Jun 2021, (Accepted/In press) In: PLoS One.

Research output: Contribution to journal › Article › peer-review

Magnetic Resonance Elastography Reconstruction for Anisotropic Tissues

Babaei, B., Fovargue, D., Lloyd, R. A., Miller, R., Jugé, L., Kaplan, M., Sinkus, R., Nordsletten, D. & Bilston, L. E., Dec 2021, In: Medical Image Analysis. 74, 102212.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods

Svensson, S. F., De Arcos, J., Darwish, O. I., Fraser-Green, J., Storås, T. H., Holm, S., Vik-Mo, E. O., Sinkus, R. & Emblem, K. E., May 2021, In: Journal of Magnetic Resonance Imaging. 53, 5, p. 1510-1521 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis

Schregel, K., Baufeld, C., Palotai, M., Meroni, R., Fiorina, P., Wuerfel, J., Sinkus, R., Zhang, Y. Z., McDannold, N., White, P. J. & Guttmann, C. R. G., 12 May 2021, In: Frontiers in Neuroscience. 15, 665722.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

2020

Biomarkers of liver fibrosis: prospective comparison of multimodal magnetic resonance, serum algorithms and transient elastography

Forsgren, M. F., Nasr, P., Karlsson, M., Dahlström, N., Norén, B., Ignatova, S., Sinkus, R., Cedersund, G., Leinhard, O. D., Ekstedt, M., Kechagias, S. & Lundberg, P., 1 Jan 2020, In: Scandinavian Journal of Gastroenterology. p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model

Schregel, K., Nowicki, M. O., Palotai, M., Nazari, N., Zane, R., Sinkus, R., Lawler, S. E. & Patz, S., 12 May 2020, In: Cancer Imaging. 20, 1, 35.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

MR elastography: Principles, guidelines, and terminology

Manduca, A., Bayly, P. J., Ehman, R. L., Kolipaka, A., Royston, T. J., Sack, I., Sinkus, R. & Van Beers, B. E., 2020, (Accepted/In press) In: Magnetic Resonance in Medicine.

Research output: Contribution to journal › Review article › peer-review

Open Access

159 Citations (Scopus)

Nonlinear viscoelastic constitutive model for bovine liver tissue

Capilnasiu, A. I., Bilston, L., Sinkus, R. & Nordsletten, D., 1 Oct 2020, In: Biomechanics and Modeling in Mechanobiology. 19, 5, p. 1641-1662 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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33 Citations (Scopus)

182 Downloads (Pure)

Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity

Troelstra, M., Runge, J., Burnhope, E., Polcaro, A., Guenthner, C., Schneider, T., Razavi, R., Ismail, T., Martorell, J. & Sinkus, R., 30 Nov 2020, (Accepted/In press) In: Nature Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

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59 Downloads (Pure)

Towards noninvasive estimation of tumour pressure by utilising MR elastography and nonlinear biomechanical models: a simulation and phantom study: a simulation and phantom study

Sinkus, R., Lee, J. & Fovargue, D., 11 Mar 2020, (Accepted/In press) In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Unipolar MR elastography: Theory, numerical analysis and implementation

Guenthner, C., Sethi, S., Troelstra, M., van Gorkum, R. J. H., Gastl, M., Sinkus, R. & Kozerke, S., 1 Jan 2020, In: NMR in Biomedicine. 33, 1, e4138.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

2019

A novel magnetic resonance elastography transducer concept based on a rotational eccentric mass: preliminary experiences with the gravitational transducer

Runge, J. H., Hoelzl, S. H., Sudakova, J., Dokumaci, A. S., Nelissen, J. L., Guenthner, C., Lee, J., Troelstra, M., Fovargue, D., Stoker, J., Nederveen, A. J., Nordsletten, D. & Sinkus, R., 6 Feb 2019, In: Physics in Medicine and Biology. 64, 4, 1 p., 045007.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Citations (Scopus)

Assessing Tumor Mechanics by MR Elastography at Different Strain Levels

Pagé, G., Tardieu, M., Besret, L., Blot, L., Lopes, J., Sinkus, R., Van Beers, B. E. & Garteiser, P., 1 Dec 2019, In: Journal of Magnetic Resonance Imaging. 50, 6, p. 1982-1989 8 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Exploration of new contrasts, targets, and MR imaging and spectroscopy techniques for neuromuscular disease-A workshop report of working group 3 of the biomedicine and molecular biosciences COST action BM1304 MYO-MRI

Strijkers, G. J., Araujo, E. C. A., Azzabou, N., Bendahan, D., Blamire, A., Burakiewicz, J., Carlier, P. G., Damon, B., Deligianni, X., Froeling, M., Heerschap, A., Hollingsworth, K. G., Hooijmans, M. T., Karampinos, D. C., Loudos, G., Madelin, G., Marty, B., Nagel, A. M., Nederveen, A. J. & Nelissen, J. L. & 9 others, Santini, F., Scheidegger, O., Schick, F., Sinclair, C., Sinkus, R., De Sousa, P. L., Straub, V., Walter, G. & Kan, H. E., 5 Feb 2019, In: Journal of Neuromuscular Diseases. 6, 1, p. 1-30 30 p.

Research output: Contribution to journal › Review article › peer-review

53 Citations (Scopus)

Imaging localized neuronal activity at fast timescales through biomechanics

Fovargue, D., Patz, S., Schregel, K., Nazari, N., Palotai, M., Barbone, P. E., Fabry , B., Hammers, A., Holm, S., Kozerke, S., Nordsletten, D. & Sinkus, R., 28 Feb 2019, (Accepted/In press) In: Science Advances.

Research output: Contribution to journal › Article › peer-review

Imaging localized neuronal activity at fast time scales through biomechanics

Patz, S., Fovargue, D., Schregel, K., Nazari, N., Palotai, M., Barbone, P. E., Fabry, B., Hammers, A., Holm, S., Kozerke, S., Nordsletten, D. & Sinkus, R., 3 Apr 2019, In: Science Advances. 5, 4, 13 p., eaav3816.

Research output: Contribution to journal › Article › peer-review

Open Access

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37 Citations (Scopus)

245 Downloads (Pure)

Investigating the contribution of collagen to the tumor biomechanical phenotype with noninvasive magnetic resonance elastography

Li, J., Zormpas-Petridis, K., Boult, J. K. R., Reeves, E. L., Heindl, A., Vinci, M., Lopes, F., Cummings, C., Springer, C. J., Chesler, L., Jones, C., Bamber, J. C., Yuan, Y., Sinkus, R., Jamin, Y. & Robinson, S. P., 15 Nov 2019, In: Cancer Research. 79, 22, p. 5874-5883

Research output: Contribution to journal › Article › peer-review

Open Access

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43 Citations (Scopus)

188 Downloads (Pure)

Magnetic resonance elastography of skeletal muscle deep tissue injury

Nelissen, J. L., Sinkus, R., Nicolay, K., Nederveen, A. J., Oomens, C. W. J. & Strijkers, G. J., Jun 2019, In: NMR in Biomedicine. 32, 6, e4087.

Research output: Contribution to journal › Article › peer-review

Open Access

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16 Citations (Scopus)

122 Downloads (Pure)

Ristretto MRE: A generalized multi-shot GRE-MRE sequence

Guenthner, C., Sethi, S., Troelstra, M., Dokumaci, A. S., Sinkus, R. & Kozerke, S., 1 May 2019, In: NMR in Biomedicine. 32, 5, p. e4049 e4049.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

2018

Analysis and improvement of motion encoding in magnetic resonance elastography

Guenthner, C., Runge, J. H., Sinkus, R. & Kozerke, S., 1 May 2018, In: NMR in Biomedicine. 31, 5, e3908.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Breast magnetic resonance elastography: A review of clinical work and future perspectives

Bohte, A. E., Nelissen, J. L., Runge, J. H., Holub, O., Lambert, S. A., de Graaf, L., Kolkman, S., van der Meij, S., Stoker, J., Strijkers, G. J., Nederveen, A. J. & Sinkus, R., Oct 2018, In: NMR in Biomedicine.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Characterization of Small Renal Tumors with MR Elastography: A Feasibility Study

Prezzi, D., Neji, R., Kelly-Morland, C., O'Brien, T., Challacombe, B., Chandra, A., Sinkus, R. & Goh, V., 1 Jun 2018, In: Investigative Radiology. 53, 6, p. 344-351

Research output: Contribution to journal › Article › peer-review

Open Access

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16 Citations (Scopus)

387 Downloads (Pure)

Magnetic resonance elastography in nonlinear viscoelastic materials under load

Capilnasiu, A., Hadjicharalambous, M., Fovargue, D., Patel, D., Holub, O., Bilston, L., Screen, H., Sinkus, R. & Nordsletten, D., 27 Aug 2018, (E-pub ahead of print) In: Biomechanics and Modeling in Mechanobiology.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Rheological determinants for simultaneous staging of hepatic fibrosis and inflammation in patients with chronic liver disease

Sinkus, R., Lambert, S., Abd-Elmoniem, K. Z., Morse, C., Heller, T., Guenthner, C., Ghanem, A. M., Holm, S. & Gharib, A. M., 30 Jul 2018, (E-pub ahead of print) In: NMR in Biomedicine. p. e3956

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Special issue on MR elastography

Sinkus, R., 1 Oct 2018, In: NMR in Biomedicine. 31, 10, e4003.

Research output: Contribution to journal › Editorial › peer-review

1 Citation (Scopus)

Stiffness reconstruction methods for MR elastography

Fovargue, D., Nordsletten, D. & Sinkus, R., 18 May 2018, (E-pub ahead of print) In: NMR in Biomedicine.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Citations (Scopus)

Thymidine metabolism as a confounding factor for 3'-Deoxy-3'-¹⁸F-fluorothymidine uptake after therapy in a colorectal cancer model

Schelhaas, S., Wachsmuth, L., Hermann, S., Rieder, N., Heller, A., Heinzmann, K., Honess, D. J., Smith, D. M., Fricke, I. B., Just, N., Doblas, S., Sinkus, R., Döring, C., Schäfers, K. P., Griffiths, J. R., Faber, C., Schneider, R., Aboagye, E. O. & Jacobs, A. H., 1 Jul 2018, In: Journal of Nuclear Medicine. 59, 7, p. 1063-1069 7 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2017

Acquisition and reconstruction conditions in silico for accurate and precise magnetic resonance elastography

Yue, J. L., Tardieu, M., Julea, F., Boucneau, T., Sinkus, R., Pellot-Barakat, C. & Maître, X., 1 Nov 2017, (E-pub ahead of print) In: Physics in Medicine and Biology. 62, 22, p. 8655-8670 16 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

A MRI-compatible combined mechanical loading and mr elastography setup to study deformation-induced skeletal muscle damage in rats

Nelissen, J. L., De Graaf, L., Traa, W. A., Schreurs, T. J. L., Moerman, K. M., Nederveen, A. J., Sinkus, R., Oomens, C. W. J., Nicolay, K. & Strijkers, G. J., 11 Jan 2017, In: PL o S One . 12, 1, 22 p., e0169864.

Research output: Contribution to journal › Article › peer-review

Open Access

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20 Citations (Scopus)

289 Downloads (Pure)

Characterization of glioblastoma in an orthotopic mouse model with magnetic resonance elastography

Schregel, K., Nazari, N., Nowicki, M. O., Palotai, M., Lawler, S. E., Sinkus, R., Barbone, P. E. & Patz, S., 1 Jan 2017, (Accepted/In press) In: NMR in Biomedicine.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Experiment for validation of fluid-structure interaction models and algorithms

Hessenthaler, A., Gaddum, N. R., Holub, O., Sinkus, R., Röhrle, O. & Nordsletten, D., 1 Sept 2017, In: International Journal For Numerical Methods In Biomedical Engineering. 33, 9, e2848.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Liver stiffness values are lower in pediatric subjects than in adults and increase with age: A multifrequency MR elastography study

Etchell, E., Jugé, L., Hatt, A., Sinkus, R. & Bilston, L. E., 1 Apr 2017, In: Radiology. 283, 1, p. 222-230 9 p.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Magnetic resonance elastography shear wave velocity correlates with liver fibrosis and hepatic venous pressure gradient in adults with advanced liver disease

Gharib, A. M., Han, M. A. T., Meissner, E. G., Kleiner, D. E., Zhao, X., McLaughlin, M., Matthews, L., Rizvi, B., Abd-Elmoniem, K. Z., Sinkus, R., Levy, E., Koh, C., Myers, R. P., Subramanian, G. M., Kottilil, S., Heller, T., Kovacs, J. A. & Morse, C. G., 5 Apr 2017, In: BioMed Research International. 2017, 2067479.

Research output: Contribution to journal › Article › peer-review

Open Access

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35 Citations (Scopus)

192 Downloads (Pure)

Robust MR elastography stiffness quantification using a localized divergence free finite element reconstruction

Fovargue, D., Kozerke, S., Sinkus, R. & Nordsletten, D., 8 Dec 2017, (E-pub ahead of print) In: Medical Image Analysis. 44, p. 126-142

Research output: Contribution to journal › Article › peer-review

Open Access

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47 Citations (Scopus)

193 Downloads (Pure)

2016

Breast conserving surgery outcome prediction: A patient-specific, integrated multi-modal imaging and mechano-biological modelling framework

Eiben, B., Lacher, R., Vavourakis, V., Hipwell, J. H., Stoyanov, D., Williams, N. R., Sabczynski, J., Bülow, T., Kutra, D., Meetz, K., Young, S., Barschdorf, H., Oliveira, H. P., Cardoso, J. S., Monteiro, J. P., Zolfagharnasab, H., Sinkus, R., Gouveia, P., Liefers, G. J. & Molenkamp, B. & 4 others, van de Velde, C. J. H., Hawkes, D. J., Cardoso, M. J. & Keshtgar, M., 17 Jun 2016, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Springer‐Verlag Berlin Heidelberg, Vol. 9699. p. 274-281 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 9699).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Changes in Rat Brain Tissue Microstructure and Stiffness during the Development of Experimental Obstructive Hydrocephalus

Jugé, L., Pong, A. C., Bongers, A., Sinkus, R., Bilston, L. E., Cheng, S. & Cercignani, M. (Editor), 5 Feb 2016, In: PL o S One . 11, 2, p. e0148652

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (Scopus)

Response Monitoring with [¹⁸F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases

Heskamp, S., Heijmen, L., Gerrits, D., Molkenboer-Kuenen, J. D. M., Ter Voert, E. G. W., Heinzmann, K., Honess, D. J., Smith, D. M., Griffiths, J. R., Doblas, S., Sinkus, R., Laverman, P., Oyen, W. J. G., Heerschap, A. & Boerman, O. C., 31 Oct 2016, (E-pub ahead of print) In: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

222 Downloads (Pure)

Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial

Meissner, E. G., McLaughlin, M., Matthews, L., Gharib, A. M., Wood, B. J., Levy, E., Sinkus, R., Virtaneva, K., Sturdevant, D., Martens, C., Porcella, S. F., Goodman, Z. D., Kanwar, B., Myers, R. P., Subramanian, M., Hadigan, C., Masur, H., Kleiner, D. E., Heller, T. & Kottilil, S. & 2 others, Kovacs, J. A. & Morse, C. G., 1 Dec 2016, In: LIVER INTERNATIONAL. 36, 12, p. 1783-1792 10 p.

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

2015

A framework for optimization-based design of motion encoding in magnetic resonance elastography

Nir, G., Sahebjavaher, R. S., Sinkus, R. & Salcudean, S. E., 1 Apr 2015, In: Magnetic Resonance in Medicine. 73, 4, p. 1514-1525 12 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

A new method for quantification of aortic stiffness in vivo using magnetic resonance elastography (MRE): A translational study from sequence design to implementation in patients

Clough, R., Holub, O., Fok, H., Gaddum, N., Alastruey, J. & Sinkus, R., 3 Feb 2015, In: Journal of cardiovascular magnetic resonance. 17, s1, 2 p., O42.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Bridging Three Orders of Magnitude: Multiple Scattered Waves Sense Fractal Microscopic Structures via Dispersion

Lambert, S. A., Näsholm, S. P., Nordsletten, D., Michler, C., Juge, L., Serfaty, J. M., Bilston, L., Guzina, B., Holm, S. & Sinkus, R., 26 Aug 2015, In: Physical Review Letters. 115, 9, 094301.

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography

Jamin, Y., Boult, J. K. R., Li, J., Popov, S., Garteiser, P., Ulloa, J. L., Cummings, C., Box, G., Eccles, S. A., Jones, C., Waterton, J. C., Bamber, J. C., Sinkus, R. & Robinson, S. P., 1 Apr 2015, In: Cancer Research. 75, 7, p. 1216-1224 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

102 Citations (Scopus)

Ralph Sinkus

Research output

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