King's College London

Research portal

Professor Richard Dobson

  1. Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

    Carbajosa, G., Malki, K., Lawless, N., Wang, H., Ryder, J. W., Wozniak, E., Wood, K., Mein, C. A., Dobson, R. J. B., Collier, D. A., O'Neill, M. J., Hodges, A. K. & Newhouse, S. J. 1 Sep 2018 In : Neurobiology of Aging. 69, p. 151-166 16 p.

    Research output: Contribution to journalArticle

  2. Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brain

    Carbajosa , G., Malki, K., Lawless, N., Wang, H., Ryder, J. W., Wozniak, E., Mein, C. A., Dobson, R. J. B., Collier, D. A., O'Neill, M. J., Hodges, A. K. & Newhouse, S. J. Sep 2018 In : Neurobiology of Aging. 69, p. 151-166

    Research output: Contribution to journalArticle

  3. The EMIF-AD Multimodal Biomarker Discovery study: Design, methods and cohort characteristics

    Bos, I. , Vos, S. , Vandenberghe, R. , Scheltens, P. , Engelborghs, S. , Frisoni, G. , Molinuevo, J. L. , Wallin, A. , Lleó, A. , Popp, J. , Martinez-Lage, P. , Baird, A. , Dobson, R. , Legido-Quigley, C. , Sleegers, K. , Van Broeckhoven, C. , Bertram, L. , Ten Kate, M. , Barkhof, F. , Zetterberg, H. & 3 others Lovestone, S., Streffer, J. & Visser, P. J. 6 Jul 2018 In : Alzheimer's Research and Therapy. 10, 1, 64

    Research output: Contribution to journalArticle

  4. CogStack: Experiences of deploying integrated information retrieval and extraction services in a large National Health Service Foundation Trust hospital

    Jackson, R., Kartoglu, I., Stringer, C., Gorrell, G., Roberts, A., Song, X., Wu, H., Agrawal, A., Lui, K., Groza, T., Lewsley, D., Northwood, D., Folarin, A., Stewart, R. & Dobson, R. 25 Jun 2018 In : BMC medical informatics and decision making. 18, 1, 13 p.

    Research output: Contribution to journalArticle

  5. Accepted/In press
  6. A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication

    Shi, L., Baird, A. L., Westwood, S., Hye, A., Dobson, R., Thambisetty, M. & Lovestone, S. 2018 In : Journal of Alzheimer's Disease. 62, 3, p. 1181-1198 18 p.

    Research output: Contribution to journalReview article

  7. ADEPt, a semantically-enriched pipeline for extracting adverse drug events from free-text electronic health records

    Iqbal, E., Mallah, R., Rhodes, D., Wu, H., Romero, A., Chang, N., Dzahini, O., Pandey, C., Broadbent, M., Stewart, R., Dobson, R. J. B., Ibrahim, Z. M. & Groza, T. (ed.) 9 Nov 2017 In : PL o S One . 12, 11, p. e0187121

    Research output: Contribution to journalArticle

  8. Network analysis of patient flow in two UK acute care hospitals identifies key sub-networks for A&E performance

    Bean, D. M., Stringer, C., Beeknoo, N., Teo, J. & Dobson, R. J. B. 2 Oct 2017 In : PLOS One.

    Research output: Contribution to journalArticle

  9. Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort

    Baker, E., Iqbal, E., Johnston, C., Broadbent, M., Shetty, H., Stewart, R., Howard, R., Newhouse, S., Khondoker, M. & Dobson, R. J. B. 7 Jun 2017 In : PLOS One. 12, 6, e0178562

    Research output: Contribution to journalArticle

  10. Mitochondrial genes are altered in blood early in Alzheimer's disease

    Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A. 1 May 2017 In : Neurobiology of Aging. 53, p. 36-47 12 p.

    Research output: Contribution to journalArticle

  11. Characterisation of mental health conditions in social media using Informed Deep Learning

    Gkotsis, G., Oellrich, A., Velupillai, S., Liakata, M., Hubbard, T. J. P., Dobson, R. J. B. & Dutta, R. 22 Mar 2017 In : Scientific Reports. 7, 45141

    Research output: Contribution to journalArticle

  12. Brain transcriptome sequencing of a natural model of alzheimer's disease

    Altimiras, F., Uszczynska-Ratajczak, B., Camara, F., Vlasova, A., Palumbo, E., Newhouse, S., Deacon, R. M. J., Farias, L. A. E., Hurley, M. J., Loyola, D. E., Vásquez, R. A., Dobson, R., Guigó, R. & Cogram, P. 20 Mar 2017 In : Frontiers in aging neuroscience. 9, 64

    Research output: Contribution to journalArticle

  13. Analysis of diagnoses extracted from Electronic health records in a large mental health Case Register

    Kovalchuk, Y., Stewart, R., Broadbent, M., Hubbard, T. J. P. & Dobson, R. J. B. 16 Feb 2017 In : PL o S One . 12, 2, p. e0171526 e0171526

    Research output: Contribution to journalArticle

  14. Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis

    Proitsi, P., Kim, M., Whiley, L., Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M. K., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Powell, J. F., Dobson, R. J. B. & Legido-Quigley, C. Feb 2017 In : Alzheimer's & Dementia. 13, 2, p. 140-151 12 p.

    Research output: Contribution to journalArticle

  15. Learning patient similarity using joint distributed embeddings of treatment and diagnoses

    Ormandy, C., Ibrahim, Z. M. & Dobson, R. J. B. 2017 In : CEUR Workshop Proceedings. 1891, p. 30-35 6 p.

    Research output: Contribution to journalArticle

  16. Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid

    Voyle, N., Patel, H., Folarin, A., Newhouse, S., Johnston, C., Visser, P. J., Dobson, R. J. B. & Kiddle, S. J. 20 Dec 2016 In : JOURNAL OF ALZHEIMERS DISEASE. 55, 4, p. 1417-1427

    Research output: Contribution to journalArticle

  17. Challenges and opportunities for system biology standards and tools in medical research

    König, M., Oellrich, A., Waltemath, D., Dobson, R. J. B., Hubbard, T. J. P. & Wolkenhauer, O. 29 Sep 2016 Proceedings of the 7th Workshop on Ontologies and Data in Life Sciences, organized by the GI Workgroup Ontologies in Biomedicine and Life Sciences. CEUR-WS, Vol. 1692

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  18. Accepted/In press

    Genetic risk as a marker of amyloid-beta and tau in cerebrospinal fluid

    Voyle, N. J., Patel, H., Folarin, A., Newhouse, S., Johnston, C., Visser, P. J., Dobson, R. J. B., Kiddle, S. J. & EDAR and DESCRIPA 29 Sep 2016 (Accepted/In press) In : JOURNAL OF ALZHEIMERS DISEASE.

    Research output: Contribution to journalArticle

  19. SleepSight: A wearables-based relapse prevention system for Schizophrenia

    Kerz, M., Folarin, A., Meyer, N., Begale, M., MacCabe, J. & Dobson, R. J. 12 Sep 2016 UbiComp 2016 Adjunct - Proceedings of the 2016 ACM International Joint Conference on Pervasive and Ubiquitous Computing. Association for Computing Machinery, Inc, p. 113-116 4 p.

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  20. Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease

    Hakobyan, S., Harding, K., Aiyaz, M., Hye, A., Dobson, R., Baird, A., Liu, B., Harris, C. L., Lovestone, S. & Morgan, B. P. 6 Sep 2016 In : JOURNAL OF ALZHEIMERS DISEASE. 54, 2, p. 707-716 10 p.

    Research output: Contribution to journalArticle

  21. Accepted/In press

    Encoding Medication Episodes for Adverse Drug Event Prediction

    Wu, H., Ibrahim, Z., Iqbal, E. & Dobson, R. J. B. 9 Jul 2016 (Accepted/In press) The Thirty-Sixth Annual International Conference of the British Computer Society's Specialist Group on Artificial Intelligence .

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  22. Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis

    Fogh, I. , Lin, K. , Tiloca, C. , Rooney, J. , Gellera, C. , Diekstra, F. P. , Ratti, A. , Shatunov, A. , Van Es, M. A. , Proitsi, P. , Jones, A. , Sproviero, W. , Chiò, A. , McLaughlin, R. L. , Sorarù, G. , Corrado, L. , Stahl, D. , Del Bo, R. , Cereda, C. , Castellotti, B. & 29 others Glass, J. D., Newhouse, S., Dobson, R., Smith, B. N., Topp, S., Van Rheenen, W., Meininger, V., Melki, J., Morrison, K. E., Shaw, P. J., Leigh, P. N., Andersen, P. M., Comi, G. P., Ticozzi, N., Mazzini, L., D'Alfonso, S., Traynor, B. J., Van Damme, P., Robberecht, W., Brown, R. H., Landers, J. E., Hardiman, O., Lewis, C. M., Van Den Berg, L. H., Shaw, C. E., Veldink, J. H., Silani, V., Al-Chalabi, A. & Powell, J. 1 Jul 2016 In : JAMA Neurology. 73, 7, p. 812-820 9 p.

    Research output: Contribution to journalArticle

  23. Combining clinical variables to optimize prediction of antidepressant treatment outcomes

    Iniesta, R., Malki, K., Maier, W., Rietschel, M., Mors, O., Hauser, J., Henigsberg, N., Dernovsek, M. Z., Souery, D., Stahl, D., Dobson, R., Aitchison, K. J., Farmer, A., Lewis, C. M., McGuffin, P. & Uher, R. Jul 2016 In : Journal of psychiatric research. 78, p. 94-102 9 p.

    Research output: Contribution to journalArticle

  24. The language of mental health problems in social media

    Gkotsis, G., Oellrich, A., Hubbard, T., Dobson, R. JB., Liakata, M., Velupillai, S. & Dutta, R. 16 Jun 2016 The Third Computational Linguistics and Clinical Psychology Workshop (CLPsych). p. 63-73

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  25. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

    Allen, G. I. , Amoroso, N. , Anghel, C. , Balagurusamy, V. , Bare, C. J. , Beaton, D. , Bellotti, R. , Bennett, D. A. , Boehme, K. L. , Boutros, P. C. , Caberlotto, L. , Caloian, C. , Campbell, F. , Chaibub Neto, E. , Chang, Y-C. , Chen, B. , Chen, C-Y. , Chien, T-Y. , Clark, T. , Das, S. & 81 others Davatzikos, C., Deng, J., Dillenberger, D., Dobson, R. J. B., Dong, Q., Doshi, J., Duma, D., Errico, R., Erus, G., Everett, E., Fardo, D. W., Friend, S. H., Fröhlich, H., Gan, J., St George-Hyslop, P., Ghosh, S. S., Glaab, E., Green, R. C., Guan, Y., Hong, M-Y., Huang, C., Hwang, J., Ibrahim, J., Inglese, P., Iyappan, A., Jiang, Q., Katsumata, Y., Kauwe, J. S. K., Klein, A., Kong, D., Krause, R., Lalonde, E., Lauria, M., Lee, E., Lin, X., Liu, Z., Livingstone, J., Logsdon, B. A., Lovestone, S., Ma, T., Malhotra, A., Mangravite, L. M., Maxwell, T. J., Merrill, E., Nagorski, J., Namasivayam, A., Narayan, M., Naz, M., Newhouse, S. J., Norman, T. C., Nurtdinov, R. N., Oyang, Y-J., Pawitan, Y., Peng, S., Peters, M. A., Piccolo, S. R., Praveen, P., Priami, C., Sabelnykova, V. Y., Senger, P., Shen, X., Simmons, A., Sotiras, A., Stolovitzky, G., Tangaro, S., Tateo, A., Tung, Y-A., Tustison, N. J., Varol, E., Vradenburg, G., Weiner, M. W., Xiao, G., Xie, L., Xie, Y., Xu, J., Yang, H., Zhan, X., Zhou, Y., Zhu, F., Zhu, H. & Zhu, S. 11 Apr 2016 In : Alzheimer's & Dementia. 12, 6, p. 645-653 9 p.

    Research output: Contribution to journalArticle

  26. Transcriptomics and the mechanisms of antidepressant efficacy

    Hodgson, K., Tansey, K. E., Powell, T., Coppola, G., Uher, R., Zvezdana Dernovšek, M., Mors, O., Hauser, J., Souery, D., Maier, W., Henigsberg, N., Rietschel, M., Placentino, A., Aitchison, K. J., Craig, I. W., Farmer, A. E., Breen, G., Mcguffin, P. & Dobson, R. 1 Jan 2016 In : European Neuropsychopharmacology. 26, 1, p. 105-112 8 p.

    Research output: Contribution to journalArticle

  27. A pathway based classification method for analyzing gene expression for Alzheimer's disease diagnosis

    Voyle, N., Keohane, A., Newhouse, S., Lunnon, K., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A., Kiddle, S. & Dobson, R. JB. 2016 In : JOURNAL OF ALZHEIMERS DISEASE. 49, 3, p. 659-669 11 p.

    Research output: Contribution to journalArticle

  28. Microduplications at the pseudoautosomal SHOX locus in autism spectrum disorders and related neurodevelopmental conditions

    Tropeano, M. , Howley, D. , Gazzellone, M. J. , Wilson, C. E. , Ahn, J. W. , Stavropoulos, D. J. , Murphy, C. , Eis, P. S. , Hatchwell, E. , Dobson, R. J. B. , Robertson, D. , Holder, M. , Irving, M. , Josifova, D. , Nehammer, A. , Ryten, M. , Spain, D. , Pitts, M. , Bramham, J. , Asherson, P. & 9 others Curran, S., Vassos, E., Breen, G., Flinter, F., Ogilvie, C. M., Collier, D. A., Scherer, S. W., Mcalonan, G. M. & Murphy, D. G. 2016 In : Journal of Medical Genetics.

    Research output: Contribution to journalArticle

  29. Microdeletions of ELP4 are Associated with Language Impairment, Autism Spectrum Disorder and Mental Retardation

    Addis, L. , Ahn, J. W. , Dobson, R. J. B. , Dixit, A. , Ogilvie, C. M. , Pinto, D. , Vaags, A. K. , Coon, H. , Chaste, P. , Wilson, S. , Parr, J. R. , Andrieux, J. , Lenne, B. , Tumer, Z. , Leuzzi, V. , Aubell, K. , Koillinen, H. , Curran, S. R. , Marshall, C. R. , Scherer, S. W. & 3 others Strug, L. J., Collier, D. A. & Pal, D. K. 1 Sep 2015 In : Human Mutation. 36, 9

    Research output: Contribution to journalArticle

  30. A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease

    Khan, W., Aguilar, C., Kiddle, S. J., Doyle, O., Thambisetty, M., Muehlboeck, S., Sattlecker, M., Newhouse, S., Lovestone, S., Dobson, R., Giampietro, V., Westman, E., Simmons, A. & Alzheimer’s Disease Neuroimaging Initiative 18 Aug 2015 In : PloS one. 10, 8, 16 p., e0134368

    Research output: Contribution to journalArticle

  31. Tract based spatial statistic reveals no differences in white matter microstructural organization between carriers and non-carriers of the APOE ε4 and ε2 alleles in young healthy adolescents

    Dell'Acqua, F. , Khan, W. , Gottlieb, N. , Giampietro, V. , Ginestet, C. , Bouls, D. , Newhouse, S. , Dobson, R. , Banaschewski, T. , Barker, G. J. , Bokde, A. L. W. , Büchel, C. , Conrod, P. , Flor, H. , Frouin, V. , Garavan, H. , Gowland, P. , Heinz, A. , Lemaítre, H. , Nees, F. & 10 others Paus, T., Pausova, Z., Rietschel, M., Smolka, M. N., Ströhle, A., Gallinat, J., Westman, E., Schumann, G., Lovestone, S. & Simmons, A. 11 Aug 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 47, 4, p. 977-984 8 p.

    Research output: Contribution to journalArticle

  32. No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease

    Chiam, J. T. W., Lunnon, K., Voyle, N., Proitsi, P., Coppola, G., Geschwind, D., Nelson, S., Johnston, C., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Hodges, A., Lovestone, S., Newhouse, S., Dobson, R. J. B., Kiddle, S. J. & Sattlecker, M. 3 Aug 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 47, 3, p. 741-750 10 p.

    Research output: Contribution to journalArticle

  33. Exploring the role of drug-metabolising enzymes in antidepressant side effects

    Hodgson, K., Tansey, K. E., Uher, R., Dernovšek, M. Z., Mors, O., Hauser, J., Souery, D., Maier, W., Henigsberg, N., Rietschel, M., Placentino, A., Craig, I. W., Aitchison, K. J., Farmer, A., Dobson, R. J. B. & McGuffin, P. Jul 2015 In : Psychopharmacology. 232, 14, p. 2609-2617 9 p.

    Research output: Contribution to journalArticle

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