Search results

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  Localised inhibition of thrombin at endothelial surfaces - a translational strategy to inhibit immune responses to localised antigen

  Dorling, A. (Primary Investigator), Smith, R. (Co-Investigator) & Wilkinson, H. (Co-Investigator)

  MRC Medical Research Council

  1/10/2017 → 3/04/2021

  Project: Research

• Development of cytotopically modified IL-15 for treatment of prostate cancer

  Galustian, C. (Primary Investigator), Dasgupta, P. (Co-Investigator), Smith, R. (Co-Investigator) & academic, A. (Co-Investigator)

  1/10/2016 → 30/09/2018

  Project: Research

• An enhanced process for cyclic peptide combinatorial biosynthesis

  Galustian, C. (Primary Investigator), Dasgupta, P. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/02/2016 → 31/01/2019

  Project: Research

• A translational strategy to prevent and treat atherosclerosis by targeting protease-activated receptors on endothelial cells

  Dorling, A. (Primary Investigator), Chen, D. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/12/2015 → 30/11/2018

  Project: Research

• NIHR Blood and Transplant Unit (Organ Donation and Transplantation)

  Dorling, A. (Primary Investigator), Dazzi, F. (Co-Investigator), Hernandez Fuentes, M. (Co-Investigator), Lombardi, G. (Co-Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/10/2015 → 30/09/2020

  Project: Research

• Design of Novel Immunotherapies for Prostate Cancer - from Bench to Bedside

  Dasgupta, P. (Primary Investigator), Galustian, C. (Co-Investigator) & Smith, R. (Co-Investigator)

  Prostate Cancer Research

  1/10/2014 → 28/02/2022

  Project: Research

• Targeting post transplant kidney injury through machine organ preconditioning

  Dorling, A. (Primary Investigator) & Smith, R. (Co-Investigator)

  ROTRF Roche Organ Transplantation Research Foundation

  1/10/2014 → 30/09/2016

  Project: Research

• Manipulating protease activated receptor (PAR) signalling on mononuclear cells to prevent intimal hyperplasia / chronic fibrosis AND promote regenerative repair

  Dorling, A. (Primary Investigator), Chen, D. (Co-Investigator), Lombardi, G. (Co-Investigator), Smith, R. (Co-Investigator) & Zhou, W. (Co-Investigator)

  1/10/2014 → 30/09/2019

  Project: Research

• Study of novel immunomodulatory drugs and targets for intervention in a novel in-vitro model of the prostate cancer microenvironment

  Dasgupta, P. (Primary Investigator), Galustian, C. (Co-Investigator), Smith, R. (Co-Investigator) & academic, A. (Co-Investigator)

  Urology Foundation

  1/08/2014 → 31/07/2015

  Project: Research

• Targeting inflammatory endothelial cells with thrombin inhibitors in atherosclerosis

  Chen, D. (Primary Investigator), Dorling, A. (Co-Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/04/2014 → 31/03/2017

  Project: Research

• Mutation of Duffy Antigen Receptor for Chemokines (DARC) as an indicator of prostate cancer severity in Afro-Caribbean men

  Galustian, C. (Primary Investigator), Dasgupta, P. (Co-Investigator), Smith, R. (Co-Investigator) & Van Hemelrijck, M. (Co-Investigator)

  Prostate Cancer UK

  1/03/2014 → 30/09/2015

  Project: Research

• Development of an in vitro model of the prostate cancer microenvironment for studies of immunomodulatory drugs and targets

  academic, A. (Primary Investigator), Dasgupta, P. (Co-Investigator), Galustian, C. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/02/2014 → 31/01/2016

  Project: Research

• Optimising islet survival/performance by cytotopic inhibition of thrombin & protease activated receptors; a strategy for clinical translation

  Dorling, A. (Primary Investigator), Amiel, S. (Co-Investigator), Chen, D. (Co-Investigator), Huang, G. (Co-Investigator), Jones, P. (Co-Investigator), Lombardi, G. (Co-Investigator), Sacks, S. (Co-Investigator), Smith, R. (Co-Investigator) & Tree, T. (Co-Investigator)

  1/10/2013 → 30/09/2016

  Project: Research

• DeepRed1 - A Novel Theranostic in Photodynamic Therapy

  Galustian, C. (Primary Investigator), Dasgupta, P. (Co-Investigator) & Smith, R. (Co-Investigator)

  TSB Technology Strategy Board

  1/09/2013 → 31/12/2014

  Project: Research

• Development of cytotopically modified antithrombotic agent for prevention of acute intra-graft thrombosis in transplantation

  Dorling, A. (Primary Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

  Wellcome Trust

  30/04/2013 → 31/08/2018

  Project: Research

• Manipulating the vascular response to injury to prevent chronic fibrosis and promote regenerative repair

  Dorling, A. (Primary Investigator), Chen, D. (Co-Investigator), Lombardi, G. (Co-Investigator), Sacks, S. (Co-Investigator), Smith, R. (Co-Investigator) & Zhou, W. (Co-Investigator)

  3/03/2013 → 2/03/2019

  Project: Research

• Development of a localisable cytotopic anti-cancer immunotherapy

  Galustian, C. (Primary Investigator), Dasgupta, P. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/01/2013 → 31/01/2014

  Project: Research

• MRC Centre for Transplantation

  Sacks, S. (Primary Investigator), Dorling, A. (Co-Investigator) & Smith, R. (Co-Investigator)

  MRC Medical Research Council

  1/10/2012 → 30/09/2017

  Project: Research

• Use of cytotopic anti-cancer drugs for targeted treatment of advanced prostate cancer

  Galustian, C. (Primary Investigator), Dasgupta, P. (Co-Investigator) & Smith, R. (Co-Investigator)

  Prostate Cancer UK

  1/07/2012 → 30/09/2014

  Project: Research

• ps20 (WFDC1) as a therapeutic target in prostate cancer

  Smith, R. (Primary Investigator), Dasgupta, P. (Co-Investigator), Galustian, C. (Co-Investigator) & Vyakarnam, A. (Co-Investigator)

  1/05/2012 → 30/04/2014

  Project: Research

• Ps20 (WFDC1) as a target for therapy in prostate cancer

  Smith, R. (Primary Investigator), Dasgupta, P. (Co-Investigator), Galustian, C. (Co-Investigator) & Vyakarnam, A. (Co-Investigator)

  1/01/2012 → 30/06/2013

  Project: Research

• Use of cytotopically modified anti-cancer proteins for treatment of prostate and breast cancer

  Smith, R. (Primary Investigator), Dasgupta, P. (Co-Investigator) & Galustian, C. (Co-Investigator)

  1/01/2012 → 31/12/2014

  Project: Research

• Targeted cytotopic immunotherpay for prostate cancer

  Smith, R. (Primary Investigator), Dasgupta, P. (Co-Investigator) & Galustian, C. (Co-Investigator)

  1/10/2011 → 30/09/2014

  Project: Research

• Non-invasive imaging of activated complement after acute myocardial infarction: a potential biomarker for ischaemia reperfusion injury

  Mullen, G. (Primary Investigator), Clark, J. (Co-Investigator), Nagel, E. (Co-Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

  BHF British Heart Foundation

  1/09/2011 → 27/02/2015

  Project: Research

• Developmental clinical studies - investigation into the efficacy of mirococept in renal transplantation

  Sacks, S. (Primary Investigator), Smith, R. (Primary Investigator), Chowdhury, S. (Co-Investigator) & Dorling, A. (Co-Investigator)

  MRC Medical Research Council

  1/06/2011 → 31/07/2019

  Project: Research

• Development of a novel immunological assay detecting anti-soluble liver antigen antibodies for the early diagnosis of autoimmune hepatitis

  Ma, Y. (Primary Investigator), Mieli-Vergani, G. (Primary Investigator), Vergani, D. (Primary Investigator), Bogdanos, D. (Co-Investigator), Rebollo-Mesa, I. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/01/2011 → 31/03/2013

  Project: Research

• Cytotopically-modified antithrombotic agents and their application in transplantation.

  Smith, R. (Primary Investigator), Dorling, A. (Co-Investigator) & Sacks, S. (Co-Investigator)

  1/01/2011 → 31/07/2013

  Project: Research

• Evaluating the immunological consequences of intercellular MHC transfer using immunotoxin

  Wong, W. (Primary Investigator), Lechler, R. (Co-Investigator), Lombardi, G. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/04/2010 → 31/03/2013

  Project: Research

• New cytotopic agents in transplantation

  Smith, R. (Primary Investigator)

  1/10/2009 → 30/09/2011

  Project: Research

• The third address: tandem low-affinity ligand ligation for therapeutic localisation of biomolecules in vivo

  Sacks, S. (Primary Investigator) & Smith, R. (Primary Investigator)

  1/04/2009 → 31/03/2011

  Project: Research

• MRC Development Pathway Funding Scheme (DPFS) Devolved Portfolio

  Barrington, S. (Primary Investigator), Bevan, S. (Primary Investigator), Beerbaum, P. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Doherty, P. (Co-Investigator), French, G. (Co-Investigator), Lombardi, G. (Co-Investigator), Moon, L. (Co-Investigator), Nasim, T. (Co-Investigator), Parker, P. (Co-Investigator), Schaeffter, T. (Co-Investigator), Smith, R. (Co-Investigator), Trembath, R. (Co-Investigator), Wells, C. (Co-Investigator) & Williams, G. (Co-Investigator)

  MRC Medical Research Council

  1/04/2009 → 31/12/2013

  Project: Research

• Developing commecialisable assays for WFDC1/ps20, a novel marker of HIV infection

  Vyakarnam, A. (Primary Investigator), Peters, B. (Co-Investigator) & Smith, R. (Co-Investigator)

  2/02/2009 → 1/02/2012

  Project: Research

• Novel cytotopically modified complement regulators in renal transplantation

  Smith, R. (Primary Investigator) & Sacks, S. (Co-Investigator)

  1/12/2008 → 31/05/2011

  Project: Research

• Cell and Molecular Studies of the HIV regulatory function of the whey acidic protein, ps20 as a novel antiviral target

  Vyakarnam, A. (Primary Investigator), Bingle, C. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/10/2008 → 30/09/2012

  Project: Research

• Visualising complement activation by whole organ imageing using PET

  De Freitas, S. (Primary Investigator), Mullen, G. (Co-Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

  5/08/2008 → 4/08/2011

  Project: Research

• Application of Cytopically-Modified CD59 to Transplantation

  Smith, R. (Primary Investigator)

  1/08/2008 → 31/01/2010

  Project: Research

• Visualising whole organ complement activation using PET & SPECT imaging

  Blower, P. (Primary Investigator), De Freitas, S. (Primary Investigator), Mullen, G. (Primary Investigator), Sacks, S. (Primary Investigator) & Smith, R. (Primary Investigator)

  Guy's & St Thomas' Charity

  1/08/2008 → 31/10/2012

  Project: Research

• Visualising Complement Activation by Whole Organ Imaging Using PET

  De Freitas, S. (Primary Investigator), Mullen, G. (Co-Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

  1/08/2008 → 31/07/2011

  Project: Research

• Visualising complement activation by whole organ imaging using PET

  De Freitas, S. (Primary Investigator), Blower, P. (Co-Investigator), Mullen, G. (Co-Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

  British Transplantation Society

  1/08/2008 → 31/01/2011

  Project: Research

• NIHR Biomedical Research Centre

  Afzali, B. (Primary Investigator), Antoniou, M. (Primary Investigator), Barker, J. (Primary Investigator), Barratt, B. (Primary Investigator), Beighton, D. (Primary Investigator), Bevan, S. (Primary Investigator), Blower, P. (Primary Investigator), Burchell, J. (Primary Investigator), Cason, J. (Primary Investigator), Chappell, L. (Primary Investigator), Cope, A. (Primary Investigator), Corrigan, C. (Primary Investigator), Cunninghame Graham, D. (Primary Investigator), Dontu, G. (Primary Investigator), Edgeworth, J. (Primary Investigator), Farzaneh, F. (Primary Investigator), Gee, T. (Primary Investigator), Gould, H. (Primary Investigator), Green, P. (Primary Investigator), Greenough, A. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Hayday, A. (Primary Investigator), Higginson, I. (Primary Investigator), Kalra, L. (Primary Investigator), Karagiannis, S. (Primary Investigator), Kelly, F. (Primary Investigator), Kemper, C. (Primary Investigator), Lau-Walker, M. (Primary Investigator), Lavender, P. (Primary Investigator), Lee, T. (Primary Investigator), Lempp, H. (Primary Investigator), Lewis, C. (Primary Investigator), Lombardi, G. (Primary Investigator), Lord, G. (Primary Investigator), Marber, M. (Primary Investigator), Mason, J. (Primary Investigator), Mathew, C. (Primary Investigator), McGrath, J. (Primary Investigator), Metcalfe, A. (Primary Investigator), Molokhia, M. (Primary Investigator), Mullen, G. (Primary Investigator), Nagel, E. (Primary Investigator), Neil, S. (Primary Investigator), Nestle, F. (Primary Investigator), Oakey, R. (Primary Investigator), Parker, P. (Primary Investigator), Peakman, M. (Primary Investigator), Perera, D. (Primary Investigator), Purushotham, A. (Primary Investigator), Rasekh Ahmadi, K. (Primary Investigator), Rashid, T. (Primary Investigator), Razavi, R. (Primary Investigator), Ridley, A. (Primary Investigator), Robson, M. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Santis, G. (Primary Investigator), Sanz Moreno, V. (Primary Investigator), Sawyer, E. (Primary Investigator), Schaeffter, T. (Primary Investigator), Shah, A. (Primary Investigator), Sharpe, P. (Primary Investigator), Simpson, M. (Primary Investigator), Smith, R. (Primary Investigator), Sorinola, I. (Primary Investigator), Spector, T. (Primary Investigator), Spicer, J. (Primary Investigator), Taams, L. (Primary Investigator), Tavassoli, M. (Primary Investigator), Taylor, D. (Primary Investigator), Tree, T. (Primary Investigator), Trembath, R. (Primary Investigator), Tribe, R. (Primary Investigator), Tutt, A. (Primary Investigator), Waltham, M. (Primary Investigator), Watt, F. (Primary Investigator), Webb, A. (Primary Investigator), Wells, C. (Primary Investigator), Whelan, K. (Primary Investigator), Whitaker, J. (Primary Investigator), Whittlesea, C. (Primary Investigator), Williamson, C. (Primary Investigator), Wolfe, C. (Primary Investigator), Yu, V. (Primary Investigator), academic, A. (Primary Investigator), Hughes, S. (Co-Investigator), Montana, G. (Co-Investigator), Rhode, K. (Co-Investigator), Schnabel, J. (Co-Investigator) & Tziotzios, C. (Co-Investigator)

  NIHR National Institute For Health & Care Research, DHSC Department of Health and Social Care

  1/04/2007 → 31/03/2017

  Project: Research

  • T-Helper Cell 100%
  • Inflammatory Arthritis 66%
  • Monocyte 36%
  • Tumor Necrosis Factor 36%
  • Cytotoxic T-Cell 33%