Research output per year
Research output per year
- 1 - 50 out of 74 results
Search results
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2023
Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival
Peng, Q., Nowocin, A., Ratnasothy, K., Smith, R. A., Smyth, L. A., Lechler, R. I., Dorling, A. & Lombardi, G., 30 Jan 2023, In: Frontiers in Immunology. 13, 980462, p. 980462 980462.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
2022
An indium-111-labelled membrane-targeted peptide for cell tracking with radionuclide imaging
Prueller, J., Pham, T., Blower, J., Charoenphun, P., Volpe, A., Sunassee, K., Mullen, G., Blower, P., Smith, R. & Ma, M., 19 Oct 2022, (E-pub ahead of print) In: RSC Chemical Biology. p. 65-73Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)99 Downloads (Pure) -
Manipulation of Tissue Factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH.
Wilkinson, H., Leonard, H., Robson, M., Smith, R., Tam, E., McVey, J. H., Kirchhofer, D., Chen, D. & Dorling, A., 12 Sept 2022, In: Frontiers in immunology. 13, 999871.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)33 Downloads (Pure) -
2021
Call for emergency action to limit global temperature increases, restore biodiversity, and protect health
Atwoli, L., Baqui, A. H., Benfield, T., Bosurgi, R., Godlee, F., Hancocks, S., Horton, R., Laybourn-Langton, L., Monteiro, C. A., Norman, I., Patrick, K., Praities, N., Olde Rikkert, M. G., Rubin, E. J., Sahni, P., Smith, R., Talley, N. J., Turale, S. & Vázquez, D., Oct 2021, In: Annals of the Royal College of Surgeons of England. 103, 9, p. 1-5 5 p.Research output: Contribution to journal › Article
2 Citations (Scopus) -
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
Atwoli, L., Baqui, A. H., Benfield, T., Bosurgi, R., Godlee, F., Hancocks, S., Horton, R., Laybourn-Langton, L., Monteiro, C. A., Norman, I., Patrick, K., Praities, N., Olde Rikkert, M. G. M., Rubin, E. J., Sahni, P., Smith, R., Talley, N., Turale, S. & Vázquez, D., Sept 2021, In: British Dental Journal. 231, 5, p. 261-263 3 p.Research output: Contribution to journal › Article
Open Access -
2020
A novel in vivo model using immunotoxin in the absence of p-glycoprotein to achieve ultra selective depletion of target cells: Applications in trogocytosis and beyond
Brown, K., Meader, L., Nowocin, A., Edwards, L. A., Cheung, L. H., Smith, R. A., Rosenblum, M. G. & Wong, W., Aug 2020, In: Journal of Immunological Methods. 483, p. 112794Research output: Contribution to journal › Article › peer-review
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Ex vivo delivery of Mirococept: A dose finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney
Kassimatis, T., Greenlaw, R., Hunter, J. P., Douiri, A., Flach, C., Rebollo-Mesa, I., Nichols, L. L., Qasem, A., Danzi, G., Olsburgh, J., Drage, M., Friend, P. J., Neri, F., Karegli, J., Horsfield, C., Smith, R. A. & Sacks, S. H., 17 Aug 2020, In: American Journal of Transplantation.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Regression of atherosclerosis in ApoE-/- mice via modulation of monocyte recruitment and phenotype, induced by weekly dosing of a novel ‘cytotopic’ anti-thrombin without prolonged anticoagulation.
Chen, D., Li, K., Festenstein, S., Karegli, J., Wilkinson, H., Leonard, H., Wei, L.-L., Ma, N., Xia, M., Henry, T., Wang, J. A., Xu, Q., McVey, J. H., Smith, R. & Dorling, A., 7 Jul 2020, In: Journal of the American Heart Association. 9, 13, p. e014811Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)37 Downloads (Pure) -
Targeting prostate cancer using intratumoral cytotopically-modified interleukin-15 immunotherapy in a syngeneic murine model
Papaevangelou, E., Smolarek, D., Smith, R., Dasgupta, P. & Galustian, C., 27 Jul 2020, In: Immunotargets and therapy. 2020, 9, p. 115—130Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)129 Downloads (Pure) -
2019
Prostate cancer cells enhance interleukin-15-mediated expansion of NK cells
Sakellariou, C., Elhage, O., Papaevangelou, E., Giustarini, G., Da Silva Esteves, A. M. E., Smolarek, D., Smith, R., Dasgupta, P. & Galustian, C., 7 Aug 2019, In: BJU International. 125, 1, p. 89-102 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)446 Downloads (Pure) -
2018
Author Correction: Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
Sharif-Paghaleh, E., Yap, M. L., Puhl, S. L., Badar, A., Torres, J. B., Chuamsaamarkkee, K., Kampmeier, F., Smith, R. A., Clark, J., Blower, P. J., Sacks, S. & Mullen, G. E., 13 Mar 2018, In: Scientific Reports. 8, 1, p. 4687 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial
Kassimatis, T., Qasem, A., Douiri, A., Ryan, E. G., Rebollo-Mesa, I., Nichols, L. L., Greenlaw, R., Olsburgh, J., Smith, R. A., Sacks, S. H. & Drage, M., 6 Jun 2017, (E-pub ahead of print) In: Trials. 18, 1, p. 1-11 11 p., 255.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Citations (Scopus)178 Downloads (Pure) -
Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
Sharif-Paghaleh, E., Clark, J., Yap, M. L., Badar, A., Baguna Torres, J., Puhl, S. L., Blower, P. J., Chuamsaamarkkee, K., Kampmeier, F., Smith, R., Sacks, S. H. & Mullen, G. E. D., 23 Nov 2017, In: Scientific Reports. 7, 1, 16090.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)232 Downloads (Pure) -
Thrombalexin: use of a cytotopic anticoagulant to reduce thrombotic microangiopathy in a highly sensitized model of kidney transplantation
Manook, M., Kwun, J., Burghuber, C., Samy, K., Mulvihill, M., Yoon, J., Xu, H., MacDonald, A. L., Freischlag, K., Curfman, V., Branum, E., Howell, D., Farris, A. B., Smith, R. A., Sacks, S., Dorling, A., Mamode, N. & Knechtle, S. J., 31 Aug 2017, In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17, 8, p. 2055-2064Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)200 Downloads (Pure) -
Thrombalexins: Cell-localized inhibition of thrombin and its effects in a model of high-risk renal transplantation
Karegli, J., Melchionna, T., Farrar, C. A., Greenlaw, R., Smolarek, D., Horsfield, C., Charif, R., McVey, J. H., Dorling, A., Sacks, S. H. & Smith, R. A. G., 1 Jan 2017Research output: Other contribution
11 Citations (Scopus) -
2016
APT070 (Mirococept), a membrane-localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model
Xiao, F., Ma, L., Zhao, M., Smith, R. A., Huang, G., Jones, P. M., Persaud, S., Pingitore, A., Dorling, A., Lechler, R. & Lombardi, G., 1 Feb 2016, In: British Journal of Pharmacology. 173, 3, p. 575-587Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)226 Downloads (Pure) -
Cathepsin-L and Transglutaminase Dependent Processing of ps20: A novel Mechanism for ps20 Regulation via ECM Cross-Linking
Hickman, O. J., Dasgupta, P., Galustian, C., Smith, R. A. & Vyakarnam, A., Sept 2016, In: Biochemistry and Biophysics Reports . 7, p. 328–337 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)202 Downloads (Pure) -
Complement—here, there and everywhere, but what about the transplanted organ?
Montero, R. M., Sacks, S. H. & Smith, R. A., 11 May 2016, (E-pub ahead of print) In: Seminars in Immunology.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)358 Downloads (Pure) -
Expression of two WFDC1/ps20 isoforms in prostate stromal cells induces paracrine apoptosis through regulation of PTGS2/COX-2
Hickman, O. J., Smith, R. A., Dasgupta, P., Rao, S. N., Nayak, S., Sreenivasan, S., Vyakarnam, A. & Galustian, C., 24 May 2016, In: British Journal of Cancer. 114, 11, p. 1235–1242Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)239 Downloads (Pure) -
HES1 in immunity and cancer
Rani, A., Greenlaw, R., Smith, R. A. & Galustian, C., 19 Mar 2016, (E-pub ahead of print) In: Cytokine and Growth Factor Reviews.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Citations (Scopus)413 Downloads (Pure) -
Immunotoxin Against a Donor MHC Class II Molecule Induces Indefinite Survival of Murine Kidney Allografts
Brown, K., Nowocin, A. K., Meader, L., Edwards, L. A., Smith, R. A. & Wong, W., Apr 2016, In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16, 4, p. 1129-38 10 p.Research output: Contribution to journal › Article › peer-review
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Immunotoxin Against a Donor MHC Class II Molecule Induces Indefinite Survival of Murine Kidney Allografts
Brown, K., Nowocin, A. K., Meader, L., Edwards, L. A., Smith, R. A. & Wong, W., 1 Apr 2016, In: American Journal of Transplantation. 16, 4, p. 1129-1138 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)186 Downloads (Pure) -
Instant Blood Mediated Inflammatory Reaction in Hepatocyte Transplantation:Current Status and Future Perspectives
Lee, C. A., Dhawan, A., Smith, R., Mitry, R. & Fitzpatrick, E. C., 18 Mar 2016, (E-pub ahead of print) In: Cell Transplantation. 25, p. 10Research output: Contribution to journal › Literature review › peer-review
Open AccessFile40 Citations (Scopus)259 Downloads (Pure) -
Organ Pretreatment with Cytotopic Endothelial Localizing Peptides to Ameliorate Microvascular Thrombosis and Perfusion Deficits in Ex Vivo Renal Hemoreperfusion Models
Hamaoui, K., Gowers, S., Boutelle, M., Cook, T. H., Hanna, G., Darzi, A., Smith, R., Dorling, A. & Papalois, V., 1 Dec 2016, In: Transplantation. 100, 12, p. e128-e139Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)388 Downloads (Pure) -
The C3-like molecule CD109 controls Th1 versus Th17 induction in CD4+ T cells: SI: XXVI ICW Kanazawa 2016
Kolev, M., Nova-Lamperti, E., Freeley, S., Smolarek, D., Chakraborthy, S., Mii, S., Takahashi, M., Smith, R. A., Afzali, B. & Kemper, C., Oct 2016, In: Immunobiology. 221, 10, p. 1195-1196 2 p.Research output: Contribution to journal › Meeting abstract › peer-review
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Thrombalexin (a cytotopic thrombin inhibitor), successfully suppresses the innate immune response in a model of hepatocyte transplantation and may be a promising approach to improving cell engraftment
Lee, C. A., Dhawan, A., Mitry, R. R., Chitongo, P., Walker, S., Fernandez-Dacosta, R., Filippi, C., Lehec, S., Iansante, V., Smith, R. & Fitzpatrick, E., Oct 2016, In: Hepatology. 64, p. 172A-173AResearch output: Contribution to journal › Meeting Abstract › peer-review
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2015
Noninvasive Imaging of Activated Complement in Ischemia-Reperfusion Injury Post–Cardiac Transplant
Sharif-Paghaleh, E., Yap, M. L., Meader, L. L., Chuamsaamarkkee, K., Kampmeier, F., Badar, A., Smith, R. A., Sacks, S. & Mullen, G. E., 2015, (E-pub ahead of print) In: American Journal of Transplantation. 8 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
2014
A Tale of Tails: A Novel Approach to Cytokine Immunotherapy
Sakellariou, C., Smolarek, D., Elhage, O., Ukimura, O., Gill, I., Smith, R., Galustian, C. & Dasgupta, P., 1 Oct 2014, In: Urology. 84, 4, p. S43Research output: Contribution to journal › Meeting abstract
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Complotype affects the extent of down-regulation by Factor I of the C3b feedback cycle in-vitro
Lay, E., Nutland, S., Smith, J. E., Hiles, I., Smith, R. A. G., Seilly, D. J., Buchberger, A., Schwaeble, W. & Lachmann, P. J., 2014, (E-pub ahead of print) In: Immunology, Clinical and Experimental Immunology,.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Detection of innate immunity post ischaemia reperfusion injury in heart transplantation using SPECT imaging
Sharif-Paghaleh, E., Yap, M. L., Meader, L. L., Smith, R. A., Sacks, S. & Mullen, G. E., Dec 2014, In: Immunology. 143, Special Issue, p. 92-92 1 p.Research output: Contribution to journal › Poster abstract › peer-review
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Interleukin-15 activates NK and CD8 T cells within the Prostate cancer microenvironment by expanding activatory NK cell receptors and attenuating inhibitory HLA ligands on tumor cells
Sakellariou, C., Elhage, O., Ukimura, O., Gill, I., Smith, R., Dasgupta, P. & Galustian, C., 1 Oct 2014, In: Cancer Research. 74, p. 1175 1 p.Research output: Contribution to journal › Meeting abstract
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Interleukin-15 boosts expansion of CD8 T, NK and NKT cells by upregulation of telomerase activity
Nayar, S., Sakellariou, C., Elhage, O., Ukimura, O., Gill, I., Smith, R., Galustian, C. & Dasgupta, P., 1 Apr 2014, In: EUROPEAN UROLOGY SUPPLEMENTS. 13Research output: Contribution to journal › Meeting abstract
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Interleukin-15 increases the lifespan and telomerase expression of CD8+ T, NK and NKT cells
Nayar, S., Sakellariou, C., Elhage, O., Ukimura, O., Gill, I., Smith, R., Galustian, C. & Dasgupta, P., 16 Apr 2014, In: British Journal of Surgery. 101, p. 56Research output: Contribution to journal › Meeting abstract
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Mechanism of activation of natural killer and CD8 T cells by interleukin 15 in the prostate cancer microenvironment: Spring Meeting for Clinician Scientists in Training February 2014
Elhage, O., Sakellariou, C., Ukimura, O., Gill, I., Smith, R. A., Galustian, C. & Dasgupta, P., 26 Feb 2014, In: The Lancet. 383, Supplement 1, p. S47 1 p., N/A.Research output: Contribution to journal › Meeting abstract › peer-review
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2013
C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage
Duehrkop, C., Banz, Y., Spirig, R., Miescher, S., Nolte, M. W., Spycher, M., Smith, R. A. G., Sacks, S. H. & Rieben, R., 26 Aug 2013, In: PLoS ONE. 8, 8, p. N/A 15 p., e72059.Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus) -
Expression of IL-15 and IL-2 cytokines and receptors on prostate cancer cells - significance in prostate immunotherapeutics
Sakellariou, C. A. S., Galustian, C., Elhage, O., Ukimura, O., Gill, I. S., Smith, R. A. & Dasgupta, P., May 2013, In: British Journal of Surgery. 100, p. 67-68 2 p.Research output: Contribution to journal › Meeting abstract › peer-review
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GRAFT PRECONDITIONING USING LOCALISING ANTICOAGULANT FUSION PROTEINS IN KIDNEY TRANSPLANTATION
Hamaoui, K., Smith, R., Gowers, S., Mastoridis, S., Boutelle, M., Darzi, A., Dorling, A. & Papalois, V., Nov 2013, In: Transplant International. 26, p. 67-67 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
63 Citations (Scopus) -
Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59
Johnson, S., Brooks, N. J., Smith, R. A. G., Lea, S. M. & Bubeck, D., 30 May 2013, In: Cell Reports. 3, 5, p. 1369-77 9 p., N/A.Research output: Contribution to journal › Article › peer-review
Open Access53 Citations (Scopus) -
Targeting complement at the time of transplantation
Sacks, S., Karegli, J., Farrar, C. A., Asgari, E., Schwaeble, W., Zhou, W. & Smith, R. A., 2013, Complement Therapeutics. New York: Springer, Vol. 734. p. 247-255 9 p. (Advances in Experimental Medicine and Biology; vol. 734).Research output: Chapter in Book/Report/Conference proceeding › Chapter
25 Citations (Scopus) -
2012
Localised inhibition of coagulation limits acute complement mediated damage in high risk renal transplantation
Karegli, J., Farrar, C., Melchionna, T., Horsfield, C., Dorling, A., Smith, R. & Sacks, S., Nov 2012, In: Immunobiology. 217, 11, p. 1183-1183 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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The CD46-Jagged1 interaction is critical for human T(H)1 immunity
Le Friec, G., Sheppard, D., Whiteman, P., Karsten, C. M., Shamoun, S.A.-T., Laing, A., Bugeon, L., Dallman, M. J., Melchionna, T., Chillakuri, C., Smith, R. A., Drouet, C., Couzi, L., Fremeaux-Bacchi, V., Koehl, J., Waddington, S. N., McDonnell, J. M., Baker, A., Handford, P. A. & Lea, S. M. & 1 others, , Dec 2012, In: Nature Immunology. 13, 12, p. 1213-1221 9 p.Research output: Contribution to journal › Article › peer-review
146 Citations (Scopus) -
The novel Jagged1/CD46 interaction: A prime target for immune modulation by viruses?
Sheppard, D., Whiteman, P., Le Friec, G., Waddington, S. N., Smith, R., Melchionna, T., Kemper, C., McDonnell, J. M., Handford, P. A. & Lea, S. M., Nov 2012, In: Immunobiology. 217, 11, p. 1210-1211 2 p.Research output: Contribution to journal › Meeting abstract › peer-review
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2011
ENDOTHELIAL TARGETED ANTICOAGULATION IN KIDNEY ALLOGRAFTS USING A PORCINE MACHINE PERFUSION THROMBOSIS MODEL
Hamaoui, K., Damji, S., Smith, R., Cook, T., Dorling, A. & Papalois, V., Sept 2011, In: Transplant International. 24, p. 126-126 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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Immunotherapy of prostate cancer: identification of new treatments and targets for therapy, and role of WAP domain-containing proteins
Galustian, C., Vyakarnam, A., Elhage, O., Hickman, O., Dasgupta, P. & Smith, R. A., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1433-1436 4 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Recombinant Complement Receptor 2 Radiolabeled with [Tc-99m(CO)(3)](+): A Potential New Radiopharmaceutical for Imaging Activated Complement
Badar, A., DeFreitas, S., McDonnell, J. M., Yahya, N., Thakor, D., Razavi, R., Smith, R., Sacks, S. & Mullen, G. E. D., 2011, In: PL o S One . 6, 4, e18275.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2010
Integrating cytotopic strategy in transplantation: (2) Localised co-inhibition of complement and coagulation in high risk renal transplantation
Karegli, J., Farrar, C. A., Melchionna, T., Smith, R. A. G. & Sacks, S. H., 2010, In: Molecular Immunology. 47, 13, p. 2203 - 2204 2 p.Research output: Contribution to journal › Meeting abstract
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In vitro characterisation of an imaging ligand for detection of C3d deposition in vivo
Badar, A., De Freitas, S., Yahya, M. N., McDonnell, J. M., Thakor, D., Smith, R. A. G., Sacks, S. H. & Mullen, G. E. D., 2010, In: Molecular Immunology. 47, 13, p. 2204 - 2204 1 p.Research output: Contribution to journal › Meeting abstract
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2009
Taking Complement to the Clinic - has the Time Finally Come?
Lachmann, P. J. & Smith, R. A. G., Jun 2009, In: Scandinavian Journal of Immunology. 69, 6, p. 471 - 478 8 p.Research output: Contribution to journal › Literature review › peer-review
28 Citations (Scopus) -
2008
Chylous ascites following radical nephrectomy: a case report
Shah, S. S., Ahmed, K., Smith, R., Mallina, R., Akhbari, P. & Khan, M. S., 11 Jan 2008, In: Journal of medical case reports. 2, p. 3Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction
Peng, Q., Li, K., Anderson, K., Farrar, C. A., Lu, B., Smith, R. A. G., Sacks, S. H. & Zhou, W. D., 15 Feb 2008, In: Blood. 111, 4, p. 2452 - 2461 10 p.Research output: Contribution to journal › Article › peer-review
143 Citations (Scopus)