Research output per year
Research output per year
Personal profile
Research interests
Myocardial adaption; signal transduction; assessment of cellular injury. Studying the mechanisms of adaptation, cardioprotection and cell death in cardiac myocytes and fibroblasts during ischaemia-reperfusion injury, post-infarction remodelling and heart failure.
Research interests (short)
Myocardial adaption; signal transduction; assessment of cellular injury.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SARS-CoV-2 Spike S1 glycoprotein is a TLR4 agonist, upregulates ACE2 expression and induces pro-inflammatory M1 macrophage polarisation: Preprint, available at: doi: https://doi.org/10.1101/2021.08.11.455921;
Aboudounya, M., Heads, R. & Holt, M., 11 Aug 2021, In: bioRxiv. p. 1 30 p., doi: https://doi.org/10.1101/2021.08.11.455921;.Research output: Contribution to journal › Article
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Signalling mechanisms in the cardiovascular protective effects of estrogen: With a focus on rapid/membrane signalling.
Niță, A. R., Knock, G. A. & Heads, R. J., Jan 2021, In: Current Research in Physiology. 4, p. 103-118 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access28 Citations (Scopus) -
COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation.
Aboudounya, M. & Heads, R., 19 Dec 2020, (Accepted/In press) In: MEDIATORS OF INFLAMMATION. 24 p., 8874339.Research output: Contribution to journal › Review article › peer-review
Open AccessFile235 Citations (Scopus)105 Downloads (Pure) -
The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart
Mele, L., Maskell, L. J., Stuckey, D. J., Clark, J. E., Heads, R. J. & Budhram-mahadeo, V. S., 14 Aug 2019, In: Cell death & disease. 10, 8, p. 621-638 18 p., 621.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)143 Downloads (Pure) -
Essential but partially redundant roles for POU4f1/Brn-3a and POU4f2/Brn-3b transcription factors in the developing heart.
LJ, M., K, Q., AA, B., TA, H., Heads, R. J. & Budhram-Mahadeo, V. S., 8 Jun 2017, In: Cell Death & Disease. 8(6), June 8Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)105 Downloads (Pure)
Projects
- 13 Finished
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Investigation of TLR4-Protein Kinase Cε Signalling in the Inhibition of Cardiac Myofibroblasts.
5/06/2017 → 4/06/2020
Project: Research
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Investigation of a Novel Non-Canonical TLR4 signaling Pathway in the Negative Regulation of Fibrosis Gene Expression in Cardiac Myofibroblasts
1/10/2016 → 30/09/2019
Project: Research
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Non-Canonical Protein Kinase C Epsilon Activation and Calcineurin Co-OperativeSignalling in Myocardial remodelling and Fibrosis
1/05/2015 → 30/04/2018
Project: Research
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Non-Canonical Protein Kinase C Epsilon Activation and Calcineurin Co-Operative Signalling in Myocardial remodelling and Fibrosis
1/05/2015 → 30/04/2018
Project: Research
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Investigating an Innate Immune Signalling Pathway in the Regulation of Gene Expression in Cardiac Fibrosis
1/10/2014 → 1/09/2017
Project: Research
Activities
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IIIrd International Symposium on Heat Shock Proteins in Biology and Medicine, Berlin, Germany. Session entitled “ Heat shock proteins in cardiovascular disease.”
Richard Heads (Chair)
2006 → …Activity: Participating in or organising an event › Participation in conference
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IIIrd International Symposium on Heat Shock Proteins in Biology and Medicine, Berlin, Germany, . “A novel mechanism of HSP27 gene regulation by the POU transcription factor Brn-3: A common pathway for neuronal, cancer and cardiomyocyte cell survival.”
Richard Heads (Keynote/plenary speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
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First International Congress on Stress Proteins in Biology and Medicine, Quebec City, Canada, Workshop W9: Chaperones in Tissue Protection. “The POU IV transcription factor Brn-3a regulates expression of HSP27 in sensory neuronal cells and induces survival
Richard Heads (Keynote/plenary speaker)
2003 → …Activity: Participating in or organising an event › Participation in conference
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Cardiovascular Symposium, British Pharmacological Society, University of Strathclyde, Glasgow, . The role of p38-MAPK in cardiac ischaemia-reperfusion injury
Richard Heads (Speaker)
Sept 2002 → …Activity: Participating in or organising an event › Participation in conference
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American Journal of Physiology (Heart and Circulatory Physiology) (Journal)
Richard Heads (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review