Research output per year
Research output per year
Personal profile
Research interests
Genetics of cholestatic liver disease.
Research interests (short)
Genetics of cholestatic liver disease
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Clinical outcomes of ABCB4 heterozygosity in infants and children with cholestatic liver disease
Hegarty, R., Gurra, O., Tarawally, J., Allouni, S., Rahman, O., Strautnieks, S., Kyrana, E., Hadzic, N., Thompson, R. J. & Grammatikopoulos, T., Feb 2024, In: Journal of pediatric gastroenterology and nutrition. 78, 2, p. 339-349 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1
Nayagam, J. S., Foskett, P., Strautnieks, S., Agarwal, K., Miquel, R., Joshi, D. & Thompson, R. J., Oct 2022, In: Hepatology Communications. 6, 10, p. 2654-2664 11 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Citations (Scopus) -
Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency
Li, C. Z., Ogawa, H., Ng, S. S., Chen, X., Kishimoto, E., Sakabe, K., Fukami, A., Hu, Y. C., Mayhew, C. N., Hellmann, J., Miethke, A., Tasnova, N. L., Blackford, S. J. I., Tang, Z. M., Syanda, A. M., Ma, L., Xiao, F., Sambrotta, M., Tavabie, O. & Soares, F. & 6 others, , Apr 2022, In: JHEP Reports. 4, 4, 100446.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study
Loomes, K. M., Squires, R. H., Kelly, D., Rajwal, S., Soufi, N., Lachaux, A., Jankowska, I., Mack, C., Setchell, K. D. R., Karthikeyan, P., Kennedy, C., Dorenbaum, A., Desai, N. K., Garner, W., Jaecklin, T., Vig, P., Miethke, A. & Thompson, R. J., Sept 2022, In: Hepatology Communications. 6, 9, p. 2379-2390 12 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Citations (Scopus) -
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial
Thompson, R. J., Arnell, H., Artan, R., Baumann, U., Calvo, P. L., Czubkowski, P., Dalgic, B., D'Antiga, L., Durmaz, Ö., Fischler, B., Gonzalès, E., Grammatikopoulos, T., Gupte, G., Hardikar, W., Houwen, R. H. J., Kamath, B. M., Karpen, S. J., Kjems, L., Lacaille, F. & Lachaux, A. & 14 others, , 1 Jul 2022, (E-pub ahead of print) In: The Lancet Gastroenterology & Hepatology.Research output: Contribution to journal › Article › peer-review
Open AccessFile97 Citations (Scopus)163 Downloads (Pure)
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An investigation on fatty liver to study non-alcoholic fatty liver disease using ex-situ normothermic machine perfusion
academic, A. (Primary Investigator), Ma, Y. (Co-Investigator), McPhail, M. (Co-Investigator), Rubino, F. (Co-Investigator) & Thompson, R. (Co-Investigator)
KFAS - Kuwait Foundation for the Advancement of Sciences
1/05/2023 → 1/01/2026
Project: Research
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ChiLDReN: Colorado Center of Childhood Liver Disease ResearchNetwork
Thompson, R. (Primary Investigator)
NIH National Institutes of Health
1/07/2024 → 31/05/2025
Project: Research
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DRIVE Health CDT - Genotype to phenotype studies of inherited metabolic liver diseases using human iPSCs
Molokhia, M. (Primary Investigator), Curcin, V. (Co-Investigator), Dobson, R. (Co-Investigator) & Thompson, R. (Co-Investigator)
1/10/2021 → 30/09/2024
Project: Research
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DRIVE Health CDT - Genotype to phenotype studies of inherited metabolic liver diseases using human iPSCs
Molokhia, M. (Primary Investigator), Curcin, V. (Co-Investigator), Dobson, R. (Co-Investigator) & Thompson, R. (Co-Investigator)
Imperial College London Imperial College of Science, Technology and Medicine
1/10/2021 → 30/09/2024
Project: Research
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Congenital portosystemic shunts - a natural model for oncogenesis in the liver
Thompson, R. (Primary Investigator) & Tyraskis, A. (Co-Investigator)
21/08/2019 → 20/02/2020
Project: Research
Activities
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XIX International Bile Acid Meeting
Thompson, R. (Keynote/plenary speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
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Postgraduate Course, American Liver meeting (AASLD)
Thompson, R. (Speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
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British Pharmacological Society, Annual Meeting
Thompson, R. (Keynote/plenary speaker)
2005 → …Activity: Participating in or organising an event › Participation in conference
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Organised “Alex Mowat Paediatric Hepatology Update”
Thompson, R. (Organiser)
2004 → …Activity: Participating in or organising an event › Participation in conference
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Working Group on “Cholestatic and metabolic liver diseases” for the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition UK Medicines for Children’s Research Network, Clinical Study Group
Thompson, R. (Chair)
2004 → …Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups
Prizes
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Wellcome Trust Advanced Fellow,
Thompson, R. (Recipient), 2001
Prize: Fellowship awarded competitively