King's College London

Research portal

Professor Sir Robert Lechler

  1. Isolation and expansion of thymus-derived regulatory T cells for use in pediatric heart transplant patients

    Romano, M., Sen, M., Scottà, C., Alhabbab, R. Y., Rico-Armada, A., Lechler, R. I., Burch, M. & Lombardi, G., Aug 2021, In: European Journal of Immunology. 51, 8, p. 2086-2092 7 p.

    Research output: Contribution to journalArticlepeer-review

  2. Isolation and expansion of thymus-derived regulatory T cells for use in paediatric heart transplant patients

    Romano, M., Sen, M., Scotta, C., Alhabbab, R. Y., Rico- Armada, A., Lechler, R., Burch, M. & Lombardi, G., 5 May 2021, In: European Journal of Immunology.

    Research output: Contribution to journalArticlepeer-review

  3. PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype

    Fanelli, G., Romano, M., Nova Lamperti, E., Werner Sunderland, M., Nerviani, A., Scotta, C., Bombardieri, M., Quezada, S. A., Sacks, S., Noelle, R. J., Pitzalis, C., Lechler, R., Lombardi, G. & Becker, P., 19 Apr 2021, (Accepted/In press) In: PLoS biology.

    Research output: Contribution to journalArticlepeer-review

  4. The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease

    Bornstein, S. R., Guan, K., Brunβen, C., Mueller, G., Kamvissi-Lorenz, V., Lechler, R., Trembath, R., Mayr, M., Poston, L., Sancho, R., Ahmed, S., Alfar, E., Aljani, B., Alves, T. C., Amiel, S., Andoniadou, C. L., Bandral, M., Belavgeni, A., Berger, I., Birkenfeld, A. & 74 others, Bonifacio, E., Chavakis, T., Chawla, P., Choudhary, P., Cujba, A. M., Delgadillo Silva, L. F., Demcollari, T., Drotar, D. M., Duin, S., El-Agroudy, N. N., El-Armouche, A., Eugster, A., Gado, M., Gavalas, A., Gelinsky, M., Guirgus, M., Hansen, S., Hanton, E., Hasse, M., Henneicke, H., Heller, C., Hempel, H., Hogstrand, C., Hopkins, D., Jarc, L., Jones, P. M., Kamel, M., Kämmerer, S., King, A. J. F., Kurzbach, A., Lambert, C., Latunde-Dada, Y., Lieberam, I., Liers, J., Li, J. W., Linkermann, A., Locke, S., Ludwig, B., Manea, T., Maremonti, F., Marinicova, Z., McGowan, B. M., Mickunas, M., Mingrone, G., Mohanraj, K., Morawietz, H., Ninov, N., Peakman, M., Persaud, S. J., Pietzsch, J., Cachorro, E., Pullen, T. J., Pyrina, I., Rubino, F., Santambrogio, A., Schepp, F., Schlinkert, P., Scriba, L. D., Siow, R., Solimena, M., Spagnoli, F. M., Speier, S., Stavridou, A., Steenblock, C., Strano, A., Taylor, P., Tiepner, A., Tonnus, W., Tree, T., Watt, F., Werdermann, M., Wilson, M., Yusuf, N. & Ziegler, C. G., 1 Mar 2021, In: Hormone and Metabolic Research. 53, 3, p. 204-206 3 p.

    Research output: Contribution to journalArticlepeer-review

  5. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

    Sawitzki, B., Harden, P., Reinke, P., Moreau, A., Hutchinson, J. A., Game, D. S., Tang, Q., Guinan, E., Battaglia, M., Burlingham, W. J., Roberts, I., Streitz, M., Josien, R., Böger, C. A., Scotta, C., Markmann, J. F., Hester, J., Juerchott, K., Braudeau, C., James, B. & 41 others, Contreras-Ruiz, L., van der Net, J. B., Bergler, T., Caldara, R., Petchey, W., Edinger, M., Dupas, N., Kapinsky, M., Mutzbauer, I., Otto, N. M., Ollinger, R., Hernandez Fuentes, M., Issa, F., Ahrens, N., Meyenberg, C., Karitzky, S., Kunzendorf, U., Knechtle, S. J., Grinyo, J., Morris, P. J., Brent, L., Bushell, A., Turka, L. A., Bluestone, J. A., Lechler, R., Schlitt, H. J., Cuturi, M. C., Schlickeiser, S., Friend, P. J., Miloud, T., Scheffold, A., Secchi, A., Crisalli, K., Kang, S-M., Hilton, R., Banas, B., Blancho, G., Volk, H-D., Lombardi, G., Wood, K. & Geissler, E. K., 23 May 2020, In: The Lancet. 395, 10237, p. 1627-1639

    Research output: Contribution to journalArticlepeer-review

  6. Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients

    Harden, P. N., Game, D. S., Sawitzki, B., Van der Net, J. B., Hester, J., Bushell, A., Issa, F., Brook, M. O., Alzhrani, A., Schlickeiser, S., Scotta, C., Petchey, W., Streitz, M., Blancho, G., Tang, Q., Markmann, J., Lechler, R. I., Roberts, I. S. D., Friend, P. J., Hilton, R. & 3 others, Geissler, E. K., Wood, K. J. & Lombardi, G., 2020, (Accepted/In press) In: American Journal of Transplantation.

    Research output: Contribution to journalArticlepeer-review

  7. Regulatory B cells: Development, phenotypes, functions, and role in transplantation

    Alhabbab, R. Y., Nova-Lamperti, E., Aravena, O., Burton, H. M., Lechler, R. I., Dorling, A. & Lombardi, G., 1 Nov 2019, In: Immunological Reviews. 292, 1, p. 164-179 16 p.

    Research output: Contribution to journalReview articlepeer-review

  8. Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress

    Laing, A. G., Fanelli, G., Ramirez-Valdez, A., Lechler, R. I., Lombardi, G. & Sharpe, P. T., 14 Mar 2019, In: PL o S One . 14, 3, e0213170.

    Research output: Contribution to journalArticlepeer-review

  9. Regulatory T cell-derived extracellular vesicles modify dendritic cell function

    Tung, S. L., Boardman, D. A., Sen, M., Letizia, M., Peng, Q., Cianci, N., Dioni, L., Carlin, L. M., Lechler, R., Bollati, V., Lombardi, G. & Smyth, L. A., Dec 2018, In: Scientific Reports. 8, 1, 6065.

    Research output: Contribution to journalArticlepeer-review

  10. Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation

    Christakoudi, S., Runglall, M., Mobillo, P., Rebollo-Mesa, I., Tsui, T-L., Nova-Lamperti, E., Norris, S., Kamra, Y., Hilton, R., Bhandari, S., Baker, R., Berglund, D., Carr, S., Game, D., Griffin, S., Kalra, P. A., Lewis, R., Mark, P. B., Marks, S. D., Macphee, I. & 12 others, McKane, W., Mohaupt, M. G., Pararajasingam, R., Kon, S. P., Serón, D., Sinha, M., Tucker, B., Viklický, O., Lechler, R. I., Lord, G. M., Stahl, D. & Hernandez-Fuentes, M. P., 15 Sep 2018, In: Molecular and Cellular Endocrinology. 473, p. 205-216 12 p.

    Research output: Contribution to journalArticlepeer-review

  11. A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

    Fraser, H., Safinia, N., Grageda, N., Thirkell, S., Lowe, K., Fry, L. J., Scottá, C., Hope, A., Fisher, C., Hilton, R., Game, D., Harden, P., Bushell, A., Wood, K., Lechler, R. I. & Lombardi, G., 16 Mar 2018, In: Molecular Therapy - Methods and Clinical Development. 8, p. 198-209 12 p.

    Research output: Contribution to journalArticlepeer-review

  12. Cell therapy in organ transplantation: Our experience on the clinical translation of regulatory T cells

    Safinia, N., Grageda, N., Scottà, C., Thirkell, S., Fry, L. J., Vaikunthanathan, T., Lechler, R. I. & Lombardi, G., Feb 2018, In: Frontiers in Immunology. 9, FEB, 354.

    Research output: Contribution to journalReview articlepeer-review

  13. Regulatory T cells: tolerance induction in solid organ transplantation

    Vaikunthanathan, T., Safinia, N., Boardman, D., Lechler, R. & Lombardi, G., Aug 2017, In: Clinical and Experimental Immunology. 189, 2, p. 197-210

    Research output: Contribution to journalArticlepeer-review

  14. An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

    Halim, L., Romano, M., McGregor, R., Correa, I., Pavlidis, P., Grageda, N., Hoong, S-J., Yuksel, M., Jassem, W., Hannen, R. F., Ong, M., Mckinney, O., Hayee, BH., Karagiannis, S. N., Powell, N., Lechler, R. I., Nova-Lamperti, E. & Lombardi, G., 18 Jul 2017, In: Cell Reports. 20, 3, p. 757-770 14 p.

    Research output: Contribution to journalArticlepeer-review

  15. Strategies for long-term preservation of kidney graft function

    Wekerle, T., Segev, D., Lechler, R. & Oberbauer, R., 25 May 2017, In: Lancet. 389, 10084, p. 2152-2162 11 p.

    Research output: Contribution to journalArticlepeer-review

  16. Diversity, creativity, and flexibility will be needed from the next generation of medical scientists

    Lechler, R., 23 Feb 2017, In: Lancet. 389, S1, p. S1

    Research output: Contribution to journalArticlepeer-review

  17. Manifesto for a healthy and health-creating society

    Crisp, N., Stuckler, D., Horton, R., Adebowale, V., Bailey, S., Baker, M., Bell, J., Bird, J., Black, C., Campbell, J., Davies, J., Henry, H., Lechler, R., Mawson, A., Maxwell, P. H., McKee, M. & Warwick, C., 7 Oct 2016, In: Lancet.

    Research output: Contribution to journalEditorialpeer-review

  18. What Is Direct Allorecognition?

    Boardman, D. A., Jacob, J., Smyth, L. A., Lombardi, G. & Lechler, R. I., 7 Oct 2016, In: Current transplantation reports. 3, 4, p. 275-283 9 p.

    Research output: Contribution to journalArticlepeer-review

  19. Increased CD40 ligation and reduced BCR signalling leads to higher IL-10 production in B-cells from tolerant kidney transplant patients

    www.GAMBITstudy.co.uk, Lord, G. M., Lechler, R. I. & Lombardi, G., 28 Jul 2016, In: Transplantation. TPA-2016-0165R1 .

    Research output: Contribution to journalArticlepeer-review

  20. Biomarkers of tolerance in kidney transplantation – are we predicting tolerance or response to immunosuppressive treatment?

    Rebollo-Mesa, I., Nova-Lamperti, E., Mobillo, P., Runglall, M., Christakoudi, S., Norris, S., Smallcombe, N., Kamra, Y., Hilton, R., Consortium, I. O. T. EU., Bhandari, S., Baker, R., Berglund, D., Carr, S., Game, D., Griffin, S., Kalra, P. A., Lewis, R., Mark, P. B., Marks, S. & 12 others, Macphee, I., McKane, W., Mohaupt, M. G., Pararajasingam, R., Kon, S. P., Serón, D., Sinha, M., Tucker, B., Viklický, O., Lechler, R. I., Lord, G. M. & Hernandez-Fuentes, M. P., 21 Jun 2016, In: American Journal of Transplantation.

    Research output: Contribution to journalArticlepeer-review

  21. Microbiota, immunity and the liver

    Vaikunthanathan, T., Safinia, N., Lombardi, G. & Lechler, R. I., 1 Mar 2016, In: Immunology Letters. 171, p. 36-49 14 p.

    Research output: Contribution to journalArticlepeer-review

  22. Humanized Mice as Preclinical Models in Transplantation

    Safinia, N., Becker, P. D., Vaikunthanathan, T., Xiao, F., Lechler, R. & Lombardi, G., 2016, Suppression and Regulation of Immune Responses. Springer, Vol. 1371. p. 177-96 20 p. (Methods in Molecular Biology ; vol. 1371 ).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  23. Tracking donor-reactive t cells: Perspectives for the development of tolerance protocols

    Martinez-Llordella, M. & Lechler, R. I., Dec 2015, In: Malaysian Oil Science and Technology. 99, 12, p. 2436-2437 2 p.

    Research output: Contribution to journalArticlepeer-review

  24. Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells

    Scottà, C., Fanelli, G., Hoong, S. J., Romano, M., Nova Lamperti, E., Sukthankar, M., Guggino, G., Fazekasova, H., Ratnasothy, K., Becker, P. D., Afzali, B., Lechler, R. I. & Lombardi, G., 15 Oct 2015, In: Haematologica. 101, 1, p. 1-35 35 p.

    Research output: Contribution to journalArticlepeer-review

  25. B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection

    Shiu, K. Y., Mclaughlin, L., Rebollo-mesa, I., Zhao, J., Semik, V., Cook, H. T., Roufosse, C., Brookes, P., Bowers, R. W., Galliford, J., Taube, D., Lechler, R. I., Hernandez-fuentes, M. P. & Dorling, A., 1 Sep 2015, In: Kidney International. 88, 3, p. 560-568 9 p.

    Research output: Contribution to journalArticlepeer-review

  26. Regulatory T cells: Serious contenders in the promise for immunological tolerance in transplantation

    Safinia, N., Scotta, C., Vaikunthanathan, T., Lechler, R. I. & Lombardi, G., 21 Aug 2015, In: Frontiers in Immunology. 6, AUG, 00438.

    Research output: Contribution to journalArticlepeer-review

  27. An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells

    Powell, J. J., Thomas-McKay, E., Thoree, V., Robertson, J., Hewitt, R. E., Skepper, J. N., Brown, A., Hernandez-Garrido, J. C., Midgley, P. A., Gomez-Morilla, I., Grime, G. W., Kirkby, K. J., Mabbott, N. A., Donaldson, D. S., Williams, I. R., Rios, D., Girardin, S. E., Haas, C. T., Bruggraber, S. F. A., Laman, J. D. & 5 others, Tanriver, Y., Lombardi, G., Lechler, R., Thompson, R. P. H. & Pele, L. C., 9 Mar 2015, In: Nature Nanotechnology. 10, p. 361–369 9 p.

    Research output: Contribution to journalArticlepeer-review

  28. MicroRNAs affect dendritic cells function and phenotype

    Smyth, L. A., Boardman, D., Tung, S., Lechler, R. & Lombardi, G., Feb 2015, In: Immunology. 144, 2, p. 197-205 9 p.

    Research output: Contribution to journalArticlepeer-review

Previous 1 2 3 4 5 6 7 Next

Export:RIS BibTex Word PDF - will at most contain 500 items

Search within the list

Refine results

Language

Language

Publication year

Publication year

Meeting and poster abstracts

Meeting and poster abstracts

Open Access Status

Open Access Status

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454