Research output per year
Research output per year
Personal profile
Research interests
The laboratory has an interest in the structure and function of HLA alleles and their polymorphism. I have a general interest in human MHC genes and protiens. This is related to transplantation and the association between HLA and disease.This is based on the critical role of HLA as the pivotal point for all immune responses, not least through its role in shaping the T cell repertoire. Much of the routine transplantation work of the laboratory revolves around HLA specific antibody characterisation, and the facilitation and monitoring of its removal. The role of HLA as a ligand for natural killer cells has lead to an interest in KIR and other NK receptors and their role in the immune response.
Research interests (short)
HLA, human MHC, transplantation immunogenetics, HLA specific antibody characterisation and removal, KIR.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
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The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population
The UK Ireland Renal Transplant Consortium, DeKAF Genomics and GEN03 Studies & The International Genetics and Translational Research in Transplantation Network, 1 Aug 2019, In: American Journal of Transplantation. 19, 8, p. 2262-2273 12 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
Sporadic pemphigus foliaceus and class II human leucocyte antigen allele associations in the white British and Indo-Asian populations in the UK
Saha, M., Harman, K., Mortimer, N. J., Binda, V., Black, M. M., Kondeatis, E., Vaughan, R. & Groves, R. W., 1 Jan 2018, (Accepted/In press) In: Clinical and Experimental Dermatology.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
3D in vitro model of a functional epidermal permeability barrier fromhuman embryonic stem cells and induced pluripotent stem cells
Petrova, A., Celli, A., Jacquet, L., Ntafou, D. D., Crumrine, D., Hupe, M., Arno, M., Hobbs, C., Cvoro, A., Karagiannis, P., Gasparini Devito, L., Sun, R., Adame, L., Vaughan, R., McGrath, J., Mauro, T. M. & Ilic, D., 6 May 2014, In: Stem Cell Reports. 2, 5, p. 675-689 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
Petrova, A., Celli, A., Jacquet, L., Dafou, D., Crumrine, D., Hupe, M., Arno, M., Hobbs, C., Cvoro, A., Karagiannis, P., Devito, L., Sun, R., Adame, L. C., Vaughan, R., McGrath, J. A., Mauro, T. M. & Ilic, D., 6 May 2014, In: Stem Cell Reports. 2, 5, p. 675-689 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile95 Citations (Scopus)109 Downloads (Pure) -
Can a combined screening/treatment programme prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies: study protocol for the multicentre randomised controlled OuTSMART trial
Dorling, A., Rebollo-Mesa, I., Hilton, R., Peacock, J. L., Vaughan, R., Gardner, L., Danzi, G., Baker, R., Clark, B., Thuraisingham, R. C., Buckland, M., Picton, M., Martin, S., Borrows, R., Briggs, D., Horne, R., McCrone, P., Kelly, J. & Murphy, C., 21 Jan 2014, (E-pub ahead of print) In: Trials. 15, 29 p., 30.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)488 Downloads (Pure)
Projects
- 11 Finished
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Optimized TracrolimuS and MMF for HLA Antibodies after Renal Transplantation (the OuTSMART study): a randomized controlled clinical trial to determine if a combined screening/treatment programme can prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies
Dorling, A., Murphy, C., Peacock, J., Rebollo-Mesa, I. & Vaughan, R.
NIHR National Institute For Health & Care Research
1/12/2012 → 31/05/2022
Project: Research
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An investigation into the potential of full HLA typing and epitope level antibody definition on renal allocation.
Hernandez Fuentes, M., Vaughan, R., Collins, R. & Hudson, G.
1/09/2008 → 31/08/2010
Project: Research
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Epityping - a new approach to the HLA system designed for solid organ transplantation
Vaughan, R. & Lougee, E.
1/04/2008 → 30/09/2009
Project: Research
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Defining the genomic and immunological signature that determines the outcome and clinical management of renal transplantation
Lord, G., Hernandez Fuentes, M., Hilton, R., Lewis, C., Sacks, S., Sheerin, N., Solomon, E., Trembath, R., Vaughan, R. & academic, A.
1/01/2008 → 29/06/2011
Project: Research
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New treatments for high-risk transplant recipients
Jurcevic, S., academic, A. & Vaughan, R.
Guy's & St Thomas' Hospital Kidney Patients' Association
1/09/2007 → 31/08/2010
Project: Research
Activities
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Transplantation (Journal)
Robert Vaughan (Editorial board member)
2001 → …Activity: Publication peer-review and editorial work › Editorial activity
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Arthritis & Rheumatism (Journal)
Robert Vaughan (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review
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INTERNATIONAL JOURNAL OF IMMUNOGENETICS (Journal)
Robert Vaughan (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review
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British Society for Immunology
Robert Vaughan (Member)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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Euorpean Federation Immunogenetics
Robert Vaughan (Speaker)
2001 → …Activity: Participating in or organising an event › Participation in conference