Research output per year
Research output per year
Personal profile
Research interests
Dendritic cell biology; IFN-alpha biology; transplantation tolerance; regulatory T cells.
Research interests (short)
Dendritic cell biology; IFN-alpha biology; transplantation tolerance; regulatory
T cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival
Peng, Q., Nowocin, A., Ratnasothy, K., Smith, R. A., Smyth, L. A., Lechler, R. I., Dorling, A. & Lombardi, G., 30 Jan 2023, In: Frontiers in Immunology. 13, 980462, p. 980462 980462.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance?
Safinia, N., Vaikunthanathan, T., Lechler, R. I., Sanchez-Fueyo, A. & Lombardi, G., Oct 2021, In: European Journal of Immunology. 51, 10, p. 2373-2386 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
B lymphocytes contribute to indirect pathway T cell sensitization via acquisition of extracellular vesicles
Becker, P. D., Ratnasothy, K., Sen, M., Peng, Q., Romano, M., Bazoer, J., Suvitra, E., Stout, A., Hylton, S. G., Dorling, A., Lechler, R. I., Smyth, L. A. & Lombardi, G., 31 Mar 2021, In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 21, 4, p. 1415-1426 12 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive
Mohseni, Y. R., Saleem, A., Tung, S. L., Dudreuilh, C., Lang, C., Peng, Q., Volpe, A., Adigbli, G., Cross, A., Hester, J., Farzaneh, F., Scotta, C., Lechler, R. I., Issa, F., Fruhwirth, G. O. & Lombardi, G., Oct 2021, In: European Journal of Immunology. 51, 10, p. 2522-2530 9 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Isolation and expansion of thymus-derived regulatory T cells for use in paediatric heart transplant patients
Romano, M., Sen, M., Scotta, C., Alhabbab, R. Y., Rico- Armada, A., Lechler, R., Burch, M. & Lombardi, G., 5 May 2021, (E-pub ahead of print) In: European Journal of Immunology.Research output: Contribution to journal › Article › peer-review
Projects
- 49 Finished
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Does COVID-19 affect the brain? Gaining mechanistic insight “in vitro” on how brain cell function is disrupted upon exposure to serum from COVID-19 patients with neurological symptoms
Borsini, A., Lechler, R., Pariante, C., Srivastava, D., Thuret, S., Vernon, A. & Williams, F.
1/02/2021 → 31/08/2022
Project: Research
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Targeting Nox2 to improve regulatory T cell function and immune tolerance in heart transplantation
Shah, A., Cellone Trevelin, S., Lombardi, G., Ivetic, A. & Lechler, R.
10/08/2018 → 9/08/2021
Project: Research
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Defining the mechanisms underlying the role of regulatory T cells in the establishment of tolerance
Lombardi, G., Sanchez Fueyo, A., Douiri, A., Lechler, R. & Martinez-Llordella, M.
9/01/2017 → 8/01/2022
Project: Research
Activities
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World Transplant Congress, Boston, USA
Robert Lechler (Speaker)
Jul 2006 → …Activity: Participating in or organising an event › Participation in conference
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26th European Immunogenetics and histocompatibility Conference, Oslo
Robert Lechler (Speaker)
Jun 2006 → …Activity: Participating in or organising an event › Participation in conference
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Physicians Centenary Meeting Guy’s Hospital
Robert Lechler (Organiser)
Apr 2006 → …Activity: Participating in or organising an event › Participation in conference
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Centenary Meeting of Association of Physicians - |Organiser and President
Robert Lechler (Organiser)
Apr 2006 → …Activity: Participating in or organising an event › Participation in conference
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32nd Annual Meeting of the European Bone Marrow Transplantation Society, Hamburg
Robert Lechler (Speaker)
Mar 2006 → …Activity: Participating in or organising an event › Participation in conference
Prizes
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King's College London Fellowship
Lechler, Robert (Recipient), 2007
Prize: Fellowship awarded competitively