Search results

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  Does COVID-19 affect the brain? Gaining mechanistic insight “in vitro” on how brain cell function is disrupted upon exposure to serum from COVID-19 patients with neurological symptoms

  Borsini, A., Lechler, R., Pariante, C., Srivastava, D., Thuret, S., Vernon, A. & Williams, F.

  Rosetrees Trust

  1/02/2021 → 31/08/2022

  Project: Research

• Targeting Nox2 to improve regulatory T cell function and immune tolerance in heart transplantation

  Shah, A., Cellone Trevelin, S., Lombardi, G., Ivetic, A. & Lechler, R.

  BHF British Heart Foundation

  10/08/2018 → 9/08/2021

  Project: Research

• Targeting recipient antigen-presenting cells with sialic acid-modified alloantigen to promote transplantation tolerance

  Lombardi, G., Lechler, R. & Smyth, L.

  BHF British Heart Foundation

  1/10/2017 → 30/09/2020

  Project: Research

• Defining the mechanisms underlying the role of regulatory T cells in the establishment of tolerance

  Lombardi, G., Sanchez Fueyo, A., Douiri, A., Lechler, R. & Martinez-Llordella, M.

  9/01/2017 → 8/01/2022

  Project: Research

• Thymus derived Tregs expanded in vitro as a treatment for paediatric heart transplant patients to prevent cardiac allograft vasculopathy.

  Lombardi, G., Botnar, R., Lechler, R. & Scotta, C.

  BHF British Heart Foundation

  1/01/2017 → 31/12/2018

  Project: Research

• Defining the mechanisms underlying the role of regulatory t cells in the establishment of tolerance

  Lombardi, G., Lechler, R., Martinez-Llordella, M., Rebollo-Mesa, I. & Sanchez Fueyo, A.

  1/06/2016 → 31/05/2021

  Project: Research

• Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes

  Lombardi, G., Huang, G., Jones, P., Lechler, R. & Xiao, F.

  1/01/2016 → 31/12/2018

  Project: Research

• Preclinical assessment of targeting DCs directly in vivo to prevent human islettransplant rejection as a cure for Type 1 diabetes

  Lombardi, G., Huang, G., Jones, P., Lechler, R. & Xiao, F.

  1/01/2016 → 31/12/2018

  Project: Research

• Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes

  Lombardi, G., Huang, G., Jones, P., Lechler, R. & Xiao, F.

  1/01/2016 → 31/12/2018

  Project: Research

• Using biomarkers of tolerance to guide immunosuppression weaning in kidney transplant recipients

  Hernandez Fuentes, M., Lechler, R., Lord, G. & Rebollo-Mesa, I.

  1/01/2014 → 31/12/2018

  Project: Research

• Optimising the efficacy of regulatory T cells: informing clinical application

  Lombardi, G. & Lechler, R.

  BHF British Heart Foundation

  1/10/2013 → 30/09/2018

  Project: Research

• ThRIL: a 'first-in-human' study, evaluating the safety, tolerability with an investigation into the efficacy of Tregs in liver transplant recipients

  Lombardi, G., Aluvihare, V., Heaton, N., Lechler, R., Peacock, J., Rebollo-Mesa, I., Safinia, N., Sanchez Fueyo, A. & Wang, Y.

  MRC Medical Research Council

  31/08/2013 → 29/06/2018

  Project: Research

• Developmental Clinical Study: using Biomarkers of tolerance to guide immunosupression weaning in kidney transplant recipients.

  Hernandez Fuentes, M., Lechler, R., Lord, G. & Rebollo-Mesa, I.

  1/01/2013 → 31/12/2017

  Project: Research

• Preclinical in vivo assessment of a combination of protein and cell therapies to prevent human islet transplant rejection as a cure for Type 1 diabetes

  Lombardi, G., Dorling, A., Huang, G., Lechler, R. & Xiao, F.

  MRC Medical Research Council

  1/12/2012 → 31/12/2015

  Project: Research

• The relevance of regulatory T cell conversion to T helper 17 for the balance between tolerance and inflammation

  Afzali, B., Lechler, R. & O'Shea, J.

  Wellcome Trust

  1/10/2012 → 4/11/2017

  Project: Research

• Dissecting regulatory T Cell subset functions in vivo using cell imaging techniques

  Lombardi, G., Lechler, R. & Mullen, G.

  1/05/2012 → 1/05/2015

  Project: Research

• Pre clinical in vivo assessment of cell therapy to prevent human islet transplant rejection to cure Type 1 diabetes

  Lombardi, G., Dorling, A., Huang, G. & Lechler, R.

  1/01/2012 → 31/12/2014

  Project: Research

• Use of chimeric antigen receptor-engineered Tregs to elicit targeted transplantation tolerance

  Lombardi, G., Maher, J. & Lechler, R.

  1/10/2011 → 30/09/2014

  Project: Research

• Role of B cells in the amplification and regulation of transplant rejection

  Lechler, R., Lombardi, G. & Noelle, R.

  BHF British Heart Foundation

  1/10/2011 → 30/09/2014

  Project: Research

• Dissecting regulatory T cell functions using cell imagingtechniques

  Lombardi, G., Lechler, R., Mullen, G. & academic, A.

  1/03/2011 → 28/02/2014

  Project: Research

• The ONE Study: a unified approach to evaluating cellular immunotherapy in solid organ transplantation

  Lombardi, G., Hernandez Fuentes, M., Lechler, R. & Noelle, R.

  EC European Commission

  1/10/2010 → 31/10/2017

  Project: Research

• Evaluating the immunological consequences of intercellular MHC transfer using immunotoxin

  Wong, W., Lechler, R., Lombardi, G. & Smith, R.

  1/04/2010 → 31/03/2013

  Project: Research

• Optimising expansion and culture of regulatory T-cells to develop safe and effective cellular therapeutics for clinical transplantation and autoimmunity

  Lechler, R., Lombardi, G., Noelle, R., Kemper, C., Marelli-Berg, F. & Nestle, F.

  Guy's & St Thomas' Charity

  1/03/2010 → 31/05/2012

  Project: Research

• Dissecting regulatory T cell functions using cell imaging techniques

  Lombardi, G., Mullen, G., Smyth, L., Lechler, R., Ng, T. & Ridley, A.

  1/10/2009 → 30/09/2012

  Project: Research

• Biomarkers of clinical transplantation tolerance. GAMBIT study

  Hernandez Fuentes, M., Lechler, R., Lord, G., Seyfert-Margolis, V. & Turka, L.

  MRC Medical Research Council, Guy's & St Thomas' Charity

  1/01/2009 → 14/02/2013

  Project: Research

• Driving Sino-UK innovation in regenerative medicine

  Salter, B., Hylands, P., Lechler, R., Mann, G. & Minger, S.

  1/01/2009 → 31/12/2011

  Project: Research

• Defining the effects of microRNAs in the activation and lineage commitment of T-cells, and their use as biomarkers of allograft rejection

  Lechler, R., Lombardi, G. & Lord, G.

  MRC Medical Research Council

  1/12/2008 → 30/11/2011

  Project: Research

• Can we use biomarkers of tolerance to predict good outcome of immunosupression minimisation?

  Hernandez Fuentes, M., Lechler, R., Lord, G., Hilton, R., Janssen, U. & Sinha, M.

  1/11/2008 → 31/10/2011

  Project: Research

• Defining the Effects of selected microRNAs in the activation and lineage commitment of T-cells, in the context of renal transplatation

  Lechler, R., Lombardi, G. & Lord, G.

  1/11/2008 → 31/10/2011

  Project: Research

• Manipulating regulatory T cells to promote clinical transplant tolerance

  Lombardi, G., Mullen, G. & Lechler, R.

  BHF British Heart Foundation

  1/09/2008 → 30/09/2013

  Project: Research

• Clinical study of regulatory T cells as cell therapy to induce donor-specific transplantation tolerance

  Lechler, R. & Lombardi, G.

  Guy's & St Thomas' Charity

  1/09/2008 → 1/09/2011

  Project: Research

• Understanding and exploiting natural mechanisms of immune regulation

  Lechler, R., Lombardi, G., Minger, S. & Sacks, S.

  1/09/2008 → 31/08/2013

  Project: Research

• Institute of analytical toxicology and therapeutics

  Kelly, F., Kicman, A. & Lechler, R.

  1/06/2008 → 31/05/2013

  Project: Research

• Define the mechanisms of Galectin-1 mediated CD4+CD25+ Tcell suppression

  Lombardi, G. & Lechler, R.

  1/01/2008 → 31/12/2010

  Project: Research

• Driving Sino-UK innovation in regenerative medicine

  Salter, B., Hylands, P., Lechler, R., Mann, G. & Minger, S.

  1/01/2008 → 31/12/2010

  Project: Research

• Novel therapeutic strategies to promote tolerance to pancreatic islet allograft.

  Lombardi, G., Mirenda, V., Amiel, S., Huang, G., Lechler, R. & Okkenhaug, K.

  Guy's & St Thomas' Charity

  1/01/2008 → 1/08/2012

  Project: Research

• Defining the transcriptional mechanisms of control of T cell regulatory and effector function in renal transplantation

  Lord, G. & Lechler, R.

  NKRF National Kidney Research Fund

  17/09/2007 → 16/09/2010

  Project: Research

• New diagnostic and treatment approaches in organ and stem cell transplantation (MRC Centre for Transplantation)

  Sacks, S., De Bari, C., Hayday, A., Lechler, R., Nestle, F., Razavi, R., Sharpe, P. & Solomon, E.

  MRC Medical Research Council

  1/04/2007 → 31/12/2012

  Project: Research

• Preclinical study of CD4+CD25+ regulatory T cells with indirect allospecificity as cell therapy to Induce donor-specific cardiac transplantation tolerance (Intermediate Research fellowship)

  Jiang, S. & Lechler, R.

  BHF British Heart Foundation

  1/01/2006 → 31/12/2008

  Project: Research

• Does cognate specificity enhance the efficacy of regulatory T cells?

  Afzali, B., Lechler, R. & Lombardi, G.

  MRC Medical Research Council

  1/10/2005 → 16/10/2008

  Project: Research

• The molecular basis of T cell immunity to metals.

  Lombardi, G. & Lechler, R.

  Asthma and Lung UK

  1/09/2005 → 31/12/2005

  Project: Research

• Targeted inhibition of co-agulation - an anti-inflammatory approach to prolonging organ graft survival

  Lechler, R. & Lombardi, G.

  MRC Medical Research Council

  1/09/2005 → 31/10/2008

  Project: Research

• Promoting Transplantation Tolerance: Adoptive T Cell therapy Using Customised Regulatory Cells

  Lechler, R.

  ROTRF Roche Organ Transplantation Research Foundation

  1/06/2005 → 31/05/2007

  Project: Research

• Reprogramming the Immune System for the Establishment of Tolerance - RISET - Validating immune-tolerant signature

  Hernandez Fuentes, M., Lechler, R., Lombardi, G. & Lord, G.

  EC European Commission

  1/03/2005 → 31/08/2010

  Project: Research

• Exploiting the role of parenchymal antigen presentation to the alloresponse and autoimmunity

  Buckland, M. & Lechler, R.

  MRC Medical Research Council

  1/01/2005 → 30/06/2006

  Project: Research

• Defining and refining T cell regulation: towards transplantation tolerance

  Lechler, R., Lombardi, G. & academic, A.

  BHF British Heart Foundation

  1/01/2005 → 30/09/2008

  Project: Research

• Modulation of inflammatory responses by genetic manipulation: potential strategies for long term xenograft survival

  Lechler, R.

  MRC Medical Research Council

  1/01/2005 → 30/09/2005

  Project: Research

• Demonstrating the applicability of novel indices of immunological tolerance to clinical practice using immunosuppression-free transplant recipients - Indices of Tolerance

  Lechler, R.

  EC European Commission

  1/01/2005 → 31/08/2006

  Project: Research

• Development of antigen-specific assays of donor-specific tolerance in renal transplant recipients

  Lechler, R.

  NIH National Institutes of Health

  1/12/2004 → 30/09/2007

  Project: Research