King's College London

Research portal

Dr Robin Hughes

Research interests

The Hepatocyte Transplantation & Biology Group is developing hepatocyte transplantation as a treatment for patients with liver disease. There are a number of advantages of cell transplantation over whole organ transplantation. Eight patients with liver-based metabolic defects have received human hepatocytes prepared in our GMP laboratory. The laboratory research is focussed on overcoming the barriers to wider use of hepatocyte transplantation. Currently this includes investigation of methods to improve the quality of hepatocytes isolated from fatty livers, which are often rejected for transplantation. In the future it is hoped that liver stem cells can be used to replace cells isolated from donor liver and this area is being investigated in collaborative studies. Isolated hepatocytes need to be cryopreserved to give good function on thawing, so that they are available for immediate clinical use when needed. Although progress has been made in our laboratory to improve cryopreservation protocols and understand the mechanisms of cryopreservation-induced damage, there is still scope for further improvement. There are also studies on-going to develop methods of cell therapy for patients with acute liver failure and to track cells once they have been administered to the patient.

Editorial activity

World Journal of Gastroenterology (Journal)

Robin Hughes (Editorial board member)
2007 → …

Activity: Publication peer-review and editorial workEditorial activity

Detoxication.net (Journal)

Robin Hughes (Editorial board member)
2003 → …

Activity: Publication peer-review and editorial workEditorial activity

International Journal of Artificial Organs (Journal)

Robin Hughes (Editorial board member)
1994 → …

Activity: Publication peer-review and editorial workEditorial activity

Participation in conference

1st European Meeting on Human HepatocyteTransplantation, Valencia, Spain,

Robin Hughes (Speaker)
Nov 2006 → …

Activity: Participating in or organising an eventParticipation in conference

8th Cell Transplant Society Meeting, Milan, Italy

Robin Hughes (Keynote/plenary speaker)
2006 → …

Activity: Participating in or organising an eventParticipation in conference

American Association for the Studyof Liver Disease, Annual Meeting, San Francisco

Robin Hughes (Keynote/plenary speaker)
Nov 2005 → …

Activity: Participating in or organising an eventParticipation in conference

Biomedical Research on Alcoholism Meeting, Canterbury, UK,

Robin Hughes (Organiser)
Sep 2005 → …

Activity: Participating in or organising an eventParticipation in conference

Session at European Society for Biomedical Research on Alcoholism Meeting, Canterbury, UK,

Robin Hughes (Chair)
Sep 2005 → …

Activity: Participating in or organising an eventParticipation in conference

Artificial Organs Liver Working Group

Robin Hughes (Organiser)
2001 → …

Activity: Participating in or organising an eventParticipation in conference

One Day on the Liver, Krems, Austria, European Society of Artificial Organs Liver WorkingGroup,

Robin Hughes (Speaker)
2001 → …

Activity: Participating in or organising an eventParticipation in conference

Types of External academic engagement - Contribution to the work of national or international committees and working groups

Liver Support Working Group of the European Society of Artificial Organs

Robin Hughes (Member)
2000 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Types of External academic engagement - Membership of peer review panel or committee

Peer Review College of the Engineering andPhysical Sciences Research Council UK

Robin Hughes (Member)
20032005

Activity: OtherTypes of External academic engagement - Membership of peer review panel or committee

Publication peer-review

Transplantation (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

PEDIATRIC TRANSPLANTATION (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Stem Cells (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Biochemical Pharmacology (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Molecular and Cellular Endocrinology (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Liver Transplantation (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Addiction Biology (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Kidney International (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Clinical Investigation (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Neurological Sciences (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Laboratory and Clinical Medicine (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

International Journal of Clinical Practice (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

International Journal of Artificial Organs (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Infection and Immunity (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Ethnopharmacology (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Drug and alcohol dependence (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Clinical Pharmacology and Therapeutics (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

The Lancet (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Cell Transplantation (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Annals of Surgery (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

European Journal of Gastroenterology and Hepatology (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Hepatology (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

LIVER INTERNATIONAL (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

European Journal of Clinical Investigation (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Alimentary Pharmacology and Therapeutics (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

International Journal of Biochemistry and Cell Biology (Journal)

Robin Hughes (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Types of External academic engagement - Membership of external research organisation

Medical Research Society,

Robin Hughes (Member)
1976 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

British Association for Study of the Liver

Robin Hughes (Member)
1974 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

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