King's College London

Research portal

Dr Robin Hughes

  1. Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children

    Dhawan, A., Chaijitraruch, N., Fitzpatrick, E., Bansal, S., Filippi, C., Lehec, S. C., Heaton, N. D., Kane, P., Verma, A., Hughes, R. D. & Mitry, R. R., May 2020, In : Journal of Hepatology. 72, 5, p. 877-884 8 p.

    Research output: Contribution to journalArticle

  2. Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation

    Jitraruch, S., Dhawan, A., Hughes, R. D., Filippi, C., Lehec, S. C., Glover, L. & Mitry, R. R., 2017, In : Cell Transplantation. 26, 8, p. 1341-1354 14 p.

    Research output: Contribution to journalArticle

  3. NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice

    Murray, T. V. A., Dong, X., Sawyer, G. J., Caldwell, A., Halket, J., Sherwood, R., Quaglia, A., Dew, T., Anilkumar, N., Burr, S., Mistry, R. K., Martin, D., Schröder, K., Brandes, R. P., Hughes, R. D., Shah, A. M. & Brewer, A. C., 1 Dec 2015, In : Free Radical Biology and Medicine. 89, p. 918-930 13 p.

    Research output: Contribution to journalArticle

  4. Pathophysiology of cerebral oedema in acute liver failure

    Scott, T. R., Kronsten, V. T., Hughes, R. D. & Shawcross, D. L., 28 Dec 2013, In : World Journal of Gastroenterology. 19, 48, p. 9240-9255 16 p.

    Research output: Contribution to journalArticle

  5. Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure

    Possamai, L. A., McPhail, M. J. W., Quaglia, A., Zingarelli, V., Abeles, R. D., Tidswell, R., Puthucheary, Z., Rawal, J., Karvellas, C. J., Leslie, E. M., Hughes, R. D., Ma, Y., Jassem, W., Shawcross, D. L., Bernal, W., Dharwan, A., Heaton, N. D., Thursz, M., Wendon, J. A., Mitry, R. R. & 1 others, Antoniades, C. G., Nov 2013, In : Critical Care Medicine. 41, 11, p. 2543-2550 8 p.

    Research output: Contribution to journalArticle

  6. Current Status of Hepatocyte Transplantation

    Hughes, R. D., Mitry, R. R. & Dhawan, A., 27 Feb 2012, In : Transplantation. 93, 4, p. 342 - 347 6 p.

    Research output: Contribution to journalArticle

  7. BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice

    Patel, N., Masaratana, P., Diaz-Castro, J., Latunde-Dada, G. O., Qureshi, A., Lockyer, P., Jacob, M., Arno, M., Matak, P., Mitry, R. R., Hughes, R. D., Dhawan, A., Patterson, C., Simpson, R. J. & McKie, A. T., 3 Feb 2012, In : Journal of Biological Chemistry. 287, 6, p. 4099 - 4106 8 p.

    Research output: Contribution to journalArticle

  8. Improving the Techniques for Human Hepatocyte Transplantation: Report From a Consensus Meeting in London

    Puppi, J., Strom, S. C., Hughes, R. D., Bansal, S., Castell, J. V., Dagher, I., Ellis, E. C. S., Nowak, G., Ericzon, B-G., Fox, I. J., Jose Gomez-Lechon, M., Guha, C., Gupta, S., Mitry, R. R., Ohashi, K., Ott, M., Reid, L. M., Roy-Chowdhury, J., Sokal, E., Weber, A. & 1 others, Dhawan, A., 2012, In : Cell Transplantation. 21, 1, p. 1-10 10 p.

    Research output: Contribution to journalLiterature review

  9. Introduction to cell culture

    Philippeos, C., Hughes, R. D., Dhawan, A. & Mitry, R. R., 2012, In : Methods in molecular biology (Clifton, N.J.). 806, p. 1-13 13 p.

    Research output: Contribution to journalArticle

  10. The Instant Blood-Mediated Inflammatory Reaction Characterized in Hepatocyte Transplantation

    Gustafson, E. K., Elgue, G., Hughes, R. D., Mitry, R. R., Sanchez, J., Haglund, U., Meurling, S., Dhawan, A., Korsgren, O. & Nilsson, B., 27 Mar 2011, In : Transplantation. 91, 6, p. 632 - 638 7 p.

    Research output: Contribution to journalArticle

  11. Use of a Clinically Approved Iron Oxide MRI Contrast Agent to Label Human Hepatocytes

    Puppi, J., Mitry, R. R., Modo, M., Dhawan, A., Raja, K. & Hughes, R. D., 2011, In : Cell Transplantation. 20, 6, p. 963 - 975 13 p.

    Research output: Contribution to journalArticle

  12. Transferrin receptor 2 is crucial for iron sensing in human hepatocytes

    Rapisarda, C., Puppi, J., Hughes, R. D., Dhawan, A., Farnaud, S., Evans, R. W. & Sharp, P. A., Sep 2010, In : AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 299, 3, p. G778 - G783

    Research output: Contribution to journalArticle

  13. Changing face of hepatic encephalopathy: Role of inflammation and oxidative stress

    Seyan, A. S., Hughes, R. D. & Shawcross, D. L., 21 Jul 2010, In : World Journal of Gastroenterology. 16, 27, p. 3347 - 3357 11 p.

    Research output: Contribution to journalEditorial

  14. Bilirubin, a Physiological Antioxidant, Can Improve Cryopreservation of Human Hepatocytes

    Galbiati, G., Muraca, M., Mitry, R. R., Hughes, R. D., Lehec, S. C., Puppi, J., Sagias, F. G., Caruso, M., Mieli-Vergani, G. & Dhawan, A., Jun 2010, In : Journal of Pediatric Gastroenterology and Nutrition. 50, 6, p. 691 - 693 3 p.

    Research output: Contribution to journalArticle

  15. Human hepatocyte transplantation: current experience and future challenges

    Dhawan, A., Puppi, J., Hughes, R. D. & Mitry, R. R., May 2010, In : Nature Reviews Gastroenterology & Hepatology. 7, 5, p. 288 - 298 11 p.

    Research output: Contribution to journalLiterature review

  16. Ammonia and the Neutrophil in the Pathogenesis of Hepatic Encephalopathy in Cirrhosis

    Shawcross, D. L., Shabbir, S. S., Taylor, N. J. & Hughes, R. D., Mar 2010, In : Hepatology. 51, 3, p. 1062 - 1069 8 p.

    Research output: Contribution to journalLiterature review

  17. N-Acetylcysteine Improves the Viability of Human Hepatocytes Isolated From Severely Steatotic Donor Liver Tissue

    Sagias, F. G., Mitry, R. R., Hughes, R. D., Lehec, S. C., Patel, A. G., Rela, M., Mieli-Vergani, G., Heaton, N. D. & Dhawan, A., 2010, In : Cell Transplantation. 19, 11, p. 1487 - 1492 6 p.

    Research output: Contribution to journalArticle

  18. Experience of Microbiological Screening of Human Hepatocytes for Clinical Transplantation

    Lehec, S. C., Hughes, R. D., Mitry, R. R., Graver, M. A., Verma, A., Wade, J. J. & Dhawan, A., 2009, In : Cell Transplantation. 18, 8, p. 941 - 947 7 p.

    Research output: Contribution to journalArticle

  19. Phenolic and terpenoid constituents from the Sri Lankan medicinal plant Osbeckia aspera

    Grayer, R. J., Thabrew, M. I., Hughes, R. D., Bretherton, S., Lever, A., Veitch, N. C., Kite, G. C., Lelli, R. & Simmonds, M. S. J., Mar 2008, In : PHARMACEUTICAL BIOLOGY. 46, 3, p. 154 - 161 8 p.

    Research output: Contribution to journalArticle

  20. Hepatocyte transplantation followed by auxiliary liver transplantation - A novel treatment for ornithine transcarbamylase deficiency

    Puppi, J., Tan, N., Mitry, R. R., Hughes, R. D., Lehec, S., Mieli-Vergani, G., Karani, J., Champion, M. P., Heaton, N., Mohamed, R. & Dhawan, A., Feb 2008, In : American Journal of Transplantation. 8, 2, p. 452 - 457 6 p.

    Research output: Contribution to journalArticle

  21. Hepatocyte transplantation in the treatment of liver diseases - Future seems bright after all

    Hughes, R. D., Mitry, R. R. & Dhawan, A., Feb 2008, In : PEDIATRIC TRANSPLANTATION. 12, 1, p. 4 - 5 2 p.

    Research output: Contribution to journalEditorial

  22. Liver After Hepatocyte Transplantation for Liver-Based Metabolic Disorders in Children

    Quaglia, A., Lehec, S. C., Hughes, R. D., Mitry, R. R., Knisely, A. S., Devereaux, S., Richards, J., Rela, M., Heaton, N. D., Portmann, B. C. & Dhawan, A., 2008, In : Cell Transplantation. 17, 12, p. 1403 - 1414 12 p.

    Research output: Contribution to journalArticle

  23. Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers

    Mitry, R. R., De Bruyne, R., Quaglia, A., Hughes, R. D. & Dhawan, A., Dec 2007, In : Hepatology. 46, 6, p. 2047 - 2048 2 p.

    Research output: Contribution to journalLetter

  24. Acute haemodynamic responses to inhaled nitric oxide and intravenous sildenafil in distal chronic thromboembolic pulmonary hypertension (CTEPH)

    Suntharalingam, J., Hughes, R. J., Goldsmith, K., Doughty, N., George, P., Toshner, M., Sheares, K. K. & Pepke-Zaba, J., Jun 2007, In : VASCULAR PHARMACOLOGY. 46, 6, p. 449-455 7 p.

    Research output: Contribution to journalArticle

  25. Serum hepatocyte growth factor and vascular endothelial growth factor in children with acute liver failure

    Aw, M. M., Mitry, R. R., Hughes, R. D. & Dhawan, A., Feb 2007, In : Journal of Pediatric Gastroenterology and Nutrition. 44, 2, p. 224 - 227 4 p.

    Research output: Contribution to journalArticle

  26. Cryopreservation-induced nonattachment of human hepatocytes: Role of adhesion molecules

    Terry, C., Hughes, R. D., Mitry, R. R., Lehec, S. C. & Dhawan, A., 2007, In : Cell Transplantation. 16, 6, p. 639 - 647 9 p.

    Research output: Contribution to journalArticle

  27. Cryopreservation of isolated human hepatocytes for transplantation: State of the art.

    Terry, C., Dhawan, A., Mitry, R. R. & Hughes, R. D., Oct 2006, In : Cryobiology. 53, 2, p. 149 - 159 11 p.

    Research output: Contribution to journalArticle

  28. Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation

    Hughes, R. D., Mitry, R. R., Dhawan, A., Lehec, S. C., Girlanda, R., Rela, M., Heaton, N. D. & Muiesan, P., May 2006, In : Liver Transplantation. 12, 5, p. 713 - 717 5 p.

    Research output: Contribution to journalArticle

  29. Hepatocyte transplantation for liver-based metabolic disorders.

    Dhawan, A., Mitry, R. R. & Hughes, R. D., Apr 2006, In : Journal of Inherited Metabolic Disease. 29, 2-3, p. 431 - 435 5 p.

    Research output: Contribution to journalArticle

  30. Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing

    Terry, C., Dhawan, A., Mitry, R. K., Lehec, S. C. & Hughes, R. D., Jan 2006, In : Liver Transplantation. 12, 1, p. 165 - 177 13 p.

    Research output: Contribution to journalArticle

  31. Analysis of the effects of cryopreservation on rat hepatocytes using SELDI-TOF mass spectrometry

    Terry, C., Bailey, M., Mitry, R. R., Lehec, S. C., Dhawan, A. & Hughes, R. D., 2006, In : Cell Transplantation. 15, 1, p. 35 - 43 9 p.

    Research output: Contribution to journalArticle

  32. The effects of immunosuppressive agents on the function of human hepatocytes in vitro

    Serrano, T., Mitry, R. R., Terry, C., Lehec, S. C., Dhawan, A. & Hughes, R. D., 2006, In : Cell Transplantation. 15, 8-9, p. 777 - 783 7 p.

    Research output: Contribution to journalArticle

  33. Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells

    Thabrew, M. I., Mitry, R. R., Morsy, M. A. & Hughes, R. D., 5 Aug 2005, In : Life Sciences. 77, 12, p. 1319 - 1330 12 p.

    Research output: Contribution to journalArticle

  34. Hepatocyte transplantation for metabolic liver disease: UK experience

    Hughes, R. D., Mitry, R. R. & Dhawan, A., Aug 2005, In : Journal of the Royal Society of Medicine. 98, 8, p. 341 - 345 5 p.

    Research output: Contribution to journalLiterature review

  35. Effects of serum from patients with acute liver failure due to paracetamol overdose on human hepatocytes in vitro.

    Mitry, R. R., Hughes, R. D., Bansal, S., Lehec, S. C., Wendon, J. A. & Dhawan, A., Jun 2005, In : Transplantation Proceedings. 37, 5, p. 2391 - 2394 4 p.

    Research output: Contribution to journalArticle

  36. Hepatocyte transplantation for metabolic disorders, experience at King's College hospital and review of literature

    Dhawan, A., Mitry, R. R. & Hughes, R. D., 2005, In : Acta Gastroenterologica Belgica. 68, 4, p. 457 - 460 4 p.

    Research output: Contribution to journalArticle

  37. The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue

    Terry, C., Mitry, R. R., Lehec, S. C., Muiesan, P., Rela, M., Heaton, N. D., Hughes, R. D. & Dhawan, A., 2005, In : Cell Transplantation. 14, 8, p. 585 - 594 10 p.

    Research output: Contribution to journalArticle

  38. Hepatocyte transplantation for inherited factor VII deficiency

    Dhawan, A., Mitry, R. R., Hughes, R. D., Lehec, S., Terry, C., Bansal, S., Arya, R., Wade, J. J., Verma, A., Heaton, N. D., Rela, M. & Mieli-Vergani, G., 27 Dec 2004, In : Transplantation. 78, 12, p. 1812 - 1814 3 p.

    Research output: Contribution to journalArticle

  39. One liver, three recipients: Segment IV from split-liver procedures as a source of hepatocytes for cell transplantation

    Mitry, R. R., Dhawan, A., Hughes, R. D., Bansal, S., Lehec, S., Terry, C., Heaton, N. D., Karani, J. B., Mieli-Vergani, G. & Rela, M., 27 May 2004, In : Transplantation. 77, 10, p. 1614 - 1616 3 p.

    Research output: Contribution to journalArticle

  40. Liver support in acute liver failure

    Hughes, R. D., 15 Sep 2003, In : Wiener Klinische Wochenschrift. 115, 15-16, p. 547 - 548 2 p.

    Research output: Contribution to journalEditorial

  41. Increased serum soluble Fas in patients with acute liver failure due to paracetamol overdose

    Tagami, A., Ohnishi, H. & Hughes, R. D., May 2003, In : Hepato-Gastroenterology. 50, 51, p. 742 - 745 4 p.

    Research output: Contribution to journalArticle

  42. Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity

    Williams, A. M., Langley, P. G., Osei-Hwediah, J., Wendon, J. A. & Hughes, R. D., 1 Apr 2003, In : LIVER INTERNATIONAL. 23, 2, p. 110 - 115 6 p.

    Research output: Contribution to journalArticle

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