Search results

• 2024

  Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19

  Cass, S. P., Nicolau, D. V., Baker, J. R., Mwasuku, C., Ramakrishnan, S., Mahdi, M., Barnes, P. J., Donnelly, L. E., Martinez-Nunez, R. T., Russell, R. E. K. & Bafadhel, M., 1 May 2024, In: ERJ Open Research. 10, 3, 00919-2023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • COVID-19 100%
  • Symptom 50%
  • Severe Acute Respiratory Syndrome Coronavirus 2 37%
  • Therapeutic Procedure 25%
  • Randomized Clinical Trial 25%

• Kcl Test: an open-source inspired asymptomatic SARS-CoV-2 surveillance programme in an academic institution

  Reis de Andrade, J., Scourfield, E., Peswani-Sajnani, S. L., Poulton, K., Ap Rees, T., Khooshemehri, P., Doherty, G., Ong, S., Ivan, I-F., Goudarzi, N., Gardiner, I., Caine, E., Maguire, T. J. A., Leightley, D., Torrico, L., Gasulla, A., Menendez-Vazquez, A., Ortega-Prieto, A. M., Pickering, S., Jimenez-Guardeño, J. M., & 19 othersBatra, R., Rubinchik, S., Tan, A. V. F., Griffin, A., Sherrin, D., Papaioannou, S., Trouillet, C., Mischo, H. E., Giralt, V., Wilson, S., Kirk, M., Neil, S. J. D., Galao, R. P., Martindale, J., Curtis, C., Zuckerman, M., Razavi, R., Malim, M. H. & Martinez-Nunez, R. T., 2024, In: Biology Methods and Protocols. 9, 1, p. bpae046 bpae046.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Open Source 100%
  • Academic Institution 100%
  • User 20%
  • Waves 20%
  • Statistics 20%
  3 Downloads (Pure)
• 2023

  Asthma innovations from the first International Collaborative Asthma Network forum

  Gaston, B., Gardner, D. D., Mahan, K., Akuthota, P., Mendonca, E. A., Durrington, H., Marozkina, N., Martinez-Nunez, R. T., Newcomb, D., Ainsworth, B., Owora, A. H., Chung, K. F., Walker, S., Fowler, S. J., Siddiqui, S., Winders, T., Zein, J., Jarjour, N., Huang, Y. J., Cahill, K. N., & 1 othersDjukanovic, R., 1 May 2023, In: ERJ Open Research. 9, 3, 00090-2023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Therapeutic Procedure 100%
  • Abilities 54%
  • Therapeutics 50%
  • Inflammation 50%
  • Disease 25%

• Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae

  Zanin, O., Eastham, M., Winczura, K., Ashe, M., Martinez-Nunez, R. T., Hebenstreit, D. & Grzechnik, P., Dec 2023, In: Communications Biology. 6, 1, 1112.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Capping Enzyme 100%
  • 7-Methylguanosine 49%
  • RNA Polymerase 37%

• The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma

  Rynne, J., Ortiz-Zapater, E., Bagley, D. C., Zanin, O., Doherty, G., Kanabar, V., Ward, J., Jackson, D. J., Parsons, M., Rosenblatt, J., Adcock, I. M. & Martinez-Nunez, R. T., 19 Oct 2023, In: Frontiers in Cell and Developmental Biology. 11, 1241008.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Asthma 100%
  • Tristetraprolin 50%
  • Lung 25%
  • Inflammatory Disorder 12%
  2 Citations (Scopus)
• 2022

  Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2: Quantum-inspired identification of SARS-CoV-2 antivirals

  Jimenez Guardeno, J., Ortega Prieto, A., Menendez Moreno, B., Maguire, T., Richardson, A., Diaz-Hernandez, J. I., Diez Perez, J., Zuckerman, M., Mercadal Playa, A., Cordero Deline, C., Malim, M. & Martinez Nunez, R., 18 Jul 2022, In: PLoS Computational Biology. 18, 7, e1010330.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Optimization 100%
  • Drug Repositioning 100%
  • Antivirus Agent 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • RNA 75%
  7 Citations (Scopus)

  49 Downloads (Pure)

• Homebrew: Protocol for glassmilk-based nucleic-acid extraction for SARS-CoV-2 diagnostics

  Page, R., Scourfield, E., Ficarelli, M., McKellar, S. W., Lee, K. L., Maguire, T. J. A., Bouton, C., Lista, M. J., Neil, S. J. D., Malim, M. H., Zuckerman, M., Mischo, H. E. & Martinez-Nunez, R. T., 17 Jun 2022, In: STAR Protocols. 3, 2, 101300.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nucleic Acid 100%
  • RNA 100%
  • Quantitative Reverse Transcription Polymerase Chain Reaction 100%
  2 Citations (Scopus)

• Homebrew: An economical and sensitive glassmilk-based nucleic-acid extraction method for SARS-CoV-2 diagnostics

  Page, R., Scourfield, E., Ficarelli, M., McKellar, S., Lee, K. L., Maguire, T., Bouton, C., Lista Brotos, M., Neil, S., Malim, M., Zuckerman, M., Mischo, H. & Martinez Nunez, R., 28 Mar 2022, In: STAR Protocols. 2, 3, 100186.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Quantitative Reverse Transcription Polymerase Chain Reaction 50%
  • Reverse Transcription Polymerase Chain Reaction 25%
  • COVID-19 25%
  • Throat 25%
  6 Citations (Scopus)

• Homebrew: an economical and sensitive glassmilk-based nucleic-acid extraction method for SARS-CoV-2 diagnostics

  Page, R., Scourfield, E., Ficarelli, M., McKellar, S., Lee, K. L., Maguire, T. J. A., Bouton, C., Lista, M. J., Neil, S. J. D., Malim, M. H., Zuckerman, M., Mischo, H. E. & Martinez-Nunez, R., 28 Mar 2022, In: Cell Reports Methods . 2, 3, 100186.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Quantitative Reverse Transcription Polymerase Chain Reaction 50%
  • Reverse Transcription Polymerase Chain Reaction 25%
  • COVID-19 25%
  • Throat 25%
  6 Citations (Scopus)
• 2021

  miR-155 overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation

  Olsson, B. A., Povoleri, G., Somma, D., Ridley, M., Rizou, T., Lalnunhlimi, S., Macdonald, L., Rajasekhar, M., Martinez Nunez, R., Kurowska-Stolarska, M. & Taams, L., 30 Nov 2021, (E-pub ahead of print) In: Clinical and Expentmental Immunology.

  Research output: Contribution to journal › Article › peer-review

  • T-Helper Cell 100%
  • Inflammatory Arthritis 100%
  • Monocyte 100%
  • T Cell Activation 100%
  • Macrophage 100%
  8 Citations (Scopus)

• Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation

  Lista, M. J., Matos, P. M., Maguire, T. J. A., Poulton, K., Ortiz-Zapater, E., Page, R., Sertkaya, H., Ortega-Prieto, A. M., Scourfield, E., O'Byrne, A. M., Bouton, C., Dickenson, R. E., Ficarelli, M., Jimenez-Guardeño, J. M., Howard, M., Betancor, G., Galao, R. P., Pickering, S., Signell, A. W., Wilson, H., & 17 othersCliff, P., Kia Ik, M. T., Patel, A., MacMahon, E., Cunningham, E., Doores, K., Agromayor, M., Martin-Serrano, J., Perucha, E., Mischo, H. E., Shankar-Hari, M., Batra, R., Edgeworth, J., Zuckerman, M., Malim, M. H., Neil, S. & Martinez-Nunez, R. T., 15 Sept 2021, In: PLoS ONE. 16, 9 September, e0256813.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diagnosis 100%
  • Heat 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Reagent 60%
  • Laboratory 40%
  15 Citations (Scopus)

• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

  The CITIID-NIHR BioResource COVID-19 Collaboration & The COVID-19 Genomics UK (COG-UK) consortium, 6 May 2021, In: Nature. 593, 7857, p. 136-141 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • mRNA Vaccine 100%
  • Receptor Binding 50%
  • Messenger RNA 20%
  • Neutralization 16%
  507 Citations (Scopus)
• 2020

  Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing

  Ghosh, A., Mizuno, K., Tiwari, S., Proitsi, P., Gomez Perez-Nievas, B., Glennon, E., Martinez Nunez, R. & Giese, P., 16 Jun 2020, In: Translational psychiatry. 10, 1, p. 192

  Research output: Contribution to journal › Article › peer-review

  File

  • Amino Acid Activation 100%
  • Tau 50%
  • Reduction (Chemistry) 50%
  • Hippocampus 33%
  • Binding Protein 25%
  40 Citations (Scopus)

  99 Downloads (Pure)

• Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings

  Pickering, S., Betancor, G., Galão, R. P., Merrick, B., Signell, A. W., Wilson, H. D., Kia Ik, M. T., Seow, J., Graham, C., Acors, S., Kouphou, N., Steel, K. J. A., Hemmings, O., Patel, A., Nebbia, G., Douthwaite, S., O'Connell, L., Luptak, J., McCoy, L. E., Brouwer, P., & 11 othersvan Gils, M. J., Sanders, R. W., Martinez Nunez, R., Bisnauthsing, K., O'Hara, G., MacMahon, E., Batra, R., Malim, M. H., Neil, S. J. D., Doores, K. J. & Edgeworth, J. D., 24 Sept 2020, In: PLoS Pathogens. 16, 9, 19 p., e1008817.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Diagnosis 100%
  • Hospital 100%
  • COVID-19 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Lateral Flow Assay 100%
  78 Citations (Scopus)

  206 Downloads (Pure)

• Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England

  Wells, P. M., Doores, K. J., Couvreur, S., Nunez, R. M., Seow, J., Graham, C., Acors, S., Kouphou, N., Neil, S. J. D., Tedder, R. S., Matos, P. M., Poulton, K., Lista, M. J., Dickenson, R. E., Sertkaya, H., Maguire, T. J. A., Scourfield, E. J., Bowyer, R. C. E., Hart, D., O'Byrne, A., & 11 othersSteel, K. J. A., Hemmings, O., Rosadas, C., McClure, M. O., Capedevilla-pujol, J., Wolf, J., Ourselin, S., Brown, M. A., Malim, M. H., Spector, T. & Steves, C. J., Dec 2020, In: Journal of Infection. 81, 6, p. 931-936 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Disease 100%
  • Infection 100%
  • COVID-19 100%
  • Symptom 100%
  • Specificity 100%
  36 Citations (Scopus)

• Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

  Seow, J., Graham, C., Merrick, B., Acors, S., Pickering, S., Steel, K. J. A., Hemmings, O., O’Byrne, A., Kouphou, N., Galao, R. P., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Huettner, I., Jimenez-Guardeño, J. M., Lista, M. J., Temperton, N., Snell, L. B., & 22 othersBisnauthsing, K., Moore, A., Green, A., Martinez, L., Stokes, B., Honey, J., Izquierdo-Barras, A., Arbane, G., Patel, A., Tan, M. K. I., O’Connell, L., O’Hara, G., MacMahon, E., Douthwaite, S., Nebbia, G., Batra, R., Martinez-Nunez, R., Shankar-Hari, M., Edgeworth, J. D., Neil, S. J. D., Malim, M. H. & Doores, K. J., 1 Dec 2020, In: Nature Microbiology. 5, 12, p. 1598-1607 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neutralizing Antibody 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • ID50 28%
  • Viral Disease 14%
  • Immunoglobulin A 14%
  893 Citations (Scopus)

  61 Downloads (Pure)

• MicroRNA23a overexpression in Crohn’s Disease targets Tumour Necrosis Factor Alpha Inhibitor Protein 3, increasing sensitivity to TNF and modifying the epithelial barrier

  Felwick, R. K., Dingley, G. J. R., Martinez-Nunez, R., Sanchez-Elsner, T., Cummings, J. R. F. & Collins, J. E., 13 Mar 2020, In: Journal of Crohn's & colitis. 14, 3, p. 381-392 12 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Tumor Necrosis Factor 100%
  • Synapsin II 100%
  • Inhibitor Protein 100%
  • microRNA 80%
  • Epithelium 60%
  9 Citations (Scopus)

  73 Downloads (Pure)

• Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome

  Shaw, A. M., Hyde, C., Merrick, B., James-Pemberton, P., Squires, B. K., Olkhov, R. V., Batra, R., Patel, A., Bisnauthsing, K., Nebbia, G., MacMahon, E., Douthwaite, S., Malim, M., Neil, S., Martinez Nunez, R., Doores, K., Mark, T. K. I., Signell, A. W., Betancor, G., Wilson, H. D., & 3 othersGalão, R. P., Pickering, S. & Edgeworth, J. D., 21 Aug 2020, In: Analyst. 145, 16, p. 5638-5646 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • COVID-19 100%
  • Patient 100%
  • Syndrome 100%
  • RNA 100%
  19 Citations (Scopus)

• Translational Research in the Time of COVID-19-Dissolving Boundaries

  Edgeworth, J. D., Batra, R., Nebbia, G., Bisnauthsing, K., MacMahon, E., Sudhanva, M., Douthwaite, S., Goldenberg, S., O'Hara, G., Shankar-Hari, M., Doores, K. J., Martinez-Nunez, R., Hemsley, C., Price, N. M., Lockett, J., Lechler, R. I., Neil, S. J. D. & Malim, M. H., Sept 2020, In: PLoS Pathogens. 16, 9, p. e1008898 e1008898.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)
• 2019

  Alzheimer’s disease-related dysregulation of protein synthesis causes key pathological features with ageing

  Ghosh, A., Mizuno, K., Tiwari, S. S., Proitsi, P., Gomez Perez-Nievas, B., Glennon, E. B. C., Martinez Nunez, R. T. & Giese, K. P., 21 Dec 2019, In: bioRxiv.

  Research output: Contribution to journal › Article

  Open Access

• Immunological biomarkers as indicators for outcome after discontinuation of nucleos(t)ide analogue therapy in patients with HBeAg negative chronic hepatitis B

  Kranidioti, H., Manolakopoulos, S., Kontos, G., Breen, M., Kourikou, A., Deutsch, M., Quesada del Bosque, M. E., Martinez Nunez, R. T., Naiyer, M., Woelk, C., Sanchez-Elsner, T., Hadziyannis, E., Papatheodoridis, G. & Khakoo, S., 1 Jun 2019, In: Journal of Viral Hepatitis. 26, 6, p. 697-709 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quantitative Reverse Transcription Polymerase Chain Reaction 100%
  14 Citations (Scopus)

  102 Downloads (Pure)

• Small RNA Species and microRNA Profiles are Altered in Severe Asthma Nanovesicles from Broncho Alveolar Lavage and Associate with Impaired Lung Function and Inflammation

  Francisco-Garcia, A. S., Garrido-Martin, E. M., Rupani, H., Lau, L. C. K., Martinez-Nunez, R. T., Howarth, P. H. & Sanchez-Elsner, T., 2 Nov 2019, (E-pub ahead of print) In: Non-Coding RNA. 5, 4, 12 p., 51.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Inflammation 100%
  • Severe Asthma 100%
  • Lung 100%
  • Exosome 25%
  • RNA-Sequencing 12%
  23 Citations (Scopus)

  116 Downloads (Pure)
• 2018

  Genome-wide post-transcriptional dysregulation by microRNAs in human asthma as revealed by Frac-seq

  Martinez-Nunez, R. T., Rupani, H., Plate, M., Niranjan, M., Chambers, R., Howarth, P. & Sanchez-Elsner, T., 1 Jul 2018, In: Journal of Immunology. 201, 1, p. 251-263

  Research output: Contribution to journal › Article › peer-review

  • MicroRNA 100%
  • Gene 62%
  • Isoform 50%
  • Messenger RNA 37%
  • Inflammatory Disorder 20%
  20 Citations (Scopus)

• MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor α-1

  Gwiggner, M., Martinez Nunez, R., Whiteoak, S., Bondanese, V. P., Claridge, A., Collins, J. E., Cummings, J. R. F. & Sanchez-Elsner, T., 13 Feb 2018, In: Genes.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-13 Receptor 100%
  • Atopic Dermatitis 12%
  • Cytokine Signaling 12%
  • CCL26 12%
  • Asthma 12%
  45 Citations (Scopus)

  174 Downloads (Pure)
• 2017

  Modulation of nonsense mediated decay by rapamycin

  Martinez Nunez, R. T., Wallace, A., Coyne, D., Bailey, J., Jansson, L., Ennajdaoui, H., Rush, M., Deinhardt, K., Sanchez-Elsner, T. & Sanford, J., 7 Apr 2017, In: Nucleic Acids Research. 45, 6, p. 3448–3459

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  20 Citations (Scopus)

  104 Downloads (Pure)
• 2016

  Toll-like receptor 7 is reduced in severe asthma and linked to altered microRNA profile

  Rupani, H., Martinez Nunez, R. T., Dennison, P., Lau, L. C. K., Jayasekera, N., Havelock, T., Francisco-Garcia, A., Grainge, C., Howarth, P. & Sanchez-Elsner, T., 1 Jul 2016, In: American Journal of Respiratory and Critical Care Medicine. 194, 1, p. 26-37

  Research output: Contribution to journal › Article › peer-review
  59 Citations (Scopus)
• 2014

  A network of microRNAs increases IL-6 expression in asthmatic epithelial cells

  Martinez-Nunez, R. T., Bondanese, V. P., Rupani, H., Francisco-Garcia, A., Davies, D., Holgate, S., Howarth, P. & Sanchez-Elsner, T., 31 Oct 2014, In: PLOS One. 9, 10, p. e111659

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-6 100%
  • Interferon 40%
  • Interferon Type I 20%
  • Inflammatory Disorder 20%
  61 Citations (Scopus)