King's College London

Research portal

Dr Sandrine Thuret

Research interests

I am head of the Neurogenesis and Mental Health Laboratory and our research focuses on environmental and molecular regulatory mechanisms controlling hippocampal neurogenesis in health and disease.

The adult mammalian brain contains small populations of neural stem cells dividing and differentiating into neurons. This process of neurogenesis occurs in the subgranular zone of the hippocampal dentate gyrus. Adult hippocampal neurogenesis (AHN) decreases with age and elderly animals display impaired learning and memory abilities, whereas increased AHN is linked to improved learning and memory. Moreover, AHN is reduced by stressful experiences and in animal models of depression, whereas many antidepressant treatments have been shown to enhance and are dependent on functional AHN. Therefore, AHN strongly emerges as an advantageous target for counteracting the effect of ageing and stress and thus preventing cognitive and mood decline.

In the Neurogenesis and Mental Health Laboratory we investigate the molecular mechanisms governing neurogenesis by using human hippocampal stem cells and we use the mouse as an animal model to study cognition and mood. We perform a wide range of molecular biology and histology techniques with both in vivo and in vitro models. We are currently studying the molecular mechanisms by which environment (i.e. diet) and diseases (i.e. Alzheimer’s Disease) impacts on AHN and subsequently affect cognition and mood.

If you want to know more about the Neurogenesis and Mental Health Laboratory please visit our webpage: http://www.kcl.ac.uk/iop/depts/neuroscience/research/centres/ccbb/groups/nnmh/about.aspx

Education interests

I support the teaching-research nexus and believe that the best learning outcomes are obtained by linking research in a discipline and student learning in -and through- this discipline. Therefore, together with the help of postdoctoral fellows in the lab, I foster currently the research-based learning of 5 PhD students and of up to 5 BSc/MSc students per year. I also lecture in 11 programmes across KCL and because teaching and assessment practices must be aligned to the aim of teaching I also took on curriculum design and examination responsibilities:

•I am Chair of the programme board of examiners for the MSc in Neuroscience. I have a leading role on reviewing strategy to improve students' experience, assessing timeliness of the course and new initiative implementation for the programme. I am also responsible for setting examinations and assessment procedures in line with KCL regulations.

•I am Academic member of the Neuroscience/Clinical Neuroscience MPhil/PhD committee and review PhD project proposals, monitor, evaluate progress reports and upgrades proposal as well as upgrade viva of our Neuroscience/Clinical Neuroscience PhD students.

•I am the Module Leader for the "Neural stem cells and nervous system repair" MSc Neuroscience module to be launched in the 2014-2015 academic year.

Editorial activity

Journal of Alzheimer's disease : JAD (Journal)

Thuret, S. (Associate Editor)
2013 → …

Activity: Publication peer-review and editorial workEditorial activity

Nutrition and Aging (Journal)

Thuret, S. (Editorial board member)
2012 → …

Activity: Publication peer-review and editorial workEditorial activity

Types of Business and Community - Membership of public/government advisory/policy group or panel

Expert for the European Food Safety Authority

Thuret, S. (Member)
2012 → …

Activity: OtherTypes of Business and Community - Membership of public/government advisory/policy group or panel

Participation in conference

9th FENS Forum of Neuroscience

Thuret, S. (Invited speaker)
2014

Activity: Participating in or organising an eventParticipation in conference

11th Dutch Endo-Neuro-Psycho Meeting (ENP 2013)

Thuret, S. (Keynote/plenary speaker)
Jun 2013

Activity: Participating in or organising an eventParticipation in conference

Eurogenesis

Thuret, S. (Invited speaker)
May 2013

Activity: Participating in or organising an eventParticipation in conference

Society for Neuroscience 43rd Annual Meeting

Thuret, S. (Invited speaker)
2013

Activity: Participating in or organising an eventParticipation in conference

The Royal Society of Medicine, Action for Rehabilitation from Neurological Injury, The ARNI Trust

Thuret, S. (Invited speaker)
2011

Activity: Participating in or organising an eventParticipation in conference

40th Annual Meeting of Society for Neuroscience

Thuret, S. (Speaker)
2010

Activity: Participating in or organising an eventParticipation in conference

Adult Neurogenesis: Structure and Function

Thuret, S. (Speaker)
2010

Activity: Participating in or organising an eventParticipation in conference

The Royal Society of Medicine, Action for Rehabilitation from Neurological Injury, The ARNI Trust

Thuret, S. (Invited speaker)
2010

Activity: Participating in or organising an eventParticipation in conference

12th annual congress on Nutriton and Health

Thuret, S. (Invited speaker)
2010

Activity: Participating in or organising an eventParticipation in conference

International Society for Stem Cell Research (ISSCR) 7th Annual meeting

Thuret, S. (Participant)
2009

Activity: Participating in or organising an eventParticipation in conference

Society for Neuroscience 35th Annual Meeting

Thuret, S. (Speaker)
2007

Activity: Participating in or organising an eventParticipation in conference

6th International Symposium on Experimental Spinal Cord Repair and Regeneration

Thuret, S. (Invited speaker)
2006

Activity: Participating in or organising an eventParticipation in conference

Types of External academic engagement - Contribution to the work of national or international committees and working groups

The Netherlands Organisation for Scientific Research (NWO) peer-reviewer

Thuret, S. (Reviewer)
2013 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

EC - European Commission peer-reviewer

Thuret, S. (Reviewer)
2013 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Hong Kong Research Grants Council peer-reviewer

Thuret, S. (Reviewer)
2012 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Biotechnology & Biological Sciences Research Council (BBSRC) peer-reviewer

Thuret, S. (Reviewer)
2010 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

AFM - Association Française contre les Myopathies peer-reviewer

Thuret, S. (Member)
2009 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Alzheimer's Society peer-reviewer

Thuret, S. (Reviewer)
2009 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Australian Research Council (ARC) peer-reviewer

Thuret, S. (Reviewer)
2007 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

HRB - Irish Health Research Board peer-reviewer

Thuret, S. (Reviewer)
2007 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Medical Research Council (MRC) peer-reviewer

Thuret, S. (Reviewer)
2007 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Types of Public engagement and outreach - Public lecture/debate/seminar

Pint of Science

Thuret, S. (Speaker)
16 May 2013

Activity: OtherTypes of Public engagement and outreach - Public lecture/debate/seminar

Feed Your Mind- King's Festival of Food and Ideas

Thuret, S. (Speaker)
2013 → …

Activity: OtherTypes of Public engagement and outreach - Public lecture/debate/seminar

Types of Public engagement and outreach - Media article or participation

Interview with the Observer on Ageing, neurogenesis and diet

Thuret, S. (Interviewee)
8 Sep 2013

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Advisor to Heston Blumenthal to improve the public sector's diet

Thuret, S. (Advisor)
2011

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Publication peer-review

Translational psychiatry (Journal)

Thuret, S. (Peer reviewer)
2014 → …

Activity: Publication peer-review and editorial workPublication peer-review

PL o S One (Journal)

Thuret, S. (Peer reviewer)
2013 → …

Activity: Publication peer-review and editorial workPublication peer-review

Molecular Psychiatry (Journal)

Thuret, S. (Peer reviewer)
2013 → …

Activity: Publication peer-review and editorial workPublication peer-review

Brain structure & function (Journal)

Thuret, S. (Peer reviewer)
2012 → …

Activity: Publication peer-review and editorial workPublication peer-review

Neuropsychopharmacology (Journal)

Thuret, S. (Peer reviewer)
2011 → …

Activity: Publication peer-review and editorial workPublication peer-review

Neurobiology of Aging (Journal)

Thuret, S. (Peer reviewer)
2010 → …

Activity: Publication peer-review and editorial workPublication peer-review

Neuroscience Letters (Journal)

Thuret, S. (Peer reviewer)
2010 → …

Activity: Publication peer-review and editorial workPublication peer-review

Behavioural Brain Research (Journal)

Thuret, S. (Peer reviewer)
2010 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Neuroscience (Journal)

Thuret, S. (Peer reviewer)
2010 → …

Activity: Publication peer-review and editorial workPublication peer-review

Genes And Nutrition (Journal)

Thuret, S. (Peer reviewer)
2009 → …

Activity: Publication peer-review and editorial workPublication peer-review

Stem Cells (Journal)

Thuret, S. (Peer reviewer)
2007 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Neurochemistry (Journal)

Thuret, S. (Peer reviewer)
2006 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Comparative Neurology (Journal)

Thuret, S. (Peer reviewer)
2004 → …

Activity: Publication peer-review and editorial workPublication peer-review

Developmental Biology (Journal)

Thuret, S. (Peer reviewer)
2003 → …

Activity: Publication peer-review and editorial workPublication peer-review

Nature Neuroscience (Journal)

Thuret, S. (Peer reviewer)
2003 → …

Activity: Publication peer-review and editorial workPublication peer-review

Annals of Neurology (Journal)

Thuret, S. (Peer reviewer)
2002 → …

Activity: Publication peer-review and editorial workPublication peer-review

Types of Business and Community - Work on advisory panel to industry or government or non-government organisation

Panellist for the Athena SWAN awards assessments

Thuret, S. (Advisor)
2014 → …

Activity: OtherTypes of Business and Community - Work on advisory panel to industry or government or non-government organisation

Types of External academic engagement - Membership of external research organisation

International Society for Nutritional Psychiatry Research (ISNPR) Founding member

Thuret, S. (Member)
2013 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

International Society for Stem Cell Research (ISSCR)

Thuret, S. (Member)
2008 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

International Brain Research Organisation (IBRO)

Thuret, S. (Member)
2007 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

British Neuroscience Association (BNA)

Thuret, S. (Member)
2007 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

Federation of European Neuroscience Societies (FENS)

Thuret, S. (Member)
2007 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

Society for Neuroscience (SFN)

Thuret, S. (Member)
2002 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

Types of External academic engagement - Invited talk

University of Bath

Thuret, S. (Speaker)
2014

Activity: OtherTypes of External academic engagement - Invited talk

University of Oxford

Thuret, S. (Speaker)
2013

Activity: OtherTypes of External academic engagement - Invited talk

Universidade Federal do Rio de Janeiro

Thuret, S. (Speaker)
2012

Activity: OtherTypes of External academic engagement - Invited talk

EPFL, The Brain Mind Institute

Thuret, S. (Speaker)
2011

Activity: OtherTypes of External academic engagement - Invited talk

University of Roehampton

Thuret, S. (Speaker)
2010

Activity: OtherTypes of External academic engagement - Invited talk

University of Reading

Thuret, S. (Speaker)
2009

Activity: OtherTypes of External academic engagement - Invited talk

Queen Mary University

Thuret, S. (Speaker)
2007

Activity: OtherTypes of External academic engagement - Invited talk

Types of Award - Fellowship awarded competitively

RCUK Academic Research Fellowship

Thuret, S. (Recipient)
1 Sep 200731 Aug 2011

Activity: OtherTypes of Award - Fellowship awarded competitively

PVA Research Foundation Fellowship

Thuret, S. (Recipient)
1 Oct 200330 Sep 2005

Activity: OtherTypes of Award - Fellowship awarded competitively

The Paralysis Project of America Fellowship

Thuret, S. (Recipient)
1 Oct 200230 Sep 2003

Activity: OtherTypes of Award - Fellowship awarded competitively

Boehringer Ingelheim Fonds PhD Fellowship

Thuret, S. (Recipient)
1 Jan 19991 Apr 2002

Activity: OtherTypes of Award - Fellowship awarded competitively

Types of Public engagement and outreach - Schools engagement

STEM Ambassador

Thuret, S. (Speaker)
2007 → …

Activity: OtherTypes of Public engagement and outreach - Schools engagement

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