Research output per year
Research output per year
Personal profile
Research interests
Molecular mechanisms involved in differentiation and axon guidance of cranial motor neurons.
Research interests
Ocular motor development and role of alpha2-chimaerin
Eye movement disorders in humans
Mechanisms of motor nucleus formation: role of cadherins and spontaneous activity
Motor neuron disease
Biographical details
Beit Memorial fellow at University College London 1985-1986
Post-doctoral researcher at Scripps Clinic, San Diego, California 1986 -1989
Post-doctoral researcher at UMDS, Guy's Hospital 1989 - 1991
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Intercellular communication and development in the early amphibian embryo, UCL University College London
Award Date: 1 Jan 1985
Bachelor of Arts, Natural Sciences, University of Cambridge
Award Date: 1 Jan 1982
Keywords
- QL Zoology
- Developmental Neurobiology
- Motor neuron development and disease
- Cranial nerve dysinnervation disorders
- Axon Guidance
- Duane Retraction Syndrome
- Amyotrophic lateral sclerosis
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Regional variation in characteristics of patients with decompensated cirrhosis admitted to hospitals in the UK
The Trainee Collaborative for Research and Audit in Hepatology UK, Tavabie, O. D., Abeysekera, K. W., Brennan, P. N., Marjot, T., Kronsten, V. T., Li, W., Nayagam, J. S., Dhaliwal, A., Hardy, T., Maurice, J. B., Zakeri, N., Abbas, N., Abbasi, A., Abbott, J., Abdul, R., Abdulaziz, M., Abduljabbar, D., Adamson, R. & Adebayo, D. & 31 others, , Jul 2023, In: The Lancet Gastroenterology and Hepatology. 8, 7, p. 604-606 3 p.Research output: Contribution to journal › Letter › peer-review
6 Citations (Scopus) -
Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study
PROTECT-ASUC Study Group, Apr 2021, In: The Lancet Gastroenterology and Hepatology. 6, 4, p. 271-281 11 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity
Lee, Y.-B., Baskaran, P., Gomez-Deza, J., Chen, H.-J., Nishimura, A. L., Smith, B. N., Troakes, C., Adachi, Y., Stepto, A., Petrucelli, L., Gallo, J.-M., Hirth, F., Rogelj, B., Guthrie, S. & Shaw, C. E., 15 Dec 2017, In: Human Molecular Genetics. 26, 24, p. 4765-4777 13 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Citations (Scopus) -
In vivo and in vitro knockdown approaches in the avian embryo as a means to study semaphorin signaling
Montague, K., Guthrie, S. & Poparic, I., 2017, In: Methods in Molecular Biology. 1493, p. 403-416 14 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
The assembly of developing motor neurons depends on an interplay between spontaneous activity, type II cadherins and gap junctions
Montague, K., Lowe, A. S., Uzquiano, A., Knüfer, A., Astick, M., Price, S. R. & Guthrie, S., 1 Mar 2017, In: Development. 144, 5, p. 830-836 7 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)
Projects
- 34 Finished
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Assembling Motor Nucleus Circuitry
Guthrie, S. (Primary Investigator)
1/07/2016 → 30/06/2021
Project: Research
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Mechanisms of wiring the ocular motor system
Guthrie, S. (Primary Investigator) & Knight, R. (Co-Investigator)
1/02/2015 → 31/01/2018
Project: Research
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Functionalised silk fibres as a scaffold for corticospinal tract regeneration
Guthrie, S. (Primary Investigator)
1/06/2014 → 31/05/2015
Project: Research
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Generating zebrafish models of human eye movement disorders to replace mouse models
Guthrie, S. (Primary Investigator) & Poparic, I. (Primary Investigator)
NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research
1/06/2014 → 31/05/2017
Project: Research
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Deciphering alpha2-chimaerin signalling pathways in ocular motor development and Duane Retraction Syndrome
Guthrie, S. (Primary Investigator)
1/05/2014 → 30/04/2017
Project: Research
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Cambridge Ophthalmological Symposium
Guthrie, S. (Invited speaker)
3 Sept 2014Activity: Participating in or organising an event › Participation in conference
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Cold Spring Harbor Meeting on Axon Guidance, Synapse Formation and Regeneration
Guthrie, S. (Chair)
2014Activity: Participating in or organising an event › Participation in conference
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BSCB-BSDB Joint Spring Meeting
Guthrie, S. (Invited speaker)
2014Activity: Participating in or organising an event › Participation in conference
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Symposium on Neuronal Communication
Guthrie, S. (Invited speaker)
2013Activity: Participating in or organising an event › Participation in conference
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Imaging Structure and Function in the Zebrafish Brain
Guthrie, S. (Invited speaker)
2012Activity: Participating in or organising an event › Participation in conference