King's College London

Research portal

Dr Sarah Mizielinska

  1. Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD

    Solomon, D. A., Smikle, R., Reid, M. J. & Mizielinska, S., 21 Apr 2021, In: Frontiers in cellular neuroscience. 15, p. 664151 664151.

    Research output: Contribution to journalArticlepeer-review

  2. Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD

    Moens, T. G., Mizielinska, S., Niccoli, T., Mitchell, J. S., Thoeng, A., Ridler, C. E., Grönke, S., Esser, J., Heslegrave, A., Zetterberg, H., Partridge, L. & Isaacs, A. M., 1 Mar 2018, In: Acta Neuropathologica. 135, 3, p. 445-457 13 p.

    Research output: Contribution to journalArticlepeer-review

  3. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism

    Swinnen, B., Bento-Abreu, A., Gendron, T. F., Boeynaems, S., Bogaert, E., Nuyts, R., Timmers, M., Scheveneels, W., Hersmus, N., Wang, J., Mizielinska, S., Isaacs, A. M., Petrucelli, L., Lemmens, R., Van Damme, P., Van Den Bosch, L. & Robberecht, W., Mar 2018, In: Acta Neuropathologica. 135, 3, p. 427-443 17 p.

    Research output: Contribution to journalArticlepeer-review

  4. Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

    Mizielinska, S., Ridler, C. E., Balendra, R., Thoeng, A., Woodling, N. S., Grässer, F. A., Plagnol, V., Lashley, T., Partridge, L. & Isaacs, A. M., 18 Apr 2017, In: Acta Neuropathologica Communications. 5, 1, 11 p., 29.

    Research output: Contribution to journalArticlepeer-review

  5. Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

    FReJA, Clayton, E. L., Mancuso, R., Tolstrup Nielsen, T., Mizielinska, S., Holmes, H., Powell, N., Norona, F., Overgaard Larsen, J., Milioto, C., Wilson, K. M., Lythgoe, M. F., Ourselin, S., Nielsen, J. E., Johannsen, P., Holm, I., Collinge, J., Oliver, P. L., Gomez-Nicola, D., Isaacs, A. M. & 9 others, Gade, A., Englund, E., Fisher, E., Brown, J., Stockholm, J., Roos, P., Gydesen, S., Lindquist, S. & Thusgaard, T., 1 Mar 2017, In: Human Molecular Genetics. 26, 5, p. 873-887 15 p., ddx003.

    Research output: Contribution to journalArticlepeer-review

  6. NEURODEGENERATION. One target for amyotrophic lateral sclerosis therapy?

    Mizielinska, S. & Isaacs, A. M., 12 Aug 2016, In: Science. 353, 6300, p. 647-8 2 p.

    Research output: Contribution to journalArticle

  7. Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology

    FReJA consortium, 1 Oct 2015, In: Acta Neuropathologica. 130, 4, p. 511-523 13 p.

    Research output: Contribution to journalArticlepeer-review

  8. A 30-unit hexanucleotide repeat expansion in C9orf72 induces pathological lesions with dipeptide-repeat proteins and RNA foci, but not TDP-43 inclusions and clinical disease

    Gami, P., Murray, C., Schottlaender, L., Bettencourt, C., De Pablo Fernandez, E., Mudanohwo, E., Mizielinska, S., Polke, J. M., Holton, J. L., Isaacs, A. M., Houlden, H., Revesz, T. & Lashley, T., Oct 2015, In: Acta Neuropathologica. 130, 4, p. 599-601 3 p.

    Research output: Contribution to journalArticlepeer-review

  9. C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis

    Rohrer, J. D., Isaacs, A. M., Mizielinska, S., Mead, S., Lashley, T., Wray, S., Sidle, K., Fratta, P., Orrell, R. W., Hardy, J., Holton, J., Revesz, T., Rossor, M. N. & Warren, J. D., Mar 2015, In: Lancet Neurology. 14, 3, p. 291-301 11 p.

    Research output: Contribution to journalReview articlepeer-review

  10. Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion

    Fratta, P., Polke, J. M., Newcombe, J., Mizielinska, S., Lashley, T., Poulter, M., Beck, J., Preza, E., Devoy, A., Sidle, K., Howard, R., Malaspina, A., Orrell, R. W., Clarke, J., Lu, C-H., Mok, K., Collins, T., Shoaii, M., Nanji, T., Wray, S. & 10 others, Adamson, G., Pittman, A., Renton, A. E., Traynor, B. J., Sweeney, M. G., Revesz, T., Houlden, H., Mead, S., Isaacs, A. M. & Fisher, E. M. C., Jan 2015, In: Neurobiology of Aging. 36, 1, p. 546.e1-7

    Research output: Contribution to journalArticlepeer-review

  11. C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia: gain or loss of function?

    Mizielinska, S. & Isaacs, A. M., Oct 2014, In: Current Opinion in Neurology. 27, 5, p. 515-23 9 p.

    Research output: Contribution to journalReview articlepeer-review

  12. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

    Mizielinska, S., Grönke, S., Niccoli, T., Ridler, C. E., Clayton, E. L., Devoy, A., Moens, T., Norona, F. E., Woollacott, I. O. C., Pietrzyk, J., Cleverley, K., Nicoll, A. J., Pickering-Brown, S., Dols, J., Cabecinha, M., Hendrich, O., Fratta, P., Fisher, E. M. C., Partridge, L. & Isaacs, A. M., 5 Sep 2014, In: Science. 345, 6201, p. 1192-1194 3 p.

    Research output: Contribution to journalArticlepeer-review

  13. C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci

    Mizielinska, S., Lashley, T., Norona, F. E., Clayton, E. L., Ridler, C. E., Fratta, P. & Isaacs, A. M., Dec 2013, In: Acta Neuropathologica. 126, 6, p. 845-57 13 p.

    Research output: Contribution to journalArticlepeer-review

  14. Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia

    Fratta, P., Poulter, M., Lashley, T., Rohrer, J. D., Polke, J. M., Beck, J., Ryan, N., Hensman, D., Mizielinska, S., Waite, A. J., Lai, M-C., Gendron, T. F., Petrucelli, L., Fisher, E. M. C., Revesz, T., Warren, J. D., Collinge, J., Isaacs, A. M. & Mead, S., Sep 2013, In: Acta Neuropathologica. 126, 3, p. 401-9 9 p.

    Research output: Contribution to journalArticlepeer-review

  15. Reversal of pathology in CHMP2B-mediated frontotemporal dementia patient cells using RNA interference

    FReJA consortium, Aug 2012, In: JOURNAL OF GENE MEDICINE. 14, 8, p. 521-9 9 p.

    Research output: Contribution to journalArticlepeer-review

  16. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice

    Ghazi-Noori, S., Froud, K. E., Mizielinska, S., Powell, C., Smidak, M., Fernandez de Marco, M., O'Malley, C., Farmer, M., Parkinson, N., Fisher, E. M. C., Asante, E. A., Brandner, S., Collinge, J. & Isaacs, A. M., Mar 2012, In: Brain : a journal of neurology. 135, Pt 3, p. 819-32 14 p.

    Research output: Contribution to journalArticlepeer-review

  17. C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

    Fratta, P., Mizielinska, S., Nicoll, A. J., Zloh, M., Fisher, E. M. C., Parkinson, G. & Isaacs, A. M., 2012, In: Scientific Reports. 2, p. 1016

    Research output: Contribution to journalArticlepeer-review

  18. Rapid dendritic and axonal responses to neuronal insults

    Mizielinska, S. M., Greenwood, S. M., Tummala, H. & Connolly, C. N., Dec 2009, In: Biochemical Society Transactions. 37, Pt 6, p. 1389-93 5 p.

    Research output: Contribution to journalArticlepeer-review

  19. Ion channels in epilepsy

    Mizielinska, S. M., 1 Nov 2007, In: Biochemical Society Transactions. 35, 5, p. 1077-1079 3 p.

    Research output: Contribution to journalArticle

  20. Mitochondrial dysfunction and dendritic beading during neuronal toxicity

    Greenwood, S. M., Mizielinska, S. M., Frenguelli, B. G., Harvey, J. & Connolly, C. N., 7 Sep 2007, In: Journal of Biological Chemistry. 282, 36, p. 26235-44 10 p.

    Research output: Contribution to journalArticlepeer-review

  21. Leptin promotes rapid dynamic changes in hippocampal dendritic morphology

    O'Malley, D., MacDonald, N., Mizielinska, S., Connolly, C. N., Irving, A. J. & Harvey, J., Aug 2007, In: Molecular and Cellular Neurosciences. 35, 4, p. 559-72 14 p.

    Research output: Contribution to journalArticlepeer-review

  22. The role of GABAA receptor biogenesis, structure and function in epilepsy

    Mizielinska, S., Greenwood, S. & Connolly, C. N., Nov 2006, In: Biochemical Society Transactions. 34, Pt 5, p. 863-7 5 p.

    Research output: Contribution to journalArticle

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