Personal profile
Education/Academic qualification
Neuroscience, Doctor of Science, Rapid neuronal responses to glutamate-induced excitotoxicity and morphological changes, University of Dundee
1 Oct 2005 → 1 Dec 2009
Award Date: 1 Feb 2010
Pharmacology and Neuroscience, Bachelor of Science, University of Bristol
1 Oct 2000 → 1 Jul 2003
Award Date: 1 Jul 2003
External positions
Post-Doctoral Research Associate, UCL University College London
1 Jul 2010 → 30 Sept 2016
PhD Student, University of Dundee
1 Oct 2005 → 31 Dec 2009
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
Hölbling, B. V., Gupta, Y., Marchi, P. M., Atilano, M. L., Flower, M., Ureña, E., Goulden, R. A., Dobbs, H. K., Katona, E., Mikheenko, A., Giblin, A., Awan, A. R., Fisher-Ward, C. L., O'Brien, N., Vaizoglu, D., Kempthorne, L., Wilson, K. M., Gittings, L. M., Carcolé, M. & Ruepp, M.-D. & 9 others, , 27 May 2025, In: Cell Reports. 44, 5, 115695.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)16 Downloads (Pure) -
Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics
Mizielinska, S., Hautbergue, G. M., Gendron, T. F., van Blitterswijk, M., Hardiman, O., Ravits, J., Isaacs, A. M. & Rademakers, R., 1 Mar 2025, In: Lancet Neurology. 24, 3, p. 261-274 14 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile25 Citations (Scopus)18 Downloads (Pure) -
Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation
Morando, M. A., D'Alessandro, V., Spinello, A., Sollazzo, M., Monaca, E., Sabbatella, R., Volpe, M. C., Gervaso, F., Polini, A., Mizielinska, S. & Alfano, C., 23 May 2025, (E-pub ahead of print) In: Scientific Reports. 15, 1, p. 17879 17879.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)47 Downloads (Pure) -
Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.
Coneys, R., Cammack, A. J., Nair, R. R., Thompson, D., Mechtersheimer, J., Carcolé, M., Gupta, Y., Rech, G. E., Flower, M., O'Brien, N., Ruepp, M.-D., Mizielinska, S., Ducotterd, F., Tabrizi, S. J., Fisher, E. M. C., Cunningham, T. J., Ward, M., Skarnes, W. C. & Isaacs, A. M., 11 Feb 2025, In: bioRxiv : the preprint server for biology.Research output: Contribution to journal › Article
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Synaptopathy: presynaptic convergence in frontotemporal dementia and amyotrophic lateral sclerosis
Clayton, E. L., Huggon, L., Cousin, M. A. & Mizielinska, S., 1 Jul 2024, In: Brain. 147, 7, p. 2289-2307 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Citations (Scopus)
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TDP-43 dysfunction in C9orf72-associated Amyotrophic Lateral Sclerosis: Mechanisms and therapeutic entry points
academic, A. (Primary Investigator), Iacoangeli, A. (Co-Investigator) & Mizielinska, S. (Co-Investigator)
MNDA Motor Neurone Disease Association
1/04/2026 → 31/03/2029
Project: Research
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Investigating molecular mechanisms of RNA binding protein ARPP21
Mizielinska, S. (Primary Investigator) & Aabdien, A. (Co-Investigator)
1/09/2025 → 31/08/2027
Project: Research
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RNA-trans-splicing as therapeutic modality for C9orf72 Amyotrophic Lateral Sclerosis
Ruepp, M.-D. (Primary Investigator), Mizielinska, S. (Co-Investigator) & academic, A. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/05/2025 → 30/04/2027
Project: Research
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Nuclear to synaptic signalling dysregulation by Annexin A11 in ALS
Smith, B. (Primary Investigator), Mitchell, J. (Co-Investigator), Mizielinska, S. (Co-Investigator), Ruepp, M.-D. (Co-Investigator), Troakes, C. (Co-Investigator) & Vance, C. (Co-Investigator)
MNDA Motor Neurone Disease Association
1/04/2025 → 31/07/2026
Project: Research
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UK DRI QQ2: UK Dementia Research Institute Centre Award QQ2
Ule, J. (Primary Investigator), Marzi, S. (Co-Investigator), Mizielinska, S. (Co-Investigator), Ruepp, M.-D. (Co-Investigator) & Shaw, C. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/04/2023 → 31/03/2028
Project: Research