Research output per year
Research output per year
Personal profile
Research interests
Research interests: scanning probe microscopy; single molecules; single molecule force spectroscopy; force-clamp spectroscopy, biophysics; protein folding; mechanochemistry; lipid bilayers; surface science; nanomechanics; thin films; wetting.
Current research: conformational dynamics of single molecules under force; protein folding; single molecule force-clamp spectroscopy; protein folding; the effect of a mechanical force on the energy landscape of a chemical reaction at the single bond level; nanomechanics of lipid bilayers; tribology.
Research interests (short)
Microscopy; spectroscopy; biophysics; protein folding; mechanonchemistry; surface science; nanomechanics.
Click here for the Garcia-Manyes webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner
Darrigrand, J-F., Salowka, A., Torres-Cano, A., Tapia-Rojo, R., Zhu, T., Garcia-Manyes, S. & Spagnoli, F. M., 5 Feb 2024, In: Developmental Cell. 59, 3, p. 326-338.E5Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales
Tapia Rojo, R., Mora Hortal, M. & Garcia-Manyes, S., 11 Mar 2024, In: Nature Protocols. 19, 6, p. 1779–1806 28 p., 19.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural anisotropy results in mechano-directional transport of proteins across nuclear pores
Panagaki, F., Tapia-Rojo, R., Zhu, T., Milmoe, N., Paracuellos, P., Board, S., Mora, M., Walker, J., Rostkova, E., Stannard, A., Infante, E. & Garcia-Manyes, S., 13 May 2024, In: Nature Physics. 20, 7, p. 1180-1193 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Allosteric activation of vinculin by talin
Franz, F., Tapia Rojo, R., Winograd-Katz, S., Boujemaa-Paterski, R., li, W., Unger, T., albeck, S., aponte-santamaria, C., Garcia-Manyes, S., Medalia, O., geiger, B. & grater, F., 18 Jul 2023, In: Nature Communications. 14, 4311, 4311 .Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)38 Downloads (Pure) -
Enzyme-less nanopore detection of post-translational modifications within long polypeptides
Martin-Baniandres, P., Lan, W-H., Board, S., Romero-Ruiz, M., Garcia-Manyes, S., Qing, Y. & Bayley, H., Nov 2023, In: Nature Nanotechnology. 18, 11, p. 1335-1340Research output: Contribution to journal › Article › peer-review
Open Access28 Citations (Scopus)
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Unlocking thermodynamically-forbidden chemical reactivity with mechanical force
1/07/2023 → 30/06/2026
Project: Research
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BHF Centre Interdisciplinary PhD Student Garcia Manyes-Brunello
Garcia-Manyes, S. & Brunello, E.
1/09/2021 → 30/09/2024
Project: Research
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Coupling optical tweezers with light microscopy to unravel the mechanical forces acting on cellular organelles
1/10/2020 → 30/09/2024
Project: Research