Simon Lovestone

2022

Effect of trazodone on cognitive decline in people with dementia: Cohort study using UK routinely collected data

Sommerlad, A., Werbeloff, N., Perera, G., Smith, T., Costello, H., Mueller, C., Kormilitzin, A., Broadbent, M., Nevado‐Holgado, A., Lovestone, S., Stewart, R. & Livingston, G., Jan 2022, In: International Journal of Geriatric Psychiatry. 37, 1

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

44 Downloads (Pure)

Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset

Homann, J., Osburg, T., Ohlei, O., Dobricic, V., Deecke, L., Bos, I., Vandenberghe, R., Gabel, S., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., Popp, J., Clark, C., Peyratout, G., & 18 othersMartinez-Lage, P., Tainta, M., Dobson, R. J. B., Legido-Quigley, C., Sleegers, K., Van Broeckhoven, C., Wittig, M., Franke, A., Lill, C. M., Blennow, K., Zetterberg, H., Lovestone, S., Streffer, J., ten Kate, M., Vos, S. J. B., Barkhof, F., Visser, P. J. & Bertram, L., 21 Mar 2022, In: Frontiers in Aging Neuroscience. 14, 840651.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

2021

A Modest Increase in ¹¹C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

NIMA Consortium, Jul 2021, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 6, 7, p. 716-724 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

the Australian Imaging Biomarkers and Lifestyle study & The Alzheimer’s Disease Neuroimaging Initiative, Dec 2021, In: Genome Biology. 22, 1, 90.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (Scopus)

Plasma Proteomic Biomarkers Relating to Alzheimer’s Disease: A Meta-Analysis Based on Our Own Studies

Shi, L., Buckley, N. J., Bos, I., Engelborghs, S., Sleegers, K., Frisoni, G. B., Wallin, A., Lléo, A., Popp, J., Martinez-Lage, P., Legido-Quigley, C., Barkhof, F., Zetterberg, H., Visser, P. J., Bertram, L., Lovestone, S. & Nevado-Holgado, A. J., 21 Jul 2021, In: Frontiers in Aging Neuroscience. 13, 712545.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Replication study of plasma proteins relating to Alzheimer's pathology

Shi, L., Winchester, L. M., Westwood, S., Baird, A. L., Anand, S. N., Buckley, N. J., Hye, A., Ashton, N. J., Bos, I., Vos, S. J. B., Kate, M. T., Scheltens, P., Teunissen, C. E., Vandenberghe, R., Gabel, S., Meersmans, K., Engelborghs, S., De Roeck, E. E., Sleegers, K., Frisoni, G. B., & 32 othersBlin, O., Richardson, J. C., Bordet, R., Molinuevo, J. L., Rami, L., Wallin, A., Kettunen, P., Tsolaki, M., Verhey, F., Lléo, A., Sala, I., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Legido-Quigley, C., Barkhof, F., Andreasson, U., Blennow, K., Zetterberg, H., Streffer, J., Lill, C. M., Bertram, L., Visser, P. J., Kolb, H. C., Narayan, V. A., Lovestone, S. & Nevado-Holgado, A. J., Sept 2021, In: Alzheimer's and Dementia. 17, 9, p. 1452-1464 13 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Serum from Older Adults Increases Apoptosis and Molecular Ageing Markers in Human Hippocampal Progenitor Cells

De Lucia, C., Murphy, T., Maruszak, A., Powell, T., Wright, P., Hartopp, N., De Jong, S., O'Sullivan, M., Breen, G., Price, J., Lovestone, S. & Thuret, S., 10 Apr 2021, (Accepted/In press) In: Aging and Disease.

Research output: Contribution to journal › Article › peer-review

Open Access

File

31 Downloads (Pure)

Sex-specific metabolic pathways were associated with alzheimer’s disease (Ad) endophenotypes in the european medical information framework for ad multimodal biomarker discovery cohort

Xu, J., Green, R., Kim, M., Lord, J., Ebshiana, A., Westwood, S., Baird, A. L., Nevado-Holgado, A. J., Shi, L., Hye, A., Snowden, S. G., Bos, I., Vos, S. J. B., Vandenberghe, R., Teunissen, C. E., Kate, M. T., Scheltens, P., Gabel, S., Meersmans, K., Blin, O., & 30 othersRichardson, J., De Roeck, E. E., Engelborghs, S., Sleegers, K., Bordet, R., Rami, L., Kettunen, P., Tsolaki, M., Verhey, F. R. J., Alcolea, D., Lleó, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Blennow, K., Zetterberg, H., Streffer, J., Jelle Visser, P., Lovestone, S., Proitsi, P. & Legido-Quigley, C., Nov 2021, In: Biomedicines. 9, 11, 1610.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

for the AddNeuroMed consortium, Jul 2021, In: Alzheimer's and Dementia. 17, 7, p. 1145-1156 12 p.

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

Alzheimer's Disease Neuroimaging Initiative (ADNI), Oct 2021, In: Alzheimer's and Dementia. 17, 10, p. 1628-1640 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

2020

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Roubroeks, J. A. Y., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., Hannon, E. J., Kłoszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Wahlund, L. O., Aarsland, D., Proitsi, P., Hodges, A., Lovestone, S., Newhouse, S. J., Dobson, R. J. B., Mill, J., & 2 othersvan den Hove, D. L. A. & Lunnon, K., Nov 2020, In: Neurobiology of Aging. 95, p. 26-45 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Citations (Scopus)

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease

AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative, Dec 2020, In: Neurology: Genetics. 6, 6, e517.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

Shi, L., Winchester, L. M., Liu, B. Y., Killick, R., Ribe, E. M., Westwood, S., Baird, A. L., Buckley, N. J., Hong, S., Dobricic, V., Kilpert, F., Franke, A., Kiddle, S., Sattlecker, M., Dobson, R., Cuadrado, A., Hye, A., Ashton, N. J., Morgan, A. R., Bos, I., & 47 othersVos, S. J. B., Ten Kate, M., Scheltens, P., Vandenberghe, R., Gabel, S., Meersmans, K., Engelborghs, S., De Roeck, E. E., Sleegers, K., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Molinuevo, J. L., Rami, L., Wallin, A., Kettunen, P., Tsolaki, M., Verhey, F., Lleó, A., Alcolea, D., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Johannsen, P., Teunissen, C. E., Freund-Levi, Y., Frölich, L., Legido-Quigley, C., Barkhof, F., Blennow, K., Rasmussen, K. L., Nordestgaard, B. G., Frikke-Schmidt, R., Nielsen, S. F., Soininen, H., Vellas, B., Kloszewska, I., Mecocci, P., Zetterberg, H., Morgan, B. P., Streffer, J., Visser, P. J., Bertram, L., Nevado-Holgado, A. J. & Lovestone, S., 2020, In: Journal of Alzheimer's Disease. 77, 3, p. 1353-1368 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Dysregulated Fc gamma receptor–mediated phagocytosis pathway in Alzheimer's disease: network-based gene expression analysis

AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative, Apr 2020, In: Neurobiology of Aging. 88, p. 24-32 9 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 2020, In: Translational psychiatry. 10, 1, 403.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology

Nho, K., Nudelman, K., Allen, M., Hodges, A., Kim, S., Risacher, S. L., Apostolova, L. G., Lin, K., Lunnon, K., Wang, X., Burgess, J. D., Ertekin-Taner, N., Petersen, R. C., Wang, L., Qi, Z., He, A., Neuhaus, I., Patel, V., Foroud, T., Faber, K. M., & 4 othersLovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J., 1 Sept 2020, In: Alzheimer's and Dementia. 16, 9, p. 1213-1223 11 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer’s pathology

Nho, K., Nudelman, K., Allen, M., Hodges, A., Kim, S., Risacher, S. L., Apostolova, L. G., Lin, K., Lunnon, K., Wang, X., Burgess, J., Ertekin-Taner, N., Petersen, R. C., Wang, L., Qi, Z., He, A., Neuhaus, I., Patel, V., Foroud, T., Faber, K. M., & 4 othersLovestone, S., Simmons, A., Weiner, M. & Saykin, A. J., 9 Mar 2020, (Accepted/In press) In: Alzheimer's & dementia : the journal of the Alzheimer's Association.

Research output: Contribution to journal › Article › peer-review

Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: A multi-national multi-database case-control study

Newby, D., Prieto-Alhambra, D., Duarte-Salles, T., Ansell, D., Pedersen, L., Van Der Lei, J., Mosseveld, M., Rijnbeek, P., James, G., Alexander, M., Egger, P., Podhorna, J., Stewart, R., Perera, G., Avillach, P., Grosdidier, S., Lovestone, S. & Nevado-Holgado, A. J., 6 Apr 2020, In: Alzheimer's Research and Therapy. 12, 1, 10 p., 38.

Research output: Contribution to journal › Article › peer-review

Open Access

File

16 Citations (Scopus)

74 Downloads (Pure)

Urinary metabolic phenotyping for Alzheimer’s disease

Kurbatova, N., Garg, M., Whiley, L., Chekmeneva, E., Jiménez, B., Gómez-Romero, M., Pearce, J., Kimhofer, T., D’Hondt, E., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Aarsland, D., Nevado-Holgado, A., Liu, B., Snowden, S., Proitsi, P., Ashton, N. J., & 7 othersHye, A., Legido-Quigley, C., Lewis, M. R., Nicholson, J. K., Holmes, E., Brazma, A. & Lovestone, S., Dec 2020, In: Scientific Reports. 10, 1, 21745.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort

Westwood, S., Baird, A. L., Anand, S. N., Nevado-Holgado, A. J., Kormilitzin, A., Shi, L., Hye, A., Ashton, N. J., Morgan, A. R., Bos, I., Vos, S. J. B., Baker, S., Buckley, N. J., Ten Kate, M., Scheltens, P., Teunissen, C. E., Vandenberghe, R., Gabel, S., Meersmans, K., Engelborghs, S., & 30 othersDe Roeck, E. E., Sleegers, K., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Molinuevo, J. L., Rami, L., Wallin, A., Kettunen, P., Tsolaki, M., Verhey, F., Lléo, A., Sala, I., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Legido-Quigley, C., Bertram, L., Barkhof, F., Zetterberg, H., Morgan, B. P., Streffer, J., Visser, P. J. & Lovestone, S., 1 Jan 2020, In: Journal of Alzheimer's Disease. 74, 1, p. 213-225 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

2019

A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

Stamate, D., Kim, M., Proitsi, P., Westwood, S., Baird, A., Nevado-Holgado, A., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Teunissen, C. E., Kate, M. T., Scheltens, P., Gabel, S., Meersmans, K., Blin, O., Richardson, J., De Roeck, E., Engelborghs, S., Sleegers, K., & 25 othersBordet, R., Ramit, L., Kettunen, P., Tsolaki, M., Verhey, F., Alcolea, D., Lléo, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Blennow, K., Zetterberg, H., Streffer, J., Visser, P. J., Lovestone, S. & Legido-Quigley, C., 1 Jan 2019, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 933-938 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Citations (Scopus)

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

Alzheimer's Disease Neuroimaging Initiative, 1 Nov 2019, In: The Lancet Neurology. 18, 11, p. 1034-1044 11 p.

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L., & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 1 May 2019, In: Alzheimer's and Dementia. 15, 5, p. 644-654 11 p.

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Karolinska Schizophrenia Project (KaSP), 1 Oct 2019, In: Nature Neuroscience. 22, 10, p. 1617-1623 7 p.

Research output: Contribution to journal › Article › peer-review

242 Citations (Scopus)

Differential associations of IL-4 with hippocampal subfields in mild cognitive impairment and Alzheimer's disease

AddNeuroMed Project, 1 Jan 2019, In: Frontiers in Aging Neuroscience. 11, JAN, 439.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Genetic and real-world clinical data, combined with empirical validation, nominate jak-stat signaling as a target for Alzheimer’s disease therapeutic development

NIMA Consortium, May 2019, In: Cells. 8, 5, 425.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer's Disease

for the AddNeuroMed consortium, 1 Dec 2019, In: Scientific Reports. 9, 1, 3147.

Research output: Contribution to journal › Article › peer-review

Open Access

File

25 Citations (Scopus)

185 Downloads (Pure)

2018

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

Smith, R. G., Hannon, E., De Jager, P. L., Chibnik, L., Lott, S. J., Condliffe, D., Smith, A. R., Haroutunian, V., Troakes, C., Al-Sarraj, S., Bennett, D. A., Powell, J., Lovestone, S., Schalkwyk, L., Mill, J. & Lunnon, K., 14 Mar 2018, In: Alzheimer's & Dementia. 14, 12, p. 1580-1588

Research output: Contribution to journal › Article › peer-review

Open Access

File

98 Citations (Scopus)

164 Downloads (Pure)

Heterogeneous patterns of brain atrophy in Alzheimer's disease

Poulakis, K., Pereira, J. B., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Soininen, H., Lovestone, S., Simmons, A., Wahlund, L-O. & Westman, E., 31 Jan 2018, (E-pub ahead of print) In: Neurobiology of Aging.

Research output: Contribution to journal › Article › peer-review

Open Access

File

87 Citations (Scopus)

546 Downloads (Pure)

MRI predictors of amyloid pathology: Results from the EMIF-AD Multimodal Biomarker Discovery study

Ten Kate, M., Redolfi, A., Peira, E., Bos, I., Vos, S. J., Vandenberghe, R., Gabel, S., Schaeverbeke, J., Scheltens, P., Blin, O., Richardson, J. C., Bordet, R., Wallin, A., Eckerstrom, C., Molinuevo, J. L., Engelborghs, S., Van Broeckhoven, C., Martinez-Lage, P., Popp, J., Tsolaki, M., & 17 othersVerhey, F. R. J., Baird, A. L., Legido-Quigley, C., Bertram, L., Dobricic, V., Zetterberg, H., Lovestone, S., Streffer, J., Bianchetti, S., Novak, G. P., Revillard, J., Gordon, M. F., Xie, Z., Wottschel, V., Frisoni, G., Visser, P. J. & Barkhof, F., 27 Sept 2018, In: Alzheimer's Research and Therapy. 10, 1, 100.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Citations (Scopus)

Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [¹⁸F]-Flutemetamol PET Scan Result

Westwood, S., Baird, A. L., Hye, A., Ashton, N. J., Nevado-Holgado, A. J., Anand, S. N., Liu, B., Newby, D., Bazenet, C., Kiddle, S. J., Ward, M., Newton, B., Desai, K., Tan Hehir, C., Zanette, M., Galimberti, D., Parnetti, L., Lleó, A., Baker, S., Narayan, V. A., & 5 othersvan der Flier, W. M., Scheltens, P., Teunissen, C. E., Visser, P. J. & Lovestone, S., 11 Dec 2018, In: Frontiers in Aging Neuroscience. 10, 409.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease

Winchester, L. M., Powell, J., Lovestone, S. & Nevado-Holgado, A. J., 28 Jun 2018, In: Genome medicine. 10, 1, 51.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Citations (Scopus)

Stability of graph theoretical measures in structural brain networks in Alzheimer’s disease

Mårtensson, G., Pereira, J. B., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Soininen, H., Lovestone, S., Simmons, A., Volpe, G. & Westman, E., 1 Dec 2018, In: Scientific Reports. 8, 1, 11592.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (Scopus)

2017

A Multi-Cohort Study of ApoE ϵ 4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease

Khan, W., Giampietro, V., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Conrod, P., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaître, H., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Smolka, M. N., Ströhle, A., & 19 othersGallinat, J., Vellas, B., Soininen, H., Kloszewska, I., Tsolaki, M., Mecocci, P., Spenger, C., Villemagne, V. L., Masters, C. L., Muehlboeck, J. S., Bäckman, L., Fratiglioni, L., Kalpouzos, G., Wahlund, L. O., Schumann, G., Lovestone, S., Williams, S. C. R., Westman, E. & Simmons, A., 3 Feb 2017, In: JOURNAL OF ALZHEIMERS DISEASE. 56, 3, p. 1159-1174 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

27 Citations (Scopus)

171 Downloads (Pure)

Amyloid beta synaptotoxicity is Wnt–planar cell polarity dependent and blocked by fasudil

Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo-Sanchís, A., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P., & 2 othersSrivastava, D. P. & Killick, R., 19 Oct 2017, (E-pub ahead of print) In: Alzheimer's & Dementia.

Research output: Contribution to journal › Article › peer-review

Open Access

File

65 Citations (Scopus)

273 Downloads (Pure)

Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

Kim, M., Nevado-Holgado, A., Whiley, L., Snowden, S. G., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Thambisetty, M., Dobson, R. J. B., Powell, J. E., Lupton, M. K., Simmons, A., Velayudhan, L., Lovestone, S., Proitsi, P. & Legido-Quigley, C., 3 Oct 2017, In: JOURNAL OF ALZHEIMERS DISEASE. 60, 3, p. 809-817

Research output: Contribution to journal › Article › peer-review

Open Access

File

59 Citations (Scopus)

198 Downloads (Pure)

Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins

Voyle, N., Kim, M., Proitsi, P., Ashton, N. J., Baird, A. L., Bazenet, C., Hye, A., Westwood, S., Chung, R., Ward, M., Rabinovici, G. D., Lovestone, S., Breen, G., Legido-Quigley, C., Dobson, R. J. B. & Kiddle, S. J., Feb 2017, In: Translational psychiatry. 6, e719.

Research output: Contribution to journal › Article › peer-review

Open Access

File

23 Citations (Scopus)

187 Downloads (Pure)

DISCOVERY, REPLICATION AND EXTENSION STUDY OF PLASMA PROTEOMIC BIOMARKERS RELATING TO BRAIN AMYLOID BURDEN (CSF Aβ OR AMYLOID-PET) IN THE EMIF-AD BIOMARKER DISCOVERY COHORT: 2017 Abstract Supplement

Westwood, S., Baird, A. L., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Scheltens, P., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Lleó, A., Popp, J., Martinez-Lage, P., Snowden, S. G., Legido-Quigley, C., Bertram, L., Barkhof, F., Zetterberg, H., Streffer, J., & 2 othersVisser, P. J. & Lovestone, S., 20 Oct 2017, (E-pub ahead of print) In: Alzheimer's & Dementia. 13, 7, Supplement, p. P361-P362

Research output: Contribution to journal › Article › peer-review

Mitochondrial genes are altered in blood early in Alzheimer's disease

Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A., 1 May 2017, In: Neurobiology of Aging. 53, p. 36-47 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

101 Citations (Scopus)

231 Downloads (Pure)

Novel genetic loci associated with hippocampal volume

Hibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., Renteria, M. E., Bis, J. C., Arias-Vasquez, A., Ikram, M. K., Desrivières, S., Vernooij, M. W., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K., Aribisala, B. S., Armstrong, N. J., Athanasiu, L., & 312 othersAxelsson, T., Beecham, A. H., Beiser, A., Bernard, M., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chen, Q., Ching, C. R. K., Chouraki, V., Cuellar-Partida, G., Crivello, F., Den Braber, A., Doan, N. T., Ehrlich, S., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Grimm, O., Griswold, M. E., Guadalupe, T., Gutman, B. A., Hass, J., Haukvik, U. K., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Jørgensen, K. N., Karbalai, N., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A. F., Matarin, M., Mather, K. A., Mattheisen, M., McKay, D. R., Milaneschi, Y., Muñoz Maniega, S., Nho, K., Nugent, A. C., Nyquist, P., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pirpamer, L., Pütz, B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Ropele, S., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Saremi, A., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Trompet, S., Vaidya, D., Van der Grond, J., Van der Lee, S. J., Van der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Wolfers, T., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Cheng, C-Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Craen, A. J. M., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Deary, I. J., Debette, S., DeCarli, C., Delanty, N., Depondt, C., DeStefano, A., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Enzinger, C., Erk, S., Espeseth, T., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Fornage, M., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Håberg, A. K., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B-C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J-J., Huentelman, M., Pol, H. E. H., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J-L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schmidt, H., Schofield, P. R., Sigursson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Tsolaki, M., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van der Brug, M., van der Lugt, A., van der Wee, N. J. A., Van Haren, N. E. M., van 't Ent, D., Van Tol, M-J., Vardarajan, B. N., Vellas, B., Veltman, D. J., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, R. H., Zonderman, A. B., Martin, N. G., Van Duijn, C. M., Wright, M. J., Longstreth, W. T., Schumann, G., Grabe, H. J., Franke, B., Launer, L. J., Medland, S. E., Seshadri, S., Thompson, P. M. & Ikram, M. A., 18 Jan 2017, In: Nature Communications. 8, p. 13624 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

191 Citations (Scopus)

157 Downloads (Pure)

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

Rojo, A. I., Pajares, M., Rada, P., Nuñez, A., Nevado-Holgado, A. J., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M. & Cuadrado, A., 5 Jul 2017, (E-pub ahead of print) In: Redox Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

138 Citations (Scopus)

163 Downloads (Pure)

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

Horgusluoglu-Moloch, E., Nho, K., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Petersen, R. C., Jack, C. R., Lovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J., 1 Dec 2017, In: Neurobiology of Aging. 60, p. 92-103 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

56 Citations (Scopus)

234 Downloads (Pure)

2016

A pathway based classification method for analyzing gene expression for Alzheimer's disease diagnosis

Voyle, N., Keohane, A., Newhouse, S., Lunnon, K., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A., Kiddle, S. & Dobson, R. JB., 2016, In: JOURNAL OF ALZHEIMERS DISEASE. 49, 3, p. 659-669 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

37 Citations (Scopus)

317 Downloads (Pure)

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

Allen, G. I., Amoroso, N., Anghel, C., Balagurusamy, V., Bare, C. J., Beaton, D., Bellotti, R., Bennett, D. A., Boehme, K. L., Boutros, P. C., Caberlotto, L., Caloian, C., Campbell, F., Chaibub Neto, E., Chang, Y-C., Chen, B., Chen, C-Y., Chien, T-Y., Clark, T., Das, S., & 81 othersDavatzikos, C., Deng, J., Dillenberger, D., Dobson, R. J. B., Dong, Q., Doshi, J., Duma, D., Errico, R., Erus, G., Everett, E., Fardo, D. W., Friend, S. H., Fröhlich, H., Gan, J., St George-Hyslop, P., Ghosh, S. S., Glaab, E., Green, R. C., Guan, Y., Hong, M-Y., Huang, C., Hwang, J., Ibrahim, J., Inglese, P., Iyappan, A., Jiang, Q., Katsumata, Y., Kauwe, J. S. K., Klein, A., Kong, D., Krause, R., Lalonde, E., Lauria, M., Lee, E., Lin, X., Liu, Z., Livingstone, J., Logsdon, B. A., Lovestone, S., Ma, T., Malhotra, A., Mangravite, L. M., Maxwell, T. J., Merrill, E., Nagorski, J., Namasivayam, A., Narayan, M., Naz, M., Newhouse, S. J., Norman, T. C., Nurtdinov, R. N., Oyang, Y-J., Pawitan, Y., Peng, S., Peters, M. A., Piccolo, S. R., Praveen, P., Priami, C., Sabelnykova, V. Y., Senger, P., Shen, X., Simmons, A., Sotiras, A., Stolovitzky, G., Tangaro, S., Tateo, A., Tung, Y-A., Tustison, N. J., Varol, E., Vradenburg, G., Weiner, M. W., Xiao, G., Xie, L., Xie, Y., Xu, J., Yang, H., Zhan, X., Zhou, Y., Zhu, F., Zhu, H. & Zhu, S., 11 Apr 2016, (E-pub ahead of print) In: Alzheimer's & Dementia. 12, 6, p. 645-653 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

60 Citations (Scopus)

196 Downloads (Pure)

Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept

Psychosis Endophenotypes International Consortium, 23 Feb 2016, In: Nature Neuroscience. 19, 3, p. 420-431 12 p.

Research output: Contribution to journal › Article › peer-review

157 Citations (Scopus)

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams, H. H. H., Hibar, D. P., Chouraki, V., Stein, J. L., Nyquist, P. A., Rentería, M. E., Trompet, S., Arias-vasquez, A., Seshadri, S., Desrivières, S., Beecham, A. H., Jahanshad, N., Wittfeld, K., Van Der Lee, S. J., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K., Aribisala, B. S., & 322 othersArmstrong, N. J., Athanasiu, L., Axelsson, T., Beiser, A., Bernard, M., Bis, J. C., Blanken, L. M. E., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chauhan, G., Chen, Q., Ching, C. R. K., Cuellar-partida, G., Braber, A. D., Doan, N. T., Ehrlich, S., Filippi, I., Ge, T., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Greven, C. U., Grimm, O., Griswold, M. E., Guadalupe, T., Hass, J., Haukvik, U. K., Hilal, S., Hofer, E., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liao, J., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A., Matarin, M., Mather, K. A., Mattheisen, M., Mazoyer, B., Mckay, D. R., Mcwhirter, R., Milaneschi, Y., Mirza-schreiber, N., Muetzel, R. L., Maniega, S. M., Nho, K., Nugent, A. C., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pappa, I., Pirpamer, L., Pudas, S., Pütz, B., Rajan, K. B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-santiañez, R., Rommelse, N., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Thomson, R., Tordesillas-gutierrez, D., Toro, R., Trabzuni, D., Vaidya, D., Van Der Grond, J., Van Der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Woldehawariat, G., Wolf, C., Wolfers, T., Xu, B., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Aggarwal, N. T., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., Van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Chen, C., Cheng, C., Cichon, S., Cookson, M. R., Corvin, A., Crespo-facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Delanty, N., Depondt, C., Destefano, A. L., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Erk, S., Espeseth, T., Evans, D. A., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Grabe, H. J., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J., Pol, H. E. H., Ikeda, M., Ikram, M. K., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Longstreth, W. T., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J., Mattay, V. S., Mcdonald, C., Mcintosh, A. M., Mcmahon, K. L., Mcmahon, F. J., Mecocci, P., Melle, I., Meyer-lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schofield, P. R., Sigurdsson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Srikanth, V., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Tiemeier, H., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van Der Brug, M., Van Der Lugt, A., Van Der Wee, N. J. A., Van Duijn, C. M., Van Haren, N. E. M., Van ′t Ent, D., Van Tol, M., Vardarajan, B. N., Veltman, D. J., Vernooij, M. W., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, H. R., Zonderman, A. B., Deary, I. J., Decarli, C., Schmidt, H., Martin, N. G., De Craen, A. J. M., Wright, M. J., Launer, L. J., Schumann, G., Fornage, M., Franke, B., Debette, S., Medland, S. E., Ikram, M. A. & Thompson, P. M., 31 Dec 2016, In: Nature Neuroscience. 19, 12, p. 1569-1582

Research output: Contribution to journal › Article › peer-review

Open Access

File

155 Citations (Scopus)

486 Downloads (Pure)

Shared genetic contribution to ischemic stroke and Alzheimer's disease: Ischemic Stroke and Alzheimer's Disease

Traylor, M., Adib-samii, P., Harold, D., Dichgans, M., Williams, J., Lewis, C. M., Markus, H. S., METASTROKE and International Genomics of Alzheimer's Project (IGAP) investigators, Lovestone, S. H. & Proitsi, P., 1 May 2016, In: Annals of Neurology. 79, 5, p. 739-747

Research output: Contribution to journal › Article › peer-review

Open Access

File

49 Citations (Scopus)

131 Downloads (Pure)

The Effect of Age Correction on Multivariate Classification in Alzheimer’s Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects

Falahati, F., Ferreira, D., Soininen, H., Mecocci, P., Vellas, B., Tsolaki, M., Kłoszewska, I., Lovestone, S., Eriksdotter, M., Wahlund, L. O., Simmons, A. & Westman, E., 1 Mar 2016, In: Brain topography. 29, 2, p. 296-307 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

29 Citations (Scopus)

152 Downloads (Pure)

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

Lupton, M. K., Strike, L., Hansell, N. K., Wen, W., Mather, K. A., Armstrong, N. J., Thalamuthu, A., McMahon, K. L., de Zubicaray, G. I., Assareh, A. A., Simmons, A., Proitsi, P., Powell, J. F., Montgomery, G. W., Hibar, D. P., Westman, E., Tsolaki, M., Kloszewska, I., Soininen, H., Mecocci, P., & 9 othersVelas, B., Lovestone, S., Brodaty, H., Ames, D., Trollor, J. N., Martin, N. G., Thompson, P. M., Sachdev, P. S. & Wright, M. J., 1 Apr 2016, In: Neurobiology of Aging. 40, p. 68-77 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

83 Citations (Scopus)

168 Downloads (Pure)

2015

A comparison of mental state examination documentation by junior clinicians in electronic health records before and after the introduction of a semi-structured assessment template (OPCRIT+)

Lobo, S. E. M., Rucker, J., Kerr, M., Gallo, F., Constable, G., Hotopf, M. H., Stewart, R. J., Broadbent, M., Baggaley, M., Lovestone, S. H., McGuffin, P., Amarasinghe, J. M., Newman, S., Schumann, G. & Brittain, P., 1 Sept 2015, In: International Journal of Medical Informatics. 84, 9, p. 675-682 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

307 Downloads (Pure)

Simon Lovestone

Research output

Search results