Simon Hughes
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Personal profile

Research interests

Lab interests include developmental genetics of striated muscle and its attachments and innervation in vertebrates, studied using zebrafish and mice; control of muscle cell size and character in the adult; the role of force in muscle growth and maintenance; morphogenesis; prevention of ageing-related muscle atrophy; comparative evolution of neuromuscular system; muscle repair in disease and after injury; cardiac growth and repair; myocardial cell proliferation, differentiation and growth; trabeculation; regulation of protein synthesis by TOR singalling; Dystrophin and associated proteins involved in muscular dystrophies. 

Our work has focused on elucidating the genes/proteins regulating defined steps in muscle development or processes in adult muscle.  Gene families of specific interest have been Hedgehog, Fgf, Wnt, Myod, Mef2, Pax3/7, p57kip2/cdkn1c, Tbx, eIF4EBP, Mtor, Tead.


Research interests (short)

Development and growth of muscle and its attachments; cardiac growth and repair; zebrafish; mechanobiology; stem cells; ageing; neuromuscular interaction; cell biology; evolution

Click here for the Hughes group webpage

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Visual transduction in retinal rod cells, University of Cambridge

Award Date: 1 Jan 1984

Master of Arts, University of Cambridge

Award Date: 1 Jan 1983

Master of Philosophy, Measurement of free divalent cations in cells and organelles, University of Cambridge

Award Date: 1 Jan 1981

External positions

External Scientific Staff, MRC Medical Research Council

1 Jul 1992 → …


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