Research output per year
Research output per year
Personal profile
Research interests
Lab interests include developmental genetics of striated muscle and its attachments and innervation in vertebrates, studied using zebrafish and mice; control of muscle cell size and character in the adult; the role of force in muscle growth and maintenance; morphogenesis; prevention of ageing-related muscle atrophy; comparative evolution of neuromuscular system; muscle repair in disease and after injury; cardiac growth and repair; myocardial cell proliferation, differentiation and growth; trabeculation; regulation of protein synthesis by TOR singalling; Dystrophin and associated proteins involved in muscular dystrophies.
Our work has focused on elucidating the genes/proteins regulating defined steps in muscle development or processes in adult muscle. Gene families of specific interest have been Hedgehog, Fgf, Wnt, Myod, Mef2, Pax3/7, p57kip2/cdkn1c, Tbx, eIF4EBP, Mtor, Tead.
Research interests (short)
Development and growth of muscle and its attachments; cardiac growth and repair; zebrafish; mechanobiology; stem cells; ageing; neuromuscular interaction; cell biology; evolution
Click here for the Hughes group webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Visual transduction in retinal rod cells, University of Cambridge
Award Date: 1 Jan 1984
Master of Arts, University of Cambridge
Award Date: 1 Jan 1983
Master of Philosophy, Measurement of free divalent cations in cells and organelles, University of Cambridge
Award Date: 1 Jan 1981
External positions
External Scientific Staff, MRC Medical Research Council
1 Jul 1992 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Isolation, Culture, and Analysis of Zebrafish Myofibers and Associated Muscle Stem Cells to Explore Adult Skeletal Myogenesis
Ganassi, M., Zammit, P. S. & Hughes, S. M., 2023, Methods in Molecular Biology. Humana Press Inc, p. 21-43 23 p. (Methods in Molecular Biology; vol. 2640).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Citation (Scopus) -
MYH13, a superfast myosin expressed in extraocular, laryngeal, and syringeal muscles
Schiaffino, S., Hughes, S., Murgia, M. & Reggiani, C., 30 Nov 2023, (Accepted/In press) In: J Physiol - London.Research output: Contribution to journal › Review article › peer-review
File16 Downloads (Pure) -
Skeletal Muscle Regeneration in Zebrafish
Pipalia, T. G., Sultan, S. H. A., Koth, J., Knight, R. D. & Hughes, S. M., 2023, Methods in Molecular Biology. Humana Press Inc, p. 227-248 22 p. (Methods in Molecular Biology; vol. 2640).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation
Hau, H. T. A., Kelu, J. J., Ochala, J. & Hughes, S. M., Jul 2023, In: Developmental Biology. 499, p. 47-58 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan
Hughes, S. M., Escaleira, R., Wanders, K., Koth, J., Wilkinson, D. G. & Xu, Q., 15 Aug 2022, In: Biology Open. 11, 8, bio059476.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)53 Downloads (Pure)
Projects
- 31 Finished
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Automated high throughout high-resolution imaging_Houart Nov2020
Houart, C., Hindges, R., Hughes, S. & Knight, R.
BBSRC Biotechnology and Biological Sciences Research Council
1/06/2021 → 31/05/2022
Project: Research
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UKRI CoA: Mechanisms of activity-dependent muscle growth & repair
EPSRC Engineering and Physical Sciences Research Council
1/04/2020 → 30/09/2021
Project: Research
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MyOrControl - Control of cell orientation within tissue: combining molecular genetic and imaging approaches in muscle
1/09/2017 → 31/08/2019
Project: Research
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Control of cell orientation: combining molecular genetics and imaging in developing muscle
1/03/2017 → 31/03/2020
Project: Research
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Activities
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PL o S Biology (Journal)
Simon Hughes (Editorial board member)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Organiser. Company of Biologists Workshop on Fish models of muscle growth and repair, Sussex, UK
Simon Hughes (Organiser)
Jun 2011 → …Activity: Participating in or organising an event › Participation in conference
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Co-organiser (on-going). London Myology Forum
Simon Hughes (Organiser)
Apr 2009 → …Activity: Participating in or organising an event › Participation in conference
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MRC College of Experts
Simon Hughes (Member)
2006 → 2010Activity: Other › Types of External academic engagement - Membership of external research organisation
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EMBO Workshop on Molecular and Cellular Mechanisms underlying Muscle Development and repair. Fontevraud, France. . Invited speaker
Simon Hughes (Invited speaker)
Sept 2005 → …Activity: Participating in or organising an event › Participation in conference