Search results

• Active

  Glycoengineering of optimal IgE antibodies for cancer therapy

  Karagiannis, S. (Primary Investigator)

  Worldwide Cancer Research

  1/02/2024 → 31/01/2027

  Project: Research

• A Cancer Research UK study of MOv18 IgE, a first in class chimeric IgE antibody against folate receptor-α, effects on monocyte phenotype and function

  Karagiannis, S. (Primary Investigator), Bax, H. (Co-Investigator) & Spicer, J. (Co-Investigator)

  CRUK Cancer Research UK

  15/01/2024 → 31/01/2025

  Project: Research

• Understanding the significance of patient B cells and expressed antibodies in melanoma

  Karagiannis, S. (Primary Investigator) & Tsoka, S. (Co-Investigator)

  British Skin Foundation

  1/11/2023 → 30/06/2025

  Project: Research

• Crosstalk Between Tumour and Draining Lymph Nodes and its Impact on Triple-negative Breast Cancer

  Grigoriadis, A. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  MRC Medical Research Council

  1/12/2022 → 30/11/2025

  Project: Research

• Antibody-drug conjugates (ADCs) for the treatment of solid tumours

  Karagiannis, S. (Primary Investigator) & Spicer, J. (Co-Investigator)

  CRUK Cancer Research UK

  1/10/2020 → 30/01/2025

  Project: Research

• Not started

  Investigating the role of CD74 in the pathogenosis of discoid lupus erythematosus

  Tull, T. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  British Skin Foundation

  1/06/2025 → 31/05/2028

  Project: Research

• Anti-EGFR antibody-drug conjugates carrying a CDK inhibitor for cancer therapy

  Chenoweth, A. (Primary Investigator), Cheung, A. (Co-Investigator) & Karagiannis, S. (Co-Investigator)

  MRC Medical Research Council

  1/03/2025 → 28/02/2026

  Project: Research

• Finished

  The impact of antibody isotype on patient monocyte and macrophage functions and activation states to manipulate anti-tumour responses in melanoma

  Karagiannis, S. (Primary Investigator)

  MRC Medical Research Council

  1/10/2021 → 30/09/2024

  Project: Research

• Preclinical validation of a novel cancer immunotherapeutic

  Karagiannis, S. (Primary Investigator)

  TSB Technology Strategy Board

  1/10/2020 → 31/12/2022

  Project: Research

• The humoral immune response in patients with melanoma undergoing checkpoint inhibitor therapy

  Karagiannis, S. (Primary Investigator) & Papa, S. (Co-Investigator)

  CRUK Cancer Research UK

  6/01/2020 → 5/01/2023

  Project: Research

• Development of a specific cancer immunotherapeutic that targets an innate immune checkpoint

  Burchell, J. (Primary Investigator), Karagiannis, S. (Co-Investigator) & Beavil, A. (Co-Investigator)

  MRC Medical Research Council

  1/02/2018 → 31/03/2019

  Project: Research

  • Malignant Neoplasm 100%
  • Immunity 100%

• IgE antibodies in cancer

  Karagiannis, S. (Primary Investigator)

  IGEM Therapeutics Ltd

  1/02/2018 → 23/12/2022

  Project: Research

• Hypobaric assisted macromolecule extraction from the skin - a novel means to investigate skin health during aging

  Jones, S. (Primary Investigator), Ameer-Beg, S. (Co-Investigator) & Karagiannis, S. (Co-Investigator)

  5/06/2017 → 6/04/2020

  Project: Research

• The needleless delivery of a malignant melanoma vaccine using a hypobaric pressure device

  Jones, S. (Primary Investigator), Ameer-Beg, S. (Co-Investigator) & Karagiannis, S. (Co-Investigator)

  3/04/2017 → 2/04/2020

  Project: Research

• Preclinical efficacy of an antibody of the IgE class against a melanoma-associated antigen

  Karagiannis, S. (Primary Investigator) & Spicer, J. (Primary Investigator)

  IGEM Therapeutics Ltd

  1/04/2017 → 31/12/2021

  Project: Research

• NIHR Biomedical Research Centre. Funding for Financial Years 2017/18, 2018/19

  Wolfe, C. (Primary Investigator), Parsons, M. (Primary Investigator), Gould, H. (Primary Investigator), Corrigan, C. (Primary Investigator), Greenough, A. (Primary Investigator), Peakman, M. (Primary Investigator), Vyse, T. (Primary Investigator), Antoniou, M. (Primary Investigator), Oakey, R. (Primary Investigator), McGrath, J. (Primary Investigator), Karagiannis, S. (Primary Investigator), Barker, J. (Primary Investigator), Flohr, C. (Primary Investigator), Tziotzios, C. (Primary Investigator), Whittaker, S. (Primary Investigator), Spector, T. (Primary Investigator), Watt, F. (Primary Investigator), Hayday, A. (Primary Investigator), Spencer, J. (Primary Investigator), Cope, A. (Primary Investigator), Malim, M. (Primary Investigator), Martin Serrano, J. (Primary Investigator), Edgeworth, J. (Primary Investigator), Cason, J. (Primary Investigator), Lord, G. (Primary Investigator), Dorling, A. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Lombardi, G. (Primary Investigator), Ostermann, M. (Primary Investigator), Shah, A. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Wells, C. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Sawyer, E. (Primary Investigator), Maher, J. (Primary Investigator), Tribe, R. (Primary Investigator), Ilic, D. (Primary Investigator), Poston, L. (Primary Investigator), Rutherford, M. (Primary Investigator), Gee, T. (Primary Investigator), Blower, P. (Primary Investigator), Edwards, D. (Primary Investigator), Sharpe, P. (Primary Investigator), Streit, A. (Primary Investigator), Naglik, J. (Primary Investigator), Tavassoli, M. (Primary Investigator) & McNaughton, P. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/04/2017 → 31/03/2022

  Project: Research

  • Biomedical Research 100%

• Defining and designing optimized IgE glycoforms

  Wagner, G. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/01/2017 → 31/10/2017

  Project: Research

• Immunoglobulin E targeted against Folate Receptor alpha for the treatment of triple-negative breast cancer

  academic, A. (Primary Investigator), Karagiannis, S. (Co-Investigator), Spicer, J. (Co-Investigator) & Tutt, A. (Co-Investigator)

  5/09/2016 → 4/09/2019

  Project: Research

• Glycoshape

  Wagner, G. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  8/03/2016 → 7/03/2019

  Project: Research

• Developing tools to study immune cell-cancer cell interactions

  Sanz Moreno, V. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  1/03/2016 → 28/02/2017

  Project: Research

• Tumour-infiltrating B cell repertoire: High through-put sequencing to therapeutic antibodies

  Grigoriadis, A. (Primary Investigator), Dunn-Walters, D. (Co-Investigator), Karagiannis, S. (Co-Investigator) & Tutt, A. (Co-Investigator)

  1/01/2016 → 31/12/2018

  Project: Research

• An interdisciplinary approach for elucidating signalling pathways in cancer immunotherapy

  Tsoka, S. (Primary Investigator), Karagiannis, S. (Co-Investigator) & Spicer, J. (Co-Investigator)

  1/01/2016 → 31/12/2019

  Project: Research

• Delineating Signalling Pathways in Cancer Immunotherapy

  Tsoka, S. (Primary Investigator), Karagiannis, S. (Co-Investigator) & Spicer, J. (Co-Investigator)

  1/12/2015 → 30/11/2018

  Project: Research

• Systems Biology for Modelling Signalling Pathways in Cancer Immunotherapy

  Tsoka, S. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  1/11/2015 → 31/10/2018

  Project: Research

• Modelling Complex Networks of Gene Interactions for Cancer Immunotherapy

  Tsoka, S. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  1/11/2015 → 31/10/2018

  Project: Research

• Systems Biology for Modelling Signalling Pathways in Cancer Immunotherapy

  Tsoka, S. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  1/11/2015 → 31/10/2018

  Project: Research

• Development of Novel Antibody Drug Conjugates (ADCs) for the Treatment of Cancer

  Karagiannis, S. (Primary Investigator), Rahman, M. (Co-Investigator), Spicer, J. (Co-Investigator) & Thurston, D. (Co-Investigator)

  1/07/2015 → 31/03/2016

  Project: Research

• Systems Biology for Modelling Signalling Pathways in Cancer Immunotherapy

  Tsoka, S. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  1/06/2015 → 31/05/2018

  Project: Research

• Phase I study of MOV18, a first in class chimeric IgE antibody against folate receptor-α, in patients with advanced solid tumours: pre-clinical and clinical evaluations.

  Karagiannis, S. (Primary Investigator), Spicer, J. (Primary Investigator), Bax, H. (Co-Investigator) & Gillett, C. (Co-Investigator)

  CRUK Cancer Research UK

  1/05/2015 → 31/07/2022

  Project: Research

• Tumour-infiltrating B cell repertoire: High throughput sequencing to therapeutic antibodies.

  Dunn-Walters, D. (Primary Investigator) & Karagiannis, S. (Co-Investigator)

  1/05/2015 → 30/04/2018

  Project: Research

• Mechanisms of a tumour specific IgE antibody for ovarian cancer immunotherapy

  Bax, H. (Primary Investigator), Josephs, D. (Primary Investigator), Karagiannis, S. (Co-Investigator) & Spicer, J. (Co-Investigator)

  1/04/2015 → 1/04/2016

  Project: Research

• Preclinical efficacy of an antibody of the IgE class against a melanoma-associated antigen

  Karagiannis, S. (Primary Investigator) & Nestle, F. (Co-Investigator)

  MRC Medical Research Council

  1/02/2015 → 31/01/2019

  Project: Research

• Functional and early safety evaluations of an IgE class antibody to target melanoma

  Karagiannis, S. (Primary Investigator) & Nestle, F. (Co-Investigator)

  1/07/2014 → 30/06/2015

  Project: Research

• Preclinical efficacy of an antibody of the IgE class against a melanoma-associated antigen

  Karagiannis, S. (Primary Investigator) & Nestle, F. (Co-Investigator)

  1/04/2014 → 31/03/2016

  Project: Research

• Novel mechanistic insights into the macrophage-activating functions of a tumour antigen-specific IgE antibody for cancer immunotherapy

  Josephs, D. (Primary Investigator), Karagiannis, S. (Co-Investigator) & Spicer, J. (Co-Investigator)

  Academy of Medical Sciences

  1/03/2014 → 1/03/2018

  Project: Research

• A clinically integrated translational science programme to progress positive biomarker and therapeutics development for forms of breast cancer currently defined as Triple Negative

  Tutt, A. (Primary Investigator), Karagiannis, S. (Co-Investigator), Nestle, F. (Co-Investigator), Ng, T. (Co-Investigator) & Grigoriadis, A. (Co-Investigator)

  Breakthrough Breast Cancer, Breast Cancer Now

  15/10/2013 → 31/10/2022

  Project: Research

• Preclinical efficacy of an antibody of the IgE class against a melanoma-associated antigen

  Karagiannis, S. (Primary Investigator) & Nestle, F. (Co-Investigator)

  1/01/2013 → 31/12/2014

  Project: Research

• Pre-clinical efficacy and safety evaluation of MOv18 IgE, a novel class of antibody targeting alpha folate receptor

  Karagiannis, S. (Primary Investigator) & Spicer, J. (Primary Investigator)

  CRUK Cancer Research UK

  1/06/2012 → 31/12/2016

  Project: Research

• Investigating the therapeutic efficacy of antibodies of the IgG and IgE classes against a melanoma-associated antigen

  Karagiannis, S. (Primary Investigator) & Nestle, F. (Co-Investigator)

  1/05/2012 → 30/04/2014

  Project: Research

• Experimental Cancer Medicine Centre

  Purushotham, A. (Primary Investigator), Spicer, J. (Primary Investigator), Farzaneh, F. (Co-Investigator), Hayday, A. (Co-Investigator), Holmberg, L. (Co-Investigator), Karagiannis, S. (Co-Investigator), Nestle, F. (Co-Investigator), Ng, T. (Co-Investigator), Parker, P. (Co-Investigator), Pinder, S. (Co-Investigator) & Sarker, D. (Co-Investigator)

  CRUK Cancer Research UK

  1/04/2012 → 31/03/2017

  Project: Research

• Discovery of human antibodies for melanoma diagnosis and therapy

  Karagiannis, S. (Primary Investigator) & Nestle, F. (Co-Investigator)

  1/01/2011 → 31/12/2012

  Project: Research

• The immunoregulatory role of B lymphocyte populations in malignant melanoma

  Karagiannis, S. (Primary Investigator), Nestle, F. (Primary Investigator) & academic, A. (Primary Investigator)

  British Skin Foundation

  1/10/2010 → 6/01/2011

  Project: Research

• Pre-clinical efficacy and safety evaluation of MOv18 IgE, a novel class of antibody targeting alpha folate receptor

  Spicer, J. (Primary Investigator), Blower, P. (Co-Investigator), Gould, H. (Co-Investigator) & Karagiannis, S. (Co-Investigator)

  CRUK Cancer Research UK

  1/11/2009 → 30/06/2012

  Project: Research

• Discovery of human antibodies for melanoma diagnosis and therapy

  Karagiannis, S. (Primary Investigator) & Nestle, F. (Primary Investigator)

  1/10/2009 → 30/09/2012

  Project: Research

• IgE as a new class of targeting molecules for radionuclide imaging and treatment of cancer

  Blower, P. (Primary Investigator), Gould, H. (Co-Investigator), Karagiannis, S. (Co-Investigator) & Sunassee, K. (Co-Investigator)

  1/04/2009 → 31/03/2012

  Project: Research

• Unspecified research

  Chambers, D. (Primary Investigator), Fentiman, I. (Primary Investigator), Fogelman, I. (Primary Investigator), Gillett, C. (Primary Investigator), Lombardi, G. (Primary Investigator), Marber, M. (Primary Investigator), Redwood, S. (Primary Investigator), Sacks, S. (Primary Investigator), Spector, T. (Primary Investigator), Spencer, J. (Primary Investigator), Whittaker, S. (Primary Investigator), Zhou, W. (Primary Investigator), academic, A. (Primary Investigator) & Karagiannis, S. (Primary Investigator)

  Guy's & St Thomas' Charity

  1/01/2009 → 31/12/2020

  Project: Research

• NIHR Biomedical Research Centre

  Afzali, B. (Primary Investigator), Antoniou, M. (Primary Investigator), Barker, J. (Primary Investigator), Barratt, B. (Primary Investigator), Beighton, D. (Primary Investigator), Bevan, S. (Primary Investigator), Blower, P. (Primary Investigator), Burchell, J. (Primary Investigator), Cason, J. (Primary Investigator), Chappell, L. (Primary Investigator), Cope, A. (Primary Investigator), Corrigan, C. (Primary Investigator), Cunninghame Graham, D. (Primary Investigator), Dontu, G. (Primary Investigator), Edgeworth, J. (Primary Investigator), Farzaneh, F. (Primary Investigator), Gee, T. (Primary Investigator), Gould, H. (Primary Investigator), Green, P. (Primary Investigator), Greenough, A. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Hayday, A. (Primary Investigator), Higginson, I. (Primary Investigator), Kalra, L. (Primary Investigator), Karagiannis, S. (Primary Investigator), Kelly, F. (Primary Investigator), Kemper, C. (Primary Investigator), Lau-Walker, M. (Primary Investigator), Lavender, P. (Primary Investigator), Lee, T. (Primary Investigator), Lempp, H. (Primary Investigator), Lewis, C. (Primary Investigator), Lombardi, G. (Primary Investigator), Lord, G. (Primary Investigator), Marber, M. (Primary Investigator), Mason, J. (Primary Investigator), Mathew, C. (Primary Investigator), McGrath, J. (Primary Investigator), Metcalfe, A. (Primary Investigator), Molokhia, M. (Primary Investigator), Mullen, G. (Primary Investigator), Nagel, E. (Primary Investigator), Neil, S. (Primary Investigator), Nestle, F. (Primary Investigator), Oakey, R. (Primary Investigator), Parker, P. (Primary Investigator), Peakman, M. (Primary Investigator), Perera, D. (Primary Investigator), Purushotham, A. (Primary Investigator), Rasekh Ahmadi, K. (Primary Investigator), Rashid, T. (Primary Investigator), Razavi, R. (Primary Investigator), Ridley, A. (Primary Investigator), Robson, M. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Santis, G. (Primary Investigator), Sanz Moreno, V. (Primary Investigator), Sawyer, E. (Primary Investigator), Schaeffter, T. (Primary Investigator), Shah, A. (Primary Investigator), Sharpe, P. (Primary Investigator), Simpson, M. (Primary Investigator), Smith, R. (Primary Investigator), Sorinola, I. (Primary Investigator), Spector, T. (Primary Investigator), Spicer, J. (Primary Investigator), Taams, L. (Primary Investigator), Tavassoli, M. (Primary Investigator), Taylor, D. (Primary Investigator), Tree, T. (Primary Investigator), Trembath, R. (Primary Investigator), Tribe, R. (Primary Investigator), Tutt, A. (Primary Investigator), Waltham, M. (Primary Investigator), Watt, F. (Primary Investigator), Webb, A. (Primary Investigator), Wells, C. (Primary Investigator), Whelan, K. (Primary Investigator), Whitaker, J. (Primary Investigator), Whittlesea, C. (Primary Investigator), Williamson, C. (Primary Investigator), Wolfe, C. (Primary Investigator), Yu, V. (Primary Investigator), academic, A. (Primary Investigator), Hughes, S. (Co-Investigator), Montana, G. (Co-Investigator), Rhode, K. (Co-Investigator), Schnabel, J. (Co-Investigator) & Tziotzios, C. (Co-Investigator)

  NIHR National Institute For Health & Care Research, DHSC Department of Health and Social Care

  1/04/2007 → 31/03/2017

  Project: Research

  • T-Helper Cell 100%
  • Inflammatory Arthritis 66%
  • Monocyte 36%
  • Tumor Necrosis Factor 36%
  • Cytotoxic T-Cell 33%