Research output per year
Research output per year
Personal profile
Research interests
My group's research if focused on the identification and functional characterisation of G-protein coupled receptors (GPCRs) and their peptide ligands in human tissues that are relevant for cardiovascular and metabolic disease.
To date we have constructed two detailed atlases describing the expression and function of all GPCRs in human pancreatic islets and human adipose tissue, and a number of additional GPCR atlases are under construction.
I am currently supervising two very talented and hard working members of my group: PhD student Ross Hawkes and postdoc Patricio Atanes. We are working hard to characterise the function of a number of orphan GPCRs and GPCR peptide ligands in pancreatic islets and to understand their role in diabetes and metabolic disease.
Our research has resulted in the initiation of a number of industry collaborations with the aim of evaluating these receptors and GPCR peptide ligands as novel drug targets for the treatment of diabetes and metabolic disease.
For more information on my research output, search 'Amisten' on PubMed and ResearchGate."
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
Dive into the research topics where Stefan Amisten is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
-
CXCL14 Inhibits Insulin Secretion Independently of CXCR4 or CXCR7 Receptor Activation or cAMP Inhibition
Atanes, P., Hawkes, R. G., Olaniru, O. E., Ruz-Maldonado, I., Amisten, S. & Persaud, S. J., 9 Apr 2019, In: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 52, 4, p. 879-892 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)209 Downloads (Pure) -
Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets
Atanes, P., Ruz-Maldonado, I., Hawkes, R., Liu, B., Zhao, M., Huang, G. C., Al-Amily, I. M., Salehi, A., Amisten, S. & Persaud, S. J., Aug 2018, In: Cellular and Molecular Life Sciences. 75, 16, p. 3039–3050Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)106 Downloads (Pure) -
Identifying signalling pathways regulated by GPRC5B in β-cells by CRISPR-Cas9-mediated genome editing
Atanes, P., Ruz-Maldonado, I., Hawkes, R., Liu, B., Persaud, S. J. & Amisten, S., Feb 2018, In: Cellular Physiology and Biochemistry. 45, 2, p. 656-666 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)127 Downloads (Pure) -
Mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation
Rackham, C. L., Amisten, S., Persaud, S. J., King, A. J. F. & Jones, P. M., 27 Oct 2018, (E-pub ahead of print) In: CYTOTHERAPY. 20, 12, p. 1427-1436Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)396 Downloads (Pure) -
A comparative analysis of human and mouse islet G-protein coupled receptor expression
Amisten, S., Atanes, P., Hawkes, R., Ruz-Maldonado, I., Liu, B., Parandeh, F., Zhao, M., Huang, G. C., Salehi, A. & Persaud, S. J., 19 Apr 2017, In: Scientific Reports. 7, 46600.Research output: Contribution to journal › Article › peer-review
Open AccessFile107 Downloads (Pure)
Projects
- 9 Finished
-
Functional evaluation of novel drug candidates targeting islets for the treatment of type 2 diabetes
Persaud, S. (Primary Investigator) & Amisten, S. (Co-Investigator)
1/06/2016 → 30/11/2018
Project: Research
-
Development of a new diabetes therapy that potentiates glucose-induced insulin secretion and maintains beta-cell mass
Persaud, S. (Primary Investigator), Amisten, S. (Co-Investigator) & Bowe, J. (Co-Investigator)
1/04/2016 → 31/03/2019
Project: Research
-
In vitro and in vivo pharmacological characterisation of a novel anti-diabetic islet peptide
Amisten, S. (Primary Investigator) & Persaud, S. (Co-Investigator)
1/02/2016 → 31/07/2017
Project: Research
-
C1QL1: Development of a new diabetes therapy that potentiates glucose-induced insulin secretion and maintains beta-cellmass
Persaud, S. (Primary Investigator), Amisten, S. (Co-Investigator) & Bowe, J. (Co-Investigator)
1/01/2016 → 30/06/2018
Project: Research
-
Identification of novel G-Protein Coupled Receptors with functional roles in diabetic nephropathy
Malik, A. (Primary Investigator) & Amisten, S. (Co-Investigator)
1/06/2015 → 30/11/2016
Project: Research