Research output per year
Research output per year
Personal profile
Biographical details
I am an interdisciplinary biomedical researcher trained in biostatistics, machine learning, maths and biology. Currently I hold a MRC Biostatistics training fellowship, which I am using to study the progression of Alzheimer's disease and how knowledge of this can be used to inform trial design.
My future work will involve Bayesian approaches to modelling heterogeneity in disease progression. These approaches will allow greater sub-typing of diseases, allowing stratified medicine approaches. This work will leverage disease progression marker data from prospective cohort studies, clinical trials and Eectronic Health Records (EHR).
In the long-term I am interested in contributing to the design of Learning Healthcare Systems (www.learninghealth.org), that automatically generate biomedical evidence during routine care. I believe that approaches I develop will be an important component of this, but I am also collaborating with researchers developing the software infrastructure necessary for automated comparative effectiveness research, a cornerstone of the Learning Healthcare System.
My future work will involve Bayesian approaches to modelling heterogeneity in disease progression. These approaches will allow greater sub-typing of diseases, allowing stratified medicine approaches. This work will leverage disease progression marker data from prospective cohort studies, clinical trials and Eectronic Health Records (EHR).
In the long-term I am interested in contributing to the design of Learning Healthcare Systems (www.learninghealth.org), that automatically generate biomedical evidence during routine care. I believe that approaches I develop will be an important component of this, but I am also collaborating with researchers developing the software infrastructure necessary for automated comparative effectiveness research, a cornerstone of the Learning Healthcare System.
For other information you can look at my linkedin profile http://uk.linkedin.com/pub/steven-kiddle/36/80a/568
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Systems Biology - Using systems biology approaches to elucidate gene regulatory networks controlling the plant defence response, University of Warwick
Award Date: 1 Jan 2012
Master of Science, Systems Biology (Distinction), University of Warwick
Award Date: 1 Jan 2008
Bachelor of Science, Mathematics, University of Warwick
Award Date: 1 Jan 2007
Fingerprint
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- 1 Similar Profiles
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Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
Shi, L., Winchester, L. M., Liu, B. Y., Killick, R., Ribe, E. M., Westwood, S., Baird, A. L., Buckley, N. J., Hong, S., Dobricic, V., Kilpert, F., Franke, A., Kiddle, S., Sattlecker, M., Dobson, R., Cuadrado, A., Hye, A., Ashton, N. J., Morgan, A. R. & Bos, I. & 47 others, , 2020, In: Journal of Alzheimer's Disease. 77, 3, p. 1353-1368 16 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Dysregulated Antibody, Natural Killer Cell and Immune Mediator Profiles in Autoimmune Thyroid Diseases
Martin, T., Ilieva, K., Visconti, A., Beaumont, M., Kiddle, S., Dobson, R., Mangino, M., Lim, E. M., Pezer, M., Steves, C., Bell, J., Wilson, S. G., Lauc, G., Roederer, M., Walsh, J. P., Spector, T. & Karagiannis, S. N., 9 Mar 2020, In: Cells. 9, 3Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)314 Downloads (Pure) -
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., Voyle, N., Proitsi, P., Witoelar, A., Stringer, S., Aarsland, D., Almdahl, I. S., Andersen, F., Bergh, S., Bettella, F. & Bjornsson, S. & 33 others, , 1 Mar 2019, In: Nature Genetics. 51, 3, p. 404-413 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1476 Citations (Scopus)751 Downloads (Pure) -
A blood test for Alzheimer’s disease: progress, challenges and recommendations
Kiddle, S. J., Voyle, N. J. & Dobson, R. J., 12 Jun 2018, In: Journal of Alzheimer's disease : JAD. 64, s1, p. S289-S297Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)231 Downloads (Pure) -
Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic
Hampel, H., O’Bryant, S. E., Molinuevo, J. L., Zetterberg, H., Masters, C. L., Lista, S., Kiddle, S. J., Batrla, R. & Blennow, K., 1 Nov 2018, In: Nature Reviews Neurology. 14, 11, p. 639-652 14 p.Research output: Contribution to journal › Review article › peer-review
492 Citations (Scopus)
Projects
- 3 Finished
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Aging and ApoE genotype effects on single cell RNA-seq expression in the entorhinal and neocortical regions of the human brain
Powell, J. (Primary Investigator), Dobson, R. (Co-Investigator), Kiddle, S. (Co-Investigator) & Newhouse, S. (Co-Investigator)
1/01/2016 → 31/12/2019
Project: Research
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Early identification of Alzheimer's Disease: dynamic biomarkers for enrichment of clinical trials
Kiddle, S. (Primary Investigator), Dobson, R. (Co-Investigator) & Mill, J. (Co-Investigator)
1/04/2014 → 31/03/2017
Project: Research
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Creating an early diagnostic test for Alzheimer's - transforming our ability to tackle the disease
Dobson, R. (Primary Investigator), Kiddle, S. (Co-Investigator) & Lewis, C. (Co-Investigator)
1/09/2013 → 31/08/2016
Project: Research