King's College London

Research portal

Dr Steven Niederer

  1. Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling

    Verheijen, M., Schrooders, Y., Gmuender, H., Nudischer, R., Clayton, O., Hynes, J., Niederer, S., Cordes, H., Kuepfer, L., Kleinjans, J. & Caiment, F. 24 May 2018 In : Toxicology Letters.

    Research output: Contribution to journalArticle

  2. Lesion Index-Guided Ablation Facilitates Continuous, Transmural, and Durable Lesions in a Porcine Recovery Model

    Whitaker, J., Fish, J., Harrison, J., Chubb, H., Williams, S. E., Fastl, T., Corrado, C., Van Zaen, J., Gibbs, J., O'Neill, L., Mukherjee, R., Rittey, D., Thorsten, J., Donskoy, E., Sohal, M., Rajani, R., Niederer, S., Wright, M. & O'Neill, M. D. Apr 2018 In : Circulation. Arrhythmia and electrophysiology. 11, 4, p. e005892

    Research output: Contribution to journalArticle

  3. Decreasing compensatory ability of concentric ventricular hypertrophy in aortic-banded rat hearts

    Lewalle, A., Land, S., Carruth, E., Frank, L. R., Lamata , P., Omens, J. H., McCulloch, A. D., Niederer, S. A. & Smith, N. P. 23 Feb 2018 In : Frontiers in Physiology. 9

    Research output: Contribution to journalArticle

  4. Accepted/In press

    An asymmetric wall-thickening pattern predicts response to Cardiac Resynchronization Therapy

    Warriner, D. R., Jackson, T. A., Zacur, E., Sammut, E. C., Sheridan, P., Hose, D. R., Lawford, P. V., Razavi, R., Niederer, S. A., Rinaldi, C. A. & Lamata de la Orden, P. 19 Jan 2018 (Accepted/In press) In : JACC Cardiovascular Imaging.

    Research output: Contribution to journalArticle

  5. Cardiac CT assessment of tissue thickness at the ostium of the left atrial appendage predicts acute success of radiofrequency ablation

    Whitaker, J., Panikker, S., Fastl, T., Corrado, C., Virmani, R., Kutys, R., Lim, E., O'Neill, M., Nicol, E., Niederer, S. & Wong, T. 1 Nov 2017 In : Pacing and clinical electrophysiology : PACE. 40, 11, p. 1218-1226 9 p.

    Research output: Contribution to journalArticle

  6. Efficient computation of electrograms and ECGs in human whole heart simulations using a reaction-eikonal model

    Neic, A., Campos, F. O., Prassl, A. J., Niederer, S. A., Bishop, M. J., Vigmond, E. J. & Plank, G. 1 Oct 2017 In : JOURNAL OF COMPUTATIONAL PHYSICS. 346, p. 191-211 21 p.

    Research output: Contribution to journalArticle

  7. A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity

    Kuepfer, L. , Clayton, O. , Thiel, C. , Cordes, H. , Nudischer, R. , Blank, L. M. , Baier, V. , Heymans, S. , Caiment, F. , Roth, A. , Fluri, D. A. , Kelm, J. M. , Castell, J. , Selevsek, N. , Schlapbach, R. , Keun, H. , Hynes, J. , Sarkans, U. , Gmuender, H. , Herwig, R. & 4 others Niederer, S., Schuchhardt, J., Segall, M. & Kleinjans, J. 29 Aug 2017 In : Archives of Toxicology. p. 1-3 3 p.

    Research output: Contribution to journalArticle

  8. Cardiac computational modeling of ventricular tachycardia and cardiac resynchronization therapy: A clinical perspective

    Chen, Z., Niederer, S., Shanmugam, N., Sermesant, M. & Rinaldi, C. A. 1 Aug 2017 In : Minerva Cardioangiologica. 65, 4, p. 380-397 18 p.

    Research output: Contribution to journalReview article

  9. Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

    Ribba, B., Grimm, H. P., Agoram, B., Davies, M. R., Gadkar, K., Niederer, S., van Riel, N., Timmis, J. & van der Graaf, P. H. 6 Jun 2017 In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  10. Restitution slope is principally determined by steady-state action potential duration

    Shattock, M. J., Park, K. C., Yang, H-Y., Lee, A. W. C., Niederer, S., MacLeod, K. T. & Winter, J. Jun 2017 In : Cardiovascular Research. 113, 7, p. 817–828 12 p., cvx063

    Research output: Contribution to journalArticle

  11. Compensatory and decompensatory alterations in cardiomyocyte Ca(2+) dynamics in hearts with diastolic dysfunction following aortic banding

    Gattoni, S., Treu Røe, Å., Aronsen, J. M., Sjaastad, I., Louch, W. E., Smith, N. P. & Niederer, S. A. 21 May 2017 In : The Journal of physiology.

    Research output: Contribution to journalArticle

  12. Comprehensive use of cardiac computed tomography to guide left ventricular lead placement in cardiac resynchronization therapy

    Behar, J. M., Rajani, R., Pourmorteza, A., Preston, R., Razeghi, O., Niederer, S., Adhya, S., Claridge, S., Jackson, T., Sieniewicz, B., Gould, J., Carr-White, G., Razavi, R., McVeigh, E. & Rinaldi, C. A. 4 May 2017 In : Heart Rhythm. 14, 9, p. 1364-1372 9 p.

    Research output: Contribution to journalArticle

  13. A predictive patient specific model for the human atrium

    Corrado, C., Williams, S., Plank, G., O'Neill, M. & Niederer, S. May 2017 CMBE 2017 Proceedings. Nithiarasu, P. & Robertson, A. (eds.). Vol. 2, p. 972-975 4 p. (CMBE series; vol. 2017, no. 2)

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  14. Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time

    Lee, A., Sohal, M., Behar, J., Claridge, S., Shetty, A., Jackson, T., Hyde, E., Plank, G., Razavi, R., Lamata, P., Rinaldi, C. A. & Niederer, S. 1 Mar 2017 Computing in Cardiology. IEEE Computer Society Press, Vol. 43, p. 757-759 3 p. 7868853

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  15. Personalized modeling pipeline for left atrial electromechanics

    Fastl, T., Tobon Gomez, C., Crozier, W. A., Whitaker, J., Rajani, R., McCarthy, K. P., Sanchez-Quintana, D., Ho, S. Y., O'Neill, M., Plank, G., Bishop, M. J. & Niederer, S. 1 Mar 2017 Computing in Cardiology Conference, CinC 2016. IEEE Computer Society, Vol. 43, p. 225-228 4 p. 7868720

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  16. Accepted/In press
  17. A platform for quantifying atrial structural remodelling

    Razeghi, O., Karim, R., Whitaker, J., Tobon-Gomez, C. & Niederer, S. 2017 In : Computing in Cardiology. 44, p. 1-4 4 p.

    Research output: Contribution to journalConference paper

  18. Accepted/In press
  19. The calcium-frequency response in the rat ventricular myocyte: an experimental and modelling study

    Gattoni, S., Røe, Å. T., Frisk, M., Louch, W. E., Niederer, S. A. & Smith, N. P. 1 Aug 2016 In : The Journal of physiology. 594, 15, p. 4193-4224 32 p.

    Research output: Contribution to journalArticle

  20. The role of myocardial wall thickness in atrial arrhythmogenesis

    Whitaker, J., Rajani, R., Chubb, H., Gabrawi, M., Varela, M., Wright, M., Niederer, S. & O'Neill, M. D. 31 May 2016 In : EUROPACE. 18, 12, p. 1758-1772 15 p.

    Research output: Contribution to journalArticle

  21. Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation

    Augustin, C. M., Neic, A., Liebmann, M., Prassl, A. J., Niederer, S. A., Haase, G. & Plank, G. 15 Jan 2016 In : JOURNAL OF COMPUTATIONAL PHYSICS. 305, p. 622-646 25 p.

    Research output: Contribution to journalArticle

  22. Image-Based Personalization of Cardiac Anatomy for Coupled Electromechanical Modeling

    Crozier, A., Augustin, C. M., Neic, A., Prassl, A. J., Holler, M., Fastl, T. E., Hennemuth, A., Bredies, K., Kuehne, T., Bishop, M. J., Niederer, S. A. & Plank, G. Jan 2016 In : Annals of Biomedical Engineering. 44, 1, p. 58-70

    Research output: Contribution to journalArticle

  23. Predicting Spiral Wave Stability by Personalized Electrophysiology models

    Corrado, C., Whitaker, J., Chubb, H., Williams, S., Wright, M., Gill, J., O'Neill, M. & Niederer, S. 2016 Computing In Cardiology 2016. Murray, A. (ed.). IEEE, Vol. 43, p. 229-232 4 p.

    Research output: Chapter in Book/Report/Conference proceedingConference paper

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