Research output per year
Research output per year
- 42 results
Search results
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2023
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation
Knight, H., Abis, G., Kaur, M., Green, H., Krasemann, S., Hartmann, K., Lynham, S., Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R., Eaton, P. & Rudyk, O., 2 Nov 2023, (Accepted/In press) In: Circulation Research. 133Research output: Contribution to journal › Article › peer-review
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GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration
Dobson, L., Barrell, W., Seraj, Z., Lynham, S., Wu, S-Y., Krause, M. & Liu, K., 10 Aug 2023, (Accepted/In press) In: Cell Reports.Research output: Contribution to journal › Article › peer-review
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2022
Allosteric Regulation of the Soluble Epoxide Hydrolase by Nitro Fatty Acids: a Combined Experimental and Computational Approach: Allosteric regulation of hsEH by nitro fatty acids
Qiu, Q., Abis, G., Mattingly-Peck, F., Lynham, S., Fraternali, F. & Conte, M. R., 15 Sept 2022, In: Journal of Molecular Biology. 434, 17, 167600.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Allosteric regulation of the soluble epoxide hydrolase by nitro fatty acids using a combined experimental and computational approach
Abis, G., Qiu, E., Mattingly-Peck, F., Lynham, S., Fraternali, F. & Conte, M. R., 15 Sept 2022, In: Journal of Molecular Biology. 434, 17Research output: Contribution to journal › Article › peer-review
Open Access -
Database search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes
Mishto, M., Horokhovskyi, Y., Cormican, J. A., Yang, X., Lynham, S., Urlaub, H. & Liepe, J., May 2022, In: Proteomics. 22, 10, 2100226.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)57 Downloads (Pure) -
MdaB and NfrA, Two Novel Reductases Important in the Survival and Persistence of the Major Enteropathogen Campylobacter jejuni
Nasher, F., Taylor, A. J., Elmi, A., Lehri, B., Ijaz, U. Z., Baker, D., Goram, R., Lynham, S., Singh, D., Stabler, R., Kelly, D. J., Gundogdu, O. & Wren, B. W., Jan 2022, In: Journal of Bacteriology. 204, 1, e00421-21.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation
Corsini Madeira, P., Wang, S., Rehman, S., Fenn, K., Sagar, A., Sirovica, S., Cleaver, L., Edwards-Gayle, C., Mastroianni, G., Dorgan, B. J., Sewell, L., Lynham, S., Iuga, D., Franks, W. T., Jarvis, J., Carpenter, G., Curtis, M., Bernado, P., Darbari, V. & Garnett, J., Dec 2022, In: npj Biofilms and Microbiomes. 8, 1, 9.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)81 Downloads (Pure) -
2021
A novel immunoassay for malondialdehyde-conjugated low-density lipoprotein measures dynamic changes in the blood of patients undergoing coronary artery bypass graft surgery
Pandey, S. S., Hartley, A., Caga-Anan, M., Ammari, T., Khan, A. H. A., Nguyen, B. A. V., Kojima, C., Anderson, J., Lynham, S., Johns, M., Haskard, D. O. & Khamis, R. Y., Aug 2021, In: Antioxidants. 10, 8, 1298.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Co-ordinated control of the Aurora B abscission checkpoint by PKCϵ complex assembly, midbody recruitment and retention
Watson, L., Soliman, T. N., Davis, K., Kelly, J., Lockwood, N., Yang, X., Lynham, S., Scott, J. D., Crossland, V., McDonald, N. Q., Mann, D. J., Armstrong, A., Eggert, U. & Parker, P. J., 25 Jun 2021, In: Biochemical Journal. 478, 12, p. 2247-2263 17 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent
Lynham, S., Grundland Freie, F., Puri, N., O'Reilly, N., Mitchell, G., Wells, T., Willcox, M. & Beatson, R., Dec 2021, In: Scientific Reports. 11, 1, 7740.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)61 Downloads (Pure) -
MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation
Betancor Quintana, G. J., Jimenez Guardeno, J., Lynham, S., Antrobus, R., Khan, H., Sobala, A., Dicks, M. & Malim, M., Aug 2021, In: Nature Microbiology. 6, p. 1031–1042Research output: Contribution to journal › Article › peer-review
Open AccessFile71 Downloads (Pure) -
Nucleolin acts as the receptor for C1QTNF4 and supports C1QTNF4-mediated innate immunity modulation
Vester, S. K., Beavil, R. L., Lynham, S., Beavil, A. J., Cunninghame Graham, D. S., McDonnell, J. M. & Vyse, T. J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 100513.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Profiling of: Haemophilus influenzae strain R2866 with carbohydrate-based covalent probes
Metier, C., Dow, J., Wootton, H., Lynham, S., Wren, B. & Wagner, G. K., 14 Jan 2021, In: ORGANIC AND BIOMOLECULAR CHEMISTRY. 19, 2, p. 476-485 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Profiling protein expression in Klebsiella pneumoniae with a carbohydrate-based covalent probe
Metier, C. C., Peng, J., Xu, Y., Wootton, H., Riesi, V., Lynham, S., Zadi, S., Turner, C., Wand, M. E., Mark Sutton, J. & Wagner, G. K., 15 Jan 2021, In: Bioorganic and Medicinal Chemistry. 30, 115900.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Agonists of orally expressed TRP channels stimulate salivary secretion and modify the salivary proteome
Proctor, G., Carpenter, G. & Lynham, S., 1 Oct 2020, In: MOLECULAR AND CELLULAR PROTEOMICS. 19, 10, p. 1664-1676Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)25 Downloads (Pure) -
2019
15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism
Abis, G., Charles, R. L., Kopec, J., Yue, W. W., Atkinson, R. A., Bui, T. T. T., Lynham, S., Popova, S., Sun, Y-B., Fraternali, F., Eaton, P. & Conte, M. R., May 2019, In: Communications Biology. 2, 1, 188.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)138 Downloads (Pure) -
A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease
Ashton, N. J., Nevado-Holgado, A. J., Barber, I. S., Lynham, S., Gupta, V. B., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Schöll, M., Zetterberg, H., Ellis, K. A., Bush, A. I., Rowe, C., Villemagne, V. L., Ames, D., Masters, C. L., Aarsland, D., Powell, J. F., & 3 others, 6 Feb 2019, In: Science Advances. 5, 2, eaau7220.Research output: Contribution to journal › Article › peer-review
Open Access50 Citations (Scopus) -
Blood pressure-lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase
Prysyazhna, O., Wolhuter, K., Switzer, C. H., Santos, C., Yang, X., Lynham, S., Shah, A. M., Eaton, P. & Burgoyne, J., 9 Jul 2019, In: Circulation. 140, 2, p. 126–137 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)222 Downloads (Pure) -
Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase"
Prysyazhna, O., Wolhuter, K., Switzer, C., Santos, C., Yang, X., Lynham, S., Shah, A. M., Eaton, P. & Burgoyne, J. R., 26 Nov 2019, In: Circulation. 140, 22, p. E810-E811Research output: Contribution to journal › Letter › peer-review
Open Access1 Citation (Scopus) -
Venom composition does not vary greatly between different nematocyst types isolated from the primary tentacles of olindias sambaquiensis (Cnidaria: Hydrozoa)
Doonan, L. B., Lynham, S., Quinlan, C., Ibiji, S. C., Winter, C. E., Padilla, G., Jaimes-Becerra, A., Morandini, A. C., Marques, A. C. & Long, A. F., 7 Aug 2019, In: Biological Bulletin. 237, 1, p. 26-35 10 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
2018
Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness
Levy, Y., Ross, J. A., Niglas, M., Snetkov, V., Lynham, S., Liao, C-Y., Puckelwartz, M., Hsu, Y-M., McNally, E., Alsheimer, M., Harridge, S. D. R., Young, S. G., Fong, L. G., Espanol, Y., Lopez-Otin, C., Kennedy, B. K., Lowe, D. A. & Ochala, J., 4 Oct 2018, In: JCI Insight. 3, 19, e120920.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)157 Downloads (Pure) -
2017
Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans
Kumar, A., Bicer, E. M., Pfeffer, P., Monopoli, M. P., Dawson, K. A., Eriksson, J., Edwards, K., Lynham, S., Arno, M., Behndig, A. F., Blomberg, A., Somers, G., Hassall, D., Dailey, L. A., Forbes, B. & Mudway, I., 22 Jun 2017, (E-pub ahead of print) In: Nanomedicine-Nanotechnology Biology And Medicine. 13, 8, p. 2517-2521Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)283 Downloads (Pure) -
Identification of a distinctive phenotype for endocarditis-associated clonal complex 22 MRSA isolates with reduced vancomycin susceptibility
Marbach, H., Boakes, E., Lynham, S., Ward, M., Otter, J. A. & Edgeworth, J. D., May 2017, In: Journal of Medical Microbiology. 66, 5, p. 584-591 8 p., 000470.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Tailoring protein nanomechanics with chemical reactivity
Beedle, A. E. M., Mora, M., Lynham, S., Stirnemann, G. & Garcia-Manyes, S., 6 Jun 2017, In: Nature Communications. 8, 1, p. 1-11 15658.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)157 Downloads (Pure) -
2016
Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly
Westwood, S., Leoni, E., Hye, A., Lynham, S., Khondoker, M. R., Ashton, N., Kiddle, S. J., Baird, A. L., Sainz-Fuertes, R., Leung, R., Graf, J., Hehir, C. T., Baker, D., Cereda, C., Bazenet, C., Ward, M., Thambisetty, M. & Lovestone, S., 10 May 2016, In: JOURNAL OF ALZHEIMERS DISEASE. 52, 2, p. 561-572 12 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Comparative analysis of phenol-soluble modulin production and Galleria mellonella killing by community-associated and healthcare-associated meticillin-resistant Staphylococcus aureus strains
Boakes, E., Marbach, H., Lynham, S., Ward, M., Edgeworth, J. D. & Otter, J. A., Dec 2016, In: Journal of Medical Microbiology. 65, 12, p. 1429-1433 5 p., 000379.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid
Kumar, A., Bicer, E. M., Morgan, A. B., Pfeffer, P., Monopoli, M., Dawson, K. A., Eriksson, J., Edwards, K., Lynham, S., Arno, M., Behndig, A. F., Blomberg, A., Somers, G., Hassall, D., Dailey, L. A., Forbes, B. & Mudway, I. S., 1 May 2016, In: Nanomedicine-Nanotechnology Biology And Medicine. 12, 4, p. 1033–1043Research output: Contribution to journal › Article › peer-review
51 Citations (Scopus) -
N-terminally truncated FOXP1 protein expression and alternate internal foxp1 promoter usage in normal and malignant B cells
Brown, P. J., Gascoyne, D. M., Lyne, L., Spearman, H., Felce, S. L., McFadden, N., Chakravarty, P., Barrans, S., Lynham, S., Calado, D. P., Ward, M. & Banham, A. H., 1 Jan 2016, In: Haematologica. 101, 7, p. 861-871 11 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Plasma biomarkers of neocortical amyloid burden; an in-depth plasma profile using LC-MS
Ashton, N., Nevado-Holgado, A. J., Lynham, S., Ward, M., Gupta, V. B., Chatterjee, P., Gooze, K., Hone, E., Pedrini, S., Laws, S., Rainey-Smith, S., Bush, A., Rowe, C., Villemagne, V. L., Ames, D., Masters, C. L., Lovestone, S., Martins, R. N. & Hye, A., 2016, In: Alzheimer's & Dementia. 12, 7, p. 878 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
Beedle, A. E. M., Lynham, S. & Garcia-Manyes, S., 22 Aug 2016, In: Nature Communications. 7, 12490.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Citations (Scopus)246 Downloads (Pure) -
2013
Axonal growth towards Xenopus skin in vitro is mediated by matrix metalloproteinase activity
Tonge, D., Zhu, N., Lynham, S., Leclere, P., Snape, A., Brewer, A., Schlomann, U., Ferdous, T., Tennyson, C., Bartsch, J. W., Ward, M. & Pizzey, J., Feb 2013, In: European Journal of Neuroscience. 37, 4, p. 519-531 13 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau and are Activated in Tangle-bearing Neurons in Alzheimer's Disease
Tavares, I. A., Touma, D., Lynham, S., Troakes, C., Schober, M., Causevic, M., Garg, R., Noble, W., Killick, R., Bodi, I., Hanger, D. P. & Morris, J. D. H., 24 May 2013, In: Journal of Biological Chemistry. 288, 21, p. 15418-15429 12 p.Research output: Contribution to journal › Article › peer-review
45 Citations (Scopus) -
2012
Plasma transthyretin as a candidate marker for Alzheimer's disease
Velayudhan, L., Killick, R., Hye, A., Kinsey, A., Güntert, A., Lynham, S., Ward, M., Leung, R., Lourdusamy, A., To, A. W. M., Powell, J. & Lovestone, S., 2012, In: JOURNAL OF ALZHEIMERS DISEASE. 28, 2, p. 369-75 7 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Citations (Scopus) -
Wnt3a induces exosome secretion from primary cultured rat microglia
Hooper, C., Sainz-Fuertes, R., Lynham, S., Hye, A., Killick, R., Warley, A., Bolondi, C., Pocock, J. & Lovestone, S., 23 Nov 2012, In: BMC NEUROSCIENCE. 13, 17 p., 144.Research output: Contribution to journal › Article › peer-review
83 Citations (Scopus) -
2010
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L-O., Westman, E., Kinsey, A., Güntert, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D. R., Williams, R. J., & 27 others, Jul 2010, In: Archives of General Psychiatry. 67, 7, p. 739-48 10 p.Research output: Contribution to journal › Article › peer-review
332 Citations (Scopus) -
Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition
Williamson, R., Thompson, A. J., Abu, M., Hye, A., Usardi, A., Lynham, S., Anderton, B. H. & Hanger, D. P., 22 Sept 2010, In: BMC NEUROSCIENCE. 11, 120.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Proteome-Based Plasma Markers of Brain Amyloid-beta Deposition in Non-Demented Older Individuals
Thambisetty, M., Tripaldi, R., Riddoch-Contreras, J., Hye, A., An, Y., Campbell, J., Sojkova, J., Kinsey, A., Lynham, S., Zhou, Y., Ferrucci, L., Wong, D. F., Lovestone, S. & Resnick, S. M., 2010, In: JOURNAL OF ALZHEIMERS DISEASE. 22, 4, p. 1099 - 1109 11 p.Research output: Contribution to journal › Article › peer-review
63 Citations (Scopus) -
2008
Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins
Tonge, D., Chan, K., Zhu, N., Panjwani, A., Arno, M., Lynham, S., Ward, M., Snape, A. & Pizzey, J., 1 Aug 2008, In: Journal of Cell Science. 121, 15, p. 2565 - 2577 13 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
2007
Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules
Gallois-Montbrun, S., Kramer, B., Swanson, CM., Byers, H., Lynham, S., Ward, M. & Malim, MH., Mar 2007, In: Journal of Virology. 81, 5, p. 2165 - 2178 14 p.Research output: Contribution to journal › Article › peer-review
219 Citations (Scopus) -
Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers
Lovestone, S., Guntert, A., Hye, A., Lynham, S., Thambisetty, M. & Ward, M., Apr 2007, In: EXPERT REVIEW OF PROTEOMICS. 4, 2, p. 227 - 238 12 p.Research output: Contribution to journal › Literature review › peer-review
43 Citations (Scopus) -
Purification and identification of the STAT5 protease in myeloid cells
Schuster, B., Hendry, L., Byers, H., Lynham, S. F., Ward, M. A. & John, S., 15 May 2007, In: Biochemical Journal. 404, 1, p. 81 - 87 7 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2006
Proteome-based plasma biomarkers for Alzheimer's disease
Hye, A., Lynham, S., Thambisetty, M., Causevic, M., Campbell, J., Byers, H. L., Hooper, C., Rijsdijk, F., Tabrizi, S. J., Banner, S., Shaw, C. E., Foy, C., Poppe, M., Archer, N., Hamilton, G., Powell, J., Brown, R. G., Sham, P., Ward, M. & Lovestone, S., Nov 2006, In: Brain. 129, 11, p. 3042 - 3050 9 p.Research output: Contribution to journal › Article › peer-review
398 Citations (Scopus)