Steven Lynham

2024

A Versatile Virus-Mimetic Engineering Approach for Concurrent Protein Nanocage Surface-Functionalization and Cargo Encapsulation

Sheng, Y., Chen, Z., Cherrier, M. V., Martin, L., Bui, T. T. T., Li, W., Lynham, S., Nicolet, Y. & Ebrahimi, K. H., 1 Aug 2024, In: Small. 20, 31, 2310913.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Siew, K., Nestler, K. A., Nelson, C., D'Ambrosio, V., Zhong, C., Li, Z., Grillo, A., Wan, E. R., Patel, V., Overbey, E., Kim, J., Yun, S., Vaughan, M. B., Cheshire, C., Cubitt, L., Broni-Tabi, J., Al-Jaber, M. Y., Boyko, V., Meydan, C., Barker, P., & 85 othersArif, S., Afsari, F., Allen, N., Al-Maadheed, M., Altinok, S., Bah, N., Border, S., Brown, A. L., Burling, K., Cheng-Campbell, M., Colón, L. M., Degoricija, L., Figg, N., Finch, R., Foox, J., Faridi, P., French, A., Gebre, S., Gordon, P., Houerbi, N., Valipour Kahrood, H., Kiffer, F. C., Klosinska, A. S., Kubik, A., Lee, H-C., Li, Y., Lucarelli, N., Marullo, A. L., Matei, I., McCann, C. M., Mimar, S., Naglah, A., Nicod, J., O'Shaughnessy, K. M., Oliveira, L. C. D., Oswalt, L., Patras, L. I., Lai Polo, S-H., Rodríguez-Lopez, M., Roufosse, C., Sadeghi-Alavijeh, O., Sanchez-Hodge, R., Paul, A. S., Schittenhelm, R. B., Schweickart, A., Scott, R. T., Choy Lim Kam Sian, T. C., da Silveira, W. A., Slawinski, H., Snell, D., Sosa, J., Saravia-Butler, A. M., Tabetah, M., Tanuwidjaya, E., Walker-Samuel, S., Yang, X., Yasmin, N. V., Zhang, H., Godovac-Zimmermann, J., Sarder, P., Sanders, L. M., Costes, S. V., Campbell, R. A. A., Karouia, F., Mohamed-Alis, V., Rodriques, S., Lynham, S., Steele, J. R., Baranzini, S., Fazelinia, H., Dai, Z., Uruno, A., Shiba, D., Yamamoto, M., A C Almeida, E., Blaber, E., Schisler, J. C., Eisch, A. J., Muratani, M., Zwart, S. R., Smith, S. M., Galazka, J. M., Mason, C. E., Beheshti, A. & Walsh, S. B., 11 Jun 2024, In: Nature Communications. 15, 1, p. 4923 4923.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness

Faleeva, M., Ahmad, S., Theofilatos, K., Lynham, S., Watson, G., Whitehead, M., Marhuenda, E., Iskratsch, T., Cox, S. & Shanahan, C. M., 2 Feb 2024, In: Circulation Research. 134, 3, p. 307-324 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

2023

Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation

Knight, H., Abis, G., Kaur, M., Green, H. L. H., Krasemann, S., Hartmann, K., Lynham, S., Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R. T., Eaton, P. & Rudyk, O., 8 Dec 2023, In: Circulation Research. 133, 12, p. 966-988 23 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation

Knight, H., Abis, G., Kaur, M., Green, H., Krasemann, S., Hartmann, K., Lynham, S., Clark, J., Zhao, L., Ruppert, C., Weiss, A., Schermuly, R., Eaton, P. & Rudyk, O., 2 Nov 2023, (Accepted/In press) In: Circulation Research. 133

Research output: Contribution to journal › Article › peer-review

GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

Dobson, L., Barrell, W., Seraj, Z., Lynham, S., Wu, S-Y., Krause, M. & Liu, K., 10 Aug 2023, (Accepted/In press) In: Cell Reports.

Research output: Contribution to journal › Article › peer-review

2022

Allosteric Regulation of the Soluble Epoxide Hydrolase by Nitro Fatty Acids: a Combined Experimental and Computational Approach: Allosteric regulation of hsEH by nitro fatty acids

Qiu, Q., Abis, G., Mattingly-Peck, F., Lynham, S., Fraternali, F. & Conte, M. R., 15 Sept 2022, In: Journal of Molecular Biology. 434, 17, 167600.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Allosteric regulation of the soluble epoxide hydrolase by nitro fatty acids using a combined experimental and computational approach

Abis, G., Qiu, E., Mattingly-Peck, F., Lynham, S., Fraternali, F. & Conte, M. R., 15 Sept 2022, In: Journal of Molecular Biology. 434, 17

Research output: Contribution to journal › Article › peer-review

Open Access

Database search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes

Mishto, M., Horokhovskyi, Y., Cormican, J. A., Yang, X., Lynham, S., Urlaub, H. & Liepe, J., May 2022, In: Proteomics. 22, 10, 2100226.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

97 Downloads (Pure)

MdaB and NfrA, Two Novel Reductases Important in the Survival and Persistence of the Major Enteropathogen Campylobacter jejuni

Nasher, F., Taylor, A. J., Elmi, A., Lehri, B., Ijaz, U. Z., Baker, D., Goram, R., Lynham, S., Singh, D., Stabler, R., Kelly, D. J., Gundogdu, O. & Wren, B. W., Jan 2022, In: Journal of Bacteriology. 204, 1, e00421-21.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation

Corsini Madeira, P., Wang, S., Rehman, S., Fenn, K., Sagar, A., Sirovica, S., Cleaver, L., Edwards-Gayle, C., Mastroianni, G., Dorgan, B. J., Sewell, L., Lynham, S., Iuga, D., Franks, W. T., Jarvis, J., Carpenter, G., Curtis, M., Bernado, P., Darbari, V. & Garnett, J., Dec 2022, In: npj Biofilms and Microbiomes. 8, 1, 9.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

122 Downloads (Pure)

2021

A novel immunoassay for malondialdehyde-conjugated low-density lipoprotein measures dynamic changes in the blood of patients undergoing coronary artery bypass graft surgery

Pandey, S. S., Hartley, A., Caga-Anan, M., Ammari, T., Khan, A. H. A., Nguyen, B. A. V., Kojima, C., Anderson, J., Lynham, S., Johns, M., Haskard, D. O. & Khamis, R. Y., Aug 2021, In: Antioxidants. 10, 8, 1298.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Co-ordinated control of the Aurora B abscission checkpoint by PKCϵ complex assembly, midbody recruitment and retention

Watson, L., Soliman, T. N., Davis, K., Kelly, J., Lockwood, N., Yang, X., Lynham, S., Scott, J. D., Crossland, V., McDonald, N. Q., Mann, D. J., Armstrong, A., Eggert, U. & Parker, P. J., 25 Jun 2021, In: Biochemical Journal. 478, 12, p. 2247-2263 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent

Lynham, S., Grundland Freie, F., Puri, N., O'Reilly, N., Mitchell, G., Wells, T., Willcox, M. & Beatson, R., Dec 2021, In: Scientific Reports. 11, 1, 7740.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

101 Downloads (Pure)

MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation

Betancor Quintana, G. J., Jimenez Guardeno, J., Lynham, S., Antrobus, R., Khan, H., Sobala, A., Dicks, M. & Malim, M., Aug 2021, In: Nature Microbiology. 6, p. 1031–1042

Research output: Contribution to journal › Article › peer-review

Open Access

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106 Downloads (Pure)

Nucleolin acts as the receptor for C1QTNF4 and supports C1QTNF4-mediated innate immunity modulation

Vester, S. K., Beavil, R. L., Lynham, S., Beavil, A. J., Cunninghame Graham, D. S., McDonnell, J. M. & Vyse, T. J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 100513.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Profiling of: Haemophilus influenzae strain R2866 with carbohydrate-based covalent probes

Metier, C., Dow, J., Wootton, H., Lynham, S., Wren, B. & Wagner, G. K., 14 Jan 2021, In: ORGANIC AND BIOMOLECULAR CHEMISTRY. 19, 2, p. 476-485 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Profiling protein expression in Klebsiella pneumoniae with a carbohydrate-based covalent probe

Metier, C. C., Peng, J., Xu, Y., Wootton, H., Riesi, V., Lynham, S., Zadi, S., Turner, C., Wand, M. E., Mark Sutton, J. & Wagner, G. K., 15 Jan 2021, In: Bioorganic and Medicinal Chemistry. 30, 115900.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Agonists of orally expressed TRP channels stimulate salivary secretion and modify the salivary proteome

Proctor, G., Carpenter, G. & Lynham, S., 1 Oct 2020, In: MOLECULAR AND CELLULAR PROTEOMICS. 19, 10, p. 1664-1676

Research output: Contribution to journal › Article › peer-review

Open Access

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11 Citations (Scopus)

39 Downloads (Pure)

2019

15-deoxy-Δ^12,14-Prostaglandin J₂ inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism

Abis, G., Charles, R. L., Kopec, J., Yue, W. W., Atkinson, R. A., Bui, T. T. T., Lynham, S., Popova, S., Sun, Y-B., Fraternali, F., Eaton, P. & Conte, M. R., May 2019, In: Communications Biology. 2, 1, 188.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

184 Downloads (Pure)

A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease

Ashton, N. J., Nevado-Holgado, A. J., Barber, I. S., Lynham, S., Gupta, V. B., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Schöll, M., Zetterberg, H., Ellis, K. A., Bush, A. I., Rowe, C., Villemagne, V. L., Ames, D., Masters, C. L., Aarsland, D., Powell, J. F., & 3 othersLovestone, S., Martins, R. N. & Hye, A., 6 Feb 2019, In: Science Advances. 5, 2, eaau7220.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Citations (Scopus)

Blood pressure-lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase

Prysyazhna, O., Wolhuter, K., Switzer, C. H., Santos, C., Yang, X., Lynham, S., Shah, A. M., Eaton, P. & Burgoyne, J., 9 Jul 2019, In: Circulation. 140, 2, p. 126–137 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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62 Citations (Scopus)

284 Downloads (Pure)

Venom composition does not vary greatly between different nematocyst types isolated from the primary tentacles of olindias sambaquiensis (Cnidaria: Hydrozoa)

Doonan, L. B., Lynham, S., Quinlan, C., Ibiji, S. C., Winter, C. E., Padilla, G., Jaimes-Becerra, A., Morandini, A. C., Marques, A. C. & Long, A. F., 7 Aug 2019, In: Biological Bulletin. 237, 1, p. 26-35 10 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

2018

Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

Levy, Y., Ross, J. A., Niglas, M., Snetkov, V., Lynham, S., Liao, C-Y., Puckelwartz, M., Hsu, Y-M., McNally, E., Alsheimer, M., Harridge, S. D. R., Young, S. G., Fong, L. G., Espanol, Y., Lopez-Otin, C., Kennedy, B. K., Lowe, D. A. & Ochala, J., 4 Oct 2018, In: JCI Insight. 3, 19, e120920.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

191 Downloads (Pure)

2017

Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans

Kumar, A., Bicer, E. M., Pfeffer, P., Monopoli, M. P., Dawson, K. A., Eriksson, J., Edwards, K., Lynham, S., Arno, M., Behndig, A. F., Blomberg, A., Somers, G., Hassall, D., Dailey, L. A., Forbes, B. & Mudway, I., 22 Jun 2017, (E-pub ahead of print) In: Nanomedicine-Nanotechnology Biology And Medicine. 13, 8, p. 2517-2521

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

338 Downloads (Pure)

Identification of a distinctive phenotype for endocarditis-associated clonal complex 22 MRSA isolates with reduced vancomycin susceptibility

Marbach, H., Boakes, E., Lynham, S., Ward, M., Otter, J. A. & Edgeworth, J. D., May 2017, In: Journal of Medical Microbiology. 66, 5, p. 584-591 8 p., 000470.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Tailoring protein nanomechanics with chemical reactivity

Beedle, A. E. M., Mora, M., Lynham, S., Stirnemann, G. & Garcia-Manyes, S., 6 Jun 2017, In: Nature Communications. 8, 1, p. 1-11 15658.

Research output: Contribution to journal › Article › peer-review

Open Access

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23 Citations (Scopus)

184 Downloads (Pure)

2016

Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly

Westwood, S., Leoni, E., Hye, A., Lynham, S., Khondoker, M. R., Ashton, N., Kiddle, S. J., Baird, A. L., Sainz-Fuertes, R., Leung, R., Graf, J., Hehir, C. T., Baker, D., Cereda, C., Bazenet, C., Ward, M., Thambisetty, M. & Lovestone, S., 10 May 2016, In: JOURNAL OF ALZHEIMERS DISEASE. 52, 2, p. 561-572 12 p.

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Comparative analysis of phenol-soluble modulin production and Galleria mellonella killing by community-associated and healthcare-associated meticillin-resistant Staphylococcus aureus strains

Boakes, E., Marbach, H., Lynham, S., Ward, M., Edgeworth, J. D. & Otter, J. A., Dec 2016, In: Journal of Medical Microbiology. 65, 12, p. 1429-1433 5 p., 000379.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid

Kumar, A., Bicer, E. M., Morgan, A. B., Pfeffer, P., Monopoli, M., Dawson, K. A., Eriksson, J., Edwards, K., Lynham, S., Arno, M., Behndig, A. F., Blomberg, A., Somers, G., Hassall, D., Dailey, L. A., Forbes, B. & Mudway, I. S., 1 May 2016, In: Nanomedicine-Nanotechnology Biology And Medicine. 12, 4, p. 1033–1043

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

N-terminally truncated FOXP1 protein expression and alternate internal foxp1 promoter usage in normal and malignant B cells

Brown, P. J., Gascoyne, D. M., Lyne, L., Spearman, H., Felce, S. L., McFadden, N., Chakravarty, P., Barrans, S., Lynham, S., Calado, D. P., Ward, M. & Banham, A. H., 1 Jan 2016, In: Haematologica. 101, 7, p. 861-871 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

Beedle, A. E. M., Lynham, S. & Garcia-Manyes, S., 22 Aug 2016, In: Nature Communications. 7, 12490.

Research output: Contribution to journal › Article › peer-review

Open Access

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54 Citations (Scopus)

410 Downloads (Pure)

2013

Axonal growth towards Xenopus skin in vitro is mediated by matrix metalloproteinase activity

Tonge, D., Zhu, N., Lynham, S., Leclere, P., Snape, A., Brewer, A., Schlomann, U., Ferdous, T., Tennyson, C., Bartsch, J. W., Ward, M. & Pizzey, J., Feb 2013, In: European Journal of Neuroscience. 37, 4, p. 519-531 13 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau and are Activated in Tangle-bearing Neurons in Alzheimer's Disease

Tavares, I. A., Touma, D., Lynham, S., Troakes, C., Schober, M., Causevic, M., Garg, R., Noble, W., Killick, R., Bodi, I., Hanger, D. P. & Morris, J. D. H., 24 May 2013, In: Journal of Biological Chemistry. 288, 21, p. 15418-15429 12 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

2012

Plasma transthyretin as a candidate marker for Alzheimer's disease

Velayudhan, L., Killick, R., Hye, A., Kinsey, A., Güntert, A., Lynham, S., Ward, M., Leung, R., Lourdusamy, A., To, A. W. M., Powell, J. & Lovestone, S., 2012, In: JOURNAL OF ALZHEIMERS DISEASE. 28, 2, p. 369-75 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Citations (Scopus)

Wnt3a induces exosome secretion from primary cultured rat microglia

Hooper, C., Sainz-Fuertes, R., Lynham, S., Hye, A., Killick, R., Warley, A., Bolondi, C., Pocock, J. & Lovestone, S., 23 Nov 2012, In: BMC NEUROSCIENCE. 13, 17 p., 144.

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

2010

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L-O., Westman, E., Kinsey, A., Güntert, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D. R., Williams, R. J., & 27 othersSharp, S. I., Mitchelmore, C., Tunnard, C., Leung, R., Foy, C., O'Brien, D., Breen, G., Furney, S. J., Ward, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Hodges, A., Murphy, D. G. M., Parkins, S., Richardson, J. C., Resnick, S. M., Ferrucci, L., Wong, D. F., Zhou, Y., Muehlboeck, S., Evans, A., Francis, P. T., Spenger, C. & Lovestone, S., Jul 2010, In: Archives of General Psychiatry. 67, 7, p. 739-48 10 p.

Research output: Contribution to journal › Article › peer-review

346 Citations (Scopus)

Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition

Williamson, R., Thompson, A. J., Abu, M., Hye, A., Usardi, A., Lynham, S., Anderton, B. H. & Hanger, D. P., 22 Sept 2010, In: BMC NEUROSCIENCE. 11, 120.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Proteome-Based Plasma Markers of Brain Amyloid-beta Deposition in Non-Demented Older Individuals

Thambisetty, M., Tripaldi, R., Riddoch-Contreras, J., Hye, A., An, Y., Campbell, J., Sojkova, J., Kinsey, A., Lynham, S., Zhou, Y., Ferrucci, L., Wong, D. F., Lovestone, S. & Resnick, S. M., 2010, In: JOURNAL OF ALZHEIMERS DISEASE. 22, 4, p. 1099 - 1109 11 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

2008

Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins

Tonge, D., Chan, K., Zhu, N., Panjwani, A., Arno, M., Lynham, S., Ward, M., Snape, A. & Pizzey, J., 1 Aug 2008, In: Journal of Cell Science. 121, 15, p. 2565 - 2577 13 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

2007

Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules

Gallois-Montbrun, S., Kramer, B., Swanson, CM., Byers, H., Lynham, S., Ward, M. & Malim, MH., Mar 2007, In: Journal of Virology. 81, 5, p. 2165 - 2178 14 p.

Research output: Contribution to journal › Article › peer-review

229 Citations (Scopus)

Purification and identification of the STAT5 protease in myeloid cells

Schuster, B., Hendry, L., Byers, H., Lynham, S. F., Ward, M. A. & John, S., 15 May 2007, In: Biochemical Journal. 404, 1, p. 81 - 87 7 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

2006

Proteome-based plasma biomarkers for Alzheimer's disease

Hye, A., Lynham, S., Thambisetty, M., Causevic, M., Campbell, J., Byers, H. L., Hooper, C., Rijsdijk, F., Tabrizi, S. J., Banner, S., Shaw, C. E., Foy, C., Poppe, M., Archer, N., Hamilton, G., Powell, J., Brown, R. G., Sham, P., Ward, M. & Lovestone, S., Nov 2006, In: Brain. 129, 11, p. 3042 - 3050 9 p.

Research output: Contribution to journal › Article › peer-review

411 Citations (Scopus)

Steven Lynham

Research output

Search results