This laboratory has established models of hypertension, peripheral blood flow and inflammation, of relevance to cardiovascular disease (especially hypertension) and inflammatory disease (especially arthritis). Studies involve the investigation of transgenic models in vivo and ex vivo. Specifically we are interested in the role of the TRPV1 and TRPA1 channels and of a range of regulatory peptides including CGRP. We investigate their expression at gene and protein levels and their activity and localisation in a range of cell and tissue based models.