Suresh Victor

Dr

    • SE1 7EH

      United Kingdom

    • 1258
      Citations

    Personal profile

    Research interests (short)

    My research focuses on improving the quality of clinical care and outcomes of sick newborn babies by developing new treatment strategies. 

    Research interests

    The goal of my research programme is to repurpose and test in the clinic a variety of neuroprotective treatments that have reached sufficient proof of efficacy in animal and experimental models of neonatal brain injury.

    Prematurity accounts for 11% of all births, and is the leading global cause of death and disability under 5 years of age. All forms of cerebral palsy are seen in preterm children. Over 30% of survivors following preterm birth experience neurocognitive and socio-emotional problems from early life lasting into adulthood. Psychiatric disorders are present in around 25% of preterm adolescentsPrematurity leads to the loss of 75 million disability adjusted life years per annum worldwide.  

    In the term infant, brain injury is most commonly due to hypoxia-ischaemia during labour. Hypoxic ischemic encephalopathy (HIE) occurs in 1.5 to 2.5 per 1000 live births in high income countries. However, 99% of the disease burden is in low and middle income countries. There is an urgent need to develop treatment strategies which supplement the protective effect of therapeutic hypothermia in high income countries and is independently safe, effective and acceptable in low and middle income countries.  

    I am the Chief Investigator of a phase1, randomised placebo controlled, single ascending dose trial to evaluate the safety, tolerability, and pharmacokinetics of cannabidiol in conjunction with hypothermia in neonates with moderate or severe hypoxic ischemic encephalopathy with commercial sponsorship. 

    I have developed a new liquid preparation of a licensed drug after extensive formulation studies in collaboration with industry and pharmaceutical manufacturing units. This work is being funded by MRC Impact Accelaration Award. Pre-clinical studies of this treatment strategy have already shown promising results. Early phase clinical trials are being planned.

    In a sustained translational research programme, other neuroprotective agents are being developed for hypoxic ischemic encephalopathy with external collaborators. This work is being funded by MRC DPFS. 

    The bulk of the world's neonatal mortality and morbidity exists in low and middle income countries with limited access to neonatal intensive care facilities. A key objective of my research programme, is to ensure that treatment strategies being developed can also be implemented world-wide. 

    I have considerable experience in conducting randomised trials in newborn babies. I have been the Chief Investigator of a multi-centre randomised trial of non-invasive ventilation in prematurity. I have also been in the trial management group of clinical trials on thyroxine supplementation and skin-care in newborn babies. 

    Biographical details

    Dr. Suresh Victor joined King's College London in August 2016. Prior to this he was worked as Senior Lecturer and Honorary Consultant Neonatologist at University of Manchester. He completed his CCT in Neonatal Medicine in 2007. He was awarded a PhD for his thesis on 'Cerebral electrical activity and cerebral fractional oxygen extraction in human preterm newborn infants' by University of Liverpool in 2007. 

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

    Education/Academic qualification

    Cerebral haemodynamics, Doctor of Medicine, Cerebral electrical activity and cerebral fractional oxygen extraction in human preterm newborn infants. , University of Liverpool

    1 Sept 20024 Jul 2007

    Award Date: 4 Jul 2007

    External positions

    Honorary Consultant Neonatologist, GSTT Guy's and St Thomas' NHS Foundation Trust

    15 Aug 2016 → …

    Keywords

    • RJ101 Child Health. Child health services
    • Neonatology
    • Brain
    • Neurophysiology
    • Haemodynamics

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