The major research interests of our lab are to understand (a) how the liver generates in utero and (b) how it regenerates in adulthood (both in homeostasis and disease), with particularly interest in the interplay between intrinsic and extrinsic factors regulating these processes. Greater understanding of these areas will be used to design novel therapeutic strategies such as cell-based therapy to address the massively increasing burden of human liver failure. Key technologies employed include induced pluripotent stem cells, 3-dimensional cell culture, gene targeting and animal models of human liver disease.

I trained clinically at Imperial College School of Medicine (St Mary’s) and in science at the University of Cambridge, where I went on to complete higher specialist training in Gastroenterology & Hepatology as a Lecturer in the Department of Medicine. I was then awarded an MRC Clinician Scientist Fellowship and moved to join the Centre for Stem Cells and Regenerative Medicine at KCL as a Senior Lecturer. My clinical work is based at the Institute of Liver Studies, King’s College Hospital, where I am an Honorary Consultant.
 
My contributions to the stem cell and liver fields have been recognised via several awards including the American Liver Association Fellows’ Prize, the British Liver Association’s Sheila Sherlock Prize and the Academy of Medical Sciences UK Young Investigator award. My research also led to the spin out of a biotech company in collaboration with colleagues at the University of Cambridge (DefiniGen).