Personal profile
Research interests
Thalia C. Eley is Professor of Developmental Behavioural Genetics at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London. She directs the Emotional Development, Intervention and Treatment (EDIT) lab, and her work focuses on the interplay between genetic and environmental factors in the development and treatment of anxiety and depression.
Her work is highly interdisciplinary using both the twin design and molecular genetic approaches, and drawing on cognitive, clinical and developmental psychology. She has written over 120 empirical papers and received numerous awards including the Spearman Medal from the British Psychological Society, the Lilly-Molecular Psychiatry Award, and most recently the James Shields Lifetime Achievement Award from the International Society for Twin Studies. She is one of the Chairs of the Psychiatric Genomics Consortium Anxiety Group and is Deputy Director of the Twins Early Development Study (TEDS).
She is particularly interested in finding ways in which genetic approaches can inform psychological practise as well as theory. Using molecular genetics she is exploring the role of specific genetic markers in the development of anxiety and depression, and as predictors of psychological therapies response for these conditions. With her close colleague Dr Gerome Breen, head of the NIHR Maudsley BioResource centre she is leading the new Genetics Links to Anxiety and Depression (GLAD) Study. You can watch the two of them describing the purpose of this study here, and can watch an animation about the study here. She is particularly excited about this area of work as it has the potential to be useful in making clinical decisions.
Research interests (short)
I run the Emotional Development Intervention and Treatment Lab (EDIT Lab) at KCL. I am interested in the reasons why people differ in how they respond to life's experiences. I am especially curious about how genetic factors are involved in the development of emotional symptoms. At present we are exploring two major themes within the group.
First, we are recruiting very large samples in order to explore genetic influences on anxiety, depression and treatment outcomes. With my close colleague Dr Gerome Breen I have just launched a major new initiative called the Genetic Links to Anxiety and Depression (GLAD) study, which forms part of the National BioResource for Mental Health. You can hear us talking about the study here, and can watch an animation about the study here.
Second, I am really interested in why anxiety and depression tend to run in families, and whether this is due to sharing home life or whether it is due to sharing genes. I am Deputy Director and Director Elect of the Twins Early Development Study (TEDS), which is the largest longitudinal twin birth cohort in the UK. As our twins reach their mid-twenties we are particualrly excited about recruiting the next generation into the Children of TEDS (CoTEDS) Study.
Education/Academic qualification
Doctor of Philosophy, Aetiology of emotional symptoms in childhood and adolescence: depression and anxiety in twins, UCL University College London
Award Date: 1 Jan 1996
Bachelor of Arts, University of Cambridge
Award Date: 1 Jan 1992
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 1 No Poverty
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 5 Gender Equality
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SDG 7 Affordable and Clean Energy
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 10 Reduced Inequalities
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SDG 12 Responsible Consumption and Production
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SDG 16 Peace, Justice and Strong Institutions
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Collaborations and top research areas from the last five years
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Chronotype and psychopathology: insights from a genetically informative design
Madrid-Valero, J. J., Ordoñana, J. R., Eley, T. & Gregory, A. M., 31 Mar 2026, In: Sleep. 49, 3, zsaf231.Research output: Contribution to journal › Article
Open AccessFile4 Downloads (Pure) -
Computational modelling reveals slower safety learning and threat extinction are associated with higher anxiety severity in remote fear conditioning
Kerr, T., Purves, K. L., McGregor, T., Craske, M. G., Barry, T., Lester, K. J., Constantinou, E., Sun, M., Robinson, O. & Eley, T., 21 Jan 2026, In: Computational Psychiatry. 10, 1, p. 18-35 18 p.Research output: Contribution to journal › Article
Open AccessFile40 Downloads (Pure) -
Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder
ter Kuile, A. R., Mitchell, B. L., Lee, S.-H., Morneau-Vaillancourt, G., Skelton, M., Coleman, J., Davies, H. L., Mundy, J., Peel, A. J., Hübel, C., Davies, M. R., Fürtjes, A. E., Ahmad, Z., Lin, Y., Adey, B. N., McGregor, T., Zvrskovec, J., Hotopf, M., Kalsi, G. & Hirsch, C. & 2 others, , 22 Apr 2026, (Accepted/In press) In: Molecular Psychiatry.Research output: Contribution to journal › Article
Open AccessFile6 Downloads (Pure) -
Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry
Skelton, M., Mitchell, B. L., Assary, E., Li, D., Morneau-Vaillancourt, G., Murphy, A. E., ter Kuile, A. R., Wang, R., Adams, M., Byrne, E. M., Corfield, E., Grimes, P. Z., Hannigan, L., Jihua, H., Kõiv, K., Kwong, A. S. F., Papiol, S., Johanne H, P., Pistis, G. & Castelao, E. & 4 others, , 13 Apr 2026, (Accepted/In press) In: Nature Human Behaviour.Research output: Contribution to journal › Article
Open AccessFile22 Downloads (Pure) -
Internalising Problems and Self-reported BMI/Physical Health: Correlated Genetic and Environmental Influences Versus Probable Causal Mechanisms
Oginni, O., Morneau-Vaillancourt, G., Peel, A. J., Assary, E., Palaiologou, E., Lockhart, C., Gregory, A. M., Zavos, H., Hotopf, M. & Eley, T., 1 Feb 2026, In: Journal of Affective Disorders. 394, 120538.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure)
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MHG-GLAD: The Mental Health Goals Omics Project (MHG Omics): A UK Multi-Omics Infrastructure and Resource for Mood Disorders
Breen, G. (Primary Investigator), Coleman, J. (Co-Investigator), Cummins, N. (Co-Investigator), Eley, T. (Co-Investigator), Herle, M. (Co-Investigator) & Vassos, E. (Co-Investigator)
1/12/2025 → 31/03/2030
Project: Research
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TOPS: Discovering therapeutic mechanisms and predicting psychological treatment outcome: towards stratified interventions for anxiety
Eley, T. (Primary Investigator), Breen, G. (Co-Investigator), Carr, E. (Co-Investigator), Hirsch, C. (Co-Investigator) & Pollitt, A. (Co-Investigator)
1/01/2025 → 31/12/2030
Project: Research
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iCASE: Personalising cognitive behavioural therapy for anxiety: from discovery to impact
Eley, T. (Primary Investigator) & Carr, E. (Co-Investigator)
1/10/2024 → 30/09/2028
Project: Research
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Identifying modifiable causes and consequences of youth mental health
Eley, T. (Primary Investigator)
1/01/2024 → 31/12/2028
Project: Research
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Cognitive and genetic mechanisms underlying fear learning and extinction
Eley, T. (Primary Investigator)
1/10/2022 → 30/09/2026
Project: Research
Activities
- 1 Editorial activity
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Journal of Child Psychiatry & Psychology (Journal)
Eley, T. (Editor)
2003 → 2008Activity: Publication peer-review and editorial work › Editorial activity
Datasets
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Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders
Munafo, M., Coleman, J., Reed, Z., Lester, K., Keers, R., Gerome Breen & Eley, T., University of Bristol, 5 Nov 2019
DOI: 10.5523/bris.13l8yadatwq602lusa9g9ss786
Dataset
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Summary statistics from - 'A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders' Cite Download all (1.24 GB) Share Embed + Collect
Rayner, C., Eley, T. & Breen, G., King's College London, 21 May 2019
DOI: 10.18742/RDM01-466, https://kcl.figshare.com/articles/dataset/Summary_statistics_from_-_A_genome-wide_association_meta-analysis_of_prognostic_outcomes_following_cognitive_behavioural_therapy_in_individuals_with_anxiety_and_depressive_disorders_/16473858
Dataset