King's College London

Research portal

Dr Thomas Eykyn

  1. Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice

    Aksentijević, D., Zervou, S., Eykyn, T. R., McAndrew, D. J., Wallis, J., Schneider, J. E., Neubauer, S. & Lygate, C. A., 21 Jan 2020, In : Frontiers in Physiology. 10, 1535.

    Research output: Contribution to journalArticle

  2. Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue

    Faulkes, C. G., Eykyn, T. R. & Aksentijevic, D., 1 Nov 2019, In : BIOLOGY LETTERS. 15, 11, 20190710.

    Research output: Contribution to journalArticle

  3. Is there a causal link between intracellular na elevation and metabolic remodelling in cardiac hypertrophy?

    Aksentijevic, D., O’Brien, B. A., Eykyn, T. R. & Shattock, M. J., 3 Jul 2018, In : Biochemical Society Transactions. 46, 4, p. 817-827 11 p.

    Research output: Contribution to journalReview article

  4. Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion

    Whittington, H. J., Ostrowski, P. J., McAndrew, D. J., Cao, F., Shaw, A., Eykyn, T. R., Lake, H. A., Tyler, J., Schneider, J. E., Neubauer, S., Zervou, S. & Lygate, C. A., 1 May 2018, In : Cardiovascular Research. 114, 6, p. 858-869 12 p.

    Research output: Contribution to journalArticle

  5. Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

    Kavanagh Williamson, M., Coombes, N., Juszczak, F., Athanasopoulos, M., Khan, M., Eykyn, T., Srenathan, U., Taams, L., Dias Zeidler, J., Da Poian, A. & Huthoff, H., 7 Mar 2018, In : Viruses-Basel. 10, 3, p. 114

    Research output: Contribution to journalArticle

  6. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation

    Nabeebaccus, A. A., Zoccarato, A., Hafstad, A. D., Santos, C. X., Aasum, E., Brewer, A. C., Zhang, M., Beretta, M., Yin, X., West, J. A., Schröder, K., Griffin, J. L., Eykyn, T. R., Abel, E. D., Mayr, M. & Shah, A. M., 21 Dec 2017, In : JCI Insight. 2, 24

    Research output: Contribution to journalArticle

  7. Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling

    Tsionou, M. I., Knapp, C. E., Foley, C. A., Munteanu, C. R., Cakebread, A., Imberti, C., Eykyn, T. R., Young, J. D., Paterson, B. M., Blower, P. J. & Ma, M. T., 25 Oct 2017, In : RSC Advances. 7, 78, p. 49586-49599

    Research output: Contribution to journalArticle

  8. Magnetic Resonance Spectroscopy to Study Glycolytic Metabolism During Autophagy

    Chung, Y-L., Leach, M. O. & Eykyn, T. R., 2017, Methods in Enzymology. Elsevier, Vol. 588. p. 133-153 21 p. http://dx.doi.org/10.1016/bs.mie.2016.09.078

    Research output: Chapter in Book/Report/Conference proceedingChapter

  9. Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

    Zervou, S., Yin, X., A. Nabeebaccus, A., O'Brien, B., L. Cross, R., McAndrew, D. J., Atkinson, A., Eykyn, T., Mayr, M., Neubauer, S. & Lygate, C. A., 3 May 2016, In : AMINO ACIDS. p. 1-13 13 p.

    Research output: Contribution to journalArticle

  10. Modeling non-linear kinetics of hyperpolarized [1-13 C] pyruvate in the crystalloid-perfused rat heart

    Mariotti, E., Orton, M. R., Eerbeek, O., Ashruf, J. F., Zuurbier, C. J., Southworth, R. & Eykyn, T. R., 18 Jan 2016, In : NMR in Biomedicine. 10 p.

    Research output: Contribution to journalArticle

  11. Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation: Heart rhythm and function assay

    Wilder, C. D. E., Masoud, R., Yazar, D., O'Brien, B. A., Eykyn, T. R. & Curtis, M. J., 1 Jan 2016, In : British Journal of Pharmacology. 173, 1, p. 39-52 14 p.

    Research output: Contribution to journalArticle

  12. Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart

    Nabeebaccus, A., Hafstad, A., Eykyn, T., Yin, X., Brewer, A., Zhang, M., Mayr, M. & Shah, A., 26 Feb 2015, In : Lancet. 385 Suppl 1, p. S73

    Research output: Contribution to journalArticle

  13. Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

    Al-Saffar, N. M. S., Marshall, L. V., Jackson, L. E., Balarajah, G., Eykyn, T. R., Agliano, A., Clarke, P. A., Jones, C., Workman, P., Pearson, A. D. J. & Leach, M. O., 1 Aug 2014, In : PL o S One . 9, 8, 14 p., e103835.

    Research output: Contribution to journalArticle

  14. Dichloroacetate induces autophagy in colorectal cancer cells and tumours

    Lin, G., Hill, D. K., Andrejeva, G., Boult, J. K. R., Troy, H., Fong, A-C. L. F. W. T., Orton, M. R., Panek, R., Parkes, H. G., Jafar, M., Koh, D-M., Robinson, S. P., Judson, I. R., Griffiths, J. R., Leach, M. O., Eykyn, T. R. & Chung, Y-L., 15 Jul 2014, In : BJC: British Journal of Cancer. 111, 2, p. 375-385 11 p.

    Research output: Contribution to journalArticle

  15. Detection of the Prodrug-Activating Enzyme Carboxypeptidase G2 Activity with Chemical Exchange Saturation Transfer Magnetic Resonance

    Jamin, Y., Eykyn, T. R., Poon, E., Springer, C. J. & Robinson, S. P., Apr 2014, In : MOLECULAR IMAGING AND BIOLOGY. 16, 2, p. 152-157 6 p., N/A.

    Research output: Contribution to journalArticle

  16. Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady-State H-1-MRS and Real-Time Hyperpolarized C-13-MRS Studies

    Lin, G., Andrejeva, G., Te Fong, A-C. W., Hill, D. K., Orton, M. R., Parkes, H. G., Koh, D-M., Robinson, S. P., Leach, M. O., Eykyn, T. R. & Chung, Y-L., 25 Mar 2014, In : PL o S One . 9, 3, 12 p., e92645.

    Research output: Contribution to journalArticle

  17. Model free approach to kinetic analysis of real-time hyperpolarized (13)c magnetic resonance spectroscopy data

    Hill, D. K., Orton, M. R., Mariotti, E., Boult, J. K. R., Panek, R., Jafar, M., Parkes, H. G., Jamin, Y., Miniotis, M. F., Al-Saffar, N. M. S., Beloueche-Babari, M., Robinson, S. P., Leach, M. O., Chung, Y-L. & Eykyn, T. R., 4 Sep 2013, In : PLoS ONE. 8, 9, p. N/A 9 p., e71996.

    Research output: Contribution to journalArticle

  18. MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells

    Falck Miniotis, M., Arunan, V., Eykyn, T. R., Marais, R., Workman, P., Leach, M. O. & Beloueche-Babari, M., 1 Jul 2013, In : Cancer Research. 73, 13, p. 4039-49 11 p.

    Research output: Contribution to journalArticle

  19. Developing Hyperpolarized C-13 Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart

    Weiss, K., Mariotti, E., Hill, D. K., Orton, M. R., Dunn, J. T., Medina, R. A., Southworth, R., Kozerke, S. & Eykyn, T. R., Jul 2012, In : APPLIED MAGNETIC RESONANCE. 43, 1-2, p. 275-288 14 p.

    Research output: Contribution to journalArticle

  20. Dynamic Nuclear Polarization and MRI for the study of cardiac metabolism

    Eykyn, T., Southworth, R. & Kozerke, S., 2012, In : Heart and Metabolism. 55, p. 13-17 5 p.

    Research output: Contribution to journalArticle

  21. The effect of experimental conditions on the detection of spermine in cell extracts and tissues

    Spencer, NG., Eykyn, TR., DeSouza, NM. & Payne, GS., Feb 2010, In : Nmr in Biomedicine. 23, 2, p. 163 - 169 7 p.

    Research output: Contribution to journalArticle

  22. Detection of cancer in cervical tissue biopsies using mobile lipid resonances measured with diffusion-weighted 1H magnetic resonance spectroscopy

    Zietkowski, D., Davidson, RL., Eykyn, TR., De Silva, SS., DeSouza, NM. & Payne, GS., 2010, In : Nmr in Biomedicine. 23, 4, p. 382 - 390 9 p.

    Research output: Contribution to journalArticle

  23. Modulating the relaxivity of hyperpolarized substrates with gadolinium contrast agents

    Gabellieri, C., Leach, MO. & Eykyn, TR., May 2009, In : Contrast Media & Molecular Imaging. 4, 3, p. 143 - 147 5 p.

    Research output: Contribution to journalArticle

  24. Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity

    Jamin, Y., Gabellieri, C., Smyth, L., Reynolds, S., Robinson, SP., Springer, CJ., Leach, MO., Payne, GS. & Eykyn, TR., 2009, In : Magnetic Resonance in Medicine. 62, 5, p. 1300 - 1304 5 p.

    Research output: Contribution to journalArticle

  25. Modulation of choline kinase activity in human cancer cells observed by dynamic 31P NMR

    Gabellieri, C., Beloueche-Babari, M., Jamin, Y., Payne, GS., Leach, MO. & Eykyn, TR., 2009, In : Nmr in Biomedicine. 22, 4, p. 456 - 461 6 p.

    Research output: Contribution to journalArticle

  26. Therapeutic target metabolism observed using hyperpolarized 15N choline

    Gabellieri, C., Reynolds, S., Lavie, A., Payne, GS., Leach, MO. & Eykyn, TR., 9 Apr 2008, In : Journal of the American Chemical Society. 130, 14, p. 4598 - 4599 2 p.

    Research output: Contribution to journalArticle

  27. Conformational exchange in pimonidazole--a hypoxia marker

    Gabellieri, C., Eykyn, TR. & Leach, MO., Aug 2007, In : Magnetic Resonance in Chemistry. 45, 8, p. 621 - 623 3 p.

    Research output: Contribution to journalArticle

  28. Selective homonuclear Hartmann-Hahn for C-13 -> C-13 polarization transfer in solution state NMR

    Eykyn, TR. & Leach, MO., 2007, In : Molecular Physics. 105, 13-14, p. 1827 - 1832 6 p.

    Research output: Contribution to journalArticle

  29. Adiabatic half-passage pulses for measuring the polarization of highly non-equilibrium spin-systems

    Oregioni, A., Eykyn, T., Hosny, N., Payne, GS. & Leach, MO., 3 Oct 2005, In : CHEMICAL PHYSICS LETTERS. 414, 1-3, p. 102-106 5 p.

    Research output: Contribution to journalArticle

  30. Measurement of compartment size in q-space experiments: Fourier transform of the second derivative

    Kuchel, PW., Eykyn, TR. & Regan, DG., Oct 2004, In : Magnetic Resonance in Medicine. 52, 4, p. 907 - 912 6 p.

    Research output: Contribution to journalArticle

  31. Frequency-switched single-transition cross-polarization: a tool for selective experiments in biomolecular NMR

    Ferrage, F., Eykyn, TR. & Bodenhausen, G., 23 Jan 2004, In : ChemPhysChem. 5, 1, p. 76 - 84 9 p.

    Research output: Contribution to journalArticle

  32. Scalar couplings as pH probes in compartmentalized biological systems: 31P NMR of phosphite

    Eykyn, TR. & Kuchel, PW., 1 Oct 2003, In : Magnetic Resonance in Medicine. 50, 4, p. 693 - 696 4 p.

    Research output: Contribution to journalArticle

  33. Selective cross-polarization in solution state nuclear magnetic resonance of scalar coupled spin 1/2 and quadrupolar nuclei

    Eykyn, TR., Philp, DJ. & Kuchel, PW., 15 Apr 2003, In : Journal of Chemical Physics. 118, 15, p. 6997 - 7004 8 p.

    Research output: Contribution to journalArticle

  34. Quasi-isotropic single-transition cross-polarization in nuclear magnetic resonance

    Eykyn, TR., Ferrage, F. & Bodenhausen, G., 23 Jun 2002, In : Journal of Chemical Physics. 116, 23, p. 10041 - 10050 10 p.

    Research output: Contribution to journalArticle

  35. Highly selective excitation in biomolecular NMR by frequency-switched single-transition cross-polarization

    Ferrage, F., Eykyn, TR. & Bodenhausen, G., 13 Mar 2002, In : Journal of the American Chemical Society. 124, 10, p. 2076 - 2077 2 p.

    Research output: Contribution to journalArticle

  36. Single-transition coherence transfer by adiabatic cross polarization in NMR

    Eykyn, TR., Ferrage, F., Winterfors, E. & Bodenhausen, G., 15 Dec 2000, In : Chemphyschem : A European journal of chemical physics and physical chemistry. 1, 4, p. 217 - 221 5 p.

    Research output: Contribution to journalArticle

  37. Coherence Transfer by Single-Transition Cross-Polarization: Quantitation of Cross-Correlation Effects in Nuclear Magnetic Resonance

    Ferrage, F., Eykyn, TR. & Bodenhausen, G., 15 Jul 2000, In : Journal of Chemical Physics. 113, 3, p. 1081 - 1087 7 p.

    Research output: Contribution to journalArticle

  38. Identification of spin diffusion pathways in isotopically labeled biomolecules

    Eykyn, TR., Fruh, D. & Bodenhausen, G., Jun 1999, In : Journal of Magnetic Resonance. 138, 2, p. 330 - 333 4 p.

    Research output: Contribution to journalArticle

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