King's College London

Research portal

Dr Thomas Eykyn

  1. Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy

    Xavier, A., Zacconi, F., Santana-Romo, F., Eykyn, T. R., Lavin, B., Phinikaridou, A., Botnar, R., Uribe, S., Oyarzún, J. E., Cabrera, D., Arrese, M. & Andia, M. E., 1 Nov 2021, In: Annals Of Hepatology. 25, 100358.

    Research output: Contribution to journalArticlepeer-review

  2. SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens

    Chung, Y. J., Park, K. C., Tokar, S., Eykyn, T., Fuller, W., Pavlovic, D., Swietach, P. & Shattock, M., 17 May 2021, (Accepted/In press) In: Cardiovascular Research.

    Research output: Contribution to journalLetterpeer-review

  3. Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart

    Zervou, S., McAndrew, D. J., Whittington, H. J., Lake, H. A., Park, K. C., Cha, K. M., Ostrowski, P. J., Eykyn, T. R., Schneider, J. E., Neubauer, S. & Lygate, C. A., 31 Mar 2021, In: Frontiers in Physiology. 12, 623969.

    Research output: Contribution to journalArticlepeer-review

  4. Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy

    Fernandez-Caggiano, M., Kamynina, A., Francois, A. A., Prysyazhna, O., Eykyn, T. R., Krasemann, S., Crespo-Leiro, M. G., Vieites, M. G., Bianchi, K., Morales, V., Domenech, N. & Eaton, P., Nov 2020, In: Nature Metabolism. 2, 11, p. 1223-1231 9 p.

    Research output: Contribution to journalArticlepeer-review

  5. Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

    Ng, T., Eykyn, T., Mustapha, R., Barber, P., Green, R., Male, V., Fruhwirth, G., Brindle, K. M., Gomez, V., Flores-Borja, F., Panagaki, F. & Ros, S., 6 Oct 2020, In: Science Signaling. 13, 652, 37 p., eaax4585.

    Research output: Contribution to journalArticlepeer-review

  6. Intracellular sodium elevation reprograms cardiac metabolism

    Aksentijević, D., Karlstaedt, A., Basalay, M. V., O'Brien, B. A., Sanchez-Tatay, D., Eminaga, S., Thakker, A., Tennant, D. A., Fuller, W., Eykyn, T. R., Taegtmeyer, H. & Shattock, M., 28 Aug 2020, In: Nature Communications. 11, 1, 14 p., 4337.

    Research output: Contribution to journalArticlepeer-review

  7. [68Ga]Ga-THP-Pam: A Bisphosphonate PET tracer with Facile Radiolabelling and Broad Calcium Mineral Affinity

    Keeling, G. P., Sherin, B., Kim, J., Sanjuan, B., Grus, T., Eykyn, T. R., Roesch, F., Smith, G., Blower, P. J., Terry, S. Y. A. & T M de Rosales, R., 6 Aug 2020, In: Bioconjugate Chemistry.

    Research output: Contribution to journalArticlepeer-review

  8. Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice

    Aksentijević, D., Zervou, S., Eykyn, T. R., McAndrew, D. J., Wallis, J., Schneider, J. E., Neubauer, S. & Lygate, C. A., 21 Jan 2020, In: Frontiers in Physiology. 10, 1535.

    Research output: Contribution to journalArticlepeer-review

  9. Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue

    Faulkes, C. G., Eykyn, T. R. & Aksentijevic, D., 1 Nov 2019, In: BIOLOGY LETTERS. 15, 11, 20190710.

    Research output: Contribution to journalArticlepeer-review

  10. Is there a causal link between intracellular na elevation and metabolic remodelling in cardiac hypertrophy?

    Aksentijevic, D., O’Brien, B. A., Eykyn, T. R. & Shattock, M. J., 3 Jul 2018, In: Biochemical Society Transactions. 46, 4, p. 817-827 11 p.

    Research output: Contribution to journalReview articlepeer-review

  11. Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion

    Whittington, H. J., Ostrowski, P. J., McAndrew, D. J., Cao, F., Shaw, A., Eykyn, T. R., Lake, H. A., Tyler, J., Schneider, J. E., Neubauer, S., Zervou, S. & Lygate, C. A., 1 May 2018, In: Cardiovascular Research. 114, 6, p. 858-869 12 p.

    Research output: Contribution to journalArticlepeer-review

  12. Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1

    Kavanagh Williamson, M., Coombes, N., Juszczak, F., Athanasopoulos, M., Khan, M., Eykyn, T., Srenathan, U., Taams, L., Dias Zeidler, J., Da Poian, A. & Huthoff, H., 7 Mar 2018, In: Viruses-Basel. 10, 3, p. 114

    Research output: Contribution to journalArticlepeer-review

  13. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation

    Nabeebaccus, A. A., Zoccarato, A., Hafstad, A. D., Santos, C. X., Aasum, E., Brewer, A. C., Zhang, M., Beretta, M., Yin, X., West, J. A., Schröder, K., Griffin, J. L., Eykyn, T. R., Abel, E. D., Mayr, M. & Shah, A. M., 21 Dec 2017, In: JCI Insight. 2, 24, p. 1-16 10.1172/jci.insight.96184.

    Research output: Contribution to journalArticlepeer-review

  14. Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling

    Tsionou, M. I., Knapp, C. E., Foley, C. A., Munteanu, C. R., Cakebread, A., Imberti, C., Eykyn, T. R., Young, J. D., Paterson, B. M., Blower, P. J. & Ma, M. T., 25 Oct 2017, In: RSC Advances. 7, 78, p. 49586-49599

    Research output: Contribution to journalArticlepeer-review

  15. Magnetic Resonance Spectroscopy to Study Glycolytic Metabolism During Autophagy

    Chung, Y-L., Leach, M. O. & Eykyn, T. R., 2017, Methods in Enzymology. Elsevier, Vol. 588. p. 133-153 21 p. http://dx.doi.org/10.1016/bs.mie.2016.09.078

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  16. Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

    Zervou, S., Yin, X., A. Nabeebaccus, A., O'Brien, B., L. Cross, R., McAndrew, D. J., Atkinson, A., Eykyn, T., Mayr, M., Neubauer, S. & Lygate, C. A., 3 May 2016, In: AMINO ACIDS. p. 1-13 13 p.

    Research output: Contribution to journalArticlepeer-review

  17. Modeling non-linear kinetics of hyperpolarized [1-13 C] pyruvate in the crystalloid-perfused rat heart

    Mariotti, E., Orton, M. R., Eerbeek, O., Ashruf, J. F., Zuurbier, C. J., Southworth, R. & Eykyn, T. R., 18 Jan 2016, In: NMR in Biomedicine. 10 p.

    Research output: Contribution to journalArticlepeer-review

  18. Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation: Heart rhythm and function assay

    Wilder, C. D. E., Masoud, R., Yazar, D., O'Brien, B. A., Eykyn, T. R. & Curtis, M. J., 1 Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 39-52 14 p.

    Research output: Contribution to journalArticlepeer-review

  19. Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart

    Nabeebaccus, A., Hafstad, A., Eykyn, T., Yin, X., Brewer, A., Zhang, M., Mayr, M. & Shah, A., 26 Feb 2015, In: Lancet. 385 Suppl 1, p. S73

    Research output: Contribution to journalArticlepeer-review

  20. Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

    Al-Saffar, N. M. S., Marshall, L. V., Jackson, L. E., Balarajah, G., Eykyn, T. R., Agliano, A., Clarke, P. A., Jones, C., Workman, P., Pearson, A. D. J. & Leach, M. O., 1 Aug 2014, In: PL o S One . 9, 8, 14 p., e103835.

    Research output: Contribution to journalArticlepeer-review

  21. Dichloroacetate induces autophagy in colorectal cancer cells and tumours

    Lin, G., Hill, D. K., Andrejeva, G., Boult, J. K. R., Troy, H., Fong, A-C. L. F. W. T., Orton, M. R., Panek, R., Parkes, H. G., Jafar, M., Koh, D-M., Robinson, S. P., Judson, I. R., Griffiths, J. R., Leach, M. O., Eykyn, T. R. & Chung, Y-L., 15 Jul 2014, In: BJC: British Journal of Cancer. 111, 2, p. 375-385 11 p.

    Research output: Contribution to journalArticlepeer-review

  22. Detection of the Prodrug-Activating Enzyme Carboxypeptidase G2 Activity with Chemical Exchange Saturation Transfer Magnetic Resonance

    Jamin, Y., Eykyn, T. R., Poon, E., Springer, C. J. & Robinson, S. P., Apr 2014, In: MOLECULAR IMAGING AND BIOLOGY. 16, 2, p. 152-157 6 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  23. Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady-State H-1-MRS and Real-Time Hyperpolarized C-13-MRS Studies

    Lin, G., Andrejeva, G., Te Fong, A-C. W., Hill, D. K., Orton, M. R., Parkes, H. G., Koh, D-M., Robinson, S. P., Leach, M. O., Eykyn, T. R. & Chung, Y-L., 25 Mar 2014, In: PL o S One . 9, 3, 12 p., e92645.

    Research output: Contribution to journalArticlepeer-review

  24. Cardiac Hypoxia Imaging: Second Generation Analogues of 64Cu-ATSM

    Handley, M. G., Medina, R. A., Mariotti, E., Kenny, G. D., Shaw, K. P., Yan, R., Eykyn, T. R., Blower, P. J. & Southworth, R., Mar 2014, In: Journal of Nuclear Medicine. 55, 3, p. 488-494

    Research output: Contribution to journalArticlepeer-review

  25. Assessing radiotracer kinetics in the Langendorff perfused heart

    Mariotti, E., Veronese, M., Dunn, J. T., Medina, R. A., Blower, P. J., Southworth, R. & Eykyn, T. R., 14 Nov 2013, In: EJNMMI Research. 3, N/A, p. N/A 14 p., 74.

    Research output: Contribution to journalArticlepeer-review

  26. Model free approach to kinetic analysis of real-time hyperpolarized (13)c magnetic resonance spectroscopy data

    Hill, D. K., Orton, M. R., Mariotti, E., Boult, J. K. R., Panek, R., Jafar, M., Parkes, H. G., Jamin, Y., Miniotis, M. F., Al-Saffar, N. M. S., Beloueche-Babari, M., Robinson, S. P., Leach, M. O., Chung, Y-L. & Eykyn, T. R., 4 Sep 2013, In: PLoS ONE. 8, 9, p. N/A 9 p., e71996.

    Research output: Contribution to journalArticlepeer-review

  27. MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells

    Falck Miniotis, M., Arunan, V., Eykyn, T. R., Marais, R., Workman, P., Leach, M. O. & Beloueche-Babari, M., 1 Jul 2013, In: Cancer Research. 73, 13, p. 4039-49 11 p.

    Research output: Contribution to journalArticlepeer-review

  28. Exploring detection limits of cardiac ischemia using dynamic imaging of hyperpolarized 13C pyruvate

    Mariotti, E., Weiss, K., Kozerke, S. & Eykyn, T., Apr 2013, International Society of Magnetic Resonance in Medicine (ISMRM).

    Research output: Chapter in Book/Report/Conference proceedingPoster abstract

  29. Laplace Inversion for Kinetic Analysis of Hyperpolarized 13C data without a priori knowledge using Hybrid Maximum Entropy Method (MEM)/Non-Linear Least Square (NLS)

    Mariotti, E., Shaughnessy, F., Medina, R., Dunn, J., Southworth, R. & Eykyn, T., Apr 2013, International Society of Magnetic Resonance in Medicine (ISMRM).

    Research output: Chapter in Book/Report/Conference proceedingPoster abstract

  30. Developing Hyperpolarized C-13 Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart

    Weiss, K., Mariotti, E., Hill, D. K., Orton, M. R., Dunn, J. T., Medina, R. A., Southworth, R., Kozerke, S. & Eykyn, T. R., Jul 2012, In: APPLIED MAGNETIC RESONANCE. 43, 1-2, p. 275-288 14 p.

    Research output: Contribution to journalArticlepeer-review

  31. Dynamic Nuclear Polarization and MRI for the study of cardiac metabolism

    Eykyn, T., Southworth, R. & Kozerke, S., 2012, In: Heart and Metabolism. 55, p. 13-17 5 p.

    Research output: Contribution to journalArticlepeer-review

  32. The effect of experimental conditions on the detection of spermine in cell extracts and tissues

    Spencer, NG., Eykyn, TR., DeSouza, NM. & Payne, GS., Feb 2010, In: Nmr in Biomedicine. 23, 2, p. 163 - 169 7 p.

    Research output: Contribution to journalArticlepeer-review

  33. Comparison of NMR lipid profiles in mitotic arrest and apoptosis as indicators of drug resistance

    Zietkowski, D., Eykyn, TR., Beloueche-Babari, M., Payne, GS., Mobberley, MA., Ryder, TA. & DeSouza, NM., 2010, In: Proceedings American Association for Cancer Research Annual Meeting. 51, p. 13 - 14 2 p.

    Research output: Contribution to journalMeeting abstract

  34. Detection of cancer in cervical tissue biopsies using mobile lipid resonances measured with diffusion-weighted 1H magnetic resonance spectroscopy

    Zietkowski, D., Davidson, RL., Eykyn, TR., De Silva, SS., DeSouza, NM. & Payne, GS., 2010, In: Nmr in Biomedicine. 23, 4, p. 382 - 390 9 p.

    Research output: Contribution to journalArticlepeer-review

  35. Modulating the relaxivity of hyperpolarized substrates with gadolinium contrast agents

    Gabellieri, C., Leach, MO. & Eykyn, TR., May 2009, In: Contrast Media & Molecular Imaging. 4, 3, p. 143 - 147 5 p.

    Research output: Contribution to journalArticlepeer-review

  36. Assessment of pyuvate dehydrogenase kinase inhibition by dichloroacetate in human colon carcinoma cells by dynamic hyperpolarized 13C MRS and steady state 1H MRS

    Chung, YL., Troy, H., Judson, IR., Griffiths, JR., Leach, MO. & Eykyn, TR., 2009, In: MOLECULAR CANCER THERAPEUTICS. 8, 12, p. A72

    Research output: Contribution to journalMeeting abstract

  37. Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity

    Jamin, Y., Gabellieri, C., Smyth, L., Reynolds, S., Robinson, SP., Springer, CJ., Leach, MO., Payne, GS. & Eykyn, TR., 2009, In: Magnetic Resonance in Medicine. 62, 5, p. 1300 - 1304 5 p.

    Research output: Contribution to journalArticlepeer-review

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